1,727,225 Works

Synthesis, Structural Stability Calculation, and Antibacterial Evaluation of Novel 3,5-Diphenylcyclohex-2-en-1-one Derivatives

, Ahmed M. El-Saghier & Asmaa M. Kadry
Starting with 3,5-diphenylcyclohex-2-en-1-one, 3,5-diphenylcyclohex-2-en-1-semicarbazone, 1-chloro-3,5-diphenylcyclohex-2-en-2-carbaldehyde, and 3,5-diphenylcyclohex-2-en-1-hydrazone were synthesized via the reactions with semicarbazide hydrochloride, POCl3/ dimethylformamide, and hydrazine hydrate, respectively. These products were used as key intermediates for the preparation of novel series of tetrahydrobenzothiadiazol-1-oxide, indazole, benzo-thiazepines, pentahydroxyhexylidene and N-thiazines. Some of these derivatives exhibit high antibacterial activity against Gram-positive bacteria.

Mechanochemical synthesis and thermal property investigation of metallomesogens and transition metal complexes

Michael G. Hyatt & Rachel J. Allenbaugh
Dialkyl 2,2′-bipyridyl-4,4′-dicarboxylate (Lβn, where βn refers to the number of carbons in β-substituted alkyl chain) complexes including PtLβ16Cl2, CdLβ16Cl2, [AgLβnNO3] and the dodecylsulfate salt [AgLβn2](DOS) were produced at reduced cost and in shorter times, compared to traditional solvent-based methods, by mechanochemical reaction in the absence of solvent. PtLβ16Cl2 and the [AgLβn2](DOS) complexes are the first mesogenic transition metal complexes to be produced via ball milling. The effectiveness of a simple ligand modification, β- versus α-attachment...

Red wines and flavonoids diminish Staphylococcus aureus virulence with anti-biofilm and anti-hemolytic activities

Hyun Seob Cho, Jin-Hyung Lee, Moo Hwan Cho &
The emergence of antibiotic resistant Staphylococcus aureus presents a worldwide problem that requires non-antibiotic strategies. This study investigated the anti-biofilm and anti-hemolytic activities of four red wines and two white wines against three S. aureus strains. All red wines at 0.5–2% significantly inhibited S. aureus biofilm formation and hemolysis by S. aureus, whereas the two white wines had no effect. Furthermore, at these concentrations, red wines did not affect bacterial growth. Analyses of hemolysis and...

Supplemental material for \"Visualization and differential analysis of protein expression data using R\"

& Nadège Richard
Supplemental material for chapter entitled "Visualization and differential analysis of protein expression data using R". A synthetic 2DE dataset is provided as example, along with the code used to analyse it.

Un repositorio digital de contenido fílmico como recurso didáctico

Miguel Angel Tobias Martinez, & Maria Do Carmo Duarte Freitas
El uso de vídeos como recurso didáctico estimula la construcción de nuevo conocimiento. A pesar de la existencia de este recurso en diversos géneros y medios, no se valora la experiencia de los profesionales que lo aprovechan en clase y además no se cuenta con espacios online que orienten y apoyen el uso apropiado de esta práctica. En el ámbito del aprendizaje online, surge la propuesta
de un repositorio de vídeos de corta duración, con el...

ANÁLISE DA CAPACIDA DE PRODUTIVA DE UMA INDÚSTRIA DE BLOCOS PRÉ-MOLDADOS UTILIZANDO O ESTUDO DE TEMPOS CRONOMETRADOS

Vitor Martins, , , & Pedro Júnior
O presente artigo apresenta um estudo de caso de Engenharia de Métodos,
realçando a ORT (Organização Racional do Trabalho), designada por Frederick W. Taylor,
tendo como principal ferramenta de análise o estudo de tempos e movimentos (motion-time
study). O objetivo geral do trabalho é a realização de uma análise do processo produtivo de
blocos de concreto em uma indústria de pré-moldados no município de Marabá, Estado do
Pará e a apresentação de uma proposta para melhoria do processo. O método...

FAST feature detector part block diagram

Marek Kraft
FAST feature detector part block diagram. Parallel, pipelined, systolic.

UTILIZAÇÃO DO MODELO SERVQUAL EM UMA REDE DE SUPERMERCADOS COMO INSTRUMENTO DE AVALIAÇÃO DA QUALIDADE

Vitor Martins, Sandro Trindade, & Renato Neves
O Artigo tem por objetivo avaliar o nível da qualidade de serviços prestados em
uma rede de supermercado ao consumidor paraense por meio de um estudo de caso. O
trabalho apresenta o conceito, desenvolvimento e adaptação da escala SERVQUAL. Desta
forma, foram comparadas as expectativas e as percepções de uma amostra probabilística
envolvendo clientes que utilizam diversos tipos de serviços disponibilizados no supermercado
e procurou-se determinar o grau de importância das cinco dimensões que estruturam o modelo
SERVQUAL: tangibilidade, confiabilidade, responsividade,...

