1,536,542 Works

KLHL40

IUFRO Annual Report 2012

Reflection on Foundations of Flexible, Online, & Distance Education

Kristoffer Greaves

A Digital Repository for #legaled Conferences?

Kristoffer Greaves

HDHD1A, STS, VCX, PNPLA4, MIR651

Maki Fukami

SPTB

Pilar Carrasco Salas

MYH11

data.sharing.xlsx

Lili Xie
any question about this data can contact with me.

Function_processing.zip

Jie Lyu
See README.md

Computational elucidation and validation of the three-dimensional structure of humanized aldolase catalytic antibody 38C2

Ranga Srinath Jayakody, &
Catalytic antibodies are immunoglobulin proteins that are capable of catalyzing multiple reactions with diverse substrates. Aldolase catalytic antibody 38C2 catalyzes aldol and retro-aldol reactions via an enamine mechanism. Therefore, 38C2 has a high potential to be used in prodrug activation, and it is currently developed for selective chemotherapy. For medical applications, its humanization is essential, and therefore, the understanding of the three-dimensional (3D) spatial atomistic structure of 38C2 is mandatory. In this study, it was...

Intraoperative ventilator settings and their association with postoperative pulmonary complications in neurosurgical patients: post-hoc analysis of LAS VEGAS study

Chiara Robba, Sabrine N. T. Hemmes, Ary Serpa Neto, Thomas Bluth, Jaume Canet, Michael Hiesmayr, , Gary H. Mills, Marcos F. Vidal Melo, Christian Putensen, Samir Jaber, Werner Schmid, Paolo Severgnini, Hermann Wrigge, Denise Battaglini, Lorenzo Ball, Marcelo Gama De Abreu, Marcus J. Schultz & Paolo Pelosi
Abstract Background Limited information is available regarding intraoperative ventilator settings and the incidence of postoperative pulmonary complications (PPCs) in patients undergoing neurosurgical procedures. The aim of this post-hoc analysis of the ‘Multicentre Local ASsessment of VEntilatory management during General Anaesthesia for Surgery’ (LAS VEGAS) study was to examine the ventilator settings of patients undergoing neurosurgical procedures, and to explore the association between perioperative variables and the development of PPCs in neurosurgical patients. Methods Post-hoc analysis...

Additional file 5 of An improved de novo genome assembly of the common marmoset genome yields improved contiguity and increased mapping rates of sequence data

Vasanthan Jayakumar, Hiromi Ishii, Misato Seki, Wakako Kumita, Takashi Inoue, , Kengo Sato, Hideyuki Okano, Erika Sasaki &
Additional file 5: Table S2. Pseudo-chromosome statistics of the marmoset genome assemblies from different assemblers.

The trehalose-6-phosphate phosphatase Tps2 regulates ATG8 transcription and autophagy in Saccharomyces cerevisiae

, , & Won-Ki Huh
Macroautophagy/autophagy is an important catabolic process for maintaining cellular homeostasis by adapting to various stress conditions. Autophagy is mediated by a double-membrane autophagosome, which sequesters a portion of cytoplasmic components for delivery to the vacuole. Several autophagy-related (ATG) genes play crucial roles in autophagosome formation. The induction of ATG genes must be tightly regulated to maintain a proper autophagic activity, but their regulatory mechanisms are still largely unknown. Here, we report that the trehalose-6-phosphate phosphatase...

The long-term health effects of attending a selective school: a natural experiment

Jessica Butler, , Peter Craig, Chris Dibben, Ruth Dundas, Michelle Hilton Boon, Marjorie Johnston & Frank Popham
Abstract Background Education is widely associated with better physical and mental health, but isolating its causal effect is difficult because education is linked with many socioeconomic advantages. One way to isolate education’s effect is to consider environments where similar students are assigned to different educational experiences based on objective criteria. Here we measure the health effects of assignment to selective schooling based on test score, a widely debated educational policy. Methods In 1960s Britain, children...

Sedentary behavior patterns and adiposity in children: a study based on compositional data analysis

Aleš Gába, , Nikola Štefelová, Jan Dygrýn, Karel Hron, Dorothea Dumuid & Mark Tremblay
Abstract Background Between-person differences in sedentary patterns should be considered to understand the role of sedentary behavior (SB) in the development of childhood obesity. This study took a novel approach based on compositional data analysis to examine associations between SB patterns and adiposity and investigate differences in adiposity associated with time reallocation between time spent in sedentary bouts of different duration and physical activity. Methods An analysis of cross-sectional data was performed in 425 children...

Dataset describing Titan's Flux Ropes

Carley Martin
Tables of data describing the flux ropes found in Titan's ionosphere. Supporting 1 shows the time, date, Cassini revolution, Titan flyby, and other fitting parameters of each flux rope found. Supporting 2 shows the environment Titan was found in during each Titan flyby, along with how many flux ropes are found along each trajectory. More information can be found in the associated papers.

Targeted Inference Involving High-Dimensional Data Using Nuisance Penalized Regression

Qiang Sun &
Analysis of high-dimensional data has received considerable and increasing attention in statistics. In practice, we may not be interested in every variable that is observed. Instead, often some of the variables are of particular interest, and the remaining variables are nuisance. To this end, we propose the nuisance penalized regression which does not penalize the parameters of interest. When the coherence between interest parameters and nuisance parameters is negligible, we show that resulting estimator can...

bioethical-challenges-arising-from-the-microbiology-andpathology-of-alzheimers-disease.pdf

Herbert Allen
Ethics of Alzheimer's disease challenged by pathology and microbiology. For 25 years the beta amyloid theory has held sway and all efforts have been directed at that compound. With the disease being a chronic infection, that hypothesis must be excluded.

Additional file 1 of State of the art in selection of variables and functional forms in multivariable analysis—outstanding issues

Willi Sauerbrei, Aris Perperoglou, Matthias Schmid, Michal Abrahamowicz, Heiko Becher, Harald Binder, Daniela Dunkler, Frank E. Harrell, Patrick Royston & Georg Heinze
Additional file 1. Web supplement.

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