23,145 Works

Artesunate-amodiaquine is associated with reduced Ebola mortality

Etienne Gignoux, Andrew S Azman, Martin De Smet, Philippe Azuma, Josephus Bolongei, Moses Massaquoi, Dorian Job, Amanda Tiffany, Roberta Petrucci, Esther Sterk, Julien Potet, Motoi Suzuki, Andreas Kurth, Angela Cannas, Anne Bocquin, Thomas Strecker, Christopher Logue, Thomas Pottage, Constanze Yue, , Micaela Serafini &
Malaria treatment is recommended for all suspected cases of Ebola virus disease (EVD), either presumptively or based on malaria diagnosis. In Foya Ebola Management Centre (EMC), Lofa County, Liberia, the first-line anti-malarial, artemether-lumefantrine (AL), ran out for a 2-week period in August 2014. During this stock rupture, patients received artesunate-amodiaquine (ASAQ); amodiaquine is known to have anti-Ebola virus activity <i>in vitro</i>. We analysed routine programme data with the aim of determining the effect of malaria...

BioSolr – building better search for bioinformatics

Tony Burdett
BioSolr aims to significantly advance the state of the art with regard to indexing and querying biomedical data with freely available open source software.

The video of this presentation is available on the BOSC YouTube channel: view video.

Systematic exploration of guide-tree topology effects for small protein alignments

Fabian Sievers, Graham Hughes & Des Higgins
Guide-trees are used as part of an essential heuristic to enable the calculation of multiple sequence alignments. They have been the focus of much method development but there has been little effort at determining systematically, which guide-trees, if any, give the best alignments. Some guide-tree construction schemes are based on pair-wise distances amongst unaligned sequences. Others try to emulate an underlying evolutionary tree and involve various iteration methods.

In vivo whole-cell recording of neocortical neurons during cortical spreading depression

We use in vivo whole-cell electrophysiology to understand cellular and synaptic mechanisms post-spreading depolarization. Our findings provide the first in vivo whole-cell phenotype of cortical spreading depression. We show that spontaneous synaptic activity at the single-cell level is drastically reduced after the depolarization and intrinsic membrane properties are affected to a lesser extent.

Investigating intra-tumour heterogeneity in prostate cancer using structural variation

Marek Cmero, Niall Corcoran, Christopher Hovens, Ke Yuan, Florian Markowetz, &
Many approaches have arisen for inferring the evolutionary dynamics of tumour cell populations from point-mutation and copy-number data. However, there are currently no methods that incorporate structural variants (SVs). We present a method, SVClone, for inferring the subclonal make-up of tumour samples using large-scale genomic rearrangements obtained from whole-genome sequencing data. This approach is particularly useful for cancers driven by structural variation, such as prostate cancer.

Student Responses

Claire Hemingway, Catrina Adams & Molly Stuhlsatz
Anonymized, raw data of student responses to optional open-ended survey question administered online following secondary school students' participation in the online mentored inquiry experience.

Device Users

Lesley J. Morrell &
Responses to the questionnaire from students who used their own devices during the lectures Please see Contents_of_data_files.rtf in supplementary files for more details.

Updated data of Borrelia spirochetes in human vaginal and seminal secretions.

Marianne J. Middelveen, Jennie Burke, Eva Sapi, Cheryl Bandoski, Katherine R. Filush, , Agustin Franco, Arun Timmaraju, Hilary A. Schlinger, Peter J. Mayne & Raphael B. Stricker
The dataset contains data files 1, 2, 2a, 3, 3a, 4, 5, 5a, 6 and 7. Detailed legends for each files can be found in the text file provided.

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