520,625 Works

MOESM10 of p53 modeling as a route to mesothelioma patients stratification and novel therapeutic identification

Kun Tian, Emyr Bakker, Michelle Hussain, Alice Guazzelli, , Parisa Meysami, , , Luciano Mutti & Marija Krstic-Demonacos
Additional file 10: Table S10. KEGG pathways.

MOESM12 of p53 modeling as a route to mesothelioma patients stratification and novel therapeutic identification

Kun Tian, Emyr Bakker, Michelle Hussain, Alice Guazzelli, , Parisa Meysami, , , Luciano Mutti & Marija Krstic-Demonacos
Additional file 12: Table S12. Stage of patients.

Alpha-1 chain of human haptoglobin as viability marker of in vitro fertilized human embryos: information beyond morphology

Gergely Montskó, Krisztina Gödöny, Róbert Herczeg, Ákos Várnagy, József Bódis & Gábor L. Kovács
Only one third of the in vitro fertilization treatments result in successful delivery following morphological viability assessment worldwide. A paper by Montskó et al. (2015) describes the identification of the alpha-1 chain of human haptoglobin as a potential marker of embryo viability. Using mass spectrometry, the concentration of the haptoglobin alpha-1 chain was determined in spent culture media samples of in vitro fertilized embryos and correlation was found with the outcome of the respective transfer....

Self-similarity along the line Re(L(χ, s)) = 1 for 1st degree L functions near (i) large peaks and (ii) points known to correspond to large Riemann Zeta function peaks

John Martin
Two types of self-similarity exhibited in 1st degree L-functions on the line S=1+i*T are examined in the
range (10 5 < T < 10 30 ). Firstly, it is observed that there is extended mesoscale structure surrounding the
large peaks of the L-function on the line S=1+i*T reflecting closely the product function of (i) a truncated
Riemann Zeta function near the real axis with (ii) simple Euler factor type terms arising from the absent
lower modulo primes of the...

Facile preparation of colorful liquid marbles and liquid marbles used in water pollutant detection

, Yan Zhang, , Bin Xiang & Jian Li
Liquid marbles are drops coated with a hydrophobic powder. Different liquid marbles can be easily distinguished by the diverse color appearance. Here, we first demonstrate colorful liquid marbles, which were encapsulated with colored superhydrophobic stearate powders. A simple method was used to generate colorful superhydrophobic stearate powders via chemical reactions between sodium stearate and inorganic salts. In addition, the contact angle meter was used to monitor the horizontal profiles of liquid marbles to investigate the...

Assessing and Monitoring Geoecological Status of West Turkish Landscapes for Sustainable Development: Processes, Activities and Problems

Polina Lemenkova
A third large metropolis of Turkey, Izmir is an industrial city of high importance for the country. It is a key seaport harbor, strategic for the country and the Mediterranean region in general, highly important for the transportation network within the Aegean, Marmara and the Mediterranean Seas. Izmir is also known as an important country’s business and fair trade center, where cross-cultural meetings, Expo exhibitions, international conferences, symposia and workshops being periodically organized. Therefore, the...

Varicella vaccination in Italy and Germany – different routes to success: a systematic review

Florence Kauffmann, Angela Bechini, Paolo Bonanni, Giacomo Casabona & Peter Wutzler
Italy (in pilot regions) and Germany (nationwide) were the first European countries to introduce universal varicella vaccination (UVV) programs. A systematic review was performed to assess varicella epidemiology before UVV programs and the impact of 1-dose and 2-dose UVV programs in Italy and Germany. Italy implemented 1- or 2-dose UVV programs successively in eight pilot regions between 2003 and 2011 and nationwide in 2017. Germany implemented 1- and 2-dose UVV programs in 2004 and 2009,...

