13,796 Works

Neuronal Antibodies and Brain alterations in APECED Patients

Giulia Corda, Antonella Meloni, Luca Saba, Stefano Mariotti, Gian-Luca Ferri & Cristina Cocco
APECED (Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Distrophy) is a rare autosomal recessive disorder. We previously found that sera samples from 9/14 patients revealed autoantibodies (Auto-Abs) reacting with cerebellum (GABAergic cells, n=5) and substantia nigra (SN; dopaminergic cells, n=5) [1]. Follow-up of the large majority of these patients was perfomed at least 10 years after the previous investigation. Indeed, on these patients, and on control age-matched subjects (n=14), we performed brain examinations using an MRI scanner. Obtained images were...

A zonzo per l’Europa centrale ovvero escursioni storiche, filosofiche e letterarie attraverso la Mitteleuropa

Andrea Trovesi
The new book of Czech author Martin C. Putna offers a ‘deep insight’ and at the same time a ‘wide overview’ of the main historical and cultural facts that contributed to shape East-Central Europe over the centuries. All historical parts of the former Habsburg Empire (Austrian) are crossed – from Vorarlberg in the far west to Bukovina in the far east, from the former Ottoman Bosnia and Herzegovina in the south to the Austrian region...

La villa di Piero Del Tovaglia a Santa Margherita a Montici presso Firenze

Kamela Guza
Piero del Tovaglia — procurator and factotum of Ludovico Gonzaga in Florence – participated actively in the tormented affaire of the building of the Tribune in Santissima Annunziata, showing a complete loyalty towards the solution proposed by Leon Battista Alberti. This successful task led him into the very core of the architectural debate in Florence and allowed him to get in touch with the most important architects and patrons of the time. In the last...

Direct Payments between Income Support and Public Goods

Angelo Frascarelli
Direct payments maintain a fundamental role in the future CAP, since they still absorb a high share of the CAP budget. However, despite some confirmations (mainly related to internal convergence, types of interventions and the role of genuine/active farmers), several relevant innovations (e.g., a reinforced cross-compliance, new eco-schemes that replace the greening payments, a new capping model) are expected to affect their implementation and the way they contribute to achieving the CAP goals. The aim...

Note bio-bibliografiche degli autori

SocietàMutamentoPolitica, Vol 4, N° 8 (2013): L’identità e i suoi confini

Ancora sulle ville lombarde del primo Rinascimento

Luisa Giordano
Throughout the 15th century, among the suburban villas in Lombardy considerations and solutions of a productive and functional nature prevail upon the research of modern forms of building and dwelling. Even Ludovico Sforza’s official meeting with Giuliano da Sangallo and his wooden model of the villa of Poggio a Caiano remains without consequences. The case of the castle of Branduzzo appears particularly advanced and ambitious but still isolated: no defensive elements apart from the traditional...

Cancer stem cells from peritumoral tissue of glioblastoma multiforme: the possible link between tumor development and progression

Alessio D’Alessio, Cristiana Angelucci, Elena Binda, Annunziato Mangiola, Gabriella Proietti, Laura Masuelli, Barbara Fazi, Silvia Anna Ciafrè & Gina Lama
In glioblastoma multiforme (GBM), cancer stem cells (CSCs) are thought to be responsible for gliomagenesis, resistance to treatment and recurrence. Unfortunately, the prognosis for GBM remains poor and recurrence frequently occurs in the peritumoral tissue within 2 cm from the tumor edge. In this area, a population of CSCs has been demonstrated which may recapitulate the tumor after surgical resection. In the present study, we aimed to characterize CSCs derived from both peritumoral tissue (PCSCs)...

The Normativity of Institutions

Francesco Guala
Some philosophers have claimed that normativity is an essential feature of social institutions, and have identified the source of normativity in collective intentionality. In this paper I argue that (1) normativity is not essential for social institutions; (2) normativity has many sources and it is unlikely that a single theory is able to account for them all; (3) a powerful conception of institutions – the “rules in equilibrium” account – provides an adequate framework to...

