47,025 Works

Campus Setting In Five Point Someone


SLC9A3R1 stimulates autophagy via BECN1 stabilization in breast cancer cells

Hong Liu, Yan Ma, Hong-Wei He, Jia-Ping Wang, Jian-Dong Jiang & Rong-Guang Shao
Autophagy, a self-catabolic process, has been found to be involved in abrogating the proliferation and metastasis of breast cancer. SLC9A3R1 (solute carrier family 9, subfamily A [NHE3, cation proton antiporter 3], member 3 regulator 1), a multifunctional scaffold protein, is involved in suppressing breast cancer cells proliferation and the SLC9A3R1-related signaling pathway regulates the activation of autophagy processes. However, the precise regulatory mechanism and signaling pathway of SLC9A3R1 in the regulation of autophagy processes in...

A meta-analysis of the ecological significance of density in tree invasions

Chloe E.L. Delmas, & Ecoblender
Species richness, resource availability, and disturbance are the primary factors considered in assessing the invasibil- ity of plant communities. Nonetheless, the density of individuals in a community is a common and easy trait to measure. The ecological significance of the density of both native and invasive tree species was assessed using a systematic review and formal meta-analysis. The densities of recipient communities and invasive exotic tree species in novel ranges were identified in the published...

Interacting domains in the epithelial sodium channel that mediate proteolytic activation

Jonathan M Berman, Ryan G Awayda & Mouhamed S Awayda
Epithelial Sodium Channel (ENaC) proteolysis at sites in the extracellular loop of the α and γ subunits leads to marked activation. The mechanism of this effect remains debated, as well as the role of the N- and C-terminal fragments of these subunits created by cleavage. We introduced cysteines at sites bracketing upstream and downstream the cleavage regions in α and γ ENaC to examine the role of these fragments in the activated channel. Using thiol...

Figures showing the bounding surfaces of a tesseroid (spherical prism)

Leonardo Uieda
View of a tesseroid (spherical prism) in a geocentric coordinate system. Red planes show the six bounding surfaces of a tesseroid: two parallels, two meridians, and two concentric spheres. This figure is used in the Tesseroids (http://tesseroids.leouieda.com) software documentation. Created using Inkscape (https://inkscape.org). Other file formats are available in the Github repository (https://github.com/leouieda/tesseroid-figures).

Using Score Equating and Measurement Invariance to Examine the Flynn Effect in the Wechsler Adult Intelligence Scale

Nicholas Benson, & Gordon E. Taub
The Flynn effect (FE; i.e., increase in mean IQ scores over time) is commonly viewed as reflecting population shifts in intelligence, despite the fact that most FE studies have not investigated the assumption of score comparability. Consequently, the extent to which these mean differences in IQ scores reflect population shifts in cognitive abilities versus changes in the instruments used to measure these abilities is unclear. In this study, we used modern psychometric tools to examine...

Curtin Library Rocking the (meta)data

Peter Green
Research data is being increasingly recognised as a valuable output of research and as a valuable resource for further research. Managing research data is a challenge that is being taken up on many fronts but it is a particular challenge for academic libraries who have a role in supporting research through maximising the discovery and reuse of research data. Traditional library skills are being deployed on a new front, but the learning curve is steep....

Prediction of multi-drug resistance transporters dataset

Jason E. McDermott, Paul Bruillard, Christopher C. Overall, Luke Gosink & Stephen R. Lindemann
Data file 1
Title: Data File PROSITE_positives_PS000125.fasta.
Legend: Sequence file in FASTA format of all positive examples for the ser/thr phosphatase model. Data file 2
Data File PROSITE_negatives_PS000125.fasta.
Sequence file in FASTA format of all randomly selected negative examples for the ser/thr phosphatase model." Data file 3
Data File PROSITE_positives_PS00028.fasta.
Sequence file in FASTA format of all positive examples for the zinc finger model. Data file 4
Data File PROSITE_negatives_PS00028.fasta.
Sequence file in FASTA format of all randomly selected negative examples for the...

Wobble↔Watson-Crick tautomeric transitions in the homo-purine DNA mismatches: a key to the intimate mechanisms of the spontaneous transversions

& Dmytro M. Hovorun
The intrinsic capability of the homo-purine DNA base mispairs to perform wobble↔Watson–Crick/Topal–Fresco tautomeric transitions via the sequential intrapair double proton transfer was discovered for the first time using QM (MP2/DFT) and QTAIM methodologies that are crucial for understanding the microstructural mechanisms of the spontaneous transversions.

Micro-/macro-responses of a ferroelectric single crystal with domain pinning and depinning by dislocations

Hong-Hui Wu
FIG. 6.The domain structures of (a1)–(a4) and (b1)–(b4), respectively, corresponding to points (a1)–(a4) and (b1)–(b4) on the curves of Fig. 5(C) (enhancedonline).

