30,013 Works

Platforms and Publishers: The End of an Era

Nushin Rashidian, Georgios Tsiveriotis, Peter D. Brown, Emily J. Bell & Abigail Hartstone
Since our last report was published in June 2018, the shift in the journalism landscape has been seismic. Advertising revenues have continued to plummet and newsrooms across the country have experienced mass layoffs. In turn, publishers have scrambled to adapt their business models and priorities in an ever-changing and volatile media ecosystem—one still dominated by platforms despite the large-scale public reckoning with their effects on society and democracy. There is no telling how publishers will...

Telemedicine for Hyperkinetic Movement Disorders

Ragini Srinivasan, Hilla Ben-Pazi, Marieke Dekker, Esther Cubo, Bas Bloem, Emile Moukheiber, Josefa Gonzalez-Santos & Mark Guttman
Telemedicine is the use of electronic communication technology to facilitate healthcare between distant providers and patients. In addition to synchronous video conferencing, asynchronous video transfer has been used to support care for neurology patients. There is a growing literature on using telemedicine in movement disorders, with the most common focus on Parkinson’s disease. There is accumulating evidence for videoconferencing to diagnose and treat patients with hyperkinetic movement disorders and to support providers in remote underserviced...

Adapting Lesson Study for Community College Mathematics Instruction: Early Observations

Susan E. Bickerstaff, Jacqueline Raphael, Diana E. Cruz Zamora & Melinda Leong
Lesson Study (LS) is a structured, collaborative professional development approach that gives instructors a framework for actively investigating how to improve student learning in their classrooms. Despite evidence of LS improving teacher practice and student learning in K-12 settings, there have been few documented examples of its use among instructors in higher education. The Adapting Lesson Study for Community College Mathematics Instruction project is investigating whether the model can be feasibly implemented by community college...

Bringing Everyone to the Table--Collaborative Ontology Development

Melanie Wacker
Metadata work thrives when it takes place in a collaborative context. Collaboration has increasingly been a part of bibliographic description, the description of digitized resources, digital humanities, ontology creation, and more. This presentations focuses on the work of the ArtFrame Group that resulted in the development of the ARM Ontology, a BIBFRAME ontology extension. This work was a collaboration between different community partners including Art Libraries Society of North America, Library of Congress and several...

Two Somatic Biallelic Lesions Within and Near SMAD4 in a Human Breast Cancer Cell Line

John Jakob, Satoru Nagase, Adi Gazdar, Minchen Chien, Irina Morozova, James J. Russo, Subhadra Nandula, Murty V. Vundavalli, Chi-Ming Li, Benjamin Tycko & Ramon E. Parsons
Loss of chromosome arm 18q is a common event in human pancreatic, colon, and breast cancers and is often interpreted as representing loss of one or more tumor-suppressor genes. In this article, we describe two novel biallelic deletions at chromo- some band 18q21.1 in a recently characterized human breast cancer cell line, HCC-1428. One lesion deletes a fragment of approximately 300 kb between SMAD4 and DCC that encodes no known genes. The second lesion is...

iPASS in Practice: Four Case Studies

Serena Constance Klempin, Lauren Pellegrino, Andrea Lopez-Salazar, Elisabeth Barnett & Julia Lawton
A range of efforts are underway to improve the effectiveness and efficiency of advising and student supports. Among these is the Integrated Planning and Advising for Student Success (iPASS) initiative. Launched in 2015, the initiative provided three years of financial, technical, and change management support to 26 two- and four-year institutions as they redesigned their advising processes and adopted and implemented new technologies. Over the three years of the grant, Achieving the Dream and EDUCAUSE...

Genetic Analysis of the APAF1 Gene in Male Germ Cell Tumors

Shashi Bala, Holt Oliver, Beatrice Renault, Kate Montgomery, Shipra Dutta, Pulivarthi Rao, Jane Houldsworth, Raju Kucherlapati, X. Wang & Murty V. Vundavalli
Cytogenetic and molecular analyses have shown that the chromosome band 12q22 is recurrently deleted in male germ cell tumors (GCTs), indicating the presence of a candidate tumor suppressor gene (TSG) in this region. To identify the TSG, we mapped the APAF1 gene, a proapoptotic mammalian homologue of ced-4, to chromosomal band 12q22, that suggested that this might be the candidate deleted gene in GCTs. We further localized the gene between the polymorphic markers D12S1671 and...

