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DOMENICO DE MARTINIS
The Editorial on the Research Topic
Engineering the Plant Factory for the Production of Biologics and Small-Molecule MedicinesThe transfer of genes into plants, that was achieved in the early 80's, paved the way for the exploitation of the potential of plant genetic engineering, to add novel agronomic traits and/or to design plants as factories for high added value molecules. For this latter area of research, the term “Molecular Farming” was coined because major crops like maize...

Plant Molecular Farming: Fast, Scalable, Cheap, Sustainable

DOMENICO DE MARTINIS
The Editorial on the Research Topic
Engineering the Plant Factory for the Production of Biologics and Small-Molecule MedicinesThe transfer of genes into plants, that was achieved in the early 80's, paved the way for the exploitation of the potential of plant genetic engineering, to add novel agronomic traits and/or to design plants as factories for high added value molecules. For this latter area of research, the term “Molecular Farming” was coined because major crops like maize...

What Ails Italy: The Competitive Issue of the Italian State American Journal of Economics, Finance and Management. Vol. 2, No. 5, 2016, pp. 49-57

DOMENICO DE MARTINIS
Italy faces a most challenging global financial and economic crisis since the end of World War II. For an economy that grew at a rapid pace between the 1950’s and the 1980’s, Italy has seen slower growth in the last twenty years. Italian policymakers are facing a series of problems that include a contracting gross domestic product (GDP), large unemployment, especially among its young people, high government deficits, large governmental borrowing along with high interest...

What Ails Italy: The Competitive Issue of the Italian State American Journal of Economics, Finance and Management. Vol. 2, No. 5, 2016, pp. 49-57

DOMENICO DE MARTINIS
Italy faces a most challenging global financial and economic crisis since the end of World War II. For an economy that grew at a rapid pace between the 1950’s and the 1980’s, Italy has seen slower growth in the last twenty years. Italian policymakers are facing a series of problems that include a contracting gross domestic product (GDP), large unemployment, especially among its young people, high government deficits, large governmental borrowing along with high interest...

Production and management of Energy; the interdisciplinary approach of ENEA to Concentrated Solar Power.

DOMENICO DE MARTINIS
Clean and efficient energy generation by environmental friendly methods and technologies is now one of the major challenges worldwide. New and heterogeneous methods to produce energy pose the challenge of how to guarantee energy security, storage of exceeding production and distribution. In addition to that, the exploitation of next generation energy sources must consider the impact it may have on other productive systems and on rural areas (e.g. solar vs agriculture, biomass vs food production)....

Production and management of Energy; the interdisciplinary approach of ENEA to Concentrated Solar Power.

DOMENICO DE MARTINIS
Clean and efficient energy generation by environmental friendly methods and technologies is now one of the major challenges worldwide. New and heterogeneous methods to produce energy pose the challenge of how to guarantee energy security, storage of exceeding production and distribution. In addition to that, the exploitation of next generation energy sources must consider the impact it may have on other productive systems and on rural areas (e.g. solar vs agriculture, biomass vs food production)....

Brand-Evoked Mental Imagery: The Role of Brands Exerting Mental Imagery

Diana Gavilan & Maria Avello
Dataset provides evidence of the moderating role of brand familiarity and brand favorability in visual mental imagery. Also experimental input is provided

CAN A WORD PAINT A THOUSAND PICTURES? BRAND-EVOKED MENTAL IMAGERY IN ADVERTISING

Diana Gavilan & Maria Avello
Dataset of Study 1: a three between-groups design to test differences on mental imagery dimensions due to the presence of the brand and brand familiarity. Dataset of Study 2 that provide evidence of the moderating role of brand familiarity and brand favorability by comparing transformational and informational advertising strategies in a three-way interaction model.

Baohuoside-I suppresses cell proliferation and migration by up-regulating miR-144 in melanoma

Ya-Guang Peng & Li Zhang
Context: Baohuoside-I was reported to induce apoptosis in non-small-cell lung cancer and inhibit the growth of multiple myeloma cells. The antitumour potential of baohuoside-I has not been demonstrated in melanoma yet. Objective: To investigate the potential antitumour activity of baohuoside-I against melanoma and elucidate its underlying molecular mechanism. Materials and methods: Cell viability was evaluated by MTT assay. The malignant invasion capacity was measured with trans-well assay. The relative expression change of microRNAs was profiled...

