131 Works

Modulation of neutrophil NADPH oxidase activity by alpha-1 antitrypsin

Alpha-1 antitrypsin is a serine protease inhibitor that demonstrates an array of additional immunomodulatory functions. Individuals with the genetic condition, alpha-1 antitrypsin deficiency (AATD) are at increased risk of early onset emphysematous lung disease. This lung disease is partly driven by neutrophil mediated lung destruction in an environment of low AAT. The diverse functions of AAT appear to point to the pathogenesis of lung disease in AATD being more complex than a mere protease/anti-protease imbalance....

Modulation of neutrophil NADPH oxidase activity by alpha-1 antitrypsin

Alpha-1 antitrypsin is a serine protease inhibitor that demonstrates an array of additional immunomodulatory functions. Individuals with the genetic condition, alpha-1 antitrypsin deficiency (AATD) are at increased risk of early onset emphysematous lung disease. This lung disease is partly driven by neutrophil mediated lung destruction in an environment of low AAT. The diverse functions of AAT appear to point to the pathogenesis of lung disease in AATD being more complex than a mere protease/anti-protease imbalance....

A social-ecological approach to examine body mass index during early childhood in Ireland

Samira Barbara Jabakhanji
Background: Childhood overweight and obesity (OWOB) is associated with adult obesity (10) and ill-health (11); however the prevalence among young children in Ireland is unknown. For prevention programmes to target those children most in need, risk factors of OWOB and critical time points when these factors occur need to be identified. This thesis investigated in-depth the OWOB prevalence and risk factors among young children in Ireland.
Methods: A literature review was conducted to identify a suitable...

A pilot randomised control trial to measure the effectiveness of combined modulated ultrasound and electric current stimulation in treating diabetic foot ulcers

Caoimhe Joyce Hearne
Background Diabetic foot ulcers (DFUs) are a growing medical problem worldwide reaching concerning levels (IDF, 2017). Advanced wound care therapies are continuing to evolve to match the growing epidemic. The effect of combined ultrasound and electric current stimulation (CUSECS) on DFUs is still only a new focus. This study aims to investigate if CUSECS is an effective adjunctive treatment for chronic DFU when compared with standard wound care (SWC). Method: A randomised controlled pilot...

Predictors of adverse outcomes and factors associated with a risk-stratification based community virtual ward model for older persons with complex health and social care needs

Clare Lewis
IntroductionPopulation ageing is occurring rapidly worldwide, particularly in more developed
countries. As a result, a greater proportion of frail older adults are expected to be livingin the community but at increased risk of emergency department (ED) presentation andhospital admission. While risk-stratification is useful in allocating limited resources, fewinstruments or models are available to support healthcare professionals to manage thecomplex health and social care needs of these patients. The recent introduction of aCommunity Virtual Ward (CVW) for...

Exploring New and Emerging Mechanisms to Target Difficult to Treat Cancers

Catherine Richards
Gastro-oesophageal cancers are associated with poor survival in patients, due to their aggressive nature, late-stage diagnosis, and a lack of specific targeted therapies. The development of new therapeutics will prove crucial to improve mortality rates. This thesis discusses two novel potential approaches which merit further investigation towards this goal.
Firstly, natural compounds have previously found several uses as chemotherapeutic agents. We found a diterpenoid compound in the same class as Taxol, Crassin, to have significant...

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