131 Works

The genomics of transplant-related outcomes and familial renal disease

Caragh Stapleton
Chronic kidney disease (CKD) is a growing global health concern with an age-standardized global prevalence of approximately 10%. Of those with CKD, approximately 2% will go on to require renal replacement therapy within any given 5-year period. Renal transplantation is accepted as the most clinically- and cost-effective treatment for end-stage kidney failure. In this thesis, we set out to examine the impact of common genetic variation on renal transplant function as well as a common...

Exploring the experiences of patients with primary and secondary, non-cancer related, lower limb lymphoedema during the intensive and maintenance phases of Complex Decongestive Therapy and its’ impact on their lives

Mary Costello
IntroductionLymphoedema is an incurable, progressive condition, which results in the swelling of a limb or limbs and impairs mobility (Lymphatic Framework, 2006). The psychosocial impact of lower limb lymphoedema is also devastating as body image and quality of life are greatly affected (Lasinski et al, 2012). Although lymphoedema is a chronic condition, it is manageable through treatment modalities which include manual lymphatic drainage, compression bandaging, compression hosiery, skin care and exercise, otherwise known as Complex...

The role of sub-epidermal moisture measurement versus traditional risk assessment and visual skin assessment in the prediction of pressure ulcer risk among adults undergoing surgery.

Ana Lucia M. De Oliveira
Aim: To compare the predictive ability of sub-epidermal moisture measurement versus traditional risk assessment and visual skin assessment as a means of detecting early pressure ulcer damage development among adults undergoing surgery. Method: A non-experimental, comparative, prospective, descriptive design was used. Participants who gave their informed consent had their skin assessed over the areas that were weight bearing during surgery, using visual skin assessment and the sub-epidermal moisture measurement. Visual pressure ulcers were graded according...

A social-ecological approach to examine body mass index during early childhood in Ireland

Samira Barbara Jabakhanji
Background: Childhood overweight and obesity (OWOB) is associated with adult obesity (10) and ill-health (11); however the prevalence among young children in Ireland is unknown. For prevention programmes to target those children most in need, risk factors of OWOB and critical time points when these factors occur need to be identified. This thesis investigated in-depth the OWOB prevalence and risk factors among young children in Ireland.
Methods: A literature review was conducted to identify a suitable...

Recommendation for Future Development of Colorectal Cancer Surgery in Ireland and Guidelines for the Management of Rectal Cancer in Ireland

Deborah McNamara
Recommendation for Future Development of Colorectal Cancer Surgery in Ireland and Guidelines for the Management of Rectal Cancer in Ireland issued by the Irish Association of Coloproctology on 5th September 2010.

Bioinspired Star-Shaped Poly(L-Lysine) Polypeptides; 2 Efficient Polymeric Nanocarriers for the Delivery of DNA 3 to Mesenchymal Stem Cells

David Walsh, Robert Murphy, Angela Panarella, Rosanne Raftery, Brenton Cavanagh, Jeremy C. Simpson, Fergal O'Brien, Andreas Heise &
The field of tissue engineering is increasingly recognizing that gene therapy can be employed for modulating in vivo cellular response thereby guiding tissue regeneration. However, the field lacks a versatile and biocompatible gene delivery platform capable of efficiently delivering transgenes to mesenchymal stem cells (MSCs), a cell type often refractory to transfection. Herein, we describe the extensive and systematic exploration of three architectural variations of star-shaped poly(l-lysine) polypeptide (star-PLL) with varying number and length of...

Evaluation of the compatibility of sildenafil during simulated Y-site and multi-lumen administration in a paediatric intensive care unit

Sildenafil, a phosphodiesterase type-5 inhibitor, is used for the treatment of infants with pulmonary hypertension (PH). Intravenous (IV) sildenafil (Revatio®) is approved for the treatment of PH in adults but is used off-label in paediatrics. The absence of compatibility data between sildenafil and other commonly used IV medications such as adrenaline, noradrenaline, vasopressin, milrinone and heparin necessitates the use of a dedicated IV line for sildenafil. In the critically unwell child, limited IV access can...

Activation of the resident Skeletal Stem Cell (SSC) for articular cartilage regeneration.

Matthew Philip Murphy
The aim of this PhD thesis is to validate that a commonly performed surgical therapy used to treat patients with osteoarthritis (OA), microfracture (MF), can activate tissue-resident Skeletal Stem Cells (SSC) from distal femurs. In Chapter 1 we introduce the topics related to the thesis including; OA overview, stem cell therapies and current stem cell trials used for OA. In Chapter 2 we show that with age there is a reduction in the number of...

Activation of the resident Skeletal Stem Cell (SSC) for articular cartilage regeneration.

