1,518 Works

MONOMER OF DNA-PACKAGING RNA (PRNA) OF BACTERIOPHAGE PHI29

P.GUO S.HOEPRICH

RIBOSOMAL RNAS AND PROTEINS AS WELL AS FACTORS IN THE PRE- TRANSLOCATIONAL STATE

N.NAGANO K.NAGANO

PfPARE

PISUM SATIVUM DEFENSIN 1(PSD1)MUTANT A18G

E.KURTENBACH P.C SATHLER

Multidrug transporter MexY of Pseudomonas aeruginosa

Secondary multidrug transporters of the resistance-nodulation-cell division (RND) superfamily contribute crucially to antibiotic resistance in Gram-negative bacteria. Compared to the most studied transporter AcrB of E. coli, little is known about the molecular determinants of distinct polyspecificities of the most important RND transporters MexB and MexY of Pseudomonas aeruginosa. The absence of an experimental structure of MexY and the availability of only one structure of MexB bound to compounds (the ABI-PP inhibitor D13-9001) have made...

HOMOLOGY MODELLED PLATELET DERIVED GROWTH FACTOR

Structure of Prototypic Peptide Transporter DtpA from E. coli in Complex with Valganciclovir Provides Insights into Drug Binding of Human PepT1

Members of the solute carrier 15 family (SLC15) transport di- and tripeptides as well as peptidomimetic drugs across the cell membrane. Structures of bacterial homologues have provided valuable information on the binding and transport of their natural substrates, but many do not transport medically relevant drugs. In contrast, a homologue from Escherichia coli, DtpA, shows a high similarity to human PepT1 (SLC15A1) in terms of ligand selectivity and transports a similar set of drugs. Here,...

COMPUTATIONAL MODEL STRUCTURE OF HIV-2 POL POLYPROTEIN

A.DAS C.BARUAH

Structure of human Orai1 based on homology with dOrai

REDUCED GLUTAREDOXIN 3 SIMULATION TRAJECTORY MODELS 1-45

L.NILSSON N.FOLOPPE

MOVEMENT PROTEIN OF TOMATO MOSAIC VIRUS

MADHUSUDHAN. K.N D SIVAKUMAR

D-AMINO ACID OXIDASE [RATTUS NORVEGICUS]

Theoretical model of complex between phosphoglycerate kinase 1 and DJ1

Telomere signalling and metabolic dysfunction are hallmarks of cell aging, and are associated with a variety of pathologies. Identification of new agents targeting these processes might provide therapeutic opportunities, including chemoprevention strategies against cancer predisposition. Here we report identification and characterization of a pyrazolopyrimidine compound series that emerged from screens focused on cell immortality pathways and whose targets are glycolytic kinase PGK1 and oxidative stress sensor DJ1. We initially performed structure-activity studies on the series...

Structural insight on ATP hydrolysis in RecA/dsDNA nucleofilament

Homologous recombination (HR) is a fundamental process that allows the faithful repair of DNA double strand breaks through the exchange of DNA strands between homologous regions of the genome. In bacteria, the exchange takes place within nucleofilaments of the RecA protein formed on a DNA strand from the damaged region. ATP is hydrolyzed in large quantity during the HR process, yet how exactly hydrolysis influences the DNA strand exchange reaction at the structural level remains...

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