1,649 Works

The role of viral regulatory protein ICP0 in herpes simplex type 1 keratitis

David Shahnazaryan
Herpes simplex keratitis (HSK) is the commonest cause of infectious blindness in the developed world. It is caused by herpes simplex virus type 1 (HSV‐1) and is characterised by recurrent episodes of infection and immune‐mediated corneal inflammation that lead to significant loss of vision. Following transmission of HSV‐1 the virus is initially suspended in the tear film, where it encounters a multi‐pronged defence comprising enzymes, complement, immunoglobulins and crucially, a range of anti‐viral and pro‐inflammatory...

Reducing Hospital Attendances for New Vascular Referrals While Improving Risk Factor Investigation

Jason Ridge
Vascular disease is strongly associated with advancing age. As Ireland’s population gets older and the prevalence of other risk factors such as diabetes increase so too does the incidence of vascular disease. In an already heavily burdened system it is important that all processes operate efficiently without sacrificing quality of care provided to the patient. A key metric of quality care provision is patient satisfaction. Something which is negatively impacted by repeated hospital attendances. This...

Profiling Frailty in a Population of Older Adults Living With Human Immunodeficiency Virus (HIV) In Ireland

Chiara Reddin
Introduction Due to advances in healthcare in recent years, people living with Human Immunodeficiency Virus (PLWH) are for the first time reaching older age since the HIV epidemic began in the 1980s. It is known that PLWH suffer from premature ageing syndromes, such as frailty, younger than the general population (Bhatia et al., 2012). This presents new challenges for healthcare professionals in facilitating older PLWH to live better for longer into older age and in...

Identifying delays occurring in out-of-hours FAST calls causing increasing door-to-treatment time

Kyra O'Dwyer
Stroke is one of the leading causes of death and disability worldwide and is a huge economic burden. The management of stroke is time dependant. Shorter times result in reduced mortality and morbidity. National Guidelines in Ireland suggest a door-to-treatment time of one hour or less from presentation to the emergency department. Despite this recommendation, delays are still occurring for patients accessing timely treatment. This quality improvement project was carried out in a busy North...

Investigating the immune response to Staphylococcus aureus bloodstream infection in haemodialysis patients

Roisin Connolly
Staphylococcus aureus bloodstream infection (SA-BSI) is a serious and potentially fatal problem in haemodialysis patients. An effective S. aureus vaccine would have significant benefits in this group. Previous antibody-inducing vaccine candidates failed to prevent or attenuate SA-BSI and it is now accepted that next-generation anti- S. aureus vaccines must also induce effective T-cell-mediated immunity. Recent advances have helped to elucidate the role of specific T-cell subsets, notably Th1 and Th17 cells, which coordinate an effective...

Investigating the correlation between job satisfaction, autonomy, and self-efficiency among school nurses in Bahrain- a mixed methods study

Faten Hasani
To understand the relationship between job satisfaction, autonomy, and self-efficacy amongst school nurses in Bahrain a total of 142 school nurses in Bahrain were surveyed. Twenty-seven school nurses were also interviewed. Data were collected using structured psychometric tools and analyzed using Burnard’s (1991) framework. Conclusion drawn remarkably shows high level of job satisfaction among school nurses in Bahrain. Herzberg’s two-factor theory was used to determine the hygiene and motivation factors. The relationship between self-efficacy correlates...

Metabolic Reprogramming of the Cystic Fibrosis Neutrophil

Oliver J. McElvaney
Cystic fibrosis (CF) is the commonest lethal genetic condition affecting Caucasians, arising from a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene on the long arm of chromosome 7. It is a chloride channelopathy, manifesting clinically as a multisystem disorder. The major cause of morbidity and mortality in CF is neutrophilic lung disease, though significant debate exists as to whether the main determinant of this is an intrinsic defect due to defective CFTR...

Elucidating the Role of Complement Activation in the Pathogenesis of Alpha-1 Antitrypsin Deficiency

Laura Fee
Alpha-1 antitrypsin deficiency (AATD) is characterised by low circulating levels of alpha-1 antitrypsin (AAT) and is associated with neutrophil-driven chronic obstructive pulmonary disease (COPD), liver disease and other autoimmune comorbidities including vasculitis and panniculitis. Complement C3 has recently been identified as a binding partner of AAT. The aim of this study was to evaluate the significance of the lack of this binding event in AATD. A significant link between AATD manifestations and those which are...

How does undergraduate teaching prepare graduates for the paediatric SHO role? A study investigating how graduates of undergraduate training in Ireland meet stakeholder minimum accepted competencies (MAC) of knowledge and expectations of good practise as new paediatric SHO recruits.

