Modelling datasets are based on CT and echo images of patients. Computer simulations are performed using an in-house finite-element software (CHeart) in different configurations for each patient to simulate the blood flow changes induced by implantation of an artificial mitral valve. More specifically, the aim of this study is to investigate the effects on ventricular hemodynamics that a partial occlusion of the left ventricular outflow tract can cause as a result of the implantation of...

Retrospective analysis of 3 patient cases who underwent coronary computed tomography angiography at Guy’s and St Thomas’ NHS Foundation Trust was performed to generate computational models suitable for electromechanical finite element simulations. Therefore, images were segmented using a statistics-based approach and the smoothed voxel representations were discretized into high-resolution tetrahedral finite element meshes. The complex atrial myofiber architectures were estimated on the endo- and epicardial surfaces according to anatomical and morphological data utilizing a Laplace-based...