1,323 Works

Analysis of drug-protein adducts and their role in drug hypersensitivity.

AA Tailor
Idiosyncratic drug reactions are extremely severe and are not attributed to the normal pharmacology of a drug. Elucidating their toxicological mechanisms have been challenging. In recent years, idiosyncratic drug-induced liver injury (iDILI) has been linked with the immune system proposing that tissue damage may be mediated by the cytotoxicity of T-cells. Furthermore, several associations have been found with iDILI and gene polymorphisms which code for human leukocyte antigen (HLA). The hapten model of drug hypersensitivity...

Television Food Advertising to Children: Exposure, Power and Potential Consequences

R Whalen

Regulating stem cell behaviour using bioengineered culture substrates

CJ Hill

Fire and Herbivory in the Serengeti-Mara

JR Probert

The nature of autonomy when living with dementia

SE Wolfe

\"It is filled with an assortment\": The Transmission of the Instruction of Ani and the Instruction of Amenemope

H Twiston-Davies
This thesis examines the textual traditions of two Late Egyptian wisdom texts: the Instruction of Amenemope and the Instruction of Ani. It hypothesises the scribal process of copying through text-critical techniques, and from the perspective of ‘Material Philology’. It does not attempt to create a stemma codicum or to reconstruct an Urtext, but considers the possible role of dictation and visual copying, in transmission, and how significant variations between manuscripts arose. The incidence of obvious...

Investigating the Effectiveness of Antiretroviral Therapy in sub-Saharan Africa

J Gini
Antiretroviral therapy (ART) has revolutionised outcomes of HIV infection among people living with HIV (PLWH). But despite these great strides, ongoing concerns of drug-drug interactions, widespread use of herbal medication while using ART, safety in pregnancy and breastfeeding are challenges of HIV treatment in PLWH. Potent new ART are not widely used in most low and middle income countries (LMIC) due to insufficient safety data and fear of adverse events. This Thesis aimed at evaluating...

Bovine Digital Dermatitis: A Reverse Vaccinology Approach.

Gareth Staton

Statin-associated muscle toxicity: clinical and genomic perspectives

Richard Myles Turner

Cross-talk between macrophages, adipocytes and preadipocytes in white adipose tissue

Adrian William Harvey O'Hara

Role of oestrogen receptor beta (ERB) in hormone responsiveness in breast cancer

Raman Vinayagam

Investigating the aetiology and physiology of postdates pregnancy

Sarah Jane Arrowsmith

Acute encephalitis, Japanese encephalitis, diagnostics and disability in Southeast Asia

Penelope Lewthwaite

Molecular ecology of shiga-toxin encoding bacteriophage

David John Rooks

The use of irreversible antagonists as anti-spasmodic agents in the radial artery

Michael John Shackcloth

Caveolins in the vasculature : a role in regulating potassium channel function

Lowri Meryl Davies

Conflict management in wild spider monkeys (Ateles geoffroyi yucatanensis)

Luisa Rebecchini

Biomechanical investigations of endografts for abdominal aortic aneurysm repair

Samuel Shunan Zhou

Genetic algorithms for multiple-input multiple-output and ultra wideband wireless communication systems

Nazmat Toyin Surajudeen-Bakinde

Interaction of circulating galectin-3 and cancer-associated MUC1 in cancer metastasis

Qi Cheng Zhao

Portable mass spectrometry for residual gas analysis

Jeyan Sreekumar

Chromatic monitoring of sulphurhexafluoride using mass spectrometry

Martin Charles Kidman

Registration Year

  • 2019
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