Patrick Mccrossan
BackgroundThere may be a gap between what students learn during medical school andtheir clinical responsibilities as first-year paediatric doctors. At undergraduatelevel, in the United Kingdom (& Ireland), each medical school sets its owngraduating assessment and successful completion by the candidate leads to thelicensed right to practise by the Medical Council. It is therefore important todefine the standard for successful completion of medical school.
AimsWe sought to determine how current Irish undergraduate education preparesdoctors commencing clinical practice...

How does undergraduate teaching prepare graduates for the paediatric SHO role? A study investigating how graduates of undergraduate training in Ireland meet stakeholder minimum accepted competencies (MAC) of knowledge and expectations of good practise as new paediatric SHO recruits.

Patrick Mccrossan
BackgroundThere may be a gap between what students learn during medical school andtheir clinical responsibilities as first-year paediatric doctors. At undergraduatelevel, in the United Kingdom (& Ireland), each medical school sets its owngraduating assessment and successful completion by the candidate leads to thelicensed right to practise by the Medical Council. It is therefore important todefine the standard for successful completion of medical school.
AimsWe sought to determine how current Irish undergraduate education preparesdoctors commencing clinical practice...

“More of an art than a science”: The development of an accreditation framework for continuing education activities for pharmacists

Sarah Rhiannon Drumm
Accreditation is a recognition that an educational activity meets certain standards. The processes for accreditation vary considerably depending on the type of activity, and currently there are differing accreditation systems in place for pharmacy continuing education (CE) across different countries. The aim of this thesis was to research a selection of these systems, which would provide an opportunity to develop a catalogue of accreditation approaches currently in place in a number of different countries, and...

The effect of a Pilates-based core exercise group on balance and gait in ambulant children with Cerebral Palsy: A Randomised Control Trial

Clodagh Coman
Children with Cerebral Palsy (CP) demonstrate dysfunctional core muscleactivation contributing to problems with postural control for functional activitiesand walking. Pilates-based core exercises aim to improve postural control byencouraging coordinated activation of deep core stabilising muscles duringfunctional movements.This thesis will present the findings of a blinded assessor, parallel, randomisedcontrolled trial (RCT), with 46 participants, on the effect of Pilates-based coreexercises on balance and gait in ambulant children with spastic CP, ages sevento 17 years.The primary objectives...

How to Empower Professionals and the Public to Improve Mental Health Care: Exploring Educational Initiatives

Dolores Keating
Irish mental health policy emphasises early intervention, interdisciplinary working, the recovery philosophy and, perhaps most importantly, partnership between healthcare professionals, patients, caregivers and the community. Pharmacists have frequent contact with people experiencing mental health problems but appear to lack the confidence to engage effectively in mental health care. This thesis explores how educational interventions can empower pharmacists and members of the public to better support people experiencing mental health problems. Pharmacy students were found generally...

Responsive polypeptide containing block copolymers and polymer particles

Elena Bobbi
The synthesis and characterisation of novel stimuli-responsive polymers designed for biomedical applications is described. The first system is temperature-sensitive and is foreseen as useful for the study of the influence of particle shape on cellular uptake while the second one for the redox-sensitive delivery of drugs. Chapter 1 contains a background on the field of synthetic polymers for biomedical applications and on the polymerisation techniques applied by researchers and particularly in this work, namely RAFT...

The Genetic Structure and Landscape of Ireland Reveals Footprints of History

Edmund Gilbert
Ireland has a fascinating history of ancient kingdoms and more modern migrations. Furthermore, Ireland’s island location at the north-western edge of Europe makes it conducive to genetic homogeneity and isolation. The impact of historical migrations on the island is largely unknown, as is the extent of genetic structure in Ireland, despite successful efforts to characterise such genetic ancestry and structure with uniparental data, and efforts within the neighbouring British Isles.The description of the impact of...

Case-based Reporting and Analysis to Enhance the Value and Use of Routine Health Facility Data for Health Policy, Programming and Research: Case Study of a New Malaria Surveillance System in The Gambia

Samuel Emetu Anya
A sustained decline in the burden of malaria from 2003 to 2007 in The Gambiahighlighted the need for real-time data to monitor the changing epidemiology ofmalaria. The aim of the studies described in this thesis was to determine thevalue and use of routine case-based health facility data for malaria policy,programming and research.To achieve this aim, individual, rather than aggregate, malaria case records atthe six sentinel sites were analysed by age, sex, month, season and location.The...