Additional file 1: of The training contents, problems and needs of doctors in urban community health service institutions in China

Shuang Shao, Tao Wu, , , Rui Chen, , Juan Du &
An questionnaire investigation of training status and needs for doctors working in community health service institutions in China. Note: The questionnaire was designed to collect some information about the training status and needs for doctors working in community health service institutions in China. (DOC 58 kb)

Additional file 3: of Helmsman: fast and efficient mutation signature analysis for massive sequencing datasets

Jedidiah Carlson, Jun Li & Sebastian Zรถllner
Figure S2. Evaluation of mutation signatures inferred by Helmsman. (PDF 250 kb)

Additional file 2: of Factors associated with preoperative attrition in bariatric surgery: a protocol for a systematic review

, , , Wendy Wrapson & Richard Siegert
Search Strategy Example for at least one electronic database PsychINFO â 1806 to present. (DOCX 38 kb)

Identification of triterpene biosynthetic genes from Momordica charantia using RNA-seq analysis

Shohei Takase, Kota Kera, Yuya Hirao, Tsutomu Hosouchi, Yuki Kotake, Yoshiki Nagashima, Kazuto Mannen, Hideyuki Suzuki & Tetsuo Kushiro
Cucurbitaceae plants contain characteristic triterpenoids. Momordica charantia, known as a bitter melon, contains cucurbitacins and multiflorane type triterpenes, which confer bitter tasting and exhibit pharmacological activities. Their carbon skeletons are biosynthesized from 2,3-oxidosqualene by responsible oxidosqualene cyclase (OSC). In order to identify OSCs in M. charantia, RNA-seq analysis was carried out from ten different tissues. The functional analysis of the resulting four OSC genes revealed that they were cucurbitadienol synthase (McCBS), isomultiflorenol synthase (McIMS), β-amyrin...

Long-term durability of immunogenicity induced by standard and triple-dose hepatitis B vaccine in patients receiving methadone maintenance treatment

Tian Yao, , Shuang Dong, , Shan Shi, , Lina Wu, Dan Feng, Jing Shi, , , &
We explored the long-term immunogenicity induced by 60 μg and 20 μg hepatitis B vaccines among patients receiving methadone maintenance treatment (MMT). In initial study, a randomized controlled trial was conducted, in which patients receiving MMT were administered 20 µg (IM20 group) or 60 µg (IM60 group) hepatitis B vaccines at months 0, 1, and 6. In this study, the responders at month 7 were followed-up at months 18, 30, and 42 to estimate long-term...

Supplementary Figures 1 - 3 from Inter-generational consequences for growing C. elegans in liquid.

Itamar Lev, Roberta Bril, , Lucila Inés Ceré & Oded Rechavi
Figure S1. F1 progeny of liquid grown worms are longer irrespectively of the concentration in which their liquid-grown parents were grown. The normalized lengths of F1 progeny of worms grown in liquid in different concentrations (x-axis) and progeny of plate-grown controls are presented. The measured length is normalized to the corresponding control progeny of plate-grown worms. ****p-value <0.0001. One-way ANOVA, Sidak's multiple comparisons test. Error bars represent standard deviations.; Figure S2. Immobile mutant worms do...

Supplementary Figure 2. Immobile mutant worms do not alter their morphology when grown in liquid, but their progeny are longer. from Inter-generational consequences for growing C. elegans in liquid

Itamar Lev, Roberta Bril, , Lucila Inés Ceré & Oded Rechavi
(A) Representative photographs of plate- and liquid- grown wild type and unc-119 adult worms. (B) Quantification of the length of the parental unc-119 mutants grown either on plates or in liquid. The measured length was normalized to the corresponding control worms. Data from three independent biological repeats are presented (N>80). ****p-value<0.0001, Sidak's multiple comparisons test. (C) Plate-grown progeny of immobile unc-119 mutant worms are longer than plate grown controls. The length of F1 plate-grown progeny...

Supplementary Figure 2. Immobile mutant worms do not alter their morphology when grown in liquid, but their progeny are longer. from Inter-generational consequences for growing C. elegans in liquid

Itamar Lev, Roberta Bril, , Lucila Inés Ceré & Oded Rechavi
(A) Representative photographs of plate- and liquid- grown wild type and unc-119 adult worms. (B) Quantification of the length of the parental unc-119 mutants grown either on plates or in liquid. The measured length was normalized to the corresponding control worms. Data from three independent biological repeats are presented (N>80). ****p-value<0.0001, Sidak's multiple comparisons test. (C) Plate-grown progeny of immobile unc-119 mutant worms are longer than plate grown controls. The length of F1 plate-grown progeny...