Antitubercular evaluation of root extract and isolated phytochemicals from Lophira lanceolata against two resistant strains of Mycobacterium tuberculosis

Jeanne Louise Nkot, Dominique Serge Ngono Bikobo, Auguste Abouem A Zintchem, Norbert Mbabi Nyemeck, Esther Del Florence Moni Ndedi, Patrick Hervé Betote Diboué, Dieudonné Emmanuel Pegnyemb, Christian G. Bochet & Ulrich Koert
Context: The roots of Lophira lanceolata Van Tiegh. Ex Keay (Ochnaceae) have numerous medicinal values in the Central African region. Even though the MeOH extract of the roots has shown antimycobacterial activities, the constituents responsible for this inhibitory activity remain unknown. Objective: Phytochemical investigation of the MeOH root extract of L. lanceolata and determination of the antimycobacterial activities of that extract and constituents against the growth of Mycobacterium tuberculosis. Materials and methods: Column chromatography was...

Crocin exerts anti-inflammatory and anti-arthritic effects on type II collagen-induced arthritis in rats

Wei Liu, Yufeng Sun, Zhenping Cheng, Yong Guo, Peiming Liu & Ying Wen
Context: Rheumatoid arthritis (RA) is a common systemic auto-immune disease, which is characterized by chronic and symmetry synovial inflammation. Crocin has been reported to exhibit anti-inflammatory effects in animal models. Objective: This study investigates the anti-inflammatory and anti-arthritic effects of crocin on type II collagen-induced arthritis (CIA) in Wistar rats. Materials and methods: The CIA rat model was established and randomly divided into five groups with or without crocin treatment (10, 20 or 40 mg/kg),...

Crocin exerts anti-inflammatory and anti-arthritic effects on type II collagen-induced arthritis in rats

Wei Liu, Yufeng Sun, Zhenping Cheng, Yong Guo, Peiming Liu & Ying Wen
Context: Rheumatoid arthritis (RA) is a common systemic auto-immune disease, which is characterized by chronic and symmetry synovial inflammation. Crocin has been reported to exhibit anti-inflammatory effects in animal models. Objective: This study investigates the anti-inflammatory and anti-arthritic effects of crocin on type II collagen-induced arthritis (CIA) in Wistar rats. Materials and methods: The CIA rat model was established and randomly divided into five groups with or without crocin treatment (10, 20 or 40 mg/kg),...

Crocin exerts anti-inflammatory and anti-arthritic effects on type II collagen-induced arthritis in rats

Wei Liu, Yufeng Sun, Zhenping Cheng, Yong Guo, Peiming Liu & Ying Wen
Context: Rheumatoid arthritis (RA) is a common systemic auto-immune disease, which is characterized by chronic and symmetry synovial inflammation. Crocin has been reported to exhibit anti-inflammatory effects in animal models. Objective: This study investigates the anti-inflammatory and anti-arthritic effects of crocin on type II collagen-induced arthritis (CIA) in Wistar rats. Materials and methods: The CIA rat model was established and randomly divided into five groups with or without crocin treatment (10, 20 or 40 mg/kg),...

Ajudecumin A from Ajuga ovalifolia var. calantha exhibits anti-inflammatory activity in lipopolysaccharide-activated RAW264.7 murine macrophages and animal models of acute inflammation

Hai Zhang, Qing-Cuo Ren, Yan Ren, Lin Zhao, Fan Yang, Yi Zhang, Wen-Ji Zhao, Yu-Zhu Tan & Xiao-Fei Shen
Context:Ajuga ovalifolia Bur. et Franch. var. calantha (Diels) C. Y. Wu et C. Chen (Labiatae), a traditional Chinese medicine, has been used to treat several inflammatory diseases. Objective: To assess the anti-inflammatory activity of ajudecumin A isolated from Ajuga ovalifolia var. calantha, and its possible mechanisms. Materials and methods: Lipopolysaccharide (LPS, 0.5 μg/mL)-stimulated RAW264.7 macrophages were used to assess the anti-inflammatory activity of ajudecumin A (1–40 μM) in vitro. Nitric oxide levels were evaluated by...