V015_IZ01_CO_PC image of the database ILEA, RAW in format NEF

Daniel Felipe Valencia Vargas & Jose Fernando Valencia
V015_IZ01_CO_PC image, RAW in format NEF, database of iris, called ILEA, built by the research group of the University of San Buenaventura LEA in Cali, Colombia. The image has features such as the medium non-ideal environment and uncontrolled lighting.

Synthesis of Novel Spiro[indol-2,2′-pyrroles] Using Isocyanide-Based Multicomponent Reaction

, , , Tetsuji Moriguchi & Akihiko Tsuge
An efficient and facile method for the synthesis of novel spiro[indole-2,2′-pyrroles] from N-methyl-3-isatin imines, t-butyl isocyanide, and dialkyl acetylenedicarboxylate has been achieved by [3 + 2] cyclo addition reaction. All the products were purified by column chromatography as yellow solids and confirmed with 1H NMR, 13C NMR, fast atom bombardment, mass, and infrared. Compound 11 was further confirmed with x-ray analysis.

New HIV Treatment Formulation For Children Approved By FDA

Ada Brown

Human population reduction is no quick fix for environmental problems

Corey Bradshaw
The inexorable demographic momentum of the global human population is rapidly eroding Earth’s life-support system. There are consequently more frequent calls to address environmental problems by advocating further reductions in human fertility. To examine how quickly this could lead to a smaller human population, we used scenario-based matrix modeling to project the global population to the year 2100. Assuming a continuation of current trends in mortality reduction, even a rapid transition to a worldwide onechild...

Not for view

Corey Bradshaw


Compounds for Plm II Model

Cameron Smith
Compounds for CHEM6128 miniproject

Training Set Data

Cameron Smith
Training set data for miniproject CHEM6128

Risk Factors for Heat-Related Illness in Washington Crop Workers

June T. Spector, Jennifer Krenz & Kristina N. Blank
ABSTRACTCrop workers are at high risk of heat-related illness (HRI) from internal heat generated by heavy physical work, particularly when laboring in hot and humid conditions. The aim of this study was to identify risk factors for HRI symptoms in Washington crop workers using an audio computer-assisted self-interview (A-CASI) instrument that has undergone reliability and validity evaluation. A cross-sectional A-CASI survey of 97 crop workers in Washington State was conducted during the summer of 2013....

Prevalence and Risk Factors of Respiratory Symptoms in Rural Population

, Louise Hagel, Donna C. Rennie, Joshua A. Lawson, James A. Dosman, & The Saskatchewan Rural Health Study Group
ABSTRACTResearch has shown that respiratory symptoms, including chronic cough, chronic phlegm, shortness of breath, and wheeze, are important markers that contribute to hospitalization, lung function decline, and other respiratory illness. This report aims to estimate the prevalence of respiratory symptoms and associated environmental risk factors in farming and nonfarming rural-dwelling people. A baseline mail-out questionnaire to assess respiratory health outcomes as well as individual and contextual determinants in farm and small town cohorts was sent...

Expression of a ULK1/2 binding-deficient ATG13 variant can partially restore autophagic activity in ATG13-deficient cells

Nora Hieke, Antje S Löffler, Takeshi Kaizuka, Niklas Berleth, Philip Böhler, Stefan Drießen, Fabian Stuhldreier, Olena Friesen, , Katharina Schmitz, Christoph Peter, Britta Diedrich, Jörn Dengjel, Petter Holland, Anne Simonsen, Sebastian Wesselborg, Noboru Mizushima & Björn Stork
Autophagy describes an intracellular process responsible for the lysosome-dependent degradation of cytosolic components. The ULK1/2 complex comprising the kinase ULK1/2 and the accessory proteins ATG13, RB1CC1, and ATG101 has been identified as a central player in the autophagy network, and it represents the main entry point for autophagy-regulating kinases such as MTOR and AMPK. It is generally accepted that the ULK1 complex is constitutively assembled independent of nutrient supply. Here we report the characterization of...

V009_DE01_CO_PC image of the database ILEA, RAW in format NEF

Daniel Felipe Valencia Vargas & Jose Fernando Valencia
V009_DE01_CO_PC image, RAW in format NEF, database of iris, called ILEA, built by the research group of the University of San Buenaventura LEA in Cali, Colombia. The image has features such as the medium non-ideal environment and uncontrolled lighting.

Introduction to Methodology Framework towards Water Quality Assessment. Case Study: A Review of Malacca River

Ang Kean Hua &
Water is a basic resources required by organisms for survival. Various activities have caused water quality to remain contaminated. These problems are present in the Malacca River, Malacca state. This research study has been carried out based on methodology framework review towards water quality assessment in Malacca River. Methodology can be divided into three processes, namely the planning process, applying process, and analyzing process. The planning process includes the design to collect and gather, analyze,...

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  • 2015

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