2 Works

Data from: Single-cell transcriptomic analysis of tumor-derived fibroblasts and normal tissue-resident fibroblasts reveals fibroblast heterogeneity in breast cancer

Nicholas Hum, Aimy Sebastian, Kelly Martin, Sean Gilmore, Stephen Byers, Elizabeth Wheeler, Matthew Coleman & Gabriela Loots
Cancer-associated fibroblasts (CAFs) are a prominent stromal cell type in solid tumors and molecules secreted by CAFs play an important role in tumor progression and metastasis. CAFs coexist as heterogeneous populations with potentially different biological functions. Although CAFs are a major component of the breast cancer stroma, molecular and phenotypic heterogeneity of CAFs in breast cancer is poorly understood. In this study, we investigated CAF heterogeneity in triple-negative breast cancer (TNBC) using a syngeneic mouse...

Single cell RNA sequencing (scRNAseq) of transplanted mT3 tumors

Ivana Peran
Background & Aims: Pancreatic ductal adenocarcinomas (PDAC) are characterized by fibrosis and an abundance of cancer-associated fibroblasts (CAFs). We investigated strategies to disrupt interactions among CAFs, the immune system, and cancer cells, focusing on adhesion molecule cadherin 11 (CDH11), which has been associated with other fibrotic disorders and is expressed by activated fibroblasts. Methods: We compared levels of CDH11mRNA in human pancreatitis and pancreatic cancer tissues and cells, compared with normal pancreas, and measured levels...

Registration Year

  • 2020
    2

Resource Types

  • Dataset
    2

Affiliations

  • Georgetown University
    2
  • Lawrence Livermore National Laboratory
    1