55 Works

Case-based Reporting and Analysis to Enhance the Value and Use of Routine Health Facility Data for Health Policy, Programming and Research: Case Study of a New Malaria Surveillance System in The Gambia

Samuel Emetu Anya
A sustained decline in the burden of malaria from 2003 to 2007 in The Gambiahighlighted the need for real-time data to monitor the changing epidemiology ofmalaria. The aim of the studies described in this thesis was to determine thevalue and use of routine case-based health facility data for malaria policy,programming and research.To achieve this aim, individual, rather than aggregate, malaria case records atthe six sentinel sites were analysed by age, sex, month, season and location.The...

Development of a Novel Pro-angiogenic SDF-1α Gene-Activated Collagen Scaffold for Diabetic Wound Healing

Diabetes is a disease that arises due to the loss or impairment of the body’s ability to control the blood glucose level. Hyperglycemia leads to alterations in the structural functions of both macro and microvascular systems, causing vascular complications in diabetic patients such as the diabetic foot ulcer. In diabetic wounds, inadequate angiogenesis is one of the significant pathological factors hindering the progression to regular healing events. During wound healing, various cells orchestrate to promote...

A study of the androgen mediated transcriptome and AR interactome in AI resistant breast cancer

Rachel Bleach
Aromatase inhibitors (AI) are the vanguard treatment for hormone receptor positive, postmenopausal breast cancer, however, acquired resistance occurs in up to 40% of patients. AI therapies, by their mechanism of action, create a predominantly androgenic steroid environment. In this study, a multi-omic approach was undertaken to elucidate the role of the androgen receptor (AR) in AI resistant breast cancer. Evidence from this study suggests that cancer cells adapt to utilise the adrenal prohormone, androstenedione and/or...

Improving Waiting Times for Outpatient Holter Monitoring

Harmonie Adams
Prolonged outpatient waiting times are a global healthcare concern affecting most hospital specialties, including in Ireland. Improvement of waiting times is a constant battle and priority for Ireland’s health service, the Health Service Executive. The result of lengthy waiting for outpatient Holter monitor appointments can mean a delay in diagnosis and the potential consequences of delay in treatment. Patient satisfaction and trust in healthcare providers is negatively impacted by long waits. This quality improvement project...

Improving Compliance with a Novel Pre-Operative Assessment Pathway for Neurosurgical Referrals.

Natasha Lynch
The clinical presentation of neurosurgical patients tends to be sporadic in nature. These patients present to healthcare settings across the country before being referred to the National Referral Centre for Neurosurgery and Neurology in Ireland. The growing demands on the healthcare sector, such as an ageing population and finite resources, has limited the luxury of in-patient pre-operative assessment days prior to surgery. The organisation in question had established a nurse-led pre-operative assessment clinic for elective...

Reducing Wait Times for Patients under Consideration for Tonsillectomy

Emma Rachel Larragy
The aim of this quality improvement project is to reduce wait times for patients under consideration for tonsillectomy. In 2017, in the Republic of Ireland, 5,267 patients presented to Otolaryngology, Head and Neck surgery services with acute and chronic tonsillitis. In the same year, 3,690 patients underwent tonsillectomy making this procedure the second most commonly performed in this surgical specialty in the country. The project focuses on the wait time between General Practitioner referral and...

Reducing Hospital Length of Stay for Low Risk Pulmonary Embolism Patients

Aaron Brady
Pulmonary embolism (PE) is a potentially fatal condition which affects millions of people globally. Traditionally, people diagnosed with a PE are treated in hospital. However, published guidelines from the European Society of Cardiology (ESC) and British Thoracic Society (BTS) suggest that the early discharge and outpatient management of low-risk PE patients is safe and non-inferior to inpatient management. Despite the evidence and the publication of these guidelines, approximately 80% of low-risk PE patients are managed...

Improving the Inpatient Management of Central Diabetes Insipidus Post- Transsphenoidal Pituitary Surgery

Pamela Moorehouse
Central diabetes insipidus is a common complication of transsphenoidal pituitary surgery. Damage to the pituitary stalk during surgery results in the disruption of water homeostasis, resulting in increased thirst and the production of large volumes of dilute urine. While symptomatic central diabetes insipidus can be managed with the administration of desmopressin, it has the potential to progress to severe dehydration, hypernatremia and become a life-threatening medical emergency. This project utilised the DMAIC framework and associated...

