Hepatocellular carcinoma (HCC) is the sixth most common cancer and the fourth leading cause of cancer-related death globally. Hepatitis B virus (HBV) and hepatitis C virus (HCV) infection are the major risk factors accounting for 75% of all HCC cases. Currently, curative treatments including surgical resection and liver transplantation can only be applied to early diagnosed patients. For advanced HCC patients, the currently available first-line molecularly targeted medications showed limited survival benefits and low response...

SDSS J1038+4849 lens models

SDSS J1038+4849 lens models

Thesis: Trace-elements in ostracods as proxy of envrionmental parameters in shallow marine waters Pictures obtained though a Zeiss microscope 305. Magnification 4X.Species: Neomonoceratina delicata and Sinocytheridea impressa

Pharmaceutical reactivation of lytic cycle of Epstein–Barr virus (EBV) represents a potential therapeutic strategy against EBV-associated epithelial malignancies, e.g., gastric carcinoma (GC) and nasopharyngeal carcinoma (NPC). A novel lytic-inducing compound, C7, which exhibits structural similarity to Di-2-Pyridyl Ketone 4, 4-Dimethyl-3-Thiosemicarbazone (Dp44mT), a known chelator of intracellular iron, is found to reactivate EBV lytic cycle in GC and NPC. This study aims to delineate the mode of action of C7 and clinically available iron chelators in...

The dataset contains immunoblots, RT-PCR data, immunofluorescence staining image, immunohistochemistry staining images, H&E staining images, MTT readings, cell count, liver-to-body weight ratio, luciferase assay data, and DNA gel photo. The results were presented in a thesis entitled "Molecular characterization of SH3 domain binding kinase 1 (SBK1) and its role in hepatic epidermal growth factor receptor (EGFR) signaling".

This PhD thesis first investigated the binding process of coronavirus spike proteins to the host cell receptors during virus entry. Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) was identified as a novel cell surface binding target of MERS-CoV using the viral overlay protein binding assay (VOPBA). This finding was validated using multiple experimental assays including overexpression, siRNA knockdown, antibody blocking assay, and recombinant protein blocking assay.
Next, we further investigated on the pathogenic mechanism...

Out laboratory has derived mEPSCs from mESCs, which represents a breakthrough in stem cell research. Unlike the standard pluripotent stem cells, mEPSCs can contribute to both embryonic and extra-embryonic lineages in the chimera assay (Yang et al., 2017a). In the development of EPSC culture conditions, many small molecules are tested to target an array of pathways involving early development. However, the mechanism of transiting from mouse ESCs to EPSCs is not fully dissected. In this...

Intervertebral discs (IVDs) are essential to spinal motion. IVD degeneration (IDD) is associated with aging and chronic inflammation, involving excessive degradation and remodeling of the extracellular matrix (ECM). However, the mechanism of IDD pathogenesis is not yet fully understood, and effective treatments for IDD remain to be investigated. Biglycan (BGN) is a member in the first class of small leucine-rich proteoglycans (SLRPs) that have been suggested to have diverse biological functions predominantly in the ECM....

There are three-part in this dataset： the first one is “Figures-Thesis” P1: list of primers used in this study. P2: Graphical Abstract P3-P10: Figures for introduction P11: table for marker genes P12-P61: Figures for results
The second one is "single-cell data", which includes the UMAP, GSEA, Pesuo-time analysis and the transcriptome analysis between zebrafish and mouse.

And the last part is "Tg embryo data", which includes Sudan black B staining and WISH...

This is an experiential project that students participated in experiential learning activities and produced a set of tourist maps of Ha Tsuen. As part of the course assignments, students from the University of Hong Kong attending course SOCI2055 Tourism, Culture and Society (2016-2017) were guided to collect primary data, produce travel guides to raise public awareness of local history, heritage preservation and future development of Ha Tsuen, as well as reflect on the impacts of...

There are three-part in this dataset： the first one is “Figures-Thesis” P1: list of primers used in this study. P2: Graphical Abstract P3-P10: Figures for introduction P11: table for marker genes P12-P61: Figures for results
The second one is "single-cell data", which includes the UMAP, GSEA, Pesuo-time analysis and the transcriptome analysis between zebrafish and mouse.

