9,538 Works

Correlating Genotype and Phenotype in the Asexual Yeast Candida orthopsilosis Implicates ZCF29 in Sensitivity to Caffeine

Kontxi Martinez De San Vicente, Markus S. Schroder, Lisa Lombardi, Elise Iracane & Geraldine Butler
Candida orthopsilosis is diploid asexual yeast that causes human disease. Most C. orthopsilosis isolates arose from at least four separate hybridizations between related, but not identical, parents. Here, we used population genomics data to correlate genotypic and phenotypic variation in 28 C. orthopsilosis isolates. We used cosine similarity scores to identify 65 variants with potential high-impact (deleterious effects) that correlated with specific phenotypes. Of these, 19 were Single Nucleotide Polymorphisms (SNPs) that changed stop or...

Winter respiratory C losses provide explanatory power for net ecosystem productivity

Matthias Haeni, Roman Zweifel, Werner Eugster, Arthur Gessler, Sebastian Zielis, Christian Bernhofer, Arnaud Carrara, Thomas Grünwald, Kateřina Havránková, Bernard Heinesch, Mathias Herbst, Andreas Ibrom, Alexander Knohl, Fredrik Lagergren, Beverly E. Law, Michal Marek, Giorgio Matteucci, John H. McCaughey, Stefano Minerbi, Leonardo Montagnani, Eddy Moors, Janusz Olejnik, Marián Pavelka, Kim Pilegaard, Gabriel Pita … & Nina Buchmann
Journal of Geophysical Research. Biogeosciences, 122 (1)

Particle filters for high-dimensional geoscience applications: A review

Peter J. Van Leeuwen, Hans R. Künsch, Lars Nerger, Roland Potthast & Sebastian Reich
Particle filters contain the promise of fully nonlinear data assimilation. They have been applied in numerous science areas, including the geosciences, but their application to high‐dimensional geoscience systems has been limited due to their inefficiency in high‐dimensional systems in standard settings. However, huge progress has been made, and this limitation is disappearing fast due to recent developments in proposal densities, the use of ideas from (optimal) transportation, the use of localization and intelligent adaptive resampling...

Study of the e+e- -> Ze+e- process at LEP

, Pablo Achard, Hans-Bruno Anderhub, Artur Barczyk, Frank Behner, Botio L. Betev, Adrian Biland, Dimitri Bourilkov, Alessandro De Salvo, Michael Dittmar, Marta Felcini, Klaus Freudenreich, Oliver Grimm, Hans Hofer, Gregor Holzner, Michael Kräber, Pierre Lecomte, Pierre Le Coultre, Werner Lustermann, Francesca Nessi-Tedaldi, Radoslaw Ofierzynski, Felicitas Pauss, Ghita Rahal-Callot, Renzo Ramelli, Daning Ren … &
The cross section of the process e+e- → Ze+e- is measured with 0.7 fb-1 of data collected with the L3 detector at LEP. Decays of the Z boson into quarks and muons are considered at centre-of-mass energies ranging from 183 GeV up to 209 GeV. The measurements are found to agree with Standard Model predictions, achieving a precision of about 10% for the hadronic channel.

Source partitioning of atmospheric methane using stable carbon isotope measurements in the Reuss Valley, Switzerland

Jacqueline Stieger, Ines Bamberger, Rolf T.W. Siegwolf, Nina Buchmann & Werner Eugster
Isotopes in environmental and health studies, 55 (1)

Closed-loop cavitation control for focused ultrasound-mediated blood–brain barrier opening by long-circulating microbubbles

Mustafa Çavuşoğlu, Jia Zhang, Giovanna D. Ielacqua, Giovanni Pellegrini, Rea D. Signorell, Alexandros Papachristodoulou, Davide Brambilla, Patrick Roth, Michael Weller, Markus Rudin, Ernst Martin, Jean-Christophe Leroux & Beat Werner
Physics in Medicine and Biology, 64 (4)

How to Take Autophagy and Endocytosis Up a Notch

Julia M.I. Barth & Katja Köhler
The interconnection of the endocytic and autophagosomal trafficking routes has been recognized more than two decades ago with both pathways using a set of identical effector proteins and sharing the same ultimate lysosomal destination. More recent data sheds light onto how other pathways are intertwined into this network, and how degradation via the endosomal/autophagosomal system may affect signaling pathways in multicellular organisms. Here, we briefly review the common features of autophagy and endocytosis and discuss...

