1,706 Works

Computer aided diagnosis of early vascular disease from ultrasound images

Liam N. Kavanagh
This thesis consists of 2 separate ultrasound (US) based studies, performed with the common aim of improving the diagnosis of early vascular disease from US images. Study 1 Introduction: Flow mediated dilatation (FMD) is an endothelium-dependent process reflecting the dilatation of a conduit artery when it is exposed to increased blood flow and therefore increased shear stress. FMD requires a healthy endothelium and is depressed in those with cardiovascular risk factors. Current 2D US...

Evidence for a Role for Coagulase-Negative Staphylococci and their Biofilms in the Historic and Future Evolution of Staphylococcus Aureus Including MRSA

Paulo Eduardo Budri
Rates of methicillin-resistant Staphylococcus aureus (MRSA) infections in Ireland are decreasing since 2006. However, MRSA and methicillin-susceptible S. aureus (MSSA) remain a major cause of healthcare-associated infections in Europe. Recent evolutionary trends indicate that MRSA lineages associated with infections in the community are causing infections in the healthcare setting with increasing frequency. It is therefore important to investigate potential reservoirs in the community that may contribute to MRSA and S. aureus evolution. The methicillin resistance...

Effects of Service Integration on Utilisation, Coverage and Workload - A Ugandan Case Study of the Integration of Prevention of Mother to Child Transmission of HIV and Maternal, Neonatal and Child Health Related Services

Anna Awor
Introduction: Following global calls to integrate the delivery of Sexual Reproductive Health (SRH) and HIV/AIDS services efforts have been focused on adopting innovative approaches to respond to the calls. These calls were premised on the belief that delivery of integrated services leads to increase in service availability, access, utilisation as well as efficiency in service delivery. In Uganda, updating of health policies and guidelines are still ongoing so as to facilitate delivery of integrated SRH...

Torticollis of infancy: the reliability of visual estimation in the assessment of cervical spine active rotation and head tilt by physiotherapists and the impact of clinical experience on that reliability.

Anthea Seager
Introduction: Torticollis is a clinical sign of asymmetric neck posture. In infancy, the most common causes are muscular in nature and can be classified as Congenital Muscular Torticollis or Postural Torticollis. Assessment of neck function is essential for diagnosis and management of torticollis. A systematic review demonstrated a paucity of reliable and valid measurement tools, in particular for the assessment of postural side-flexion (head tilt) and active neck rotation, in the upright position. Furthermore, most...

The current state of surgical training in East, Central and Southern Africa

Stephen WO Ogendo &
The current state of surgical training in East, Central and Southern Africa

The Role of COSECSA in Surgical Training

Chris Lavy &
The Role of COSECSA in Surgical Training

Training non-physician clinicians to deliver surgical care in Africa

Ruairi Brugha &
Training non-physician clinicians to deliver surgical care in Africa

UROLINK British Association of Urological Surgeons

Christine Evans &
UROLINK British Association of Urological Surgeons

Interburns contribution to train Burns Surgeons and Care Providers in Africa

Interburns contribution to train Burns Surgeons and Care Providers in Africa

WHO Global Initiative for Emergency & Essential Surgical Care

Meena Nathan Cherian &
WHO Global Initiative for Emergency & Essential Surgical Care

WHO Global Initiative for Emergency & Essential Surgical Care

Meena Nathan Cherian &
WHO Global Initiative for Emergency & Essential Surgical Care

COSECSA - A Malawi Perspective

COSECSA - A Malawi Perspective

Identifying New Drug Targets to Treat Breast Cancer Brain Metastasis

Siobhan Purcell
Breast cancer brain metastasis (BrM) is indicative of poor prognosis, with a short median survival time and limited disease management strategies. Current treatment options are restricted to surgical resection, radiation therapy and limited targeted therapies. Therefore, there is an urgent need to uncover alterations responsible for BrM and to define novel effective therapeutic targets. RNA-sequencing (RNA-Seq) was performed to analyse gene expression differences between patient-matched breast tumours and their associated resected BrM. Importantly, common transcriptional...

Aldosterone-Mineralocorticoid Receptor: Cell Biology to Translational Medicine

Brian Harvey
This book is an open access dissemination of the EU COST Action ADMIRE in Aldosterone/Mineralocorticoid Receptor (MR) physiology and pathophysiology. Aldosterone is the major hormone regulating blood pressure. Alterations in blood levels of aldosterone and genetic mutations in the MR receptor are major causes of hypertension and comorbidities. Many of the drugs in clinical use, and in development for treating hypertension, target aldosterone and MR actions in the kidney and cardiovascular system. The ADMIRE book...

An Exploration of Carers of Stroke-Survivors in Ireland Experiences of the Discharge Planning Process and Transition of Care to the Home Setting

Shelagh O'Connor
IntroductionIn Ireland, it is estimated that 10,000 people have a stroke annually. A high numberof stroke-survivors with residual deficits requiring care are discharged to their own.Informal carers are often central in homecare provision. The discharge planningprocess (DPP) is the process used to establish the requirements necessary for apatient to transition from one level of care to another, and may involve carers.
Aims and ObjectivesThe aim of this study was to explore the experiences of carers of...

