4,198 Works

Influence of Fluid-Structure Interaction on Human Eye Biomechanics Under Air Puff Non-Contact Tonometry

O Maklad
Biomechanical properties of biological tissues are important health indicators and multiple clinical decisions and surgical planning can be made based on their dynamic response to loading. But until now, some of the mechanical and dynamic responses are not fully understood due to the non-linearity and viscoelastic behaviour of biological tissues. The relevant biological tissues of interest in the current study are the cornea and sclera of the human ocular globe. Cornea contributes with two-thirds of...

Death in post-palatial Greece: Reinterpreting burial practices and social organisation after the collapse of the Mycenaean palaces

P Bulmer
The principle aim of this thesis is to develop a better understanding of social organisation in Greece after the collapse of the palace system c.1190 BCE. This is achieved through a multi-level analysis of burial practices, focussing specifically on the post-palatial cemetery at Perati, burial practices before and after the collapse in the Argolid, and the custom of burial with weapons, from the Shaft Grave period to the post-palatial period in Greece. The main theoretical...

Fractional Differential Equations in Risk Theory

Wei Zhu
This thesis considers one of the central topics in the actuarial mathematics literature, deriving the probability of ruin in the collective risk model. The classical risk model and renewal risk models are focused in this project, where the claim number processes are assumed to be Poisson counting processes and any general renewal counting processes, respectively. The first part of this project is about the classical risk model. We look at the case when claim sizes...

Charles Lever and Ireland

A Maria Skinner
Following imposition of the Act of Union, which came into force on 1 January (1801), a literary market developed amongst English readers who wanted to understand more about Ireland. The market for novels about Ireland flourished. Charles James Lever, a writer whose work too few are really familiar with today, and whose reputation deserves rescuing from obscurity, rose to tremendous popularity in the late 1830s. Charles Lever’s remarkable commercial success was initially established using some...

Incorporating the 3Rs (Refinement, Replacement and Reduction of animals in research) into the preclinical assessment of snake venom toxicity and antivenom efficacy

FM Bolton
Antivenom is the only effective treatment for snakebite and comprise immunoglobulins obtained from venom-immunised horses or sheep. Globally, more than 45 manufacturers make over 120 snake antivenoms; it is a regulatory requirement that the venom-neutralising efficacy of all antivenoms are assessed preclinically. The World Health Organisation (WHO) recommended preclinical tests of efficacy are the median lethal venom dose (LD50) and median effective antivenom dose (ED50) assays performed in mice. They result in substantial pain and...

After COVID-19: Supporting Learning Recovery Through a Blended Approach to Education and Culture

Practice and Place Heseltine Institute for Public Policy

An investigation of mechanistic and prognostic aspects of BAP1 in uveal melanoma

N Farquhar
BRCA1-associated protein 1 (BAP1) is a deubiquitylase (DUB) that is inactivated through mutation in several cancers, including uveal melanoma (UM). BAP1 inactivation is associated with significantly poorer prognoses in UM, though the mechanisms underpinning this are unclear. BAP1 has diverse roles, both through its DUB activity and as a transcriptional regulator. In addition, it has recently been shown that BAP1-deficiency may sensitise UM cells to therapeutic compounds called histone deacetylase inhibitors (HDACi), and this presents...

'The tale is the map which is the territory': From Fantasy and Metafiction to Metafantasy and Neil Gaiman

L Garcia-Siino
Critical theory concerning the genre of fantasy has been steadily growing since the 1970s, yet one area concerning the dynamics of its narrative structure and the self-revealing nature of that structure has been left largely, and surprisingly, unexplored. Analysing the critical theories about fantasy, its functions and components, reveals the inherent connections between the genre and the literary technique of metafiction, and demonstrates that fantasy is a metafictive genre of literature. This occurs because fantasy...

The Greek Reception of Alexander the Great

GD Taietti
The present thesis explores how the personality, image, and deeds of Alexander the Great have been interpreted, reshaped, and exploited by the Greeks from Antiquity to the Modern era. The main focus is the understanding of the metamorphosis of the historical persona of Alexander into a god-like mythological figure and a Hellenic national hero, researching the origins of the Alexander-myth and how it operates in response to different historico-political, social and cultural stimuli for the...

