498 Works

Role of Conformational Changes in G Protein-Coupled Receptor Activation

Caitlin Eileen Scott
Transmembrane signal transduction is achieved by activation of G protein-coupled receptors (GPCRs) like the human cannabinoid type 1 (CB1) receptor, the human cannabinoid type 2 (CB2) receptor, and the human mu-opioid receptor. These receptors exist in the membrane in an ensemble of conformations each of which might bind to different signaling molecules and cause different physiological effects. Understanding the structural basis of their activation will eventually help us in designing drugs that target these receptors...

Graph Clustering: Algorithms, Analysis and Query Design

Ramya Korlakai Vinayak
A wide range of applications in engineering as well as the natural and social sciences have datasets that are unlabeled. Clustering plays a major role in exploring structure in such unlabeled datasets. Owing to the heterogeneity in the applications and the types of datasets available, there are plenty of clustering objectives and algorithms. In this thesis we focus on two such clustering problems: Graph Clustering and Crowdsourced Clustering. In the first part, we consider the...

Akt Phosphorylation of Drosophila Heat-Shock Factor: A Signature for Stress Resistance

Sarina Mohanty
The heat-shock response is vital to cellular homeostasis. Drosophila melanogaster heat-shock factor (dHSF) is the primary transcriptional activator in the stress response pathway for induction of heat-shock-mediated gene transcription. This work investigates the potential for dHSF to undergo post-translational modification by phosphorylation and lysine tagging, specifically, direct phosphorylation by kinases and covalent-lysine tagging by ubiquitin, acetyl, and SUMO groups. Direct phosphorylation of, and binding to, dHSF was demonstrated by Akt/PKB kinase. Knock-down of this kinase...

Thermoelectric Properties of Bismuth Antimony Telluride Alloys

Hyun-Sik Kim
Commonly used ozone-depleting refrigerants in refrigerators will be completely phased out in less than 15 years according to the Montreal Protocol. This imminent challenge can be tackled effectively by replacing the current vapor-compression cooling with environmentally sustainable thermoelectric cooling. P-type (Bi0.25Sb0.75)2Te3 alloys have been intensively studied over the past 50 years for cooling applications because of their high thermoelectric performance near room temperature. However, the electronic origin of the high thermoelectric efficiency of (Bi0.25Sb0.75)2Te3 alloys...

2014 TCCON Data Release

Total Carbon Column Observing Network (TCCON) Team
The Total Carbon Column Observing Network (TCCON) is a network of ground-based Fourier Transform Spectrometers that record direct solar absorption spectra of the atmosphere in the near-infrared. From these spectra, accurate and precise column-averaged abundances of atmospheric constituents including CO2, CH4, N2O, HF, CO, H2O, and HDO, are retrieved. This is the 2014 data release.

TCCON data from Réunion Island (RE), Release GGG2014.R1

M. De Mazière, M. K. Sha, F. Desmet, C. Hermans, F. Scolas, N. Kumps, J.-M. Metzger, V. Duflot & J.-P. Cammas
The Total Carbon Column Observing Network (TCCON) is a network of ground-based Fourier Transform Spectrometers that record direct solar absorption spectra of the atmosphere in the near-infrared. From these spectra, accurate and precise column-averaged abundances of atmospheric constituents including CO2, CH4, N2O, HF, CO, H2O, and HDO, are retrieved. This data set contains observations from the TCCON station on Réunion Island.

TCCON data from Park Falls (US), Release GGG2014.R1

P. O. Wennberg, C. M. Roehl, D. Wunch, G. C. Toon, J.-F. Blavier, R. Washenfelder, G. Keppel-Aleks, N. T. Allen & J. Ayers
The Total Carbon Column Observing Network (TCCON) is a network of ground-based Fourier Transform Spectrometers that record direct solar absorption spectra of the atmosphere in the near-infrared. From these spectra, accurate and precise column-averaged abundances of atmospheric constituents including CO2, CH4, N2O, HF, CO, H2O, and HDO, are retrieved. This data set contains observations from the TCCON station at Park Falls, U.S.A..

TCCON data from Izana (ES), Release GGG2014.R1

T. Blumenstock, F. Hase, M. Schneider, O. E. García & E. Sepúlveda
The Total Carbon Column Observing Network (TCCON) is a network of ground-based Fourier Transform Spectrometers that record direct solar absorption spectra of the atmosphere in the near-infrared. From these spectra, accurate and precise column-averaged abundances of atmospheric constituents including CO2, CH4, N2O, HF, CO, H2O, and HDO, are retrieved. This data set contains observations from the TCCON station at Izana, Spain.