Evaluated kinetic and photochemical data for atmospheric chemistry: Volume V – heterogeneous reactions on solid substrates

John N. Crowley, Markus Ammann, R.A. Cox, R.G. Hynes, Mike E. Jenkin, Abdelwahid Mellouki, Michel J. Rossi, Jürgen Troe & Timothy J. Wallington
This article, the fifth in the ACP journal series, presents data evaluated by the IUPAC Subcommittee on Gas Kinetic Data Evaluation for Atmospheric Chemistry. It covers the heterogeneous processes on surfaces of solid particles present in the atmosphere, for which uptake coefficients and adsorption parameters have been presented on the IUPAC website in 2010. The article consists of an introduction and guide to the evaluation, giving a unifying framework for parameterisation of atmospheric heterogeneous processes....

Mortality rates and division of labor in the leaf-cutting ant, Atta colombica

Mark J.F. Brown, Adrianne N.M. Bot & Adam G. Hart
Division of labor in social groups is affected by the relative costs and benefits of conducting different tasks. However, most studies have examined the dynamics of division of labor, rather than the costs and benefits that presumably underlie the evolution of such systems. In social insects, division of labor may be simplistically described as a source-sink system, with external tasks, such as foraging, acting as sinks for the work force. The implications of two distinct...

Wall-crossing, Rogers dilogarithm, and the QK/HK correspondence

Sergei Alexandrov, Daniel Persson & Boris Pioline
When formulated in twistor space, the D-instanton corrected hypermultiplet moduli space in N=2 string vacua and the Coulomb branch of rigid N=2 gauge theories on R3 × S 1 are strikingly similar and, to a large extent, dictated by consistency with wall-crossing. We elucidate this similarity by showing that these two spaces are related under a general duality between, on one hand, quaternion-Kähler manifolds with a quaternionic isometry and, on the other hand, hyperkähler manifolds...

3d-SPADE: Significance evaluation of spatio-temporal patterns of various temporal extents

Alessandra Stella, Pietro Quaglio, Emiliano Torre & Sonja Grün
The Spike Pattern Detection and Evaluation (SPADE) analysis is a method to find reoccurring spike patterns in parallel spike train data, and to determine their statistical significance. Here we introduce an extension of the original statistical testing procedure which explicitly accounts for the temporal duration of the patterns. The extension improves the performance in the presence of patterns with different durations, as here demonstrated by application to various synthetic data. We further introduce an implementation...

Reserve Flux Capacity in the Pentose Phosphate Pathway by NADPH Binding Is Conserved across Kingdoms

Dimitris Christodoulou, Andreas Kuehne, Alexandra Estermann, Tobias Fuhrer, Paul Lang & Uwe Sauer
All organisms evolved defense mechanisms to counteract oxidative stress and buildup of reactive oxygen species (ROS). To test whether a potentially conserved mechanism exists for the rapid response, we investigated immediate metabolic dynamics of Escherichia coli, yeast, and human dermal fibroblasts to oxidative stress that we found to be conserved between species. To elucidate the regulatory mechanisms that implement this metabolic response, we developed mechanistic kinetic models for each organism's central metabolism and systematically tested...

