69 Works

Audience and Expert Perspectives on Second Screens

Gorkovenko & Taylor
This dataset contains transcripts of co-design workshops and expert interviews carried out as part of a research project exploring how second screens (i.e. devices used while watching television) could be used to support engagement with televised political debates. We conducted four two-hour workshops with 18 participants in total, where they discussed the issues with political discourse online at large and the opportunities for second screens. The discussions were structured around four open-ended topics: (1) content,...

Structural characterisation of a novel E3 ligase module and activity-based probe development for UBL E3 ligases

Lu Barnsby-Greer
E3 ligase enzymes are key regulators of many aspects of eukaryotic biology via the promotion of the ubiquitylation and subsequent degradation of proteins. There have been over 700 E3s identified within the ubiquitin system with diverse mechanisms of E3 ligase activity, however, significantly less have been identified for ubiquitin-like proteins. Recently developed activity-based probes allowed for the identification of novel E3 ligase proteins involved in the ubiquitin system that carry out unconventional ubiquitylation. The development...

A Study of Care Leavers Lived Experiences of Social Orphanhood in Latvia

Zoe Kessler
This study set out to investigate social orphanhood through narratives of young people with experiences of growing up in care in Latvia. The study uses the life histories of participants to explore the phenomenon of social orphans. To date, narratives about the lived experiences of social orphans in Latvia have been told in the third person as most studies have used methodologies that kept participants passive rather than active. In this study the research process...

New approaches to studying the GPI biosynthesis pathway in T. brucei: uncovering the missing links

Zhe Ji
Trypanosoma brucei is a protozoan that causes Human African Trypanosomiasis and nagana in cattle. The bloodstream form (BSF) of T. brucei has a dense surface-coat of variant surface glycoprotein (VSG) that acts as the first line of defence against the host immune system while the main cell surface glycoproteins of the procyclic form (PCF) are the procyclins. VSGs and procyclins are attached to the cell membrane through glycosylphosphatidylinositol (GPI) anchors. Despite its importance, the GPI...

The Development and Characterisation of a Novel and Modular Virus-like Particle Platform

Aleksandra Moleda

A study of teacher wellbeing in post-primary schools in the West of Ireland

Teresa Crawford
This thesis explores teacher wellbeing in two post-primary schools in the West of Ireland. The research was conducted using a qualitative case study methodology, through semi-structured interviews with twenty-six newly qualified and experienced teachers in two urban schools, one located in a disadvantaged area and the other in a middle-class area. Research on wellbeing suggests that it is a multi-dimensional concept and difficult to define despite a steep increase in scholarly research across a myriad...

Investigating the Effect of Cytokines on the Proliferation and Metabolism of Intraepithelial Lymphocytes

Nicole Salgado Fernandez
The gut is exposed constantly to invading bacterial populations and dietary antigens. To protect it from harm, a complex and diverse network of patrolling immune cells can be found spread throughout the gut and in specialized lymphoid structures. One immune cells type playing a key role in the protection and homeostasis of the gut, are the intraepithelial T-lymphocytes (IELs). This population of T cells, reside within the epithelial layer of the gut and are primarily...

Evaluation of the Clinical Efficacy of Cine CMR Texture Analysis in Myocardial Quantification

Ping Tie
Recently, researchers have reported the potential value of CMR texture, especially for evaluation of ischemic and non-ischemic cardiomyopathy. However, these studies were mostly based on more advanced CMR sequences, and focused on myocardial disease at a later stage. Just one paper reports the application of TA using conventional CINE CMR sequences, and only one paper mentions healthy population myocardial TA with a small cohort. There are three main aims of this thesis. Firstly, to explore...

Work related stress and wellbeing in critical care nurses and their relationship with patient safety

Carol Louise McCallum
Background: In the United Kingdom 2,460 per 100,000 nurses reported high work stress (Health & Safety Executive, 2020). The prevalence of work stress in critical care nurses (CCNs) is unknown. Despite a large literature base, the causes, and consequences of CCN work stress cannot be determined. Little is known of the effects of CCN work stress on patient outcomes. Methods: Phase I explored the work-related stress literature and identified measures to capture work-related stress and...

The Construction of the \"Mad\" Female Criminal in Medical Discourse and Legal Practice at London's Old Bailey, 1863-1913

Fiona Aisling MacHugh
This thesis looks at the practical application of medical discourse to women found insane at London’s Old Bailey between 1863 and1913. Through in-depth analysis of all cases of women found insane at the Old Bailey, 1863-1913, this PhD thesis analyses the various discourses, medical, legal and cultural which appear to have been applied to these women in order to achieve a successful insanity plea. Using trial transcripts, newspaper reports, and published medical discourse the thesis...

Investigation of the biofilm contributing eps gene operon of Bacillus subtilis

Jonathan William Archibald Blackburn

An exploration of technologies for targeted protein modification

Luke Martin Simpson
Targeted protein degradation (TPD) is a promising strategy for both therapeutics and research, providing new opportunities to overcome some of the current limitations associated with traditional small-molecule therapeutics, RNA interference (RNAi) and genome editing approaches. Proteolysis-targeting chimeras (PROTACs) are typically heterobifunctional molecules which bring a protein of interest (POI) into spatial proximity of an E3 ubiquitin ligase, triggering POI ubiquitylation and proteasomal degradation. The Sapkota lab previously developed an affinity-directed protein missile (AdPROM) system for...

