1,656 Works

Renin-Angiotensin-Aldosterone System in Heart Failure: Focus on Nonclassical Angiotensin Pathways as Novel Upstream Targets Regulating Aldosterone

Urszula Tyrankiewicz, Agnieszka Kij, Tasnim Mohaissen, Mariola Olkowicz, Ryszard T. Smolenski & Stefan Chlopicki
Aldosterone plays an important role in the regulation of blood pressure, body fluid, and electrolyte homeostasis. Overactivation of aldosterone/mineralocorticoid receptor (MR) pathway leads to hypertension, atherosclerosis, vascular damage, heart failure, and chronic kidney disease and is involved in many other diseases associated with endothelial dysfunction, inflammation, fibrosis, and metabolic disorders. Aldosterone is a final product of the renin-angiotensin-aldosterone system (RAAS), and its production is activated by angiotensin II, while angiotensin-(1–7) negatively regulates angiotensin II-mediated aldosterone...

The Irish Study of Sexual Health and Relationships Sub-Report 1: Learning About Sex and First Sexual Experiences

Kay Rundle, Richard Layte & Hannah McGee
The ISSHR was commissioned by the Department of Health and Children and the Crisis Pregnancy Agency in response to a recommendation by the National AIDS Strategy Committee. It is the largest nationally representative studyof sexual knowledge, attitudes and behaviour ever undertaken in Ireland. International evidence indicates that aspects of sexual health, such as contraception, crisis pregnancy and sexually transmitted infections, should be examined jointly. To this end, the Crisis Pregnancy Agency and the Department of...

Evaluation Research in Education

Pauline Joyce
This paper gives an overview of evaluation and evaluation research, particularly how it fits with education. Reference to some evaluation debates over the years is presented as well as some seminal works in the topic area. A brief synopsis of evaluation in the education setting is then presented before outlining various approaches to evaluation.

Chlamydia Screening in Ireland: a pilot study of opportunistic screening for genital Chlamydia trachomatis infection in Ireland (2007-2009). Summary Integrated Report

Myles Balfe, Ruairi Brugha, Emer O'Connell, Deirdre Vaughan, Diarmuid O’Donovan, Claire Coleman, Ronan Conroy, Martin Cormican, Margaret Fitzgerald, Catherine Fleming, Hannah Mc Gee, Andrew Murphy, Grainne Ni Fhoghlu, Ciaran O’Neill & Paddy Gillespie
Genital Chlamydia trachomatis (CT) infection is the most common curable, bacterial sexually transmitted infection (STI) worldwide [1, 2]. The number of cases notified in Ireland increased from 3,353 in 2005 to 5,781 in 2009 [3]. Notifications have increased since 2004 when legislation requiring laboratory notification came into effect. Chlamydia is usually a ‘silent’ asymptomatic infection, spread without the knowledge of those transmitting and contracting it: most cases remain undetected and thus untreated. It is a...

Implementation of the 4th Joint Societies’ Task Force Guidelines on Cardiovascular Disease Prevention in Clinical Practice. Evaluating implementation across 13 European countries. Main report

Hannah Mc Gee, Karen Morgan & Helen Burke
The Guidelines of the 4th Joint Societies Task Force on Cardiovascular Disease Prevention in Clinical Practice (4th JTF)* were issued in 2007, summarising and evaluating available evidence on reducing the incidence of atherosclerotic events arising from coronary heart disease, cerebrovascular disease and peripheral arterial disease. The purpose of the guidelines is to assist physicians in selecting the best strategies for managing cardiovascular disease. They are an important agreed protocol across countries and professionals that have...

SLAN 2007: Survey of Lifestyle, Attitudes and Nutrition in Ireland. Alcohol use in Ireland: A profile of drinking patterns and alcohol-related harm from SLAN 2007.

Karen Morgan, Hannah McGee, Patrick Dicker, Ruairi Brugha, Mark Ward, Emer Shelley, Eric Van Lente, Janas Harrington, Margaret Barry, Ivan Perry & Dorothy Watson
The SLÁN 2007 survey contained a series of questions relating to alcohol use. These included questions about frequency (how often) an quantity (how much) of alcohol consumed, as well as questions about alcohol-related harm. Quantity of alcohol consumed was assessed by asking respondents how many standard drinks were taken, a ‘standard’ drink being defined as a half pint or a glass of beer, lager or cider; a single measure of spirits; a single glass of...

