254,754 Works

Supplementary Material for \"The Effects on Adaptive Behaviour of Negatively Valenced Signals in Reinforcement Learning\"

Nicolás Navarro-Guerrero, Robert Lowe & Stefan Wermter
zip files with raw data from the 10 random initializations of the 4 best hyperparameter sets per condition and per activation function. Organized by function and per condition.

pdf file containing the pair-wise comparison of the three tested conditions against the baseline.

Link to the supplementary material of the original paper, includes matlab command and data set for learning:
https://figshare.com/s/becd4366e4ed38731353
References:
Navarro-Guerrero, N., Lowe, R., & Wermter, S. (2017). The Effects on Adaptive Behaviour of Negatively Valenced Signals in Reinforcement...

Coastal segments shapefile

Claudia Wolff
Coastal segment shapefile, including information on segment length, latitude, longitude, country_name, administrative_unit_name, admin_id and locationid.

Impact of a pharmacist-provided information booklet on knowledge and attitudes towards oral contraception among Jordanian women: an interventional study

Amal Akour, Sanaa Bardaweel, Oriana Awwad, Suha Al-Muhaissen & Rand Hussein
Objectives: Jordan has high rate of unintended pregnancy, which is largely attributed to limited knowledge and misconceptions about contraceptive methods, namely oral contraceptive pills (OCPs). The aim of this study was to examine the effect of a pharmacist-provided information booklet on increasing the knowledge of Jordanian women about safe and effective OCP use. Methods: This was a randomised interventional study. One hundred and sixty women who had used OCPs at least once in their lifetime...

Drugging tRNA aminoacylation

Joanne M. Ho, Erol Bakkalbasi, Dieter Söll & Corwin A. Miller
Inhibition of tRNA aminoacylation has proven to be an effective antimicrobial strategy, impeding an essential step of protein synthesis. Mupirocin, the well-known selective inhibitor of bacterial isoleucyl-tRNA synthetase, is one of three aminoacylation inhibitors now approved for human or animal use. However, design of novel aminoacylation inhibitors is complicated by the steadfast requirement to avoid off-target inhibition of protein synthesis in human cells. Here we review available data regarding known aminoacylation inhibitors as well as...

Drugging tRNA aminoacylation

Joanne M. Ho, Erol Bakkalbasi, Dieter Söll & Corwin A. Miller
Inhibition of tRNA aminoacylation has proven to be an effective antimicrobial strategy, impeding an essential step of protein synthesis. Mupirocin, the well-known selective inhibitor of bacterial isoleucyl-tRNA synthetase, is one of three aminoacylation inhibitors now approved for human or animal use. However, design of novel aminoacylation inhibitors is complicated by the steadfast requirement to avoid off-target inhibition of protein synthesis in human cells. Here we review available data regarding known aminoacylation inhibitors as well as...

Correcting Estimation Bias in Randomized Clinical Trials with a Test of Treatment-by-Biomarker Interaction

& Shigeyuki Matsui
The key elements in recent drug development aiming toward personalized medicine involve the development of baseline predictive biomarkers to predict the responsiveness to new treatments. When biological evidence to support the biomarker hypothesis is not strong, it is particularly important to evaluate the clinical validity of a predictive biomarker based on data from clinical trials. All-comers randomized clinical trials stratified with biomarker measurements can provide the opportunity to evaluate the predictive value of the biomarker,...

A “Backward” Bayesian Method for Determination of Criteria for Making Go/No-Go Decisions in the Early Phases

Yin Yin
We introduce a “backward” Bayesian method to assist sponsors formulating early phase Go/No-Go criteria based on the ultimate efficacy or safety target which is usually clearer for Phase 3. Derived from the definition of success for Phase 3, involving prior information and cost of later phases, this work presents the quantitative relationships among the following factors: previous and current study results, study designs (e.g., sample size, duration, or dose), true effect, target probability of success...

Les parasites à l'origine de coliques chez les chevaux

Mohamed Gharbi
Présentation sur les parasites des équidés à l'origine de coliques chez chevaux.

Additional file 3: of Overexpressed HSF1 cancer signature genes cluster in human chromosome 8q

Christopher Zhang, , Thomas Prince & Eric Ho
Rank of HSF1 among primary sites. Syntenty visualization by Cinteny. An example showing the output web page of WebGestalt (PDF 738Â kb)

Additional file 4 of Super-delta: a new differential gene expression analysis procedure with robust data normalization

, & Xing Qiu
Gene set enrichment analysis. This file lists all the significant KEGG pathways obtained by the significant gene lists in Additional file 1. This gene set enrichment analysis was implemented in DAVID. (XLSX 15 kb)

Additional file 7 of Super-delta: a new differential gene expression analysis procedure with robust data normalization

, & Xing Qiu
Simulation study. This file contains the simulation result tables similar to Table 2 of the main text, for all the sample size combinations used. (XLSX 3229 kb)

Super-delta: a new differential gene expression analysis procedure with robust data normalization

, & Xing Qiu
Abstract Background Normalization is an important data preparation step in gene expression analyses, designed to remove various systematic noise. Sample variance is greatly reduced after normalization, hence the power of subsequent statistical analyses is likely to increase. On the other hand, variance reduction is made possible by borrowing information across all genes, including differentially expressed genes (DEGs) and outliers, which will inevitably introduce some bias. This bias typically inflates type I error; and can reduce...