Submicron Systems Architecture Project : Semiannual Technical Report

Computer Science Technical Reports

Ck Continuity of Subdivision Surfaces

Computer Science Technical Reports

Providing Easier Access to Remote Objects in Client-Server Systems

Computer Science Technical Reports

Surface Drawing

Computer Science Technical Reports

The Deformations of Thin Nematic Elastomer Sheets

Paul P. Plucinsky
Thin structures exhibit a broad range of mechanical responses as the competition between stretching and bending in these structures can result in buckling and localized deformations like folding and tension wrinkling. Active materials also exhibit a broad range of mechanical responses as features that manifest themselves at the microscale in these materials result in mechanical couplings at the engineering scale (thermal/electrical/dissipative) and novel function (e.g., the shape memory effect and piezoelectricity in select metal alloys...

Insights into the Geologic History of Mars’ Northern Lowlands from Near-Infrared Spectroscopy

Lu Pan
Hydrated minerals, identified on Mars using near-infrared spectroscopy data, reveal new insights into the aqueous processes and evolution of climate in the history of Mars. Through investigations of the mineralogical record using near-infrared spectroscopy, this dissertation focuses on the geologic history and aqueous processes in the northern lowlands of Mars in order to assess the existence of a long-lived global ocean, the extent and volume of Noachian-Hesperian volcanic flows filling the northern lowlands, the nature...

Tailoring the Permanent Formula to Problem Instances

Computer Science Technical Reports

Understanding the Symbiosis in Anaerobic Oxidation of Methane Through Metabolic, Biosynthetic and Transcriptomic Activities

Hang Yu
Microorganisms provide essential ecological services to our planet. Their combined activities control and shape our environment as we know today. In the deep sea, a microbial mediated process known as anaerobic oxidation of methane (AOM) consumes large amounts of methane, a potent greenhouse gas and a valuable energy resource. How this symbiosis works is poorly understood. In this thesis, I tested current hypotheses on the symbiotic mechanisms in AOM microbial consortia, consisting of a partnership...

Recurrence-Based Reductions for Inclusion and Exclusion Algorithms Applied to P Problems

Computer Science Technical Reports

Transition Metals as Catalysts for Cross-Coupling and Dinitrogen Fixation

Trixia Marie Buscagan
Transition metals are used as catalysts in the laboratory and by nature to facilitate difficult chemical transformations. Herein, three different metal containing catalysts are discussed: Pd and Ni catalysts towards the formation of carbon-carbon (C-C) bonds and Fe catalysts towards the reduction of N2 to NH3. In Chapter 2, mechanistic studies of Pd- and Ni-catalyzed cross-coupling reactions are discussed. The mechanism of transmetalation of a Pd-catalyzed Suzuki cross-coupling reaction is studied using a stereochemical probe,...

Optimal Distributed Resource Allocation

Computer Science Technical Reports

Global and local properties of asynchronous circuits optimized for energy efficiency

Computer Science Technical Reports

Thermo-Acoustic Coupling and Dynamic Response of a Premixed Methane-Air Flame

Steven Leslie Palm
The work herein generally applies to the problem of combustion instability. Combustion instabilities first arose in engineering practice in the 1940s when they were experienced during the development of solid and liquid propellant rocket engines. Later, similar problems arose in gas turbine combustors and afterburners. However, the earliest technical case of the phenomenon dates back to Rijke in 1859 with his "singing" tube. The presented work focuses on the study of a simple, stagnation plane...

Coherent Structures, their Interactions, and their Effects on Passive Scalar Transport and Aero-optic Distortion in a Turbulent Boundary Layer

Theresa Ann Saxton-Fox
This thesis focused on the characterization of coherent structures and their interactions in a turbulent boundary layer using data from particle image velocimetry (PIV) measurements performed at Caltech and from a direct numerical simulation (DNS) of Wu et al. (2017). Connections were identified between instantaneous and statistical descriptions of coherent velocity structures, through the analysis of representative models for their structures derived from the resolvent analysis of McKeon and Sharma (2010). The representative models were...

Theory and Use of Conditional Composition

Computer Science Technical Reports

2009 TCCON Data Release

Total Carbon Column Observing Network (TCCON) Team
The Total Carbon Column Observing Network (TCCON) is a network of ground-based Fourier Transform Spectrometers that record direct solar absorption spectra of the atmosphere in the near-infrared. From these spectra, accurate and precise column-averaged abundances of atmospheric constituents including CO2, CH4, N2O, HF, CO, H2O, and HDO, are retrieved. This is the 2009 data release.

The Geometry of Moduli Spaces of Maps from Curves

Seunghee Ye
A class of moduli spaces that has long been the interest of many algebraic geometers is the class of moduli spaces parametrizing maps from curves to target spaces. Different such moduli spaces have distinct geometry and also invariants associated to them. In this thesis, we will study the geometry of three such moduli spaces. By understanding the global geometry of each moduli space, we will produce a stratification, which plays a central role in proving...

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