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Lili Xie
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Intraoperative ventilator settings and their association with postoperative pulmonary complications in neurosurgical patients: post-hoc analysis of LAS VEGAS study

Chiara Robba, Sabrine N. T. Hemmes, Ary Serpa Neto, Thomas Bluth, Jaume Canet, Michael Hiesmayr, , Gary H. Mills, Marcos F. Vidal Melo, Christian Putensen, Samir Jaber, Werner Schmid, Paolo Severgnini, Hermann Wrigge, Denise Battaglini, Lorenzo Ball, Marcelo Gama De Abreu, Marcus J. Schultz & Paolo Pelosi
Abstract Background Limited information is available regarding intraoperative ventilator settings and the incidence of postoperative pulmonary complications (PPCs) in patients undergoing neurosurgical procedures. The aim of this post-hoc analysis of the ‘Multicentre Local ASsessment of VEntilatory management during General Anaesthesia for Surgery’ (LAS VEGAS) study was to examine the ventilator settings of patients undergoing neurosurgical procedures, and to explore the association between perioperative variables and the development of PPCs in neurosurgical patients. Methods Post-hoc analysis...

The long-term health effects of attending a selective school: a natural experiment

Jessica Butler, , Peter Craig, Chris Dibben, Ruth Dundas, Michelle Hilton Boon, Marjorie Johnston & Frank Popham
Abstract Background Education is widely associated with better physical and mental health, but isolating its causal effect is difficult because education is linked with many socioeconomic advantages. One way to isolate education’s effect is to consider environments where similar students are assigned to different educational experiences based on objective criteria. Here we measure the health effects of assignment to selective schooling based on test score, a widely debated educational policy. Methods In 1960s Britain, children...

Sedentary behavior patterns and adiposity in children: a study based on compositional data analysis

Aleš Gába, , Nikola Štefelová, Jan Dygrýn, Karel Hron, Dorothea Dumuid & Mark Tremblay
Abstract Background Between-person differences in sedentary patterns should be considered to understand the role of sedentary behavior (SB) in the development of childhood obesity. This study took a novel approach based on compositional data analysis to examine associations between SB patterns and adiposity and investigate differences in adiposity associated with time reallocation between time spent in sedentary bouts of different duration and physical activity. Methods An analysis of cross-sectional data was performed in 425 children...

Deep learning-based cancer survival prognosis from RNA-seq data: approaches and evaluations

Zhi Huang, Travis S. Johnson, Zhi Han, Bryan Helm, Sha Cao, Chi Zhang, Paul Salama, Maher Rizkalla, Christina Y. Yu, Jun Cheng, , , Jie Zhang & Kun Huang
Abstract Background Recent advances in kernel-based Deep Learning models have introduced a new era in medical research. Originally designed for pattern recognition and image processing, Deep Learning models are now applied to survival prognosis of cancer patients. Specifically, Deep Learning versions of the Cox proportional hazards models are trained with transcriptomic data to predict survival outcomes in cancer patients. Methods In this study, a broad analysis was performed on TCGA cancers using a variety of...

Extracranial-intracranial bypass surgery for occlusive atherosclerotic disease of the anterior cerebral circulation: protocol for a systematic review and meta-analysis

, Yao Feng, Kun Yang, Tao Wang, , Xue Wang, Feng Ling, Yan Ma &
Abstract Background Occlusive atherosclerotic disease of the anterior cerebral circulation is one of the most common causes of anterior circulation ischemia and stroke. Treatment options include medical therapies (including antiplatelet use, blood pressure control, lipid reduction, and lifestyle modification) and extracranial-intracranial bypass surgery (such as superficial temporal artery-middle cerebral artery bypass). However, the optimal treatment remains unclear. The objective of this study will be to compare the efficacy of and extracranial-intracranial bypass surgery with that...

Dense module searching for gene networks associated with multiple sclerosis

Astrid M. Manuel, , , &
Abstract Background Multiple sclerosis (MS) is a complex disease in which the immune system attacks the central nervous system. The molecular mechanisms contributing to the etiology of MS remain poorly understood. Genome-wide association studies (GWAS) of MS have identified a small number of genetic loci significant at the genome level, but they are mainly non-coding variants. Network-assisted analysis may help better interpret the functional roles of the variants with association signals and potential translational medicine...

Inflammation-related gene polymorphisms associated with Parkinson’s disease: an updated meta-analysis

Zulvikar Syambani Ulhaq & Cristian Peinado Garcia
Abstract Background Strong evidence supports the involvement of inflammation processes in the development and progression of Parkinson’s disease (PD), where increasingly correlations have been identified between genetic variations in inflammation-related genes and PD. However, data varies between studies. Therefore, we conducted a meta-analysis to clarify associations between inflammation-related gene polymorphisms and PD risk. Methods All studies were identified through online databases. Pooled and stratified groups based on racial descent were assembled to evaluate associations between...