Additional file 14: of An elevated plus-maze in mixed reality for studying human anxiety-related behavior

Sarah Biedermann, Daniel Biedermann, Frederike Wenzlaff, Tim Kurjak, , Matthias Auer, Klaus Wiedemann, Peer Briken, Jan Haaker, Tina Lonsdorf & Johannes Fuss
Supplemental file 3. Original psychophysiological data from Study 1. (CSV 5 kb)

Additional file 4: Figure S2. of An elevated plus-maze in mixed reality for studying human anxiety-related behavior

Sarah Biedermann, Daniel Biedermann, Frederike Wenzlaff, Tim Kurjak, , Matthias Auer, Klaus Wiedemann, Peer Briken, Jan Haaker, Tina Lonsdorf & Johannes Fuss
An exemplary depiction of the psychophysiological reaction to the elevated plus-maze of one participant. The black arrow marks the change from baseline testing (virtual room) to the beginning of the elevated plus-maze test (being in a new virtual environment on a rocky mountain above the sea) and the red arrow marks the moment when the participant entered the open arm for the first time. (TIF 1453 kb)

Additional file 5: Table S3. of An elevated plus-maze in mixed reality for studying human anxiety-related behavior

Sarah Biedermann, Daniel Biedermann, Frederike Wenzlaff, Tim Kurjak, , Matthias Auer, Klaus Wiedemann, Peer Briken, Jan Haaker, Tina Lonsdorf & Johannes Fuss
Results of regression analyses with Acrophobia Questionnaire (AQ), Sensation Seeking Scale Form V (SSSV), Spielberger State-Trait Anxiety Inventory (STAI), and Liebowitz Social Anxiety Scale (LSAS) (*P 

Wild eel microbiome reveals that skin mucus of fish could be a natural niche for aquatic mucosal pathogen evolution

Miguel Carda-DiĂŠguez, , Francisco RodrĂ­Guez-Valera & Carmen Amaro
Abstract Background Fish skin mucosal surfaces (SMS) are quite similar in composition and function to some mammalian MS and, in consequence, could constitute an adequate niche for the evolution of mucosal aquatic pathogens in natural environments. We aimed to test this hypothesis by searching for metagenomic and genomic evidences in the SMS-microbiome of a model fish species (Anguilla Anguilla or eel), from different ecosystems (four natural environments of different water salinity and one eel farm)...

Additional file 2 of An integrated meta-analysis approach to identifying medications with potential to alter breast cancer risk through connectivity mapping

, Fabio Liberante, Liam Murray, Chris Cardwell, Ken Mills & Shu-Dong Zhang
Power and sample size. A description of the methods used for the calculation of power and sample size for gene differential expression analysis. (DOCX 13 kb)

Additional file 1: Table S1. of Promoting deceased organ and tissue donation registration in family physician waiting rooms (RegisterNow-1 trial): study protocol for a pragmatic, stepped-wedge, cluster randomized controlled registry

Alvin Li, Amit Garg, , Jeremy Grimshaw, Monica Taljaard, Joanna Mitchell, Danny Matti, Stefanie Linklater, Kyla L. Naylor, Stephanie Dixon, Cathy Faulds, Rachel Bevan, Leah Getchell, Greg Knoll, , Jessica Sontrop, Lise Bjerre, Allison Tong & Justin Presseau
SPIRIT Checklist. (DOC 121 kb)

Additional file 5: Table S5. of Copeptin in acute decompensation of liver cirrhosis: relationship with acute-on-chronic liver failure and short-term survival

, Hein Verspaget, , Rajiv Jalan, Elsa Solà, Daniel Benten, François Durand, Pere Ginès, Johan Van Der Reijden, Bart Van Hoek &
Correlation coefficients of changes in laboratory and clinical values of patients with a sample available at days 0–2 and days 3–7 (n = 179). (PDF 23 kb)

Copeptin in acute decompensation of liver cirrhosis: relationship with acute-on-chronic liver failure and short-term survival

, Hein Verspaget, , Rajiv Jalan, Elsa Solà, Daniel Benten, François Durand, Pere Ginès, Johan Van Der Reijden, Bart Van Hoek &
Abstract Background Acute-on-chronic liver failure (ACLF) is characterized by the presence of acute decompensation (AD) of cirrhosis, organ failure, and high short-term mortality rates. Hemodynamic dysfunction and activation of endogenous vasoconstrictor systems are thought to contribute to the pathogenesis of ACLF. We explored whether copeptin, a surrogate marker of arginine vasopressin, is a potential marker of outcome in patients admitted for AD or ACLF and whether it might be of additional value to conventional prognostic...