Poly(phenylene methylene)-Based Coatings for Corrosion Protection: Replacement of Additives by Use of Copolymers

Marco F. D’Elia, Mirko Magni, Stefano P.M. Trasatti, Thomas B. Schweizer, Markus Niederberger & Walter Caseri
Poly(phenylene methylene) (PPM) is a thermally stable, hydrophobic, fluorescent hydrocarbon polymer. Recently, blended PPM has been proposed as a valuable anti-corrosion coating material, and, in particular, rheological additives such as external plasticizers resulted crucial to prevent crack formation. Accordingly, to avoid common problems related to the use of external plasticizers, the development of PPM-related copolymer-based coatings containing n-octyloxy side chains and their anti-corrosion behavior were explored in this study. The aluminum alloy AA2024, widely employed...

Structural Characterization and Analysis of High-Strength Laminated Composites from Recycled Newspaper and HDPE

Binwei Zheng, Chuanshuang Hu, Litao Guan, Jin Gu, Huizhang Guo & Weiwei Zhang
Recycled newspaper (NP) shows excellent potential as a reinforcement for polymer composites. Herein, high-strength laminated composites were prepared by using NP laminas as reinforcement and high-density polyethylene (HDPE) films as matrix. Physical and mechanical properties of the laminated composites were measured. It was found that the flexural strength of the composites had a good linear relationship to its density, with R2 = 0.9853. The flexural and tensile strength of the composites at the maximum density...

Agent-based modelling for transport planning

Kay W. Axhausen

Rostral growth of commissural axons requires the cell adhesion molecule MDGA2

Pascal Joset, Andrin Wacker, Régis Babey, Esther A. Ingold, Irwin Andermatt, Esther T. Stoeckli & Matthias Gesemann
Background Long-distance axonal growth relies on the precise interplay of guidance cues and cell adhesion molecules. While guidance cues provide positional and directional information for the advancing growth cone, cell adhesion molecules are essential in enabling axonal advancement. Such a dependence on adhesion as well as guidance molecules can be well observed in dorsal commissural interneurons, which follow a highly stereotypical growth and guidance pattern. The mechanisms and molecules involved in the attraction and outgrowth...

IFN-γ Hinders Recovery from Mucosal Inflammation during Antibiotic Therapy for Salmonella Gut Infection

Tamas Dolowschiak, Anna A. Mueller, Lynn J. Pisan, Rounak Feigelman, Boas Felmy, Mikael E. Sellin, Sukumar Namineni, Bidong D. Nguyen, Sandra Y. Wotzka, Mathias Heikenwaelder, Christian Von Mering, Christoph Mueller & Wolf-Dietrich Hardt
Cell Host & Microbe, 20 (2)

Electronic and vibrational relaxation dynamics of NH3 Rydberg states probed by vacuum-ultraviolet time-resolved photoelectron imaging

Vít Svoboda, Chuncheng Wang, Max Waters & Hans Jakob Wörner
Time-resolved dynamics of high-lying Rydberg states of ammonia (NH3) prepared by using a vacuum ultraviolet (VUV) pump (∼9.3 eV) and an ultraviolet (UV) probe (∼4.7 eV) pulse are reported using photoelectron imaging detection. After photoexcitation, two main features appear in the photoelectron spectrum with vertical binding energies of ∼1.8 eV and ∼3.2 eV and with distinctly different anisotropy parameters β of ∼1.3 and ∼0.7, respectively. This information allows the unambiguous assignment of the respective Rydberg...

Autophagy Proteins Promote Repair of Endosomal Membranes Damaged by the Salmonella Type Three Secretion System 1

Saskia Kreibich, Mario Emmenlauer, Jennifer Fredlund, Pauli Rämö, Christian Münz, Christoph Dehio, Jost Enninga & Wolf-Dietrich Hardt
Cell Host & Microbe, 18 (5)

Advanced Fabrication of Single-Mode and Multi-Wavelength MIR-QCLs

Jérôme Faist, Martin J. Süess, Romain Peretti, Yong Liang, Johanna M. Wolf, Christopher Bonzon, Borislav Hinkov, Selamnesh Nida, Pierre Jouy, Wondwosen Metaferia, Sebastian Lourdudoss & Mattias Beck
In this article we present our latest work on the optimization of mid-infrared quantum cascade laser fabrication techniques. Our efforts are focused on low dissipation devices, broad-area high-power photonic crystal lasers, as well as multi-wavelength devices realized either as arrays or multi-section distributed feedback (DFB) devices. We summarize our latest achievements and update them with our most recent results.

