Chronic infection with hepatitis b virus (HBV) is a global health problem estimated to affect 240 million people worldwide. A successful prophylactic vaccine has contributed to lowering the incidence, but individuals with established infection often remain committed to life-long antiviral therapy. For these reasons, increased clinical and scientific scrutiny is being applied to develop new therapeutic approaches with an ultimate goal of achieving cure. The adaptive immune response is recognized to play a crucial role...

This Data Supplements Firth, JA. & Sheldon, BC. 2016. Social carry-over effects underpin trans-seasonally linked structure in a wild bird population. Ecology Letters; 10.1111/ele.12669 http://onlinelibrary.wiley.com/doi/10.1111/ele.12669/full

Previous work has demonstrated the potential of magnetically functionalized microbubbles to localize and enhance cavitation activity under focused ultrasound exposure in vitro. The aim of this study was to investigate magnetic targeting of microbubbles for promotion of cavitation in vivo. Fluorescently labelled magnetic microbubbles were administered intravenously in a murine xenograft model. Cavitation was induced using a 0.5 MHz focused ultrasound transducer at peak negative focal pressures of 1.2-2.0 MPa and monitored in real-time using...

We present a straightforward, sound, Hindley-Milner polymorphic type system for algebraic effects and handlers in a call-by-value calculus, which, to our surprise, allows type variable generalisation of arbitrary computations, and not just values. The soundness of unrestricted call-by-value Hindley-Milner polymorphism is known to fail in the presence of computational effects such as reference cells and continuations, and many programming examples can be recast to use effect handlers instead of these effects. This file formalises in...