The FOUNDATION study “Follow-Up for NeuroDevelopmentally AT risk Infants Of Neonatal care”- a qualitative study on the views of parents and caregivers

A Komoriyama
Introduction: Infants born prematurely or who have had neurological complications are at increased risk of neurodevelopmental disorders. Early identification of infants with signs of neurodevelopmental delay is crucial to achieve their full developmental potentials. Currently, there is variable guidance on the follow up and referral process for such children. Little information is available on the needs of patients, families and health care of professionals regarding current practice and experience of follow-up. Aims: To understand the...

Extended Markov numbers and integer geometry

Matty Van-Son

'The worst of drunkards': female drunkenness in mid-Victorian Lancashire

CN Stafford

Representation, Self-Representation, and Journalism: 1880-1905.

Rachel Harriet Cleaver

Efficient Manufacture of Emulsion Intermediates in Cavity-design Mixers

Ryan Burger
Emulsions are ubiquitous across the process industries and are often utilised in applications where controlled delivery of a key ingredient (e.g. an oil or water soluble compound) is an important consideration. Their functional properties e.g. the rate of absorption or coverage of a surface is generally determined by the size and size distribution of dispersed domains or microstructure. Control over the formulation, process route and type of equipment all influence the resulting microstructure. The focus...

Other people’s children: representations of paid-childcare in Britain, 1867-1908

James Hinks
This thesis critically examines how informal child-care, performed for money, was subject to sustained scrutiny between 1867-1908. This period saw women who took children into their home in exchange for payment being subject to judicial sanction,press comment and legislative intervention. The passage of the 1908 Children Act marked the point at which all women who took in children for money were subjected to legislation for the first time. Existing scholarship on this topic has largely...

Molecular ecological characterization of a honey bee ectoparasitic mite, Tropilaelaps mercedesae.

Xiaofeng Dong
Tropilaelaps mercedesae (small mite) is one of two major honey bee ectoparasitic mite species responsible for the colony losses of Apis mellifera in Asia. Although T. mercedesae mites are still restricted in Asia (except Japan), they may diffuse all over the world due to the ever-increasing global trade of live honey bees (ex. Varroa destructor). Understanding the ecological characteristics of T. mercedesae at molecular level could potentially result in improving the management and control programs....

Independent Sets in Line of Sight Networks

PS Sangha
In this thesis we study the maximum independent set problem in both 2 and higher dimensional line of sight networks. The maximum independent set problem seeks to find a largest set of pairwise disjoint vertices and we will study both the decision version and the optimisation version of the problem in this thesis. The line of sight network model was introduced to provide a model of geometric graph that incorporates both range and line of...

Factors that influence capital structure decisions between owners of family businesses and their administrators in medium sized organizations

B Tejuoso
Family businesses are known to have problems with capital structure decision making, and this is evident within the Nigerian family business context. While other areas in the family business field have been well studied, the factors that influence capital structure decisions have been grossly understudied; particularly from the perspective of family business owners and the administrators that manage their businesses. This dissertation addresses this understudied section in the family business literature while simultaneously addressing a...

Television Food Advertising to Children: Exposure, Power and Potential Consequences

R Whalen

Speed Sensorless Induction Motor Drive Control for Electric Vehicles

SJ Rind
Fast diminishing fossil fuel resources, deterioration in air quality and concerns for environmental protection, continuously promote the interest in the research and development of Alternative Energy Vehicles (AEVs). Traction motor drive is an integral part and common electric propulsion system in all kinds of AEVs. It plays an utmost significant role in the development of electrified transport industry. Application of Induction Motor (IM) drive is not only limited to the domestic and industrial applications but...

Regulating stem cell behaviour using bioengineered culture substrates

CJ Hill

Bucolic Politics: The Administration of Sir Robert Walpole and the Rise of the Country Interest

P Sargeant
Through an examination of a variety letters and printed works, this thesis argues that the political influence of the Country interest during the administration of Robert Walpole has been systematically underestimated in the historiography. New and previously neglected archival sources have been uncovered to form a better understanding of how the Country interest operated during the period. The emergence of the Country helps to address wider historical issues, such as why a ‘rage of party’...

Fire and Herbivory in the Serengeti-Mara

JR Probert

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