Intuizioni linguistiche e filosofia sperimentale: metodi a confronto

Bianca Cepollaro
Nell’ultimo decennio si è infittito il dibattito sul ruolo della filosofia sperimentale rispetto alla cosiddetta filosofia ‘in poltrona’ (‘armchair philosophy’). La discussione, che riguarda i metodi della filosofia analitica in generale, ha ricadute di grande interesse per la filosofia del linguaggio in particolare. In questo articolo presento un caso in cui una questione centrale nello studio dei termini espressivi – cioè se il contenuto offensivo delle espressioni denigratorie sopravviva o no nell’interazione con operatori semantici...

Diffusion Tensor Imaging (DTI) in Head and Neck Oncology; a new method of Virtual Biopsy

Alessandro Calvo, Michele Runci Anastasi, Antonio Duca, Giuseppe Anastasi, Demetrio Milardi & Francesco Saverio De Ponte
The objective of our study is to explore the feasibility and utility of Diffusion Tensor Imaging (DTI) in the non invasive evaluation of any lesion [1] in Head and Neck structure. We would reach a verified and certified step of Virtual biopsy. Ten patients with different histological lesions were recruited for this study. Morphological and diffusion weighted images were acquired with a 3T scanner during last 3 months. Probabilistic tensor-based tractography reconstruction of any lesions...

The Social Impact Theory of Law

Joshua Keton
Margaret Gilbert’s work on sociality covers a wide range of topics, and as she puts it “addresses matters of great significance to several philosophical specialties – including ethics, epistemology, political philosophy, philosophy of science, and philosophy of law – and outside philosophy as well” (Gilbert 2013, p. 1). Herein I argue that Mark Greenberg’s recent call to eliminate the problem of legal normativity is well motivated. Further, I argue that Gilbert’s work on joint commitment,...

What is the Phenomenological Approach? Revisiting Intentional Explication

Dermot Moran
In this paper I outline the main features of the phenomenological approach, focusing on the central themes of intentionality, embodiment, empathy, intersubjectivity, sociality and the life-world. I argue that phenomenology is primarily a philosophy of intentional explication that identifies the a priori, structural correlations between subjectivity and all forms of constituted objectivities apprehended in their horizonal contexts. Intentional description reveals the structurally necessary, meaning-informing interactions between embodied subjectivity (already caught in the nexus of intersubjectivity)...

«Ridurre li drammi all’esigenza». Il modello performativo dell’opera in musica dai libretti del ‘Fondo Bonamici’ della Biblioteca Marucelliana di Firenze: disseminazione e adattamenti (1600-1737)

Luca Degl’Innocenti & Caterina Pagnini
The essay is a synthesis of a project financed by the University of Florence, focused on the dissemination processes of the Italian opera in the Baroque era. The original perspective of the research sees the libretto as a privileged witness of these ‘adjustments’, through the analysis of the witnesses related to the different occasions which can define the different ways of reception and adaptation of the staging practice and the dramaturgical structure.

Двенадцать А. Блока между Россией и Италией

Чезаре Де Микелис
The perception of a literary text in a language and culture different from the author's can aid the analysis of the poetics and the translation of the work. Examples taken from mistaken translations and the Italian notes to the text in fact highlight the symbology of The Twelve. At the same time, it is possible to see some literary fragments—Italian, of course—which act as the hypotext of Blok’s poem.

Shared Norms and Nomotrophic Behaviour

Lorenzo Passerini Glazel
The paper proposes to construe the “interventions in the lives of others when one thinks that the others’ behaviour is wrong” (Devlin and Gilbert), and the “reactions to disappointment of normative expectations” (Niklas Luhmann) under the notion of “nomotrophic behaviour”, i.e. a behaviour that aims at the maintenance of a norm in the event of its infringement. Subsequently, some of the implications of nomotrophic behaviour at an epistemological level (as a clue for inferring norms...

Learning disability at university: a survey through the students’ perspective

Marco Nenzioni & Giacomo Guaraldi
The research, oriented by the pedagogical approach of the Student Voice, aims to explore the state of the art of the didactic inclusion of students with specific learning disorder in the universities of Bologna and Modena-Reggio Emilia. Students’ perceptions about the practices useful to promote access and participation in academic life are reported and discussed. With the promulgation of some laws in support of inclusion issue and thanks to the spread of many frameworks for...

May Joint Commitment Stabilize Modus Vivendi?