Antiproliferative and cytotoxic activities of furocoumarins of Ducrosia anethifolia

Javad Mottaghipisheh, Márta Nové, Gabriella Spengler, Norbert Kúsz, Judit Hohmann & Dezső Csupor
Context: Phytochemical and pharmacological data on Ducrosia anethifolia (DC.) Boiss. (Apiaceae), an Iranian medicinal plant, are scarce; however, furocoumarins are characteristic compounds of D. anethifolia. Objective: Our experiments identify the secondary metabolites of D. anethifolia and assess their antitumor and anti-multidrug resistance activities. Materials and methods: Pure compounds were isolated from the extract of aerial parts of the plant by chromatographic methods. Bioactivities were tested on multidrug resistant and sensitive mouse T-lymphoma cell lines. The...

Ajudecumin A from Ajuga ovalifolia var. calantha exhibits anti-inflammatory activity in lipopolysaccharide-activated RAW264.7 murine macrophages and animal models of acute inflammation

Hai Zhang, Qing-Cuo Ren, Yan Ren, Lin Zhao, Fan Yang, Yi Zhang, Wen-Ji Zhao, Yu-Zhu Tan & Xiao-Fei Shen
Context:Ajuga ovalifolia Bur. et Franch. var. calantha (Diels) C. Y. Wu et C. Chen (Labiatae), a traditional Chinese medicine, has been used to treat several inflammatory diseases. Objective: To assess the anti-inflammatory activity of ajudecumin A isolated from Ajuga ovalifolia var. calantha, and its possible mechanisms. Materials and methods: Lipopolysaccharide (LPS, 0.5 μg/mL)-stimulated RAW264.7 macrophages were used to assess the anti-inflammatory activity of ajudecumin A (1–40 μM) in vitro. Nitric oxide levels were evaluated by...

Antitubercular evaluation of root extract and isolated phytochemicals from Lophira lanceolata against two resistant strains of Mycobacterium tuberculosis

Jeanne Louise Nkot, Dominique Serge Ngono Bikobo, Auguste Abouem A Zintchem, Norbert Mbabi Nyemeck, Esther Del Florence Moni Ndedi, Patrick Hervé Betote Diboué, Dieudonné Emmanuel Pegnyemb, Christian G. Bochet & Ulrich Koert
Context: The roots of Lophira lanceolata Van Tiegh. Ex Keay (Ochnaceae) have numerous medicinal values in the Central African region. Even though the MeOH extract of the roots has shown antimycobacterial activities, the constituents responsible for this inhibitory activity remain unknown. Objective: Phytochemical investigation of the MeOH root extract of L. lanceolata and determination of the antimycobacterial activities of that extract and constituents against the growth of Mycobacterium tuberculosis. Materials and methods: Column chromatography was...

Mangosteen ethanol extract alleviated the severity of collagen-induced arthritis in rats and produced synergistic effects with methotrexate

Jian Zuo, Qin Yin, Lin Wang, Wen Zhang, Yan Fan, Yu-Yan Zhou, Yan Li & Guo-Dong Wang
Context:Garcinia mangostana Linn. (Guttiferae) pericarp is used as a traditional medicine in South Asia to treat inflammatory diseases. Objective: This study investigates therapeutic effects of G. mangostana pericarp ethanol extract (MAN) on collagen-induced arthritis (CIA) and interactions with methotrexate in vivo. Materials and methods: Male Sprague-Dawley rats with CIA were treated with MAN (0.5 g/kg/day), methotrexate (0.5 mg/kg, bw) or combination of both for 36 days, respectively (n = 8/group). Another eight healthy and CIA...

Bioinformatics analysis to identify action targets in NCI-N87 gastric cancer cells exposed to quercetin

Yun Zeng, Zhengjie Shen, Wenzhe Gu & Mianhua Wu
Context: Quercetin exerts antiproliferative effects on gastric cancer. However, its mechanisms of action on gastric cancer have not been comprehensively revealed. Objective: We investigated the mechanisms of action of quercetin against gastric cancer cells. Materials and methods: Human NCI-N87 gastric cancer cells were treated with 15 μM quercetin or dimethyl sulfoxide (as a control) for 48 h. DNA isolated from cells was sequenced on a HiSeq 2500, and the data were used to identify differentially...

Mangosteen ethanol extract alleviated the severity of collagen-induced arthritis in rats and produced synergistic effects with methotrexate

Jian Zuo, Qin Yin, Lin Wang, Wen Zhang, Yan Fan, Yu-Yan Zhou, Yan Li & Guo-Dong Wang
Context:Garcinia mangostana Linn. (Guttiferae) pericarp is used as a traditional medicine in South Asia to treat inflammatory diseases. Objective: This study investigates therapeutic effects of G. mangostana pericarp ethanol extract (MAN) on collagen-induced arthritis (CIA) and interactions with methotrexate in vivo. Materials and methods: Male Sprague-Dawley rats with CIA were treated with MAN (0.5 g/kg/day), methotrexate (0.5 mg/kg, bw) or combination of both for 36 days, respectively (n = 8/group). Another eight healthy and CIA...