The female postabdomen of five species of Trixoscelis RONDANI 1856 (Diptera: Trixoscelididae)

Andrzej Jozef Woznica
Morphology of female postabdominal part, including spermathecae, of five Trixoscelis species is described. Among analyzed characters the shape of sternite VII and VIII as well as the shape of spermathecae are useful in females identification to the species level

A new ellagic acid derivative from Polygonum runcinatum

Zhi-Hong Zhou, , Meng-Hua Wang, Wei Qu, Jian-Bo Sun, Jing-Yu Liang & Fei-Hua Wu
A new ellagic acid derivative, 3,3′-dimethylellagic acid-4′-O-(6″-galloyl)-β-d-glucoside, named runcinatside (5), together with four known compounds 3,3′-dimethylellagic acid (1), 3,3′,4′-trimethylellagic acid (2), 3,3′-dimethylellagic acid-4′-O-β-d-glucoside (3) and 3-methylellagic acid-4′-O-α-l-rhamno-pyranoside (4), was isolated from the roots of Polygonum runcinatum Buch.-Ham. ex D.Don Var. sinense Hemsl and the structures of these compounds were established by spectroscopic methods and comparison with previously reported data. All compounds showed antioxidant activities in vitro and compound 5 possessed the highest activity.

Antimicrobial activity of human β-defensins against lactic acid bacteria

Xiao-Fang Wang, Fei Tian, Rui-Ming Cao, Jing Li, Sheng-Mei Wu, Xiao-Kui Guo & Tong-Xin Chen
In this study, we evaluated the antimicrobial activity of human β-defensin-1 (hBD-1), human β-defensin-2 (hBD-2) and human β-defensin-3 (hBD-3) against three internationally common probiotic strains of lactic acid bacterium. Our results indicated that hBD-1, hBD-2 and hBD-3 at the range of 0.08–10 μg/mL do not have obvious antimicrobial activity against these strains. Viability of Bifidobacterium longum JDM301 (B. longum JDM301), Bifidobacterium lactis HN019 (B. lactis HN019) and Lactobacillus rhamnosus GG (LGG) were still very high...

Antispasmodic effect of Ocimum selloi essential oil on the guinea-pig ileum

Sylvia D.F. Souza, Carolina S.L. Franca, , Larissa C.B. Costa, José E.B. Pinto, &
Ocimum selloi is an herbal species popularly used in Brazil as antispasmodic. Herein, we report the antispasmodic effect of O. selloi essential oil (OS) in segments of guinea-pig ileum. OS did not reduce the tonus of the ileum. In contrast, OS reduced the contraction induced by carbachol (100 μM), BaCl2 (0.03 M) and low- and high-K+ concentrations (25 and 60 mM, respectively). OS shifted the concentration–response curve for calcium to the right in a parallel...

An N-terminal region of a Myb-like protein is involved in its intracellular localization and activation of a gibberellin-inducible proteinase gene in germinated rice seeds

Keita Sutoh, Kenji Washio, Ryozo Imai, Masamitsu Wada, Tomonori Nakai & Daisuke Yamauchi
The expression of the gene for a proteinase (Rep1) is upregulated by gibberellins. The CAACTC regulatory element (CARE) of the Rep1 promoter is involved in the gibberellin response. We isolated a cDNA for a CARE-binding protein containing a Myb domain in its carboxyl-terminal region and designated the gene Carboxyl-terminal Myb1 (CTMyb1). This gene encodes two polypeptides of two distinctive lengths, CTMyb1L and CTMyb1S, which include or exclude 213 N-terminal amino acid residues, respectively. CTMyb1S transactivated...

Design, Synthesis, and Antimicrobial Evaluation of Novel Thienopyrimidines and Triazolothienopyrimidines

Mahmoud R. Mahmoud, Fatma S. M. Abu El-Azm, Amira T. Ali &
2-Cyanoacetohydrazide and 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene derivatives were exploited as starting materials for the syntheses of novel thienopyrimidines and triazolothienopyrimidines. The proclivity of these compounds toward one-carbon donor reagents such as carbon disulfide, phenyl isothiocyanate, and aromatic aldehydes was investigated. The structures of all synthesized compounds were ascertained by spectral and analytical data. The antimicrobial activity of the target synthesized compounds was tested against various microorganisms.

Design, Synthesis, and Antimicrobial Evaluation of Novel Thienopyrimidines and Triazolothienopyrimidines

Mahmoud R. Mahmoud, Fatma S. M. Abu El-Azm, Amira T. Ali &
2-Cyanoacetohydrazide and 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene derivatives were exploited as starting materials for the syntheses of novel thienopyrimidines and triazolothienopyrimidines. The proclivity of these compounds toward one-carbon donor reagents such as carbon disulfide, phenyl isothiocyanate, and aromatic aldehydes was investigated. The structures of all synthesized compounds were ascertained by spectral and analytical data. The antimicrobial activity of the target synthesized compounds was tested against various microorganisms.