Early Outcomes of Texas Community College Students Enrolled in Dana Center Mathematics Pathways Prerequisite Developmental Courses

Lauren Schudde & Akiva Yonah Meiselman
To improve outcomes in math, many Texas colleges are adopting mathematics pathways, which accelerate developmental math and tailor math courses to different majors instead of requiring all students to take algebra. This study examines whether students participating in Dana Center Mathematics Pathways (DCMP) developmental courses enroll in and pass college-level math courses at higher rates than students who take traditional developmental math courses. It employs regression analysis controlling for student characteristics using student-level data compiled...

Integrating Technology and Advising: Studying Enhancements to Colleges’ iPASS Practices

Alexander K. Mayer, Hoori Santikian Kalamkarian, Benjamin Cohen, Lauren Pellegrino, Melissa Boynton & Edith Yang
Integrated Planning and Advising for Student Success (iPASS) is an initiative funded by the Bill & Melinda Gates Foundation to support colleges seeking to incorporate technology into their advising and student services. In iPASS, such technology is intended to increase advising’s emphasis on a student’s entire college experience, enabling advisors to more easily: intervene when students show early warning signs of academic and nonacademic challenges, regularly follow up as students progress through college, refer students...

Mapping the Sites of Putative Tumor Suppressor Genes at 6p25 and 6p21.3 in Cervical Carcinoma: Occurrence of Allelic Deletions in Precancerous Lesions

Anupam Chatterjee, Hugo Arias-Pulido, Sanjay Koul, Nestor Beleño, Ana Perilla, Hector Posso, Mahesh M. Mansukhani & Murty V. Vundavalli
Allelic deletions on the short arm of chromosome 6 (6p) are one of the common, possibly early, genetic changes that occur in the pathogenesis of cervical carcinoma (CC). Previous loss of heterozygosity (LOH) studies in CC identified a number of critical regions of deletions on 6p. However, the precise location of minimally deleted regions and their role in precancer- ous lesions have not been well characterized. To address these questions, we first performed a detailed...

Early Momentum Metrics: Leading Indicators for Community College Improvement

Clive Belfield, Paul Davis Jenkins & John Fink
As community colleges across the country implement large-scale reforms to improve student success, they need timely and actionable metrics to determine if the changes they are making in a given year or term will likely improve student outcomes in the long run. In this brief, the authors examine how well nine measures of students’ progress in their first year predict student completion in subsequent years, and thus how suitable these early momentum metrics are as...

A 3-Mb High-Resolution BAC/PAC Contig of 12q22 Encompassing the 830-kb Consensus Minimal Deletion in Male Germ Cell Tumors

Murty V. Vundavalli, Kate Montgomery, Shipra Dutta, Shashi Bala, Beatrice Renault, George Bosl, Raju Kucherlapati & R. S. Chaganti
Cytogenetic and molecular genetic analyses have shown that the 12q22 region is recurrently deleted in male germ cell tumors (GCTs), suggesting that this site may harbor a tumor suppressor gene (TSG). Previous loss of heterozygosity (LOH) analyses identified a consensus minimal deleted region between the markers D12S377 and D12S296, and a YAC clone contig covering the region was generated. Here, we describe a high-resolution sequence-ready physical map of this contig covering a 3-Mb region. The...

Humanities and Liberal Arts Education at Community College: How It Affects Transfer and Four-Year College Outcomes

Theo Pippins & Clive Belfield
Using transcript-level data from two community college state systems and a nationally representative survey, this short report examines how course-taking in humanities and liberal arts at community colleges affects transfer and outcomes at four-year colleges. Key findings Transfer students typically complete only a few courses in humanities and liberal arts at community college before they transfer to a four-year college. Grades in humanities and liberal arts courses at community colleges are a strong predictor of...

