Innovator presentation at partnering for cures 2012 given with Jill Wood.
Presented at the Aquaculture Workshop at PAG XXI, San Deigo CA 2013. This material is based upon work supported by the National Science Foundation under Grant Number 1158119. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation.
Identification of microRNA (miRNA) target recognition and binding motifs (miRNA response elements, MRE) is a major unsolved problem in non-coding RNA (ncRNA) research, given its myriad and important implications in post-transcriptional gene regulation, and by extension, physiological effects. While evolution is a central theme permeating biology, attempts at identifying a conserved canonical binding sequence between miRNA and mRNA targets reveal that a variety of non-canonical interactions likely dominate those dependent on a defined “seed” sequence...