A study of the androgen mediated transcriptome and AR interactome in AI resistant breast cancer

Rachel Bleach
Aromatase inhibitors (AI) are the vanguard treatment for hormone receptor positive, postmenopausal breast cancer, however, acquired resistance occurs in up to 40% of patients. AI therapies, by their mechanism of action, create a predominantly androgenic steroid environment. In this study, a multi-omic approach was undertaken to elucidate the role of the androgen receptor (AR) in AI resistant breast cancer. Evidence from this study suggests that cancer cells adapt to utilise the adrenal prohormone, androstenedione and/or...

Guidelines for the development of multiple choice items & assessments.

Jane Holland & Niall Stevens
All assessment methods have varying strengths and weaknesses, and it is appropriate that multiple formats, such as MCQs, OSCEs and portfolios, are used within a robust programme of assessment for undergraduate and postgraduate medical programmes. This booklet is designed to provide guidance to RCSI staff on the development of multiple choice items and assessments specifically. As such, it is an introduction to multiple facets of this process, such as item writing, assessment blueprinting, standard setting...

Knowledge, Behavior and Attitude of Nurses Regarding Prevention of Central Line Associated Blood Stream Infections

Iyad Salem Ahmad Al-Yateem
The level of knowledge of nursing staff handling patients with Central Venous Catheters has been reported internationally as one of the factors contributing to the increasing incidence of Central Line Associated Blood Stream Infections (Alkubati et al., 2015; Chen et al., 2015). This study aimed to identify the Level of knowledge, behavior, and attitude of nurses in Adult and Hemodialysis Units in a military hospital in the Kingdom of Saudi Arabia regarding Central Line Associated...

Attitudes of Emergency Nurses to Evidence Based Practice in the Emergency Department of a Multi-Specialty Hospital

Ciara Rooney
Background: Despite the growing body of evidence produced by and for nurses, moving evidence from research into practice remains challenging. These challenges can be attributed in part, to attitudes of nurses towards evidence based practice. This study examined attitudes to evidence based practice among Emergency Department nurses and factors which influenced these attitudes such as: years of experience in nursing, country of education, practice outside country of education, perception of the culture of the organisation,...

Attitudes of Emergency Nurses to Evidence Based Practice in the Emergency Department of a Multi-Specialty Hospital

Ciara Rooney
Background: Despite the growing body of evidence produced by and for nurses, moving evidence from research into practice remains challenging. These challenges can be attributed in part, to attitudes of nurses towards evidence based practice. This study examined attitudes to evidence based practice among Emergency Department nurses and factors which influenced these attitudes such as: years of experience in nursing, country of education, practice outside country of education, perception of the culture of the organisation,...

Improving Waiting Times for Outpatient Holter Monitoring

Harmonie Adams
Prolonged outpatient waiting times are a global healthcare concern affecting most hospital specialties, including in Ireland. Improvement of waiting times is a constant battle and priority for Ireland’s health service, the Health Service Executive. The result of lengthy waiting for outpatient Holter monitor appointments can mean a delay in diagnosis and the potential consequences of delay in treatment. Patient satisfaction and trust in healthcare providers is negatively impacted by long waits. This quality improvement project...

Recommendation for Future Development of Colorectal Cancer Surgery in Ireland and Guidelines for the Management of Rectal Cancer in Ireland

Deborah McNamara
Recommendation for Future Development of Colorectal Cancer Surgery in Ireland and Guidelines for the Management of Rectal Cancer in Ireland issued by the Irish Association of Coloproctology on 5th September 2010.

Frailty Measures and their Association with Post-Acute Rehabilitation Outcomes

Louise Mccarron
Introduction: With frailty a worldwide concern in a rapidly expanding ageing population, proactive approaches to the management and identification of frailty are recommended to help reduce hospitalisations and adverse outcomes. Yet, there is lack of evidence for frailty screening and rehabilitation of adults in an Irish post-acute rehabilitation setting.
Aims and Objective: The primary aim of this study was to compare clinicians’ appraisal and patients’ subjective appraisal of frailty and explore their association with each...

Exploring Therapists’ Perceptions of Facilitating Family Involvement in Neurorehabilitation: A Qualitative Study

Marie Keegan
Introduction: There is a high prevalence of Acquired Brain Injury (ABI) in the Republic of Ireland and ABI can result in a range of physical, cognitive and communicative issues. Post ABI patients frequently go through the inpatient rehabilitation process to help to remediate these impairments. Current research advocates the involvement of family members in the rehabilitation process and further research is needed to expand on what this involvement entails and how to best facilitate this....

Registration Year

  • 2021
    64
  • 2020
    131
  • 2019
    1,454

Resource Types

  • Text
    1,333
  • Other
    239
  • Audiovisual
    49
  • Image
    26
  • Collection
    2