Solvent-Controlled Spatial Distribution of SI-AGET-ATRP Grafted Polymers in Lignocellulosic Materials

Marta Vidiella Del Blanco, Vera Gomez, Tobias Keplinger, Etienne Cabane & Luiz F. Grafulha Morales
Biomacromolecules, 20 (1)

The importance of the representation of air pollution emissions for the modeled distribution and radiative effects of black carbon in the Arctic

Jacob Schacht, Bernd Heinold, Johannes Quaas, John Backman, Ribu Cherian, Andre Ehrlich, Andreas Herber, Wan T.K. Huang, Yutaka Kondo, Andreas Massling, P.R. Sinha, Bernadett Weinzierl, Marco Zanatta & Ina Tegen
Aerosol particles can contribute to the Arctic amplification (AA) by direct and indirect radiative effects. Specifically, black carbon (BC) in the atmosphere, and when deposited on snow and sea ice, has a positive warming effect on the top-of-atmosphere (TOA) radiation balance during the polar day. Current climate models, however, are still struggling to reproduce Arctic aerosol conditions. We present an evaluation study with the global aerosol-climate model ECHAM6.3-HAM2.3 to examine emission-related uncertainties in the BC...

Positive plant–plant interactions expand the upper distributional limits of some vascular plant species

Morgan J. Raath‐Krüger, Melodie A. McGeoch, Christian Schöb, Michelle Greve & Peter C. Le Roux
Biotic interactions can shape species’ distributions through their impact on species’ realized niches, potentially constraining or expanding the range of conditions under which species occur. We examine whether fine‐scale plant–plant interactions scale up to shape broad‐scale species’ distributions, using Azorella selago, a widespread cushion plant that facilitates other species, and the rest of the vascular flora of sub‐Antarctic Marion Island as a model system. We compared the upper elevational distributional limit of each species when...

A way forward with eco evo devo: an extended theory of resource polymorphism with postglacial fishes as model systems

Skúli Skúlason, Kevin J. Parsons, Richard Svanbäck, Katja Räsänen, Moira M. Ferguson, Colin E. Adams, Per‐Arne Amundsen, Pia Bartels, Colin W. Bean, Janette W. Boughman, Göran Englund, Johannes Guðbrandsson, Oliver E. Hooker, Alan G. Hudson, Kimmo K. Kahilainen, Rune Knudsen, Bjarni K. Kristjánsson, Camille A.‐L. Leblanc, Zophonías Jónsson, Gunnar Öhlund, Carl Smith & Sigurður S. Snorrason
A major goal of evolutionary science is to understand how biological diversity is generated and altered. Despite considerable advances, we still have limited insight into how phenotypic variation arises and is sorted by natural selection. Here we argue that an integrated view, which merges ecology, evolution and developmental biology (eco evo devo) on an equal footing, is needed to understand the multifaceted role of the environment in simultaneously determining the development of the phenotype and...

The investigation of permeability calculation using digital core simulation technology

Lei Zhang, Wenlong Jing, Yongfei Yang, Hainan Yang, Yaohao Guo, Hai Sun, Jianlin Zhao & Jun Yao
Digital core simulation technology, as an emerging numerical simulation method, has gradually come to play a significant role in the study of petrophysical properties. By using this numerical simulation method, the influence of micro factors on seepage properties of reservoir rock is taken into consideration, making up the shortcomings of the traditional physical experiment. Three-dimensional core images are reconstructed by a computed tomography scanning technique. Different sizes of the sub-region were simulated by three methods...

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