Warming with a chance of 25 years of slowdown

Oliver Bothe
This is the pdf-version for a blog-post at 14terstock.wordpress.com. The short note presents a simple guesstimate for the potential length of the apparent current slowdown in the warming of global surface temperatures.

The tumor-targeting immunocytokine F16-IL2 in combination with doxorubicin: dose escalation in patients with advanced solid tumors and expansion into patients with metastatic breast cancer

Chiara Catania, Michela Maur, Rossana Berardi, Andrea Rocca, Anna Maria Di Giacomo, Gianluca Spitaleri, Cristina Masini, Chiara Pierantoni, , Giulia Zigon, , Leonardo Giovannoni, Valeria Lovato, Giuliano Elia, Hans D Menssen, Dario Neri, Stefano Cascinu, Pier Franco Conte & Filippo De Braud
A phase Ib/II trial was performed to evaluate safety, tolerability, recommended dose (RD) and efficacy of F16-IL2, a recombinant antibody-cytokine fusion protein, in combination with doxorubicin in patients with solid tumors (phase Ib) and metastatic breast cancer (phase II). Six patient cohorts with progressive solid tumors (n = 19) received escalating doses of F16-IL2 [5–25 Million International Units (MIU) of IL2 equivalent dose] in combination with escalating doses of doxorubicin (0–25 mg/m2) on day 1,...

A Convenient Modification of the Fischer Indole Synthesis with a Solid Acid

& Somnath Mukherjee
A new one-pot version of the titled reaction involves heating a mixture of a carbonyl compound, a phenylhydrazine, and the cation exchange resin Amberlite IR 120 in refluxing ethanol. A variety of enolizable aldehydes, and ketones and several substituted phenylhydrazines could thus be converted to the corresponding indoles in excellent yields (70–88%). Reaction times were typically 6–10 h, with the resin being then filtered off and the product isolated after minimal workup.

Trusting the Press and Political Trust: A Conditional Relationship

Gal Ariely
Despite the fact that the media serves as a vital source of information about politics, the relation between media trust and political trust has largely been overlooked, especially outside the USA. Adopting a comparative approach, this study examines the way(s) in which trust in the press and political trust are related across dissimilar media environments. Analyzing survey data from 32 European countries, we found that while trust in the press and political trust are positively...

Data storage & retention - presentation. RDM Support basic training course for information specialists session 3

Mariette Van Selm
Presentation for session 3 of RDM Support. RDM Support is a basic training course in research data management (support) for information specialists. The training course was developed by Mariëtte van Selm for the information specialists of the Library of the University of Amsterdam (UvA), within the framework of the RDM Support project (2013-2015). The training course was held from January to April 2014.

Data organisation & description - presentation. RDM Support basic training course for information specialists session 4

Mariette Van Selm
Presentation for session 4 of RDM Support. RDM Support is a basic training course in research data management (support) for information specialists. The training course was developed by Mariëtte van Selm for the information specialists of the Library of the University of Amsterdam (UvA), within the framework of the RDM Support project (2013-2015). The training course was held from January to April 2014.

Data organisation & description - exercise. RDM Support basic training course for information specialists session 4

Mariette Van Selm
Exercise for session 4 of RDM Support. RDM Support is a basic training course in research data management (support) for information specialists. The training course was developed by Mariëtte van Selm for the information specialists of the Library of the University of Amsterdam (UvA), within the framework of the RDM Support project (2013-2015). The training course was held from January to April 2014.

Data sharing & reuse - presentation. RDM Support basic training course for information specialists session 6

Mariette Van Selm
Presentation for session 6 of RDM Support. RDM Support is a basic training course in research data management (support) for information specialists. The training course was developed by Mariëtte van Selm for the information specialists of the Library of the University of Amsterdam (UvA), within the framework of the RDM Support project (2013-2015). The training course was held from January to April 2014.

Data sharing & reuse - exercise. RDM Support basic training course for information specialists session 6

Mariette Van Selm
Exercise for session 6 of RDM Support. RDM Support is a basic training course in research data management (support) for information specialists. The training course was developed by Mariëtte van Selm for the information specialists of the Library of the University of Amsterdam (UvA), within the framework of the RDM Support project (2013-2015). The training course was held from January to April 2014.

Data storage & retention. Training materials RDM Support basic training course for information specialists session 3

Mariette Van Selm
Training materials for 'Data storage & retention', session 3 of the RDM Support basic training course for information specialists. RDM Support is a basic training course in research data management (support) for information specialists. The training course was developed by Mariëtte van Selm for the information specialists of the Library of the University of Amsterdam (UvA), within the framework of the RDM Support project (2013-2015). The training course was held from January to April 2014.

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