The Health of Hostel-Dwelling Men in Dublin. Perceived health status, lifestyle and health care utilisation of homeless men in south inner city Dublin hostels

Anne Feeney, Hannah Mc Gee, Tony Holohan, William Shannon, Department of Health & Eastern Health Board
The overall objective of this study was to provide new information about the health of homeless hostel-dwelling men in Dublin which will be of value in the planning and implementation of service plans for them in the new Eastern Regional Health Authority in the coming years.

Effects of the global fund HIV/AIDS programmes in Ukraine

Global HIV/AIDS Initiatives Network
Ukraine has one of the highest and most rapidly growing rates of HIV/AIDS in Europe with estimated numbers of people living with HIV/AIDS (PLWHA) reaching 400,000 in 2008. Since 2003 several Global Health Initiatives (GHIs) have committed to providing over US$ 300 million towards the control of HIV/AIDS in Ukraine. These funding mechanisms have had a significant impact on the availability of services for PLWHA and populations at risk of being infected. GHIs have also...

Chlamydia Screening in Ireland: a pilot study of opportunistic screening for genital Chlamydia trachomatis infection in Ireland (2007-2009). Economic evaluation

Myles Balfe, Ruairi Brugha, Emer O'Connell, Deirdre Vaughan, Claire Coleman, Ronán Conroy, Martin Cormican, Margaret Fitzgerald, Catherine Fleming, Hannah McGee, Andrew Murphy, Grainne Ni Fhoghlu, Ciaran O'Neill & Paddy Gillespie
Economic Evaluation The aim of the economic evaluation was to examine the cost effectiveness of the two screening models tested in the Chlamydia Screening in Ireland Pilot (CSIP) study: (a) Clinical Setting screening, and (b) ’Pee-in-a-pot’ periodic screening in third level institution/college settings. The methodological approach comprised of a dynamic transmission model paired with an economic model. In both analyses, screening was compared to a control strategy of no organised screening, that is existing care...

Chlamydia Screening in Ireland: a pilot study of opportunistic screening for genital Chlamydia trachomatis infection in Ireland (2007-2009). Economic evaluation

Myles Balfe, Ruairi Brugha, Emer O'Connell, Deirdre Vaughan, Claire Coleman, Ronan Conroy, Martin Cormican, Margaret Fitzgerald, Catherine Fleming, Hannah Mc Gee, Andrew Murphy, Grainne Ni Fhoghlu & Ciaran O'Neill
Economic Evaluation The aim of the economic evaluation was to examine the cost effectiveness of the two screening models tested in the Chlamydia Screening in Ireland Pilot (CSIP) study: (a) Clinical Setting screening, and (b) ’Pee-in-a-pot’ periodic screening in third level institution/college settings. The methodological approach comprised of a dynamic transmission model paired with an economic model. In both analyses, screening was compared to a control strategy of no organised screening, that is existing care...

Promoting Healthy Behaviour Choices: Understanding Patient Challenges by Undertaking a Personal Behaviour Change Task

Frank Doyle, Anne Hickey, Karen Morgan, Ian Grey, Eva Doherty & Hannah Mc Gee
INTRODUCTION: Unhealthy behaviours such as poor diet, smoking and physical inactivity contribute significantly to chronic disease. Our first year medical school project aims to increase student awareness of: the importance of these behaviours and their systematic measurement; recommended behaviour targets in health professional guidelines; challenges in achieving patient behaviour change; and psychological theories which aid behaviour change. METHODS: Students are provided with evidence-based health behaviour guidelines for prevention of heart disease. Students select whichever behaviour...

Aldosterone-Mineralocorticoid Receptor: Cell Biology to Translational Medicine

Brian Harvey
This book is an open access dissemination of the EU COST Action ADMIRE in Aldosterone/Mineralocorticoid Receptor (MR) physiology and pathophysiology. Aldosterone is the major hormone regulating blood pressure. Alterations in blood levels of aldosterone and genetic mutations in the MR receptor are major causes of hypertension and comorbidities. Many of the drugs in clinical use, and in development for treating hypertension, target aldosterone and MR actions in the kidney and cardiovascular system. The ADMIRE book...