Assignment of the Human TYRP (brown) Locus to Chromosome Region 9p23 by Nonradioactive in Situ Hybridization

Murty V. Vundavalli, Brigitte Bouchard, Susan Mathew, Setaluri Vijayasaradhi & Alan Houghton
The TYRP (brown) locus determines pigmentation and coat color in the mouse. The human homolog of the TYRP locus has been recently identified and shown to encode a 75-KDA transmembrane melanosomal glycoprotein called gp75. The gp 75 glycoprotein is homologous to tyrosinase, an enzyme in evolved in the synthesis of melanin, forming a family of tyrosinase-related proteins. A genomic clone of human gp75 was used to map the human TYRP locus to chromosome 9, region...

Humanities and Liberal Arts Education Across America's Colleges: How Much Is There?

Theo Pippins, Clive Belfield & Thomas R. Bailey
This short report provides a systematic accounting of the provision of humanities and liberal arts education at public colleges in the United States, including community colleges. Key findings: Humanities and liberal arts education in America’s colleges is not in decline. Across the nation’s community colleges, the number and share of humanities and liberal arts degrees awarded annually have risen since 2000. Although over the past 15 years the share of bachelor’s degrees awarded at four-year...

Allelic deletions in the long arm of chromosome 12 identify sites of candidate tumor suppressor genes in male germ cell tumors

Murty V. Vundavalli, Jane Houldsworth, S. Baldwin, V. Reuter, W. Hunziker, P. Besmer, George Bosl & R. S. Chaganti
Human male germ cell tumors (GCTs) result from malignant transformation of premeiotic or early meiotic germ cells and exhibit embryonal-like differentiation of the three germinal layers. The genetic basis of origin and expression of differentiated phenotypes by GCTs are poorly understood. Our recent cytogenetic analysis of a large series of GCTs has shown that two chromosome 12 abnormalities, an isochromosome for the short arm [i(12p)] and deletions in the long arm [del(12q)], characterize these tumors,...

Teaching Matters and So Does Curriculum: How CUNY Start Reshaped Instruction for Students Referred to Developmental Mathematics

Susan E. Bickerstaff & Nicole Diane Edgecombe
Adult proficiency in numeracy in the United States lags behind that of other developed nations, and the nonselective institutions that dominate the higher education sector struggle to address the learning needs of the sizeable proportion of students who enroll in their institutions and are deemed academically underprepared in mathematics. Research on curriculum and pedagogy in developmental (or remedial) mathematics indicates that typical teaching approaches emphasize memorization, often at the expense of the kinds of conceptual...

Identification of a 6-cM Minimal Deletion at 11q23.1–23.2 and Exclusion of PPP2R1B Gene as a Deletion Target in Cervical Cancer

Hugo Arias-Pulido, Mohamed J. Fakruddin, Anupam Chatterjee, Edward D. Esplin, Nestor Beleño, Gilberto Martínez, Hector Posso, Glen A. Evans & Murty V. Vundavalli
Previous functional and deletion mapping studies on cervical cancer (CC) have implicated one or more tumor suppressor genes (TSGs) on chromosome 11 at q13 and q22–24 regions. Of these, the 11q22–24 region exhibits frequent allelic deletions in a variety of solid tumor types, sug- gesting the presence of critical genes for tumor suppression in this region. However, the precise region of deletion on 11q is not clearly defined in CC. In an attempt to accurately...

Scaling Success: Lessons From the ASAP Expansion at Bronx Community College

Maria Scott Cormier, Jasmine Sanders, Julia Raufman & Diana Strumbos
he City University of New York’s (CUNY) Accelerated Study in Associate Programs (ASAP) provides wraparound services for eligible students, including financial, academic, and personal support. First piloted in 2007, ASAP has been shown to substantially increase three-year completion rates at CUNY’s community colleges. To build on the program’s early success, in 2011 CUNY began an initiative to expand its ASAP enrollment from around 1,300 students to 25,000 students in the 2018–19 academic year. CUNY selected...

