4,336 Works

Analysis of drug-protein adducts and their role in drug hypersensitivity.

AA Tailor
Idiosyncratic drug reactions are extremely severe and are not attributed to the normal pharmacology of a drug. Elucidating their toxicological mechanisms have been challenging. In recent years, idiosyncratic drug-induced liver injury (iDILI) has been linked with the immune system proposing that tissue damage may be mediated by the cytotoxicity of T-cells. Furthermore, several associations have been found with iDILI and gene polymorphisms which code for human leukocyte antigen (HLA). The hapten model of drug hypersensitivity...

Implementing computational techniques to investigate immune-mediated adverse drug reactions

G Ghattaoraya
The highly polymorphic human leukocyte antigens are an important player in the immune response against pathogens. However, the variability can also cause problems to patients, clinicians and drug manufacturers due to the phenomenon of immunologically based adverse drug reactions (ADRs) where the interaction between the drug and antigen presenting proteins can interfere with the body’s ability to recognise host cells leading the immune system to mount a response against the host. The underlying mechanisms by...

Efficient Manufacture of Emulsion Intermediates in Cavity-design Mixers

Ryan Burger
Emulsions are ubiquitous across the process industries and are often utilised in applications where controlled delivery of a key ingredient (e.g. an oil or water soluble compound) is an important consideration. Their functional properties e.g. the rate of absorption or coverage of a surface is generally determined by the size and size distribution of dispersed domains or microstructure. Control over the formulation, process route and type of equipment all influence the resulting microstructure. The focus...

Other people’s children: representations of paid-childcare in Britain, 1867-1908

James Hinks
This thesis critically examines how informal child-care, performed for money, was subject to sustained scrutiny between 1867-1908. This period saw women who took children into their home in exchange for payment being subject to judicial sanction,press comment and legislative intervention. The passage of the 1908 Children Act marked the point at which all women who took in children for money were subjected to legislation for the first time. Existing scholarship on this topic has largely...

Molecular ecological characterization of a honey bee ectoparasitic mite, Tropilaelaps mercedesae.

Xiaofeng Dong
Tropilaelaps mercedesae (small mite) is one of two major honey bee ectoparasitic mite species responsible for the colony losses of Apis mellifera in Asia. Although T. mercedesae mites are still restricted in Asia (except Japan), they may diffuse all over the world due to the ever-increasing global trade of live honey bees (ex. Varroa destructor). Understanding the ecological characteristics of T. mercedesae at molecular level could potentially result in improving the management and control programs....

Independent Sets in Line of Sight Networks

PS Sangha
In this thesis we study the maximum independent set problem in both 2 and higher dimensional line of sight networks. The maximum independent set problem seeks to find a largest set of pairwise disjoint vertices and we will study both the decision version and the optimisation version of the problem in this thesis. The line of sight network model was introduced to provide a model of geometric graph that incorporates both range and line of...

Factors that influence capital structure decisions between owners of family businesses and their administrators in medium sized organizations

B Tejuoso
Family businesses are known to have problems with capital structure decision making, and this is evident within the Nigerian family business context. While other areas in the family business field have been well studied, the factors that influence capital structure decisions have been grossly understudied; particularly from the perspective of family business owners and the administrators that manage their businesses. This dissertation addresses this understudied section in the family business literature while simultaneously addressing a...

Television Food Advertising to Children: Exposure, Power and Potential Consequences

R Whalen

Speed Sensorless Induction Motor Drive Control for Electric Vehicles

SJ Rind
Fast diminishing fossil fuel resources, deterioration in air quality and concerns for environmental protection, continuously promote the interest in the research and development of Alternative Energy Vehicles (AEVs). Traction motor drive is an integral part and common electric propulsion system in all kinds of AEVs. It plays an utmost significant role in the development of electrified transport industry. Application of Induction Motor (IM) drive is not only limited to the domestic and industrial applications but...

Bucolic Politics: The Administration of Sir Robert Walpole and the Rise of the Country Interest

P Sargeant
Through an examination of a variety letters and printed works, this thesis argues that the political influence of the Country interest during the administration of Robert Walpole has been systematically underestimated in the historiography. New and previously neglected archival sources have been uncovered to form a better understanding of how the Country interest operated during the period. The emergence of the Country helps to address wider historical issues, such as why a ‘rage of party’...

