434 Works

Development and implementation of ¹H magnetic resonance techniques for an improved in vivo assessment of models of cerebral metabolic disorders

Mélanie Craveiro
Nuclear magnetic resonance (NMR) is a physical phenomenon that is widely used in the biomedical field due to its non-invasive and non-destructive properties, which make it an optimal tool for the in vivo investigation of living organs such as the brain. This thesis focused on the development of 1H magnetic resonance (MR) techniques at ultra-high magnetic field strength to improve the measurement and quantification of the 1H MR signal in the rodent brain, and to...

Inhibition of Sepiapterin Reductase through Formation of a Ternary Complex with Sulfasalazine or other Sulfa Drugs and NADP+

Miriam Grønlund Pedersen
The mechanism of action of sulfasalazine, an anti-inflammatory drug used against inflammatory bowel diseases and rheumatoid arthritis is, despite its medical importance, still not well understood. Recently, it was shown that sulfasalazine and its metabolite sulfapyridine are potent inhibitors of sepiapterin reductase (SPR). Additionally, it has been proposed that inhibition of tetrahydrobiopterin (BH4) biosynthesis contributes to the anti-inflammatory activity of sulfasalazine. The final step in BH4 biosynthesis from GTP is a NADPH dependent reduction of...

Testing Software Systems Against Realistic User Errors

Silviu Andrica

Novel Approaches Toward Area- and Energy-Efficient Embedded Memories

Pascal Andreas Meinerzhagen

The Cavity Method in Coding Theory

Marc Vuffray

Parametric estimation of sparse channels:theory and applications

Yann Barbotin

Object Classification and Detection in High Dimensional Feature Space

Charles Dubout

Gating, sensing and templating with polymer brushes

Caroline Sugnaux

Near-Field Enhancement in Plasmonic Arrays

Thomas Gerd Siegfried

On Voltage and Frequency Control in Multi-Area Power Systems Security

Omid Alizadeh Mousavi

Human Body Proximity Effects on Ultra-Wideband Antennas

Mohsen Koohestani
Body-centric applications include wearable communication systems that can be integrated in many different applications, as for instance in military, security forces, sport, fashion, or medical. In the latter, the quality of life of patients can be greatly improved by the use of implants or wearable systems allowing the continuous monitoring of health related parameters (heart beat, level of glucose, temperature, etc). Ultra-Wideband (UWB) systems have been developed for some of the mentioned applications, and improved...

Integrating Rate Based Models into a Multi-Objective Process Design & Optimisation Framework using Surrogate Models

Levent Sinan Teske
In the development of energy and chemical processes, the process engineers extensively apply computer aided methods to design & optimise these processes and corresponding process units. Such applications are multi-scale modelling and multi-objective optimisation methods. Multi-objective optimisation of super-structured process designs are expensive in CPU-time due to the high number of potential configurations and operation conditions to be calculated. Thus single process units are generally represented by simple models like equilibrium based (chemical or phase...

Gas sensing technology based on carbon nanotube arrays

Hoël Maxime Guerin

New Tools for Hydrogel-Based 3D Bioprinting

Andrea Negro
The in vitro recapitulation of tissue and organ function represents one of the main objectives of tissue engineering. Developments in this field have numerous applications, from alleviating the shortage of donor organs to providingmore representative platforms for drug testing. As such, there is an increasingly significant body of literature devoted to the development of better strategies to reconstruct living matter outside of the body. The three-dimensional (3D) architecture of a tissue, its histoarchitecture, is a...

Reliability of packaging in high-temperature control electronics

Conor Joseph Slater

Improving Comparative Genomic Studies:Definitions and Algorithms for Syntenic Blocks

Cristina Gabriela Ghiurcuta
Comparative genomics aims to understand the structure of genomes and the function of various genomic fragments, by transferring knowledge gained from well studied genomes, to the new object of study. Rapid and inexpensive high-throughput sequencing is making available more and more complete genome sequences. Despite the significant scientific advance, we still lack good models for the evolution of the genomic architecture, therefore analyzing these genomes presents formidable challenges. Early approaches used pairwise comparisons, but today...

Registration Year

  • 2014

Resource Types

  • Text