Pentameric ligand-gated ion channels (pLGICs) are important neuroreceptors, embedded in neuronal membranes, that mediate fast synaptic transmission. The molecular details of their working mechanisms have still to be fully unravelled due to their complexity and limited structural information available. Here we focus on a potential molecular switch in a prototypical pLGIC, the serotonin-activated 5-HT3 receptor, consisting of the trans–cis isomerization of a proline at the interface between the extracellular and transmembrane domain. We investigate this...

People of Medieval Scotland (PoMS) project is a database of all known people of Scotland between 1093 and 1314 mentioned in over 8600 contemporary legal documents. It has also recently been extended to 1371 to include all those lands, peoples and relationships mentioned in royal charters between 1314 and 1371. The People of Medieval Scotland website is an outcome of three projects: The Paradox of Medieval Scotland (2007-2010); The Breaking of Britain (2010-2013); and The...

Dynamic PET & structural MRI images with accompanying blood sample data for repeatability study investigating human cerebral ammonia metabolism with 15O-H2O and 13N-NH3 PET tracers. Data from eight healthy subjects. Each subject had a 15O-H2O PET-CT brain scan followed by a 13N-NH3 scan; both scans repeated same day. Continuous and manual arterial blood sampling was acquired on all scans, with metabolite analysis on the NH3 scan blood manual samples. This data was used in the...

Motivation: Computational models of the heart are increasingly being used in the development of devices, patient diagnosis and therapy guidance. While software techniques have been developed for simulating single hearts, there remain significant challenges in simulating cohorts of virtual hearts from multiple patients. Dataset Description: We present the first database of left-ventricular (LV) models suitable for electrophysiology simulations. Our database consists of twenty-four LV models including infarct scar morphology. These were generated from LGE-MRI acquired...

Pentameric ligand-gated ion channels (pLGICs) are important neuroreceptors, embedded in neuronal membranes, that mediate fast synaptic transmission. The molecular details of their working mechanisms have still to be fully unravelled due to their complexity and limited structural information available. Here we focus on a potential molecular switch in a prototypical pLGIC, the serotonin-activated 5-HT3 receptor, consisting of the trans–cis isomerization of a proline at the interface between the extracellular and transmembrane domain. We investigate this...

We investigate, by means of molecular dynamics simulations, the behaviour of the lipid membrane at the interface with the pentameric ligand-gated ion channel 5-HT3 receptor. Three lipid compositions are studied, spanning different concentrations of the phospholipids POPC and POPE and of cholesterol, hence a range of viscosities. A variety of lipid interactions and persistent binding events to different parts of the receptor are revealed in the investigated models. Some of these events result in lipid...

The Project Viennese musician and teacher Heinrich Schenker (1868-1935), the twentieth century's leading theorist of tonal music, produced a series of innovative studies and editions between 1903 and 1935, while exerting a powerful and sustained influence, directly and through his pupils, on the teaching of music from the 1930s onward in the USA, and since the 1970s in Europe and elsewhere. Schenker left behind approximately 130,000 manuscript and typescript leaves comprising unpublished works, preparatory materials,...

This study presents the first work into the hand-sewing of electrodes for surface electromyography to assess its feasibility as an affordable, alternative means of production. In experiments reported here, batches of hand-sewn electrodes from Nm = 6 novice embroiderers are tested for (i) manufacturing consistency, and (ii) myographic data acquisition against conventional gelled and machine-sewn electrodes.

Background: Atrial anisotropy affects electrical propagation patterns, anchor locations of atrial reentrant drivers, and atrial mechanics. However, patient-specific atrial fibre fields and anisotropy measurements are not currently available, and consequently assigning fibre fields to atrial models is challenging. We aimed to construct an atrial fibre atlas from a high-resolution DTMRI dataset that optimally reproduces electrophysiology simulation predictions corresponding to patient-specific fibre fields, and to develop a methodology for automatically assigning fibres to patient-specific anatomies.Dataset Description:...

The Project Mapping the Medieval Countryside is a major research project dedicated to creating a digital edition of the medieval English inquisitions post mortem (IPMs) from c. 1236 to 1509. IPMs recorded the lands held at their deaths by tenants of the crown. They comprise the most extensive and important body of source material for landholding in medieval England. Describing the lands held by thousands of families, from nobles to peasants, they are a key...

Studies of the methylation state of DNA preserved in oak heartwood can help identify epigenetic tree ring features informing on past environmental conditions. Heartwood contains little DNA; large amounts of phenolic compounds are known to hinder the preparation of high-throughput sequencing libraries. To complement experiments, we simulated the interaction of double-stranded DNA (dsDNA) with a potential PCR inhibitor, the phenolic compound ellagic acid, by molecular dynamics and metadynamics techniques. Specifically, we investigated with molecular dynamics:...