3,349 Works

Core outcomes In neonatology: a core outcome set based on routinely collected data

James Webbe, Ginny Brunton, Shohaib Ali, Neena Modi & Chris Gale
Poster describing the development of a core outcome set for neonatal medicine which will identify which outcomes are most important to all affected by neonatal care.
This will facilitate evidence synthesis in neonatal medicine and be used to improve the national registry, audit and benchmarking processes.

Integrative analysis of expression profiles in healthy and preeclampsia-affected human placenta

Alina Frolova, Maria Obolenska, Judith E. Cartwright, Anne C. Staff, Ralf Dechend & Florian Herse
Here we performed direct integration of two independent microarray datasets: third-trimester placental samples obtained after cesarean sections from preeclamptic women (n = 25) and women with uncomplicated pregnancies (n = 23) and placental samples from gestational age matched first-trimester pregnancies with normal uterine artery Doppler resistance indexes (n = 11). By using differential expression analysis, gene set enrichment analysis and reconstruction of gene regulatory networks we obtained two networks that represent broad view of the...

Mutations, level of resistance and treatment outcomes of isoniazid-resistant tuberculosis in Brazil

Juliana Maira Watanabe Pinhata, Ana Angelica Bulcao Portela Lindoso, Maria Gisele Goncalves, Lucilaine Ferrazoli & Rosangela Siqueira De Oliveira
Mutations in katG and inhA, resistance levels and treatment outcomes of isoniazid-resistant TB patients from the state of São Paulo, Brazil, were described.

The quarter-ellipsoid foot: a clinically accessible 3-dimensional composite measure of foot deformation.

John J Fraser & Jay Hertel
The foot is an important structure that allows for bipedal standing and propulsion during gait. The architecture of the foot is comprised of two longitudinal arches and the transverse arches that normally deform during loading. Foot pliability varies by morphotype and is clinically important when managing foot and ankle pathology. The architecture of the foot can be characterized as being quarter-ellipsoid shaped that may be quantified to assess change in size and shape during loading....

PathSys: Integrating pathway curation, profiling methods, and public repositories: An infrastructure for functional molecular data sharing

Sokratis Kariotis, Gabriel Altschuler, Yered Pita-Juárez, Wenbin Wei & Winston Hide
Data integration at the level of high dimensional molecular interrogation is confounded by the diaspora of platforms and annotations of molecular events. To unify interpretation of functional activity within and between samples, we are developing a suite of tools that confer a highly standardised representation of pathway activity, networked pathway activity correlation, and pathway/disease/drug interaction. We have discovered that using the concept of higher order gene set interactions, using gene sets as the unit of...

Bolstering inter-observer differences to study the mechanisms behind perceptual bistability

Jan Brascamp, Mark W. Becker & David Z. Hambrick
Individuals systematically differ in the rate of perceptual changes when viewing ambiguous or conflicting visual stimuli. Some observers report more frequent changes, and may be called ‘fast switchers’; others are ‘slow switchers’. Previous research suggests that these individual differences during perceptual bistability could be related to differences in sensory adaptation and/or attentional processes. Here we investigate these possibilities by determining whether inter-observer variability in switch rate correlates with inter-observer differences on tasks designed to tap...

Referee report. For: Unintended consequences of machine learning in medicine? [version 1; referees: 1 approved]

Arturo Gonzalez-Izquierdo, Maria Pikoula & Spiros Denaxas

Keynote speech: Peter Redfield - Innovation Sans Frontières?

Peter Redfield
Presentation slides for Keynote Session 3.

Fine scale spatial variation in woody regeneration following ecologically based timber harvest

Skye M. Greenler & Mike R. Saunders
Canopy heterogeneity results from inherent landscape characteristics, such as slope, aspect, and soil type, and from transient environmental conditions created by weather and by natural and anthropogenic disturbances. In particular, disturbances dramatically alter the forest understory microenvironment, causing compositional shifts in the regeneration layer that influence the future forest canopy. However, the historic disturbance regime and the resulting understory conditions that led to current overstory communities are no longer observable or measurable, making them difficult...

Enrichment of PRC2-binding RNA motifs for RNA-mediated regulation

Haroon Naeem, Stuart Archer, David Powell & Chen Davidovich
Motivation: Polycomb repressive complex 2 (PRC2) has been discovered as an important chromatin regulator of epigenetic gene silencing. PRC2 functions by interacting with nascent RNAs, repressing thousands of target transcripts. However, little is known about how PRC2 identifies these RNAs.

Results: We empirically quantified the genome-wide and transcriptome-wide association between PRC2 and G-tract rich motifs of the sequences [GnNm]k, where G is a guanine and N can be any nucleotide. We show that motifs composed...

Very high and rapidly decreasing malnutrition and mortality in Banki IDP camp in northern Nigeria

Franck Ale, Bahya-Batinda Dang, Kaouther Chammam, Moussa Ousmane, Dorian Job, Geza Harczi, Klaudia Porten, Iza Ciglenecki, Hugues Robert-Nicoud, Florent Uzzeni & Etienne Gignoux
This presentation looks at malnutrition and mortality rates in Banki, Nigeria, attained from survey data.

Journal of Open Source Software (JOSS)

Arfon M Smith, Loreana A Barba, George Githinji, Melissa Gymrek, Kathryn D Huff, Daniel S Katz, Christopher R Madan, Abigail Cabunoc Mayes, Kevin M Moerman, Kyle E Niemeyer, Pjotr Prins, Karthik Ram, Ariel Rokem, Tracy K Teal, Roman Valls Guimera & Jacob T Vanderplas
Presenting JOSS at the Bioinformatics Open Source Conference.

Agricultural science: three bibliometric systems compared

Ellen Fest & Hugo Besemer
Wageningen University & Research (WUR) uses bibliometric analyses extensively to assess the scientific performance of research groups. Since we built our current systems two new systems became available on the market. We are considering whether to adopt one of these systems or stay with our current own. To inform that decision we have compared three bibliometric tools: The current system that uses Web of Science citation data and uses Essential Science Indicators as baselines. Scival...

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