Matthew Philip Murphy
The aim of this PhD thesis is to validate that a commonly performed surgical therapy used to treat patients with osteoarthritis (OA), microfracture (MF), can activate tissue-resident Skeletal Stem Cells (SSC) from distal femurs. In Chapter 1 we introduce the topics related to the thesis including; OA overview, stem cell therapies and current stem cell trials used for OA. In Chapter 2 we show that with age there is a reduction in the number of...

How to Empower Professionals and the Public to Improve Mental Health Care: Exploring Educational Initiatives

Dolores Keating
Irish mental health policy emphasises early intervention, interdisciplinary working, the recovery philosophy and, perhaps most importantly, partnership between healthcare professionals, patients, caregivers and the community. Pharmacists have frequent contact with people experiencing mental health problems but appear to lack the confidence to engage effectively in mental health care. This thesis explores how educational interventions can empower pharmacists and members of the public to better support people experiencing mental health problems. Pharmacy students were found generally...

The effect of a Pilates-based core exercise group on balance and gait in ambulant children with Cerebral Palsy: A Randomised Control Trial

Clodagh Coman
Children with Cerebral Palsy (CP) demonstrate dysfunctional core muscleactivation contributing to problems with postural control for functional activitiesand walking. Pilates-based core exercises aim to improve postural control byencouraging coordinated activation of deep core stabilising muscles duringfunctional movements.This thesis will present the findings of a blinded assessor, parallel, randomisedcontrolled trial (RCT), with 46 participants, on the effect of Pilates-based coreexercises on balance and gait in ambulant children with spastic CP, ages sevento 17 years.The primary objectives...

Investigating the immune response to Staphylococcus aureus bloodstream infection in haemodialysis patients

Roisin Connolly
Staphylococcus aureus bloodstream infection (SA-BSI) is a serious and potentially fatal problem in haemodialysis patients. An effective S. aureus vaccine would have significant benefits in this group. Previous antibody-inducing vaccine candidates failed to prevent or attenuate SA-BSI and it is now accepted that next-generation anti- S. aureus vaccines must also induce effective T-cell-mediated immunity. Recent advances have helped to elucidate the role of specific T-cell subsets, notably Th1 and Th17 cells, which coordinate an effective...

“More of an art than a science”: The development of an accreditation framework for continuing education activities for pharmacists

Sarah Rhiannon Drumm
Accreditation is a recognition that an educational activity meets certain standards. The processes for accreditation vary considerably depending on the type of activity, and currently there are differing accreditation systems in place for pharmacy continuing education (CE) across different countries. The aim of this thesis was to research a selection of these systems, which would provide an opportunity to develop a catalogue of accreditation approaches currently in place in a number of different countries, and...

Predictors of adverse outcomes and factors associated with a risk-stratification based community virtual ward model for older persons with complex health and social care needs

Clare Lewis
IntroductionPopulation ageing is occurring rapidly worldwide, particularly in more developed
countries. As a result, a greater proportion of frail older adults are expected to be livingin the community but at increased risk of emergency department (ED) presentation andhospital admission. While risk-stratification is useful in allocating limited resources, fewinstruments or models are available to support healthcare professionals to manage thecomplex health and social care needs of these patients. The recent introduction of aCommunity Virtual Ward (CVW) for...

A pilot randomised control trial to measure the effectiveness of combined modulated ultrasound and electric current stimulation in treating diabetic foot ulcers

Caoimhe Joyce Hearne
Background Diabetic foot ulcers (DFUs) are a growing medical problem worldwide reaching concerning levels (IDF, 2017). Advanced wound care therapies are continuing to evolve to match the growing epidemic. The effect of combined ultrasound and electric current stimulation (CUSECS) on DFUs is still only a new focus. This study aims to investigate if CUSECS is an effective adjunctive treatment for chronic DFU when compared with standard wound care (SWC). Method: A randomised controlled pilot...

Risk Factors for Repeat Healthcare Use following Hospitalisation with an Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Breda Cushen
Chronic Obstructive Pulmonary Disease (COPD) is one of the leading causes of deathworldwide. Up to one-tenth of patients hospitalised with a COPD exacerbation dieduring admission and, of those surviving to discharge, more than one-third will bereadmitted within 90 days with many more treated for a repeat exacerbation in theemergency department or in the community. These figures are reported universally,despite significant variation in the access to, structure and resources of healthcaresystems across different jurisdictions. However, even...

Risk Factors for Repeat Healthcare Use following Hospitalisation with an Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Breda Cushen
Chronic Obstructive Pulmonary Disease (COPD) is one of the leading causes of deathworldwide. Up to one-tenth of patients hospitalised with a COPD exacerbation dieduring admission and, of those surviving to discharge, more than one-third will bereadmitted within 90 days with many more treated for a repeat exacerbation in theemergency department or in the community. These figures are reported universally,despite significant variation in the access to, structure and resources of healthcaresystems across different jurisdictions. However, even...