Roberta Sala
This contribution intends to extend my previous attempt to defend modus vivendi as an alternative way to include people who do not share the essentials of a liberal society. The idea was to respond to a claim to realism: besides loyal citizens, whose doctrines overlap on the basics of a fair society, there are people whose loyalty towards institutions is not be wholehearted – since they do not concur to their public justification – but...

The Anatomy of Collusion

Helen Lauer
Received models of cooperative action overlook the way that the social environment itself features in collective intentions; recognising the divergent ways that norms function can help explain how people collaborating covertly are not considered irrational even though the things they are doing are totally contrary to the principles and convictions they sustain as individual agents.

Sulla pista, in scena. Le pantomime di Félicien Champsaur al circo Molier e al Noveau Cirque

Elena Mazzoleni
The varied universe of the performances of Molier circus and the Nouveau Cirque finds its synthesis in Félicien Champsaur’s pantomimes, Les Éreintés de la vie (Circus Molier, 6th and 11th June 1888) and Lulu (Nouveau Cirque, 1st October 1888), not just as spectacular form of entertainment, but also as awareness of the fin de siècle anxieties. These pantomimes attest, on the one hand, Champsaur’s style which, in line with the principles of the Cercle Funambulesque,...

Spinoza on Metaphysical Doubt and the “Cartesian Circle”

Marcos André Gleizer
This article offers an analysis and defense of the solution proposed by Spinoza to the “Cartesian circle” problem. Taking into consideration Spinoza’s sound analysis of the epistemic conditions of an authentic doubt, it will try to show, against the interpreters who maintain that Spinoza’s most explicit and consistent solution fails, that his solution offers a perfectly coherent account of the self-justification of the objective value of reason. I will also briefly indicate the intimate connection...

‘Il quinto evangelista’ di Mario Pomilio-Orazio Costa. Apocrifo del dissenso

Teresa Megale
The essay reconstructs Orazio Costa’s direction of Il quinto evangelista by Mario Pomilio. The drama is included by the author in the final chapter of the award-winning novel Il quinto evangelio and staged during the 29th Festa del Dramma Popolare di San Miniato (September 1975), a few months after the publication but, after a short tour, never represented. The novel had the same lot: after eighteen editions and translations in many languages it was re-published...

God, Eternal Truths and the Rationality of the World in Descartes

Ethel Menezes Rocha
In this paper I examine Descartes’s thesis of the free creation of eternal truths in conjunction with what he claims to be the divine attributes known by us. Considering the Cartesian claims of God’s simplicity and that eternal truths freely created by God include logical principles as the structure of finite minds, I argue that the Cartesian thesis of the free creation of eternal truths involves: a) God necessarily establishes (and thus creates) within/as himself...

Principles of Quoting the Holy Scriptures in Works by 17th Century Ukrainian Authors: Approaching the Issue

Larysa Dovga & Roman Kyselov
Ukrainian attitudes towards the holy scriptures, and the ways in which they were quoted and referred to, indicate the specificity of the Ukrainian intellectual culture and the range of freedom that this culture set as a frame for its own development. The Bible quotations used in the selected 17th century texts in Old Ukrainian (prosta mova) and Church Slavonic show that the scriptures were treated by Ukrainian religious intellectuals as the most authoritative source for...

La predicazione cappuccina per le quarantore e un sermonario annotato della fine del Seicento

Carla M. Bino
The essay explores the dramatic and performative dimension of the Forty Hours Devotion – one of the most important liturgical services of the Counter-Reformation – promoted by Capuchin Friars Minor between the 16th and 17th centuries. The first part summarizes the salient steps that marked the emergence of a precise system of celebration developed by the Order, highlighting those elements that made it original in choice of time, organization and, above all, detailed meditation practice....

Descartes e il problema della teodicea nella prima modernità

Alfredo Gatto
The article deals with the critical reception of the Cartesian theory of the eternal truths. It aims to analyze the central role played by Descartes’ doctrine in Early Modern Philosophy, with particular regard to the reflections of Leibniz, Malebranche and Spinoza. Indeed, part of their philosophy can be considered as an attempt to criticize the premises of the Cartesian theory in order to avoid their consequences. There are then strong reasons for believing that the...

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