Computational analysis reveals the coupling between bistability and the sign of a feedback loop in a TGF-β1 activation model

, Lakshmi Venkatraman, , Jacob White, & Lisa Tucker-Kellogg
Abstract Background Bistable behaviors are prevalent in cell signaling and can be modeled by ordinary differential equations (ODEs) with kinetic parameters. A bistable switch has recently been found to regulate the activation of transforming growth factor-β1 (TGF-β1) in the context of liver fibrosis, and an ordinary differential equation (ODE) model was published showing that the net activation of TGF-β1 depends on the balance between two antagonistic sub-pathways. Results Through modeling the effects of perturbations that...

Additional file 3 Figure S1. of Comparison of the efficacy of three topical antiseptic solutions for the prevention of catheter colonization: a multicenter randomized controlled study

Hideto Yasuda, Masamitsu Sanui, Takayuki Abe, Nobuaki Shime, Tetsuya Komuro, Junji Hatakeyama, Shohei Matsukubo, Shinji Kawano, Hiroshi Yamamoto, , Ryutaro Seo, Kyo Inoue, Eiichiro Noda, Nobuyuki Saito, Satoshi Nogami, Kentaro Okamoto, Ryota Fuke, Yasuhiro Gushima, Atsuko Kobayashi, Toru Takebayashi & Alan Lefor
(B) Colonization of arterial catheters. Cumulative catheter colonization and catheter-related bloodstream infection risk in each subgroup (Kaplanâ Meier curves). CHG chlorhexidine gluconate, PVI povidone-iodine. (JPG 102Â kb)

Additional file 4 Figure S1. of Comparison of the efficacy of three topical antiseptic solutions for the prevention of catheter colonization: a multicenter randomized controlled study

Hideto Yasuda, Masamitsu Sanui, Takayuki Abe, Nobuaki Shime, Tetsuya Komuro, Junji Hatakeyama, Shohei Matsukubo, Shinji Kawano, Hiroshi Yamamoto, , Ryutaro Seo, Kyo Inoue, Eiichiro Noda, Nobuyuki Saito, Satoshi Nogami, Kentaro Okamoto, Ryota Fuke, Yasuhiro Gushima, Atsuko Kobayashi, Toru Takebayashi & Alan Lefor
(C) Catheter-related bloodstream infection of central venous catheters. Cumulative catheter colonization and catheter-related bloodstream infection risk in each subgroup (Kaplanâ Meier curves). CHG chlorhexidine gluconate, PVI povidone-iodine. (JPG 116Â kb)

Comparison of the efficacy of three topical antiseptic solutions for the prevention of catheter colonization: a multicenter randomized controlled study

Hideto Yasuda, Masamitsu Sanui, Takayuki Abe, Nobuaki Shime, Tetsuya Komuro, Junji Hatakeyama, Shohei Matsukubo, Shinji Kawano, Hiroshi Yamamoto, , Ryutaro Seo, Kyo Inoue, Eiichiro Noda, Nobuyuki Saito, Satoshi Nogami, Kentaro Okamoto, Ryota Fuke, Yasuhiro Gushima, Atsuko Kobayashi, Toru Takebayashi & Alan Lefor
Abstract Background To compare the efficacy of three antiseptic solutions [0.5%, and 1.0% alcohol/chlorhexidine gluconate (CHG), and 10% aqueous povidone-iodine (PVI)] for the prevention of intravascular catheter colonization, we conducted a randomized controlled trial in patients from 16 intensive care units in Japan. Methods Adult patients undergoing central venous or arterial catheter insertions were randomized to have one of three antiseptic solutions applied during catheter insertion and dressing changes. The primary endpoint was the incidence...

Comparison of the efficacy of three topical antiseptic solutions for the prevention of catheter colonization: a multicenter randomized controlled study

Hideto Yasuda, Masamitsu Sanui, Takayuki Abe, Nobuaki Shime, Tetsuya Komuro, Junji Hatakeyama, Shohei Matsukubo, Shinji Kawano, Hiroshi Yamamoto, , Ryutaro Seo, Kyo Inoue, Eiichiro Noda, Nobuyuki Saito, Satoshi Nogami, Kentaro Okamoto, Ryota Fuke, Yasuhiro Gushima, Atsuko Kobayashi, Toru Takebayashi & Alan Lefor
Abstract Background To compare the efficacy of three antiseptic solutions [0.5%, and 1.0% alcohol/chlorhexidine gluconate (CHG), and 10% aqueous povidone-iodine (PVI)] for the prevention of intravascular catheter colonization, we conducted a randomized controlled trial in patients from 16 intensive care units in Japan. Methods Adult patients undergoing central venous or arterial catheter insertions were randomized to have one of three antiseptic solutions applied during catheter insertion and dressing changes. The primary endpoint was the incidence...

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