Diss., Eidgenössische Technische Hochschule ETH Zürich, Nr. 21870
Sauerstoff- und Kohlenstoff-Isotopensystematik schwach metamorpher Sedimentgesteine des Oberhalbsteins (Graubünden, Schweiz)Herbert Eppel
Diss. Naturwiss. ETH Zürich, Nr. 12369, 1997. Ref.: A. B. Thompson ; Korref.: G. L. Bernasconi Green ; Korref.: M. Burkhard
Zugl. Diss., Technische Wissenschaften, Eidgenössische Technische Hochschule ETH Zürich, Nr. 15321, 2004
Physical Review A, 95 (4)
KOF Studies, 84
gene regulation network orchestrates processes ensuring the maintenance of cellular identity and genome integrity. Small RNAs generated by the RNAse III DICER have emerged as central players in this network. Moreover, deletion of Dicer in mice leads to early embryonic lethality. To better understand the underlying mechanisms leading to this phenotype, we generated Dicer-deficient mouse embryonic stem cells (mESCs). Their detailed characterization revealed an impaired differentiation potential, and incapacity to exit from the pluripotency state....
Precise manipulation of human cell fate is a long-standing goal in biological engineering; it underpins efforts to advance new cellular therapeutics, and to develop disease models for fundamental research. Human pluripotent stem cells (hPSC) are emerging as the cells of choice for many of these applications. Currently, most advanced methods for manipulation of hPSC fate involve recapitulating developmental processes by mimicking stem cell niche-associated signals. Alternately, advances in engineering synthetic decision-making gene circuits provide an...
Pre-infection transcript levels of FAM26F in peripheral blood mononuclear cells inform about overall plasma viral load in acute and post-acute phase after simian immunodeficiency virus infectionAneela Javed, Nicole Leuchte, Gabriela Salinas, Lennart Opitz, Christiane Stahl-Hennig, Sieghart Sopper & Ulrike Sauermann
CD8+ cells from simian immunodeficiency virus (SIV)-infected long-term non-progressors and some uninfected macaques can suppress viral replication in vitro without killing the infected cells. The aim of this study was to identify factors responsible for non-cytolytic viral suppression by transcriptional profiling and to investigate their potential impact on SIV replication. Results of microarray experiments and further validation with cells from infected and uninfected macaques revealed that FAM26F RNA levels distinguished CD8+ cells of controllers and...
Characterizing half-a-degree difference: a review of methods for identifying regional climate responses to global warming targetsRachel James, Richard Washington, Carl-Friedrich Schleussner, Joeri Rogelj & Declan Conway
The Paris Agreement long-term global temperature goal refers to two global warming levels: well below 2°C and 1.5°C above preindustrial. Regional climate signals at specific global warming levels, and especially the differences between 1.5°C and 2°C, are not well constrained, however. In particular, methodological challenges related to the assessment of such differences have received limited attention. This article reviews alternative approaches for identifying regional climate signals associated with global temperature limits, and evaluates the extent...
Global Environmental Assessment Project. 1997. A Critical Evaluation of Global Environmental Assessments: The Climate Experience. Calverton, MD: CARE.
The relationship between the built environment and travel behavior is well-documented. However, inferring general conclusions from different studies remains a challenge. Zegras points out to several of these challenges: scales of analysis differ, built environment measures vary, the travel behavior data used varies, control variables employed differ and the ultimate outcomes measured are different. This study contributes to previous work by evaluating the usage of a global points of interest database to calculate destination diversity...