And the last part is "Tg embryo data", which includes Sudan black B staining and WISH...

Our society is facing increasing burden of health care associated with cancer disease. At present, there are more than hundreds of anti-cancer drugs. At the same time, the number of compositions made from these clinically approved anti-cancer drugs is up to 1300-1500.[1] Among the clinically used anti-cancer drugs, cytotoxic platinum (II) compounds are the most extensively used in chemotherapy. In this project, the platinum(II) complexes bearing different bis-N-heterocyclic carbene and 1- (3-hydroxybenzo[b]thiophen-2-yl)ethanone (HO^O) ligand were...

This is a poster presentation for AACR 2022 Annual Meeting

This is a poster presentation for AACR 2022 Annual Meeting

Genome editing is a powerful tool for forward genetic screens. With the recent advances in Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology, manipulation in human genome has become faster, easier, and more accurate. By adopting and repurposing the CRISPR-Cas9 system through the use of nuclease-deficient Cas9 (dCas9), a wide range of target genes can be upregulated in their endogenous context. In addition to the programmable RNase activity of Cas9, a novel type of enzyme,...

Liver cancer is currently the sixth most common malignancy and the second leading cause of cancer-related mortalities worldwide. Hepatocellular carcinoma (HCC), the predominant type of primary liver cancer, is particularly prevalent in East Asia, South East Asia, and Sub-Saharan Africa, due to chronic hepatitis B endemic in these regions. However, therapeutic options for advanced stage HCC are extremely limited and often provide unsatisfactory survival benefits. Activation of the HIF-1 pathway by tumor hypoxia is a...

This record contains hand drawings of the selected traditional objects that could be found in the Shanghai Street, which are used in the production of the smartphone app guiding users through Shanghai Street with the Augmented Reality technique.

The dataset contains immunoblots, RT-PCR data, immunofluorescence staining image, immunohistochemistry staining images, H&E staining images, MTT readings, cell count, liver-to-body weight ratio, luciferase assay data, and DNA gel photo. The results were presented in a thesis entitled "Molecular characterization of SH3 domain binding kinase 1 (SBK1) and its role in hepatic epidermal growth factor receptor (EGFR) signaling".

Raw data of "C-terminal truncated HBx initiates hepatocarcinogenesis by down-regulating TXNIP and reprogramming glucose metabolism", including RNA-sequencing data, data of qPCR, IF and IHC staining, in vivo and in vitro functional assay result, glycolysis assay result and so on.

Raw data of "C-terminal truncated HBx initiates hepatocarcinogenesis by down-regulating TXNIP and reprogramming glucose metabolism", including RNA-sequencing data, data of qPCR, IF and IHC staining, in vivo and in vitro functional assay result, glycolysis assay result and so on.

A. Data showing the gene expression level of tubulin (TUBB), aurora kinase B (AURKB), CDK4 and CDK6 in HCC tissue and corresponding non-tumorous liver tissues (NT) in HCC patients. Scatter dot plot: mean with SD. Student’s t test: * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001.
B. Data showing the correlation between HCC patients with normal or high expression level of TUBB, AURKB, CDK4 and DDX41...

Intervertebral discs (IVDs) are essential to spinal motion. IVD degeneration (IDD) is associated with aging and chronic inflammation, involving excessive degradation and remodeling of the extracellular matrix (ECM). However, the mechanism of IDD pathogenesis is not yet fully understood, and effective treatments for IDD remain to be investigated. Biglycan (BGN) is a member in the first class of small leucine-rich proteoglycans (SLRPs) that have been suggested to have diverse biological functions predominantly in the ECM....

Images of coffee shop, cafe storefronts in Singapore, Hong Kong.

Using a multimodal approach and textual analysis from sociolinguistics and film studies, this thesis resituates Wong Kar-wai’s ‘idiosyncratic’ on-screen languaging practices in a discussion of Translanguaging and Sinophone theories.
The analysis collects in-film speech data, dialogues, visual, and audio data from Wong Kar-wai’s nine feature films As Tears Go By (1988), Days of Being Wild (1990), Chungking Express (1994), Fallen Angels (1995), Happy Together (1997), In the Mood for Love (2000), Ashes of Time...