The ability to invade its surrounding tissue is one of the acknowledged hallmarks of cancer. This complex multi-scale process is affected by many players of the tumour microenvironment (TME), including the extracellular matrix (ECM) and various stromal cells such as macrophages. One of these key processes is the secretion of matrix degrading enzymes that enables the degradation of the neighbouring ECM and cell-matrix adhesion. By varying the strength of cell-matrix and multiple cell-cell adhesions, cancer...