GaitRec: A large-scale ground reaction force dataset of healthy and impaired gait

Brian Horsak, , , , Marianne Worisch & Matthias Zeppelzauer
The quantification of ground reaction forces (GRF) is a standard tool for clinicians to quantify and analyze human locomotion. Such recordings produce a vast amount of complex data and variables which are difficult to comprehend. This makes data interpretation challenging. Machine learning approaches seem to be promising tools to support clinicians in identifying and categorizing specific gait patterns. However, the quality of such approaches strongly depends on the amount of available annotated data to train...

Isabella's Power Workout

Daniel West

Supplementary material from \"Overexpression of chloroplast-targeted ferrochelatase 1 results in a genomes uncoupled chloroplast-to-nucleus retrograde signalling phenotype\"

Mike Page, Tania Garcia-Becerra, Alison Smith & Matthew Terry
Chloroplast development requires communication between the progenitor plastids and the nucleus, where most of the genes encoding chloroplast proteins reside. Retrograde signals from the chloroplast to the nucleus control the expression of many of these genes, but the signalling pathway is poorly understood. Tetrapyrroles have been strongly implicated as mediators of this signal with the current hypothesis being that haem produced by the activity of ferrochelatase 1 (FC1) is required to promote nuclear gene expression....

Supplementary material from \"Chloroplast-to-nucleus retrograde signalling controls intercellular trafficking via plasmodesmata formation\"

Elena E. Ganusova, Brandon C. Reagan, Jessica C. Fernandez, Mohammad F. Azim, Amie F. Sankoh, Kyle M. Freeman, Tyra N. McCray, Kelsey Patterson, & Tessa M. Burch-Smith
The signalling pathways that regulate intercellular trafficking via plasmodesmata (PD) remain largely unknown. Analyses of mutants with defects in intercellular trafficking led to the hypothesis that chloroplasts are important for controlling PD, likely by retrograde signalling to the nucleus to regulate expression of genes that influence PD formation and function, an idea encapsulated in the organelle-nucleus-PD signalling (ONPS) hypothesis. ONPS is supported by findings that point to chloroplast redox state as also modulating PD. Here,...

Low-dose human menopausal gonadotrophin versus natural cycles in intrauterine insemination for subfertile couples with regular menstruation

, , , &
Abstract Background Women with irregular menstruation should be considered to benefit from the ovarian stimulation. However, most literature did not separate ovulatory disorders from normal menstrual cycles. Our purpose was to assess the superiority of ovarian mild stimulation compared with the natural cycle in IUI for subfertile couples when the women with regular menstruation. Methods A retrospective study in a single medical center in which 2413 couples with 3573 IUI cycles were studied from 2013...

MSX2 suppression through inhibition of TGFβ signaling enhances hematopoietic differentiation of human embryonic stem cells

, , Yu Wang, , , Dan Wu, Pei Su, Wen Zhou, &
Abstract Background Strategies of generating functional blood cells from human pluripotent stem cells (hPSCs) remain largely unsuccessful due to the lack of a comprehensive understanding of hematopoietic development. Endothelial-to-hematopoietic transition (EHT) serves as the pivotal mechanism for the onset of hematopoiesis and is negatively regulated by TGF-β signaling. However, little is known about the underlying details of TGF-β signaling during EHT. Methods In this study, by applying genome-wide gene profiling, we identified muscle segment homeobox2...

General formula to design a freeform singlet free of spherical aberration and astigmatism: Comment

Juan Valencia-Estrada & Jorge Garcia-Marquez
In their article [Appl. Opt. 58, 1010–1015 (2019)] González-Acuña et al claimed: “an analytical closed-form formula for the design of freeform lenses free of spherical aberration and astigmatism.” However, as we show here, their formula can only be applied when the object and image are both real and the image is inversed. Here, we present the complete solution of this particular family of lenses.

Epidemiology of schizophrenia and its management over 8-years period using real-world data in Spain

, , , &
Abstract Background Real-World Data (RWD) studies provide important insights in disease epidemiology, in real clinical populations, with long follow-up periods. The aim of the present study was to describe the epidemiology of schizophrenia spectrum disorders (SD) during an 8-year period in Spain. Methods A retrospective cohort of subjects aged 15 to 64 years was followed-up using electronic healthcare databases of the Valencia region (2008–2015). SD cases included outpatient and inpatient settings (ICD 9 codes 295.XX)....

Long noncoding RNA HOST2, working as a competitive endogenous RNA, promotes STAT3-mediated cell proliferation and migration via decoying of let-7b in triple-negative breast cancer

, , , , , , & Lin Fang
Abstract Background Human ovarian cancer specific transcript 2 (HOST2) is a long non-coding RNA (lncRNA) reported to be specifically high expressed in human ovarian cancer. However, the mechanism that how HOST2 regulates triple negative breast cancer (TNBC) need to be explored. Methods In this study, expression of HOST2 was determined in 40 TNBC patients and matched non-cancerous tissues by qRT-PCR and in situ hybridization (ISH) assay. The biological functions of HOST2 was measured by losing...