Bioinspired Star-Shaped Poly(L-Lysine) Polypeptides; 2 Efficient Polymeric Nanocarriers for the Delivery of DNA 3 to Mesenchymal Stem Cells

David Walsh, Robert Murphy, Angela Panarella, Rosanne Raftery, Brenton Cavanagh, Jeremy C. Simpson, Fergal O'Brien, Andreas Heise &
The field of tissue engineering is increasingly recognizing that gene therapy can be employed for modulating in vivo cellular response thereby guiding tissue regeneration. However, the field lacks a versatile and biocompatible gene delivery platform capable of efficiently delivering transgenes to mesenchymal stem cells (MSCs), a cell type often refractory to transfection. Herein, we describe the extensive and systematic exploration of three architectural variations of star-shaped poly(l-lysine) polypeptide (star-PLL) with varying number and length of...

A qualitative exploration of adolescents with severe haemophilia and their caretakers regarding their future transition to adult services

Objective: To qualitatively explore the views of adolescents with severe haemophilia A or haemophilia B and their caretakers such as parents and multidisciplinary staff relating to transition from child to adult services.Methods: Qualitative design using semi-structured interviews based upon the Critical Incident Technique (CIT).Results: Thematic analysis using the CIT approach identified five themes all of which pertained to either the positive or negative aspects of the transition programme for adolescents with severe haemophilia and their...

Design and Development of Multi-Targeted Metallodrugs as Potential Chemotherapeutic Agents

Reece G. Kenny
Cancer remains a major global health burden despite significant advances in treatmentregimens. Current drug treatments, including those involving platinum drugs, havedrawbacks including dose limiting toxic side effects and either acquired or intrinsicdrug resistance. The development of safer and more effective drug treatments remainsa major research focus. The platinum drugs in clinical use primarily target DNA.Our Group previously developed novel multi-targeted platinum(II) complexes capableof not only binding cancer cell DNA but also possessing the ability to...

Examining the relationships between attendance, online engagement and summative examinations performance

Jane C. Holland, Eric Clarke, Morag Monro, Evelyn Kelleher & Mark Glynn
Background: Non-attendance correlates with poor performance, but manual recording of attendance is problematic. Online activity reports may be a more efficient method of identifying at-risk students. Summary of work: This research is part of a prospective study examining physical attendance, online activity reports (Moodle), continuous assessments and summative examination performance. Ethical approval was granted by RCSI Ethics Committee. Two modules within the first year of the undergraduate medical program were identified for inclusion. Results: Data...

Is a picture worth a thousand words?

Jane C. Holland, Robin O'Sullivan & Richard Arnett
Background: It has previously been suggested that the use of illustrations in MCQs may have variable effects on individual items. This study examines the effect of illustrated questions, as opposed to pure text, to discern if any overall bias between the two formats is detectable. Summary of work: We reviewed 6 Histology MCQ papers from our Medical Junior Cycle. Classical test theory analysis was performed on all MCQs, which were then divided into two groups,...

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Global Emergency Care Skills

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Global Emergency Care Skills

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Global Emergency Care Skills

The Importance of Inhaler Technique in Measuring and Calculating Inhaler Adherence, and its Clinical Outcomes

Imran Sulaiman
Depending on the population studied, cross-sectional observational studies suggest that between 14%-90% of patients do not use their pressurized metered dose inhaler correctly, while 50-60% misuse a dry powder inhaler. This means that unless incorrect technique is acounted for a significant underestimation of how much medication the person actually obtained may be made. The aim of this thesis was to objectively determine the frequency and importance of inhaler technique errors and to combine these with...

Cardiovascular and temperature actions of cathinones

The main aims of these studies were to investigate cardiovascular and temperature actions of the main constituent of khat, cathinone, and to study possible gender differences. Also, since caffeine is often taken together with cathinone, the interaction between caffeine and cathinone was examined. Cathinone had cardiovascular effects in the anaesthetised rat similar to those of methylenedioxymethamphetamine (MDMA), and like MDMA, cathinone acts predominantly as an indirect sympathomimetic acting at the noradrenaline transporter. The indirect actions...

Quality of End-of-Life Care in Acute and Community Hospitals from Relatives' Perspectives and Stakeholder Perceptions of the Potential of their Views to Inform Positive Change in Care

Siobhan E. McCarthy
The study investigated the quality of end-of-life care in hospitals settings and the utility of bereaved relatives’ views for improving care. It was conducted over ten years utilizing a multi-phased mixed methods design. In Ireland, 30,000 people die each year. Two thirds die in hospital settings. Yet prior to the initiation of this study in 2007, there was little research examining bereaved relatives’ perspectives of the quality of end-of-life care in hospital settings. There was...

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