ETICA STOA policy brief final.pdf

Bernd Stahl &
Policy brief developed in collaboration of the ETICA project with the EU Parliament's STOA panel

Synthesis of 2,5-disubstituted-1,3,4-thiadiazole derivatives from (2S)-3-(benzyloxy)-2-[(tert-butoxycarbonyl) amino] propanoic acid and evaluation of anti-microbial activity

Amit A. Pund, Shweta S. Saboo, , &
The new compounds AP-1 to AP-10 were synthesized from starting material (2S)-3-(benzyloxy)-2-[(tert-butoxycarbonyl) amino]propanoic acid (1). The intermediate 2,5-disubstituted-1,3,4-thiadiazole amine (5) was prepared by coupling of (2S)-3-(Benzyloxy)-2-[(tert-butoxycarbonyl) amino]propanoic acid (1) with pyridine-2-carboxylic acid hydrazide (2) in the presence of carbonyldiimidazole (CDI) followed by 1,3,4-thiadiazole ring formation via diacylhydrazines derivative (3) and deprotection with shorter reaction time and excellent yield. The structures of new compounds were confirmed by spectral analysis. The series of new synthesized compounds AP-1...

On the Quantum Computing Delusion

John Smith
The prospect of an up-coming quantum computer revolution is big news these days, with some technologists predicting that a scalable quantum computer is a mere 4 - 5 years away. It has even been claimed -by D-Wave cofounder Eric Ladizinsky- that this prospective revolution will be civilization's next big revolution. The truth is that quantum computers that are anything more than toys are, not merely difficult to engineer, but mathematically impossible, and based on a...

Guia de Direitos de Titulares de Dados Pessoais

Fabiano Castello
Guia de Direitos de Titulares de Dados Pessoais

Guia de Direitos de Titulares de Dados Pessoais

Fabiano Castello
Guia de Direitos de Titulares de Dados Pessoais

Harnessing Platform Cooperatives to Reconcile the Digital and Social Economies

& Iris Wuisman
Online Platform Enterprises such as Uber are now ubiquitous. How can these initiatives stemming from the digital economy be squared with aspirations for a European social economy?

Between a Rock and a Hard Place: Pressing Corporations to Comply with CSR Instruments

Many corporations have adopted voluntary corporate social responsibility (CSR) instruments, but the extent to which they have been implemented is questionable. What are shareholders and governments doing to ensure stricter compliance?

Figure S8 from Accurate wisdom of the crowd from unsupervised dimension reduction

& Tom Michoel
Neither SML nor CUBAM converged to PCA as the number of questions increased. The proportion of differences in aggregated responses are shown as a function of the number of questions in simulated binary datasets. Markers and shades represent mean and standard deviation in 2000 random repeats of 20 individuals each.

Figure S10 from Accurate wisdom of the crowd from unsupervised dimension reduction

& Tom Michoel
Simulation 1 confirmed superior and consistent performances of dimension reduction methods, especially PCA and Isomap. (A) Comparison of dimension reduction, individual predictions, and the class probability in AUROC and AUPR (cf Figure 3A) for simulation 1 (Table S2). (B) Comparison of dimension reduction and supervised learning in cross validation at 25% training data (cf Figure 4) for simulation 1. Color reflects relative ranking. (C, D, E, F) ROC (C, E) and Precision-Recall (D, F) curves...

محرمات الطعام والشراب في القرآن الكريم وأثرها الصحي على المجتمعات الإسلامية

Mohamed Abouzeid
نشر في مجلة جامعة أم القرى لعلوم الشريعة والدراسات الإسلامية في العدد ٧٩ الجزء ١يتناول هذا البحث محرمات الطعام والشراب الواردة في القرآن الكريم، كما يوضح كيف كان لتحريم هذه الأطعمة والأشربة الأثر الواضح في تمتُّعِ الأمة الإسلامية بأفضل أحوال الصحة البدنية والنفسية. ويهدف الباحث إلى تحديد محرمات الطعام والشراب في النص القرآني، وبيان ما توصل إليه علماء الشريعة وغيرهم من علماء الطب إلى أضرار تلك المحرمات، وتوضيح أثر تحريم هذه الأطعمة على الصحة في...

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