1,640 Works

Bioinspired Star-Shaped Poly(L-Lysine) Polypeptides; 2 Efficient Polymeric Nanocarriers for the Delivery of DNA 3 to Mesenchymal Stem Cells

David Walsh, Robert Murphy, Angela Panarella, Rosanne Raftery, Brenton Cavanagh, Jeremy C. Simpson, Fergal O'Brien, Andreas Heise &
The field of tissue engineering is increasingly recognizing that gene therapy can be employed for modulating in vivo cellular response thereby guiding tissue regeneration. However, the field lacks a versatile and biocompatible gene delivery platform capable of efficiently delivering transgenes to mesenchymal stem cells (MSCs), a cell type often refractory to transfection. Herein, we describe the extensive and systematic exploration of three architectural variations of star-shaped poly(l-lysine) polypeptide (star-PLL) with varying number and length of...

A qualitative exploration of adolescents with severe haemophilia and their caretakers regarding their future transition to adult services

Objective: To qualitatively explore the views of adolescents with severe haemophilia A or haemophilia B and their caretakers such as parents and multidisciplinary staff relating to transition from child to adult services.Methods: Qualitative design using semi-structured interviews based upon the Critical Incident Technique (CIT).Results: Thematic analysis using the CIT approach identified five themes all of which pertained to either the positive or negative aspects of the transition programme for adolescents with severe haemophilia and their...

Design and Development of Multi-Targeted Metallodrugs as Potential Chemotherapeutic Agents

Reece G. Kenny
Cancer remains a major global health burden despite significant advances in treatmentregimens. Current drug treatments, including those involving platinum drugs, havedrawbacks including dose limiting toxic side effects and either acquired or intrinsicdrug resistance. The development of safer and more effective drug treatments remainsa major research focus. The platinum drugs in clinical use primarily target DNA.Our Group previously developed novel multi-targeted platinum(II) complexes capableof not only binding cancer cell DNA but also possessing the ability to...

Examining the relationships between attendance, online engagement and summative examinations performance

Jane C. Holland, Eric Clarke, Morag Monro, Evelyn Kelleher & Mark Glynn
Background: Non-attendance correlates with poor performance, but manual recording of attendance is problematic. Online activity reports may be a more efficient method of identifying at-risk students. Summary of work: This research is part of a prospective study examining physical attendance, online activity reports (Moodle), continuous assessments and summative examination performance. Ethical approval was granted by RCSI Ethics Committee. Two modules within the first year of the undergraduate medical program were identified for inclusion. Results: Data...

Is a picture worth a thousand words?

Jane C. Holland, Robin O'Sullivan & Richard Arnett
Background: It has previously been suggested that the use of illustrations in MCQs may have variable effects on individual items. This study examines the effect of illustrated questions, as opposed to pure text, to discern if any overall bias between the two formats is detectable. Summary of work: We reviewed 6 Histology MCQ papers from our Medical Junior Cycle. Classical test theory analysis was performed on all MCQs, which were then divided into two groups,...

Overseas Training

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Overseas Training

ENT for Zambia

ENT for Zambia

ENT for Zambia

ENT for Zambia

Global Emergency Care Skills

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Global Emergency Care Skills

Global Emergency Care Skills

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Global Emergency Care Skills

The Importance of Inhaler Technique in Measuring and Calculating Inhaler Adherence, and its Clinical Outcomes

Imran Sulaiman
Depending on the population studied, cross-sectional observational studies suggest that between 14%-90% of patients do not use their pressurized metered dose inhaler correctly, while 50-60% misuse a dry powder inhaler. This means that unless incorrect technique is acounted for a significant underestimation of how much medication the person actually obtained may be made. The aim of this thesis was to objectively determine the frequency and importance of inhaler technique errors and to combine these with...

Cardiovascular and temperature actions of cathinones

The main aims of these studies were to investigate cardiovascular and temperature actions of the main constituent of khat, cathinone, and to study possible gender differences. Also, since caffeine is often taken together with cathinone, the interaction between caffeine and cathinone was examined. Cathinone had cardiovascular effects in the anaesthetised rat similar to those of methylenedioxymethamphetamine (MDMA), and like MDMA, cathinone acts predominantly as an indirect sympathomimetic acting at the noradrenaline transporter. The indirect actions...

Quality of End-of-Life Care in Acute and Community Hospitals from Relatives' Perspectives and Stakeholder Perceptions of the Potential of their Views to Inform Positive Change in Care

Siobhan E. McCarthy
The study investigated the quality of end-of-life care in hospitals settings and the utility of bereaved relatives’ views for improving care. It was conducted over ten years utilizing a multi-phased mixed methods design. In Ireland, 30,000 people die each year. Two thirds die in hospital settings. Yet prior to the initiation of this study in 2007, there was little research examining bereaved relatives’ perspectives of the quality of end-of-life care in hospital settings. There was...

Exercise Beliefs In Elderly Nursing Home Residents: A Cross-Sectional, Case Control Study

Introduction The number of Irish older adults receiving long term care is steadily growing in line with increased life expectancy. Nursing home residents are typically sedentary, leading to poor health and functional outcomes in this population. There is a lack of research concerning the exercise beliefs of this inactive subgroup of the older adult population. Aims and Objectives The primary aim of this study was to examine the hypothesis that older adults in...

Exercise Beliefs In Elderly Nursing Home Residents: A Cross-Sectional, Case Control Study

Introduction The number of Irish older adults receiving long term care is steadily growing in line with increased life expectancy. Nursing home residents are typically sedentary, leading to poor health and functional outcomes in this population. There is a lack of research concerning the exercise beliefs of this inactive subgroup of the older adult population. Aims and Objectives The primary aim of this study was to examine the hypothesis that older adults in...