Comprehensive Molecular Cytogenetic Characterization of Cervical Cancer Cell Lines

Charles P. Harris, Xin-Yan Lu, Gopeshwar Narayan, Bhuvanesh Singh, Murty V. Vundavalli & Pulivarthi Rao
We applied a combination of molecular cytogenetic methods, including comparative genomic hybridization (CGH), spectral karyotyping (SKY), and fluorescence in situ hybridization (FISH), to characterize the genetic aberrations in eight widely used cervical cancer (CC) cell lines. CGH identified the most frequent chromosomal losses including 2q, 3p, 4q, 6q, 8p, 9p, 10p, 13q, and 18q; gains including 3q, 5p, 5q, 8q, 9q, 11q, 14q, 16q, 17q, and 20q; and high-level chromosomal amplification at 3q21, 7p11, 8q23–...

Genomic surveys by methylation-sensitive SNP analysis identify sequence-dependent allele-specific DNA methylation

Kristi Kerkel, Alexandra Spadola, Eric Yuan, Jolanta Kosek, Le Jiang, Eldad Arie Hod, Kerry Li, Murty V. Vundavalli, Nicole Schupf, Eric Vilain, Mitzi Morris, Fatemeh Haghighi & Benjamin Tycko
Allele-specific DNA methylation (ASM) is a hallmark of imprinted genes, but ASM in the larger nonimprinted fraction of the genome is less well characterized. Using methylation-sensitive SNP analysis (MSNP), we surveyed the human genome at 50K and 250K resolution, identifying ASM as recurrent genotype call conversions from heterozygosity to homozygosity when genomic DNAs were predigested with the methylation-sensitive restriction enzyme HpaII. Using independent assays, we confirmed ASM at 16 SNP-tagged loci distributed across various chromosomes....

English Learners and ESL Programs in the Community College: A Review of the Literature

Julia Raufman, Jessica R. Brathwaite & Hoori Santikian Kalamkarian
Demographic and postsecondary enrollment data suggest that the proportion of community college students who need support to access curricula in English is large and will continue to grow in the coming years. Yet there is limited research on the postsecondary experiences and outcomes of these English learners, and most of the studies that are available focus exclusively on the subset of English learners who enroll in ESL courses. Informed by relevant research literature, this paper...

Altered DNA Methylation in Leukocytes with Trisomy 21

Kristi Kerkel, Nicole Schupf, Kota Hatta, Deborah I. Pang, Martha Salas, Alexander Kratz, Mark Minden, Murty V. Vundavalli, Warren Zigman, Richard Paul Mayeux, Edmund C. Jenkins, Ali Torkamani, Nicholas J. Schork, Wayne Silverman, B. Anne Croy & Benjamin Tycko
The primary abnormality in Down syndrome (DS), trisomy 21, is well known; but how this chromosomal gain produces the complex DS phenotype, including immune system defects, is not well understood. We profiled DNA methylation in total peripheral blood leukocytes (PBL) and T-lymphocytes from adults with DS and normal controls and found gene-specific abnormalities of CpG methylation in DS, with many of the differentially methylated genes having known or predicted roles in lymphocyte development and function....

American Honors: The Life and Death of a Public-Private Partnership

Shanna Jaggars, Margaret P. Fay & Negar Farakish
In fall 2012, a public-minded privately held firm, Quad Learning (QL), partnered with two community colleges to pilot a new program dubbed “American Honors” (AH), which was designed to help academically talented community college students overcome the challenges of transferring to more selective four-year destinations. By fall 2018, QL had dissolved the AH program for domestic students. This paper traces the components of the program’s socially conscious theory of change and its for-profit business model,...

Role of promoter hypermethylation in Cisplatin treatment response of male germ cell tumors

Gopeshwar Narayan, Jane Houldsworth, Jennifer Bacik, Deborah Dobrzynski, Adel Assaad, Mahesh M. Mansukhani, Victor Reuter, George Bosl, Raju Chaganti, Murty V. Vundavalli, Sanjay Koul & James M. McKiernan
Male germ cell tumor (GCT) is a highly curable malignancy, which exhibits exquisite sensitivity to cisplatin treatment. The genetic pathway(s) that determine the chemotherapy sensitivity in GCT remain largely unknown. We studied epigenetic changes in relation to cisplatin response by examining promoter hypermethylation in a cohort of resistant and sensitive GCTs. Here, we show that promoter hypermethylation of RASSF1A and HIC1 genes is associated with resistance. The promoter hypermethylation and/or the down-regulated expression of MGMT...

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