66,723 Works

Formation of the beta-barrel assembly machinery complex in lipid bilayers as seen by solid-state NMR

Cecilia Pinto, Deni Mance, Tessa Sinnige, Mark Daniels, Markus Weingarth & Marc Baldus
The β-barrel assembly machinery (BAM) is a pentameric complex (BamA–E), which catalyzes the essential process of β-barrel protein insertion into the outer membrane of E. coli. Thus far, a detailed understanding of the insertion mechanism has been elusive but recent results suggest that local protein motion, in addition to the surrounding membrane environment, may be of critical relevance. We have devised a high-sensitivity solid-state NMR approach to directly probe protein motion and the structural changes...

Grand challenges in biogeoscience

Timothy I. Eglinton
“The term ‘holistic’ refers to my conviction that what we are concerned with here is the fundamental interconnectedness of all things”…. “I see the solution to each problem as being detectable in the pattern and web of the whole. The connections between causes and effects are often much more subtle and complex than we with our rough and ready understanding of the physical world might naturally suppose…” These quotes are from Dirk Gently's Holistic Detective...

Hazards due to large wood accumulations: Local scour and backwater rise

Isabella Schalko, Lukas Schmocker, Volker Weitbrecht & Robert M. Boes
E3S Web of Conferences, 40

Feature Tracking Velocimetry Applied to Airborne Measurement Data from Murg Creek

Liekai Cao, Volker Weitbrecht, Danxun Li & Martin Detert
A new image feature tracking velocimetry is presented and tested on airborne video data available from a previous study at Murg Creek (Canton Thurgau, Switzerland). Here, the seeded flow scenery had been recorded by an off-the-shelf action camera mounted to a low-cost quadcopter, and video frames were ortho-rectified to sizes of 4482×2240 px2 at a scale of 64 px/m. The new velocimetry approach is as follows: An adaptive Gaussian mixture model is used for video...

Morphological development of river widenings with variable sediment supply

Cristina Rachelly, Volker Weitbrecht, David F. Vetsch & Robert M. Boes
River widening is a common restoration approach to mitigate the adverse effects of past stream alterations on infrastructure and the riparian ecosystem by stabilizing the river bed and enhancing habitat heterogeneity. In this study, two river widening approaches, excavated and dynamic, are described for the case of moderately steep gravel-bed rivers in the Alpine foothills, with a focus on dynamic river widening. As most channelized rivers exhibit ongoing degradation due to the lack of sediment...

Estimating Rank-One Spikes from Heavy-Tailed Noise via Self-Avoiding Walks

Jingqiu Ding, Samuel B. Hopkins & David Steurer
Advances in Neural Information Processing Systems 33 pre-proceedings (NeurIPS 2020)

Utilization of ancient permafrost carbon in headwaters of Arctic fluvial networks

Paul J. Mann, Timothy I. Eglinton, Cameron P. McIntyre, Nikita Zimov, Anna Davydova, Jorien Vonk, Robert M. Holmes & Robert G.M. Spencer
Northern high-latitude rivers are major conduits of carbon from land to coastal seas and the Arctic Ocean. Arctic warming is promoting terrestrial permafrost thaw and shifting hydrologic flowpaths, leading to fluvial mobilization of ancient carbon stores. Here we describe 14C and 13C characteristics of dissolved organic carbon from fluvial networks across the Kolyma River Basin (Siberia), and isotopic changes during bioincubation experiments. Microbial communities utilized ancient carbon (11,300 to >50,000 14C years) in permafrost thaw...

BEAST 2: A Software Platform for Bayesian Evolutionary Analysis

Remco Bouckaert, Joseph Heled, Denise Kühnert, Timothy Vaughan, Chieh-Hsi Wu, Dong Xie, Marc A. Suchard, Andrew Rambaut & Alexei J. Drummond
We present a new open source, extensible and flexible software platform for Bayesian evolutionary analysis called BEAST 2. This software platform is a re-design of the popular BEAST 1 platform to correct structural deficiencies that became evident as the BEAST 1 software evolved. Key among those deficiencies was the lack of post-deployment extensibility. BEAST 2 now has a fully developed package management system that allows third party developers to write additional functionality that can be...

