34 Works

Master regulator, DnrI of Streptomyces peucetius

Hpa2 protein modelling and protein-protein docking

JYOTI SINGH TOMAR

full-length wild-type p53 tetramer with DNA

DARC - Duffy Antigen / Receptor for Chemokine (model 1)

Alexandre G. De Brevern

Open conformation SHP2

The tyrosine phosphatase SHP2 interconverts between open, active, and closed, inactive, structures to regulate crucial cell signaling pathways. Oncogenic mutations such as E76K shifts the equilibrium towards the open state making SHP2 200 fold more active than WT. In contrast to the closed state of SHP2 that has been well described mainly by crystal structures, the open structure is unknown and possibly adopts a ensemble of states in solution that hampers crystallization. Using homology modeling...

TAG protein model

JYOTI SINGH TOMAR

Xn-RelT toxin from X. nematophila in complex with RNA substrate.

IBDV VP5

Bhaskar Ganguly

Homology model of Arabidopsis thaliana nitrile-specifier protein 3 (AtNSP3)

Daniela Eisenschmidt-Bönn
Glucosinolates, a group of sulfur-rich thioglucosides found in plants of the order Brassicales, have attracted a lot of interest as chemical defenses of plants and health promoting substances in human diet. They are accumulated separately from their hydrolyzing enzymes, myrosinases, within the intact plant, but undergo myrosinase-catalyzed hydrolysis upon tissue disruption. This results in various biologically active products, e.g. isothiocyanates, simple nitriles, epithionitriles, and organic thiocyanates. While formation of isothiocyanates proceeds by a spontaneous rearrangement...

Allosteres to Regulate Neurotransmitter Sulfonation

Catecholamine neurotransmitter levels in the synapses of the brain shape human disposition — cognitive flexibility, aggression, depression, reward seeking… — and manipulating these levels is a major objective of the pharmaceutical industry. Certain transmitters are extensively sulfonated — an inactivating modification catalyzed by human sulfotransferase 1A3 (SULT1A3). To our knowledge, sulfonation as therapeutic means of regulating transmitter activity has not been explored. Here we describe the discovery of a SULT1A3 allosteric site that can be...

PfPARE

Registration Year

  • 2018
    34

Resource Types

  • Physical Object
    21
  • Model
    13