(PLEASE NOTE: a newer version of this dataset (Version 2) is available. Please see the Links section for the link to access it.)R code to conduct a sex-stratified latent class analysis of trauma in the UK Biobank Mental Health Questionnaire cohort. Associations of resultant classes and recent/current mental health are explored using regressions. Associations of socio-demographic variables with class membership are additionally reported.

People of Medieval Scotland (PoMS) project is a database of all known people of Scotland between 1093 and 1314 mentioned in over 8600 contemporary legal documents. It has also recently been extended to 1371 to include all those lands, peoples and relationships mentioned in royal charters between 1314 and 1371. The People of Medieval Scotland website is an outcome of three projects: The Paradox of Medieval Scotland (2007-2010); The Breaking of Britain (2010-2013); and The...

Pentameric ligand-gated ion channels (pLGICs) are important neuroreceptors, embedded in neuronal membranes, that mediate fast synaptic transmission. The molecular details of their working mechanisms have still to be fully unravelled due to their complexity and limited structural information available. Here we focus on a potential molecular switch in a prototypical pLGIC, the serotonin-activated 5-HT3 receptor, consisting of the trans–cis isomerization of a proline at the interface between the extracellular and transmembrane domain. We investigate this...

This report presents the key findings of a small-scale research project exploring the mortality and health needs of clients of Tenancy Sustainment Team (TST) services. The research was commissioned in response to concerns by the Greater London Authority (GLA) and TST service managers about premature deaths among TST clients and the need to learn more about the health needs of this group, particularly the incidence of chronic or long-term health conditions (LTCs).

Dynamic PET & structural MRI images with accompanying blood sample data for repeatability study investigating human cerebral ammonia metabolism with 15O-H2O and 13N-NH3 PET tracers. Data from eight healthy subjects. Each subject had a 15O-H2O PET-CT brain scan followed by a 13N-NH3 scan; both scans repeated same day. Continuous and manual arterial blood sampling was acquired on all scans, with metabolite analysis on the NH3 scan blood manual samples. This data was used in the...

UK election 2015: setting the agenda builds on innovative work by Dr Martin Moore and Dr Gordon Ramsay started in January 2015. Using new methods for collecting and analysing news and social media content, the report provides a fresh perspective on how political communication is changing in the digital era. Moore and Ramsay began collecting and analysing media coverage of the UK 2015 election campaign at the beginning of 2015, using a software tool they...

Motivation: Computational models of the heart are increasingly being used in the development of devices, patient diagnosis and therapy guidance. While software techniques have been developed for simulating single hearts, there remain significant challenges in simulating cohorts of virtual hearts from multiple patients. Dataset Description: We present the first database of left-ventricular (LV) models suitable for electrophysiology simulations. Our database consists of twenty-four LV models including infarct scar morphology. These were generated from LGE-MRI acquired...

Pentameric ligand-gated ion channels (pLGICs) are important neuroreceptors, embedded in neuronal membranes, that mediate fast synaptic transmission. The molecular details of their working mechanisms have still to be fully unravelled due to their complexity and limited structural information available. Here we focus on a potential molecular switch in a prototypical pLGIC, the serotonin-activated 5-HT3 receptor, consisting of the trans–cis isomerization of a proline at the interface between the extracellular and transmembrane domain. We investigate this...

This study is about the new and growing phenomenon of global tech giants, their increasing civic power, and what this means for democracies. It might best be described as an essay, in the sense of an extended argument and a series of observations and provocations. It aims to open debate about the role of the tech giants – notably Google, Facebook, Apple and others – in democracy and civic life, as distinct from their impact...

We investigate, by means of molecular dynamics simulations, the behaviour of the lipid membrane at the interface with the pentameric ligand-gated ion channel 5-HT3 receptor. Three lipid compositions are studied, spanning different concentrations of the phospholipids POPC and POPE and of cholesterol, hence a range of viscosities. A variety of lipid interactions and persistent binding events to different parts of the receptor are revealed in the investigated models. Some of these events result in lipid...

This study presents the first work into the hand-sewing of electrodes for surface electromyography to assess its feasibility as an affordable, alternative means of production. In experiments reported here, batches of hand-sewn electrodes from Nm = 6 novice embroiderers are tested for (i) manufacturing consistency, and (ii) myographic data acquisition against conventional gelled and machine-sewn electrodes.

The Project Viennese musician and teacher Heinrich Schenker (1868-1935), the twentieth century's leading theorist of tonal music, produced a series of innovative studies and editions between 1903 and 1935, while exerting a powerful and sustained influence, directly and through his pupils, on the teaching of music from the 1930s onward in the USA, and since the 1970s in Europe and elsewhere. Schenker left behind approximately 130,000 manuscript and typescript leaves comprising unpublished works, preparatory materials,...

This report was commissioned by the BBC Trust in order to explore ways to better protect the BBC’s financial independence beyond Charter Renewal. The ideas presented in the report are derived from ten interviews with expert sources conducted for the study in October and November 2015, supplemented by relevant publicly available information. The study was completed in six weeks. The results presented here are intended to invite further debate and exploration of questions regarding the...

Background: Atrial anisotropy affects electrical propagation patterns, anchor locations of atrial reentrant drivers, and atrial mechanics. However, patient-specific atrial fibre fields and anisotropy measurements are not currently available, and consequently assigning fibre fields to atrial models is challenging. We aimed to construct an atrial fibre atlas from a high-resolution DTMRI dataset that optimally reproduces electrophysiology simulation predictions corresponding to patient-specific fibre fields, and to develop a methodology for automatically assigning fibres to patient-specific anatomies.Dataset Description:...

In this work, molecular dynamics simulations were carried out to study the dynamical properties of a monomer and a dimer of green fluorescent protein (GFP) in order to provide an in-silico validation of FRET (Förster resonance energy transfer) efficiency, calculated from the fit of the fluorescence anisotropy decays with a stretched exponential decay model. An excellent agreement was found between model and experiments. Dynamical insights on the dimer linker and on the protein tumbling were...