Fire and Herbivory in the Serengeti-Mara

JR Probert

Dynamic and static cues for binocular vision – a systematic comparison

L Tidbury
Background Patients who are diagnosed as stereo blind, during clinical assessment have reported a compelling, volumetric perception of depth during stereoscopic viewing at the cinema. This effect cannot entirely be explained by the monocular cues present in the cinematic presentation. This lead to the theory that depth from binocular cues may be more apparent when motion is included in the scene. As an object approaches in space is detected through the use of two binocular...

Recruitment to clinical trials in adult and child settings: qualitative case study in cystic fibrosis

Emma R Sowden

The nature of autonomy when living with dementia

SE Wolfe

\"It is filled with an assortment\": The Transmission of the Instruction of Ani and the Instruction of Amenemope

H Twiston-Davies
This thesis examines the textual traditions of two Late Egyptian wisdom texts: the Instruction of Amenemope and the Instruction of Ani. It hypothesises the scribal process of copying through text-critical techniques, and from the perspective of ‘Material Philology’. It does not attempt to create a stemma codicum or to reconstruct an Urtext, but considers the possible role of dictation and visual copying, in transmission, and how significant variations between manuscripts arose. The incidence of obvious...

Investigating the Effectiveness of Antiretroviral Therapy in sub-Saharan Africa

J Gini
Antiretroviral therapy (ART) has revolutionised outcomes of HIV infection among people living with HIV (PLWH). But despite these great strides, ongoing concerns of drug-drug interactions, widespread use of herbal medication while using ART, safety in pregnancy and breastfeeding are challenges of HIV treatment in PLWH. Potent new ART are not widely used in most low and middle income countries (LMIC) due to insufficient safety data and fear of adverse events. This Thesis aimed at evaluating...

Statin-associated muscle toxicity: clinical and genomic perspectives

Richard Myles Turner

Influence of Fluid-Structure Interaction on Human Eye Biomechanics Under Air Puff Non-Contact Tonometry

O Maklad
Biomechanical properties of biological tissues are important health indicators and multiple clinical decisions and surgical planning can be made based on their dynamic response to loading. But until now, some of the mechanical and dynamic responses are not fully understood due to the non-linearity and viscoelastic behaviour of biological tissues. The relevant biological tissues of interest in the current study are the cornea and sclera of the human ocular globe. Cornea contributes with two-thirds of...

Death in post-palatial Greece: Reinterpreting burial practices and social organisation after the collapse of the Mycenaean palaces

P Bulmer
The principle aim of this thesis is to develop a better understanding of social organisation in Greece after the collapse of the palace system c.1190 BCE. This is achieved through a multi-level analysis of burial practices, focussing specifically on the post-palatial cemetery at Perati, burial practices before and after the collapse in the Argolid, and the custom of burial with weapons, from the Shaft Grave period to the post-palatial period in Greece. The main theoretical...

Investigations Into Dual-Grating Dielectric Laser-Driven Accelerators

Y Wei
Dielectric laser-driven accelerators (DLAs) utilizing the large electric fields from commercial laser systems to accelerate particles with high gradients - in the range of GV/m - have the potential to dramatically reduce the size and cost of future particle accelerators. Dual-gratings are one of the candidates for DLAs. They can be mass-produced using currently-available nanofabrication techniques, due to their simpler structural geometry compared to other types of DLA. So far, dual-grating structures have experimentally demonstrated...

Investigation into mycobacterial persistence and early markers of outcome in the treatment of pulmonary tuberculosis

Derek Sloan
Background: Development of ultra-short chemotherapy for tuberculosis (TB) is thwarted by drug-tolerant bacillary persistence and a lack of surrogate endpoints to predict outcome from early clinical studies. Characterising bacillary elimination amongst TB patients may provide important new information. Bacilli harbouring intra-cytoplasmic lipid bodies (LBs) may represent a drug-tolerant phenotype, responsible for delayed bacterial clearance. Methods: Malawian adults with pulmonary TB were treated with standard 6 month therapy. Two quantitative sputum culture methods were used to...

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