Community-Based Cardiac Rehabilitation To Improve Medication Adherence and Quality of Life in Stable Coronary Artery Disease

Tonny Adriyanto, Cholid Tri Tjahjono, Mohammad Saifur Rohman &
Cardiovascular disease contributes to 48% of deaths in the world. A cohort study at the Harapan Kita NationalHeart Center and 5 Indonesia hospitals in 2006 showed that the death rate due to heart disease in hospitals wasaround 6-12%. Rehospitalization rate reached 29% and the all-out expense of INA-CBG claimed for inpatient wasRp 42.4 trillion. The major problem causing rehospitalization was poor compliance to medication in coronaryartery disease (CAD) patients. Education to improve compliance has been...

m6A-dependent glycolysis enhances colorectal cancer progression

, , , , , , , , Dan Ma, , , Jing-Yuan Fang, & Jie Hong
Abstract Background Epigenetic alterations are involved in various aspects of colorectal carcinogenesis. N6-methyladenosine (m6A) modifications of RNAs are emerging as a new layer of epigenetic regulation. As the most abundant chemical modification of eukaryotic mRNA, m6A is essential for the regulation of mRNA stability, splicing, and translation. Alterations of m6A regulatory genes play important roles in the pathogenesis of a variety of human diseases. However, whether this mRNA modification participates in the glucose metabolism of...

Additional file 1 of Modeling of shotgun sequencing of DNA plasmids using experimental and theoretical approaches

Sergey Shityakov, Elena Bencurova, Carola Förster & Thomas Dandekar
Additional file 1. Input and output data for modeling of shotgun sequencing of DNA plasmids. All the necessary files (tested in Linux environment) required for the virtual sequencing, including executable programs, bash scripts, FASTA format files, and program outputs.

Comprehensive analysis of skeletal muscle- and bone-derived mesenchymal stem/stromal cells in patients with osteoarthritis and femoral neck fracture

Klemen Čamernik, , Rene Mihalič, Gregor Haring, Simon Herman, Darja Marolt Presen, Andrej Janež, Rihard Trebše, Janja Marc & Janja Zupan
Abstract Background Mesenchymal stem/stromal cells (MSCs) can replenish the aged cells of the musculoskeletal system in adult life. Stem cell exhaustion and decrease in their regenerative potential have been suggested to be hallmarks of aging. Here, we investigated whether muscle- and bone-derived MSCs of patients with osteoarthritis and osteoporosis are affected by this exhaustion, compared to healthy donors. Methods Patients with primary osteoarthritis, femoral neck fractures due to osteoporosis, and healthy donors (controls) were included....

Transcriptomic and metabolomic analyses reveal mechanisms of adaptation to salinity in which carbon and nitrogen metabolism is altered in sugar beet roots

Lei Liu, Bin Wang, Dan Liu, , , , &
Abstract Background Beta vulgaris L. is one of the main sugar-producing crop species and is highly adaptable to saline soil. This study explored the alterations to the carbon and nitrogen metabolism mechanisms enabling the roots of sugar beet seedlings to adapt to salinity. Results The ionome, metabolome, and transcriptome of the roots of sugar beet seedlings were evaluated after 1 day (short term) and 7 days (long term) of 300 mM Na+ treatment. Salt stress...

Inactivation of the T6SS inner membrane protein DotU results in severe attenuation and decreased pathogenicity of Aeromonas veronii TH0426

, , , , Ying Li, Lei Zhang, &
Abstract Background The inner membrane protein DotU of Aeromonas veronii is an important component of the minimal core conserved membrane proteome required for the formation of an envelope-transmembrane complex. This protein functions in a type VI secretion system (T6SS), and the role of this T6SS during the pathogenic process has not been clearly described. Results A recombinant A. veronii with a partial disruption of the dotU gene (720 bp of the in-frame sequence) (defined as...

Inactivation of the T6SS inner membrane protein DotU results in severe attenuation and decreased pathogenicity of Aeromonas veronii TH0426

, , , , Ying Li, Lei Zhang, &
Abstract Background The inner membrane protein DotU of Aeromonas veronii is an important component of the minimal core conserved membrane proteome required for the formation of an envelope-transmembrane complex. This protein functions in a type VI secretion system (T6SS), and the role of this T6SS during the pathogenic process has not been clearly described. Results A recombinant A. veronii with a partial disruption of the dotU gene (720 bp of the in-frame sequence) (defined as...

Determinants of Acute Asthma Attack among adult asthmatic patients visiting hospitals of Tigray, Ethiopia, 2019: case control study

, , , , , , &
Abstract Introduction Acute asthma attack is one of the most common causes of visits to hospital emergency departments in all age groups of the population and accounts for the greater part of healthcare burden from the disease. Despite, Acute asthma attack is an important public health problem that affects not only the patients, but also to the family, health professionals, health care institutions and development of the nation, little is known about the risk factors...

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