Size distribution, mixing state and source apportionment of black carbon aerosol in London during wintertime

Dantong Liu, James D. Allan, Dominique E. Young, Hugh Coe, David Beddows, Zoe L. Fleming, Michael J. Flynn, Martin W. Gallagher, Roy M. Harrison, James Lee, André S.H. Prévôt, Jonathan W. Taylor, J. Yin, P.I. Williams & Peter Zotter
Black carbon aerosols (BC) at a London urban site were characterised in both winter- and summertime 2012 during the Clean Air for London (ClearfLo) project. Positive matrix factorisation (PMF) factors of organic aerosol mass spectra measured by a high-resolution aerosol mass spectrometer (HR-AMS) showed traffic-dominant sources in summer but in winter the influence of additional non-traffic sources became more important, mainly from solid fuel sources (SF). Measurements using a single particle soot photometer (SP2, DMT),...

Remotely monitoring cancer-related fatigue using the smart-phone:: Results of an observational study

Vanessa C. Klaas, Gerhard Tröster, Heinrich Walt & Josef Jenewein
Cancer related fatigue is a chronic disease that may persist up to 10 years after successful cancer treatment and is one of the most prevalent problems in cancer survivors. Cancer related fatigue is a complex symptom that is not yet explained completely and there are only a few remedies with proven evidence. Patients do not necessarily follow a treatment plan with regular follow ups. As a consequence, physicians lack of knowledge how their patients are...

Millennial soil retention of terrestrial organic matter deposited in the Bengal Fan

Katherine L. French, Christopher J. Hein, Negar Haghipour, Lukas Wacker, Hermann R. Kudrass, Timothy I. Eglinton & Valier Galy
The abundance of organic carbon (OC) in vegetation and soils (~2,600 PgC) compared to carbon in the atmosphere (~830 PgC) highlights the importance of terrestrial OC in global carbon budgets. The residence time of OC in continental reservoirs, which sets the rates of carbon exchange between land and atmosphere, represents a key uncertainty in global carbon cycle dynamics. Retention of terrestrial OC can also distort bulk OC- and biomarker-based paleorecords, yet continental storage timescales remain...

Injury Signals Cooperate with Nf1 Loss to Relieve the Tumor-Suppressive Environment of Adult Peripheral Nerve

Sara Ribeiro, Ilaria Napoli, Ian J. White, Simona Parrinello, Adrienne M. Flanagan, Ueli Suter, Luis F. Parada & Alison C. Lloyd
Schwann cells are highly plastic cells that dedifferentiate to a progenitor-like state following injury. However, deregulation of this plasticity, may be involved in the formation of neurofibromas, mixed-cell tumors of Schwann cell (SC) origin that arise upon loss of NF1. Here, we show that adult myelinating SCs (mSCs) are refractory to Nf1 loss. However, in the context of injury, Nf1-deficient cells display opposing behaviors along the wounded nerve; distal to the injury, Nf1−/− mSCs redifferentiate...

Nonlinearities of organic electro-optic materials in nanoscale slots and implications for the optimum modulator design

Wolfgang Heni, Christian Haffner, Delwin L. Elder, Andreas F. Tillack, Yuriy Fedoryshyn, Raphael Cottier, Yannick Salamin, Claudia Hössbacher, Ueli Koch, Bojun Cheng, Bruce Robinson, Larry R. Dalton & Juerg Leuthold
Optics Express, 25 (3)

Hardware-Friendly Two-Stage Spatial Equalization for All-Digital mmWave Massive MU-MIMO

Oscar Castaneda Fernandez, Sven Jacobsson, Giuseppe Durisi, Tom Goldstein & Christoph Studer
Next generation wireless communication systems are expected to combine millimeter-wave communication with massive multi-user multiple-input multiple-output technology. All-digital base-station implementations for such systems need to process high-dimensional data at extremely high rates, which results in excessively high power consumption. In this paper, we propose two-stage spatial equalizers that first reduce the problem dimension by means of a hardware-friendly, low-resolution linear transform followed by spatial equalization on a lower-dimensional signal. We consider adaptive and non-adaptive dimensionality...

Errors in dialog design and how to avoid them

Jürg Nievergelt
ETH, Eidgenössische Technische Hochschule Zürich, Institut für Informatik, 47

Analyzing Covert Channels on Mobile Devices

Hubert Ritzdorf

Objects in context: An empirical study of object relationships

Stephanie Balzer, Alexandra Burns & Thomas Gross
Technical Report / ETH Zurich, Department of Computer Science, 594

Numerical option pricing beyond Lévy

Oleg Reichmann

Zur Dimensionsstabilisierung des Holzes

Rudolf Popper
SAH Bulletin, 1

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