207,314 Works


Tetrasilylmethane Derivatives: Syntheses, Structures and their Potential as Precursors to Silyl Cations

Karin Bätz
This thesis describes studies of the gas phase structures and dynamic behaviour of several tetrasilylmethane derivatives as well as the use of silanes bearing the trisyl ligand (Tsi), (Me3Si)3C-, or closely related ligands in attempts to prepare silyl cations R3Si+. Hydride abstraction reactions between the silanes TsiSiMe2H, TsiSi(OMe)2H, (PhMe2Si)3CSiMe2H and (Me3Si)2C(SiMe2H)2 and the trityl salt Ph3C+B(C6F5)4¯ in a chlorobenzene/toluene-d8 solvent mixture were carried out and monitored by 1H, 29Si and 13C NMR spectroscopy, which indicated...

C 8 H 8 O 1


Rossella Alfano


Henry Rzepa

I24 pbepbe/Def2-TZVPPD+PP + water, constrained to 74.1

Henry Rzepa
Gaussian Calculation

Investigating competitive interactions between normal and transformed neural stem cells

Katerina Marie Lawlor
Glioblastoma is the most aggressive subtype of malignant glioma and, despite intensive research efforts, has an extremely poor prognosis with a median survival of just 15 months. It has long been speculated that adult neural stem cells (NSCs) that reside in the subventricular zone (SVZ) of the brain could be the cell of origin in glioblastoma. Indeed, it has been demonstrated that murine SVZ NSCs, which have lost the Ink4a/Arf tumour suppressor locus and express...


Henry Rzepa

The UBE2L3 ubiquitin conjugating enzyme: interplay with inflammasome signalling and bacterial ubiquitin ligases

Matthew James George Eldridge
Inflammasome-controlled immune responses such as IL-1β release and pyroptosis play key roles in antimicrobial immunity and are heavily implicated in multiple hereditary autoimmune diseases. Despite extensive knowledge of the mechanisms regulating inflammasome activation, many downstream responses remain poorly understood or uncharacterised. The cysteine protease caspase-1 is the executor of inflammasome responses, therefore identifying and characterising its substrates is vital for better understanding of inflammasome-mediated effector mechanisms. Using unbiased proteomics, the Shenoy grouped identified the ubiquitin...

The use of satellite data, meteorology and land use data to define high resolution temperature exposure for the estimation of health effects in Italy

Francesca Katherine De' Donato
Introduction. Despite the mounting evidence on heat-related health risks, there is limited evidence in suburban and rural areas. The limited spatial resolution of temperature data also hinders the evidence of the differential heat effect within cities due to individual and area-based characteristics. Methods. Satellite land surface temperature (LST), observed meteorological and spatial and spatio-temporal land use data were combined in mixed-effects regression models to estimate daily mean air temperature with a 1x1km resolution for the...

Exploring the utility of metabolic profiling in stratifying patient groups in Inflammatory Bowel Disease

Lucy Charlotte Hicks
The pathogenesis of IBD, involving dynamic interactions between the microbiome, innate and adaptive immune systems, genetics and environmental factors, is a major focus of academic interest, in order to reveal more about the heterogeneous clinical course of the disease and in pursuit of improved therapeutic targets. Metabonomics has been previously used with a variety of biofluids to successfully distinguish IBD from controls, but the complex metabolic data also have potential to unlock insights into pathogenesis...


Henry Rzepa


Henry Rzepa


Henry Rzepa

Choreographing a chemical ballet: a story of the mechanism of 1,4-Michael addition.

Henry Rzepa


Dongmyung Park
1) Appraisal Criteria for Toolkits of 255 FFE Studies, 2) Analysis Table of Toolkits of 255 FFE Studies, 3) Analysis Pie Chart of Toolkits of 255 FFE Studies, 4) A List of FFE Studies


Dominic Wales

Layered double hydroxides (LDHs) – carbon nanostructure (CNS) composites: synthesis and application in base-catalysed condensation reactions

Nicolas Morales Vega
The activity and selectivity produced by novel Layered Double Hydroxides (LDH) supported in both multi-walled carbon nanotubes (MWNT) and graphene oxide (GO) was investigated for a set of base-catalysed aldol condensation reactions. The MWNT/LDH composites were studied in the self-condensation of acetone and retroaldolization of diacetone alcohol (DAA), while the GO/LDH materials were used in the latter reaction, as well as the benzaldehyde-acetone condensation, where the material was activated in-situ. The effect of carbon content...


Dominic Wales

Chemical and morphological stability of Perovskite and organic solar cells

Sebastian Andrew Victor Pont
The stability of perovskite and organic solar cells remains a major challenge to realise their potential. To overcome the numerous degradation mechanisms, it is important to understand the underlying causes. This thesis will present device and material characterisation on two areas: firstly, elucidating perovskite environmental stability and, secondly, the effects of PCBM dimerisation in organic solar cells. The first results chapter investigates the environmental stability of methylammonium lead iodide. In this thesis, degradation under light...

Molecular diversity of neurons in the ventral tegmental area and substantia nigra pars compacta

Eleanor Jane Paul
Neurons in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) are central to motivation and reward processing. These nuclei contain three core neuronal cell types: dopamine, GABA and glutamate (as well as combinatorial neurons). Dopamine neurons - the largest population - have been intensely studied, but little is known about the GABA neurons- the second largest population. They provide local inhibitory control of dopamine neurons with behavioural consequences, as well as sending...

Experimental investigation and numerical simulation of creep age forming with aluminium-copper-lithium alloy 2050

Yong Li
This thesis presents a comprehensive research on experimental investigation and numerical modelling of the creep-ageing behaviour of a newly developed Al-Cu-Li alloy, AA2050-T34, building a solid foundation for the alloy to be manufactured through creep age forming (CAF) technology for panel products in the aerospace industry. An experimental programme has been designed and carried out to investigate the creep deformation and age hardening behaviours of the alloy at 155 ºC under both tension and compression...

Identification and characterisation of novel T3SS effector proteins of Salmonella enterica serovar Typhi

Alexander Matthew Patrick Byrne
Salmonella enterica serovar Typhi (S. Typhi) is a Gram-negative, intracellular, human pathogen that is the causative agent of typhoid fever, responsible for 200,000 deaths worldwide, per year. Central to S. enterica pathogenesis are two type III secretion systems (T3SS), that are used to translocate up to 40 effector proteins to enable invasion, replication and manipulation of host immune responses. These proteins have been largely characterised in other S. enterica serovars and many are pseudogenes or...

Dataset for paper: \"Induced neural stem cell differentiation on a drawn fiber scaffold—toward peripheral nerve regeneration\"

Dominic Wales
This dataset contains the raw data and raw images that were used for the journal publication "Induced neural stem cell differentiation on a drawn fiber scaffold—toward peripheral nerve regeneration". A .txt file is included that states the contents of this dataset.

Thermodynamics of sensing, correlations and computation

Rory A. Brittain
In this thesis we discuss several aspects of the thermodynamics of information. In some cases this is motivated by its application to biological organisms. First we examine the interpretation of a quantity proposed to measure sensors and find that it is not a general measure of sensor quality in the steady state. Then we propose a biochemical version of the Szilard engine and use it as the basis for a simple feeding model of a...

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  • Imperial College London