Investor and Assuror perspectives on materiality for sustainability reporting: An exploratory case study of Nigeria's oil and gas industry

Osai Simeon Nnodim
This thesis utilises the materiality concept of accounting to investigate institutional investor and assuror practitioner perspectives on sustainability reporting in the Nigerian oil and gas sector. The outcome of this investigation is expected to provide some insight into the prospects of success for the Nigerian financial sector’s drive to normalise sustainability reporting. For this purpose, a qualitative case study research was undertaken, which involved interviews of investors in decision making roles and auditors with social...

Drug target deconvolution in Leishmania donovani

Luciana De Sousa Paradela
The lack of robustly validated drug targets in Leishmania spp. is a major impediment to the discovery of new drugs and effective treatments for leishmaniasis. Here, 6 phenotypically-active anti-leishmanial compounds were selected from GSKs Kinetobox compound collections for subsequent target deconvolution studies. The principal aim of these studies was to identify molecular targets that can be exploited by subsequent target-focused anti-leishmanial drug discovery. Using multiple orthogonal genome-wide genetic, chemical proteomic and biochemistry-based approaches, two compounds...

Tweets from #leadersdebate (2015 UK General Election TV Debates)

Nick Taylor
Tweets using #leadersdebate hashtag collected during ITV Leader's Debate on 2nd April 2015 in the lead-up to the 2015 UK General Election. 100 tweets were requested from the Search API every 30 seconds, beginning at the start of the debate and continuing for approximately 90 minutes afterwards. Retweets were excluded. 772 tweets (every 20th message) were analysed and are provided here. Due to licensing restrictions, only the tweet IDs can be made available. Users of...

Charting the Digital Lifespan Work Package 1 Interview Guides: Digital Experience at Life Transitions 2

Kathryn Orzech & Wendy Moncur
This file includes the interview guides from the EPSRC-funded Charting the Digital Lifespan project [PI: Moncur. EPSRC Reference EP/L00383X/1]. This project investigated digital personhood and digital experience at the life transitions of leaving secondary school, becoming a parent, and retiring from work in the UK. This file contains three Interview guides, used to structure interviews with individuals at each life transition point. The guides set out questions and also notes (including types of internet activity...

Ardler Inventor Days

Loraine Clarke & Nick Taylor
Anonymised data collected from a one-day Inventor Kits workshop held as part of the EPSRC Hacking for Situated Civic Engagement projects. The dataset includes transcripts of interviews held with participants and researchers after the event. Further information about this work can be found in: Taylor, N., Clarke, L., Skelly, M. and Nevay, S. (2018). Strategies for engaging communities in creating physical civic technologies. Proceedings of CHI 2018.

Multiscale modelling of cancer evolution: the role of fibres and macrophages in invasion patterns

Szabolcs Süveges
The ability to invade its surrounding tissue is one of the acknowledged hallmarks of cancer. This complex multi-scale process is affected by many players of the tumour microenvironment (TME), including the extracellular matrix (ECM) and various stromal cells such as macrophages. One of these key processes is the secretion of matrix degrading enzymes that enables the degradation of the neighbouring ECM and cell-matrix adhesion. By varying the strength of cell-matrix and multiple cell-cell adhesions, cancer...

Individual and Work Environment Factors that Influence Nursing Faculties’ Well-being, Engagement and Intention to Remain

Alya Alghamdi
Background: Saudi Arabian higher education institutions are facing major problems in retaining nursing faculty members. The reasons for this are unclear and there is limited literature specific to the Middle East and Saudi Arabia. Methods/Design: This current study adopted a mixed methods approach (sequential, explanatory) to understand the factors that contribute to the retention of nursing staff in higher education institutions in Saudi Arabia. This research was carried out in four phases–two scoping and a...

Visual Narration in Comics and Graphic Novels

Yufei Gong
The past year I have investigated storyboards and the processes of visual narration. I have also looked at illustration, and the first experiment in photo-etching. I see visual narration as influenced by the camera's framing, and through the use of the imaginary camera, I have drawn storyboards and made many pages of compositions.

A Bliss Writing System

Palatuwa Nandadasa
Being able to communicate in the natural environment and sufficiently meet daily communication needs is the essence of communication. The majority of the population in the world does not think about the mechanics required to communicate effectively. However, there is a significant number of people who experience difficulties in communication due to speech and/or cognitive impairments. Alternative methods of communication can be used to help people with disabilities to maximise the competence of communication. These...

Patterns and Fronts in Cross-Diffusion Systems

Mohammed Aldandani
Reaction-diffusion systems continue to attract increasing attention from the scientific community, with investigators seeking insights into the patterns that occur in living organisms, in ecological systems, in geochemistry, and in physiochemical systems. Cross-diffusion is a special case of reaction-diffusion system and refers to the phe- nomenon in which a gradient in the concentration of one species induces a flux of another species. Pattern formation is a sub-area of complexity science, where non-linear spatial process dynamics...

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  • University of Dundee
  • University of Edinburgh
  • University of Franche-Comté
  • James Hutton Institute