The Assessment of Myocardial Performance and the Impact of Pathological Processes on Cardiac Adaptation in the Neonatal Population using Functional Echocardiography

Colm Breatnach
Introduction: Functional echocardiography is a rapidly expanding field in both research and clinical settings. Newer techniques facilitate comprehensive and objective assessments of myocardial performance not previously possible. Although work has been done to assess feasibility and obtain reference values for several new modalities in normal term and preterm infants, data is still lacking in several important disease states. Objectives: We aim to study the impact of several important conditions on neonatal myocardial function over the...

Cognitive impairment and medication adherence in stroke

Daniela Rohde
Aim The overarching aim of this thesis was to explore the bidirectional association between adherence to secondary prevention medications and cognitive impairment in stroke survivors. A secondary aim was to provide an updated account of the longer-term outcomes of cognitive impairment post-stroke. Methods and results Five interrelated studies were conducted to address these aims. Study 1 explored the association between cognitive impairment and cardiovascular medication use in an Irish sample of the general population aged...

The Prevalence of Frailty in Older Adults Referred to Primary Care Physiotherapy and the Influence of Frailty Screening on the Clinical Practice of Physiotherapists : A Mixed Methods Study

Melissa Boland
IntroductionGlobally, the proportion of the population of older adults (aged 65 and older) is growing rapidly. Frailty is a state of increased vulnerability to poor resolution of homeostasis following a stress and is the most problematic expression of population ageing. Physiotherapy is a heavily utilised social and community care service by older adults in the Republic of Ireland. An increasing number of older adults, with the potential presence of frailty, are likely to present to...

The Perceptions of Older Patients and their Family or Caregivers Towards Physical Activity and Exercise on a Specialist Geriatric Ward: A Qualitative Study

Bláthnaid Mealy
IntroductionFunctional decline or deconditioning is considered the main complication of hospitalisation for older people, often resulting in adverse outcomes. Low levels of activity and mobility accelerate this decline, yet despite this, evidence demonstrates how activity levels of hospitalised older adults remains very low. Family or caregiver involvement may have a positive impact on patient physical activity during a hospital admission. Given the aging population and the likelihood of the problem of hospital associated deconditioning escalating,...

Improving the Patient Journey for Hip Fracture Patients from Arrival in the Emergency Department to Admission to the Orthopaedic Ward

Mary Jones
This Quality Improvement (QI) Project focuses on the admission pathway of hip fracture patients in a large acute hospital in Dublin. Hip fractures are the most common fragility fracture in the over 50’s in Ireland, accounting for 36.5% of orthopaedic admissions and 46.7% of orthopaedic bed days (Kelly et al 2018). It is a common injury but its effects on patients and carers is often underestimated by clinical staff (Saletti-Cuesta et al 2018)The National Office...

Improving Nursing Handovers in a Voluntary Mental Health Facility

Around the globe, ineffective handovers have resulted in grave consequences, leading to handover improvement strategies being introduced, along with guidelines beingformulated in many countries. Despite this, however, few studies focused on improving handovers in a psychiatric setting. This current Quality Improvement Project aims tofill this gap and improve nursing handovers in a mental health facility by 50% over eight months. Using Lean Six Sigma's, Define Measure Analyse Improve Control framework and various quality improvement tools,...

A qualitative exploration of adolescents with severe haemophilia and their caretakers regarding their future transition to adult services

Objective: To qualitatively explore the views of adolescents with severe haemophilia A or haemophilia B and their caretakers such as parents and multidisciplinary staff relating to transition from child to adult services.Methods: Qualitative design using semi-structured interviews based upon the Critical Incident Technique (CIT).Results: Thematic analysis using the CIT approach identified five themes all of which pertained to either the positive or negative aspects of the transition programme for adolescents with severe haemophilia and their...

End-Stage Renal DiseaseSleep Disturbance in Patients with Advanced Chronic Kidney Disease or End-Stage Renal Disease

Claire Kennedy
Patients with advanced chronic kidney disease (CKD) or end-stage renal disease (ESRD) have a large burden of symptoms, with sleep disturbance, restless legs syndrome and fatigue among the most prevalent (1). These sleep-related symptoms are considered an absolutepriority for both treatment and research by patients and their caregivers (2). Despite this, clinicians consistently underestimate and overlook these symptoms in clinical encounters (3). The impact of RRT modality choiceon such symptoms is not well defined and...

An investigation into the expression, content and function of exosomes in an experimental model of epilepsy

Epilepsy is a serious neurological disease characterised by recurrent unprovoked seizures affecting 65 million people worldwide. Current anti-epileptic therapies target only symptomatic seizures and are not fully effective in ameliorating disease pathophysiology. Temporal lobe epilepsy is the most common form of epilepsy in adults and a third of temporal lobe epilepsy patients are drug refractory, and the underlying pathophysiology remains to be fully elucidated. Recent work revealed microRNAs serve important functions in cells, in post-transcriptional...

Improving the utilisation and the awareness of high-sensitivity cardiac troponin test

Reginald Imasuen
Cardiac troponin is one of the biomarkers to diagnose a myocardial infarction and has been in use for many years. There has been many improvements in these biomarkers to aid in the diagnosis of a myocardial infarction. An improvement in troponin sensitivity to be specific. Each new generation of troponin has led to improved diagnostic sensitivity. The new generation of troponin are known as the high-sensitivity troponin. The advantage of the high-sensitivity troponin is the...

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