The role of α2 agonists in paediatric critical care sedation

John Hayden
Background There are two α2 agonists used in sedation in paediatric critical care in Ireland. Firstly, the older medication clonidine and secondly the newer, more selective, α2 agonist dexmedetomidine. Neither agent is licensed for use in paediatrics despite both being in routine clinical use. Not being licensed in children has meant both medications bypassed formal efficacy and safety studies in children during their development. This thesis aimed to address current knowledge deficits and provide an...

The Perceptions of Older Patients and their Family or Caregivers Towards Physical Activity and Exercise on a Specialist Geriatric Ward: A Qualitative Study

Bláthnaid Mealy
IntroductionFunctional decline or deconditioning is considered the main complication of hospitalisation for older people, often resulting in adverse outcomes. Low levels of activity and mobility accelerate this decline, yet despite this, evidence demonstrates how activity levels of hospitalised older adults remains very low. Family or caregiver involvement may have a positive impact on patient physical activity during a hospital admission. Given the aging population and the likelihood of the problem of hospital associated deconditioning escalating,...

An investigation into the expression, content and function of exosomes in an experimental model of epilepsy

Epilepsy is a serious neurological disease characterised by recurrent unprovoked seizures affecting 65 million people worldwide. Current anti-epileptic therapies target only symptomatic seizures and are not fully effective in ameliorating disease pathophysiology. Temporal lobe epilepsy is the most common form of epilepsy in adults and a third of temporal lobe epilepsy patients are drug refractory, and the underlying pathophysiology remains to be fully elucidated. Recent work revealed microRNAs serve important functions in cells, in post-transcriptional...

The Impact of Technology on Medication Safety in Paediatric Critical care

Introduction:Evidence for the benefits of health information technology (HIT) in the paediatricsetting is currently limited. In 2012, electronic-prescribing, standardisedconcentration infusions (SCIs) and smart-pump technology were implemented intothe paediatric critical care unit (PCCU) in Our Lady’s Children’s Hospital, Crumlin.Aim:To assess the impact of this new HIT on PCCU medication errors.Methodology:A Delphi consensus process developed a list of novel or previously unaddressedmedication errors. The results, combined with published medication errorsdefinitions, were applied to three further studies: a...

The Optimisation and Derivative Design of Lead Compounds to Inhibit Staphylococcus aureus Surface Proteins Using Computational Tools

Atopic dermatitis (AD), also known as eczema, is a genetically transmitted chronic skin disorder that is associated with other conditions such as asthma and allergic rhinitis. It affects people at all stages of life and can seriously impair quality of life due to repeated itching and scratching resulting in crusted lesions and sleep loss. Staphylococcus aureus colonisation on the skin of patients with AD exacerbates the symptoms. Current treatments for S. aureus colonised AD skin...

Metabolic Reprogramming of the Cystic Fibrosis Neutrophil

Oliver J. McElvaney
Cystic fibrosis (CF) is the commonest lethal genetic condition affecting Caucasians, arising from a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene on the long arm of chromosome 7. It is a chloride channelopathy, manifesting clinically as a multisystem disorder. The major cause of morbidity and mortality in CF is neutrophilic lung disease, though significant debate exists as to whether the main determinant of this is an intrinsic defect due to defective CFTR...

Progressive Resistance Training in an Older Post-acute Inpatient Population

IntroductionMany older adults are at risk of functional decline following an acute hospital admission. Many of these older adults are pre-sarcopenic or sarcopenic and are extremely vulnerable to a further deterioration of function and dependence in Activities of Daily Living ability. Progressive Resistance Training (PRT) is an intervention that involves exercising a muscle against a load that is progressively increased as the muscle strengthens. PRT has been shown to successfully target both functional decline and...

Comparing the Outcomes of Tubularized Incised Plate Urethroplasty and Dorsal Inlay Graft Urethroplasty in Children with Hypospadias: A Systematic Review and Meta-Analysis

Background: Due to their simplicity and excellent outcomes, the tubularized incised plate urethroplasty (TIPU) and the dorsal inlay graft urethroplasty (DIGU) are two of the most commonly used techniques for hypospadias repair in children. However, there is a lack of consensus on which technique offers more favourable results and less added morbidity to the patient. Aims: This study aimed to systematically compare the reported outcomes of the TIPU and DIGU techniques in an effort to...

Registration Year

  • 2020
    131

Resource Types

  • Text
    129
  • Collection
    2