Bioinformatics analysis to identify action targets in NCI-N87 gastric cancer cells exposed to quercetin

Yun Zeng, Zhengjie Shen, Wenzhe Gu & Mianhua Wu
Context: Quercetin exerts antiproliferative effects on gastric cancer. However, its mechanisms of action on gastric cancer have not been comprehensively revealed. Objective: We investigated the mechanisms of action of quercetin against gastric cancer cells. Materials and methods: Human NCI-N87 gastric cancer cells were treated with 15 μM quercetin or dimethyl sulfoxide (as a control) for 48 h. DNA isolated from cells was sequenced on a HiSeq 2500, and the data were used to identify differentially...

Antiproliferative and cytotoxic activities of furocoumarins of Ducrosia anethifolia

Javad Mottaghipisheh, Márta Nové, Gabriella Spengler, Norbert Kúsz, Judit Hohmann & Dezső Csupor
Context: Phytochemical and pharmacological data on Ducrosia anethifolia (DC.) Boiss. (Apiaceae), an Iranian medicinal plant, are scarce; however, furocoumarins are characteristic compounds of D. anethifolia. Objective: Our experiments identify the secondary metabolites of D. anethifolia and assess their antitumor and anti-multidrug resistance activities. Materials and methods: Pure compounds were isolated from the extract of aerial parts of the plant by chromatographic methods. Bioactivities were tested on multidrug resistant and sensitive mouse T-lymphoma cell lines. The...

Andrographolide relieved pathological pain generated by spared nerve injury model in mice

Huang-Chi Wang, Hsin-Sheng Tsay, Hui-Nung Shih, Yi-An Chen, Kai-Ming Chang, Dinesh Chandra Agrawal, Siendong Huang, Yi-Lo Lin & Meng-Jen Lee
Context: Andrographolide (Andro), found in large quantities in Andrographis paniculata Nees (Acanthaceae), is anti-inflammatory, especially in the central nervous system (CNS) glia. Objective: The objective of this study is to test Andro’s ability to reduce allodynia in a spared nerve injury model. Material and methods: Male 30 g BalbC mice were divided into four groups: (1) Sham-operated control (Sham-group); (2) nerve injured and treated with saline (Saline-group); (3) nerve injured and treated with Andro (Andro-group);...

Protective effect of compound Danshen (Salvia miltiorrhiza) dripping pills alone and in combination with carbamazepine on kainic acid-induced temporal lobe epilepsy and cognitive impairment in rats

Chen Jia, Shanshan Han, Liming Wei, Xiangji Dang, Qianqian Niu, Mengyu Chen, Boqun Cao, Yuting Liu & Haisheng Jiao
Context: Temporal lobe epilepsy (TLE) is resistant to antiepileptic drugs (AEDs) and is associated with cognitive impairment. The modern Chinese medicine, compound Danshen dripping pills (CDDP), is clinically effective in treating epilepsy and improving cognitive impairment. Objective: This study evaluated the protective effects of CDDP alone and in combination with carbamazepine (CBZ) on kainic acid-induced TLE and cognitive impairment in rats. Materials and methods: Sprague–Dawley rats were randomly divided into five groups: control (sham operated),...

Protective effect of compound Danshen (Salvia miltiorrhiza) dripping pills alone and in combination with carbamazepine on kainic acid-induced temporal lobe epilepsy and cognitive impairment in rats

Chen Jia, Shanshan Han, Liming Wei, Xiangji Dang, Qianqian Niu, Mengyu Chen, Boqun Cao, Yuting Liu & Haisheng Jiao
Context: Temporal lobe epilepsy (TLE) is resistant to antiepileptic drugs (AEDs) and is associated with cognitive impairment. The modern Chinese medicine, compound Danshen dripping pills (CDDP), is clinically effective in treating epilepsy and improving cognitive impairment. Objective: This study evaluated the protective effects of CDDP alone and in combination with carbamazepine (CBZ) on kainic acid-induced TLE and cognitive impairment in rats. Materials and methods: Sprague–Dawley rats were randomly divided into five groups: control (sham operated),...

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