The Relationship Between Performance On Cognitive Screening Tests And Everyday Functioning In Older Adults With Mild Cognitive Impairment

Elaine Scally
Introduction: Occupational therapists (OTs) play an important role in evaluating the cognitive and functional abilities of older adults with mild cognitive impairment (MCI) in the acute hospital setting. Cognitive screening tools such as the Montreal Cognitive Assessment (MoCA) and the Addenbrooke’s Cognitive Examination (ACE-III) are regularly administered by acute hospital OTs to assist in predicting the functional capacities of individuals with MCI. However findings from clinical practice show that performance on cognitive screening tools is...

The Assessment Of The Usability Of The Vestibular Rehabilitation Application

Patricia Hassett
Introduction Vestibular rehabilitation is used for decreased vestibular function and dizziness. Adaptation exercises are one aspect of vestibular rehabilitation and are recommended in the treatment of these conditions. These exercises are predominantly paper-based which may lead to difficulty in progression of the exercises and monitoring of compliance. Aims and Objectives The aim of the study was to assess the usability of an electronic tablet application; the Vestibular Rehabilitation Application (VRA) in patients with a complaint...

Large-Amplitude Group Exercise Training Programme For Individuals With Mild To Moderate Parkinson’s Disease: A Pilot Intervention Study

Eimear R. Manley
Parkinson’s disease (PD) is a complex neurodegenerative disorder, which affects the physical, psychological and functional status of individuals. It is the second most common neurodegenerative disease in the world today affecting approximately 8,000 people in Ireland. The most common motor disturbances related to PD are reduced balance and mobility which can lead to a reduction in physical functional performance and health-related quality of life. Pharmacology is the cornerstone of treatment in PD. However, even with...

Large-Amplitude Group Exercise Training Programme For Individuals With Mild To Moderate Parkinson’s Disease: A Pilot Intervention Study

Eimear R. Manley
Parkinson’s disease (PD) is a complex neurodegenerative disorder, which affects the physical, psychological and functional status of individuals. It is the second most common neurodegenerative disease in the world today affecting approximately 8,000 people in Ireland. The most common motor disturbances related to PD are reduced balance and mobility which can lead to a reduction in physical functional performance and health-related quality of life. Pharmacology is the cornerstone of treatment in PD. However, even with...

Wrong site surgery & surgical time out

Mohammad Faraz Khan
“In 1935, the US Army Air Corps held a flight competition for airplane manufacturers vying to build its next generation long range bomber. In early evaluations, the Boeing plane had surpassed designs. The flight competition, was regarded as a mere formality. With the most technically gifted test pilot in the army on board, the plane roared down the tarmac, lifted off smoothly, and climbed sharply to three hundred feet. Then it stalled, turned on one...

Introduction of a Preoperative Protocol for Management of Iron-Deficiency Anemia in Patients undergoing Elective Colorectal Surgery

Edel Marie Quinn
Preoperative anaemia is a risk factor for poorer postoperative outcomes and patients undergoing colorectal cancer surgery frequently have iron-deficiency anaemia. The aim of this project was to implement a preoperative anaemia management protocol for elective colorectal surgery patients. An organisational development project was undertaken according to the Senior and Swailes organisational development model. A protocol for early detection of iron-deficiency anaemia, and treatment with intravenous iron replacement, for colorectal cancer patients was developed and implemented...

A proposed improvement of the patient experience pre and post thyroid fine needle aspiration biopsy

Jessica Maddock
The patient experience is a crucial and at times complex journey in the medical setting. Improving this experience can have positive outcomes for both the patient and clinician. In the setting of a private hospital, the patient journey was reviewed for patients attending the radiology department for an ultrasound-guided fine needle aspiration biopsy (FNAB) of the thyroid. The form in which this project plan took place was through the implementation of a quality improvement model...

An Analysis of the Challenges Encountered by Anaesthetists when Obtaining Consent for Obstetric Epidurals

Rebecca Conlon
Background Obtaining informed consent for obstetric epidurals is a complex area of anaesthesia. Practice among obstetric anaesthetists in this jurisdiction is widely varied. This paper provides an analysis of the ethical and legal challenges encountered by anaesthetists when endeavouring to obtain informed consent to administer the obstetric epidural and makes recommendations as to how these challenges might be lessened. Methods A systematic review of research papers sourced from relevant data bases and websites was conducted....

Improving Huntington’s Disease Education for New Staff in a Voluntary Mental Health Facility

Joe Ogunbode
Huntington’s Disease (HD) is rare neuro-degenerative disease that affects over 700 people in Ireland with a further 9,000 requiring information, support and care. Given the rarity of HD it appears that more education for healthcare professionals is needed. Without this education, people with HD may not receive the high quality care they require. Using the DMAIC framework for quality improvement (QI), this project investigated the need for HD education for healthcare staff in a voluntary...

Improving the Prescription of Antibiotics in Acute Exacerbations of Chronic Obstructive Pulmonary Disease

Aoife Sartini-Bhreathnach
The proposed quality improvement (QI) project aims to improve the prescription of antibiotics in acute exacerbations of COPD. The literature states that there is overprescription of antibiotics in AECOPD. Data was collected to review the management of AECOPD in an emergency department in Dublin. The management of patients admitted with AECOPD, over a set period of time, was reviewed with a detailed focus on the prescription of antibiotics in patients with no infiltrate on chest...

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