The Association Between Medication Adherence Across Multiple Medications and Health Outcomes in Ageing Populations

Caroline Walsh
Aim: The overarching aim of this thesis is to explore the association between medication (non-) adherence and a range of health outcomes, particularly healthcare utilisation and health-related quality of life, in older adults. A specific focus of the thesis was the objective measurement of adherence across multiple medications in older adults with multimorbidity.
Methods and results: Four inter-related studies were conducted to address the thesis aims. The first study involved a systematic review of the literature...

Exploring Therapists’ Perceptions of Facilitating Family Involvement in Neurorehabilitation: A Qualitative Study

Marie Keegan
Introduction: There is a high prevalence of Acquired Brain Injury (ABI) in the Republic of Ireland and ABI can result in a range of physical, cognitive and communicative issues. Post ABI patients frequently go through the inpatient rehabilitation process to help to remediate these impairments. Current research advocates the involvement of family members in the rehabilitation process and further research is needed to expand on what this involvement entails and how to best facilitate this....

The development of novel inhibitors for the treatment of sepsis

Sepsis is a potentially dangerous disease that is caused by the response of the body toan infection. Its major cause is the invasion of microorganisms in the sterile regions of thebody. In septic patients, platelets are activated by the bacteria leading to haemostaticcomplications including thrombocytopenia and associated bleeding complications. Withthe widespread development of antibiotic resistance, we have explored the developmentof inhibitors that prevent host colonization as well as inhibitors of platelet activation thatprevent the bacterial...

Development of a Novel Pro-angiogenic SDF-1α Gene-Activated Collagen Scaffold for Diabetic Wound Healing

Diabetes is a disease that arises due to the loss or impairment of the body’s ability to control the blood glucose level. Hyperglycemia leads to alterations in the structural functions of both macro and microvascular systems, causing vascular complications in diabetic patients such as the diabetic foot ulcer. In diabetic wounds, inadequate angiogenesis is one of the significant pathological factors hindering the progression to regular healing events. During wound healing, various cells orchestrate to promote...

Reduce the Waiting Time for New Referrals in a Private Dermatology Clinic

Sandy Luc
Long waiting lists are continuing to be a global healthcare issue and Ireland is no exception. The World Health Organisation declared a global pandemic in early 2020 and as a consequence, waiting lists are lengthened even further. Data collection from this study revealed that in November 2019, a total of 181 patients attended the private dermatology clinic yet only 8% were new patients. The average time new patients waited for this appointment was 121.77 days....

Reducing Wait Times for Patients under Consideration for Tonsillectomy

Emma Rachel Larragy
The aim of this quality improvement project is to reduce wait times for patients under consideration for tonsillectomy. In 2017, in the Republic of Ireland, 5,267 patients presented to Otolaryngology, Head and Neck surgery services with acute and chronic tonsillitis. In the same year, 3,690 patients underwent tonsillectomy making this procedure the second most commonly performed in this surgical specialty in the country. The project focuses on the wait time between General Practitioner referral and...

Reducing Hospital Length of Stay for Low Risk Pulmonary Embolism Patients

Aaron Brady
Pulmonary embolism (PE) is a potentially fatal condition which affects millions of people globally. Traditionally, people diagnosed with a PE are treated in hospital. However, published guidelines from the European Society of Cardiology (ESC) and British Thoracic Society (BTS) suggest that the early discharge and outpatient management of low-risk PE patients is safe and non-inferior to inpatient management. Despite the evidence and the publication of these guidelines, approximately 80% of low-risk PE patients are managed...

Improving the Inpatient Management of Central Diabetes Insipidus Post- Transsphenoidal Pituitary Surgery

Pamela Moorehouse
Central diabetes insipidus is a common complication of transsphenoidal pituitary surgery. Damage to the pituitary stalk during surgery results in the disruption of water homeostasis, resulting in increased thirst and the production of large volumes of dilute urine. While symptomatic central diabetes insipidus can be managed with the administration of desmopressin, it has the potential to progress to severe dehydration, hypernatremia and become a life-threatening medical emergency. This project utilised the DMAIC framework and associated...

Frailty Awareness in the Adult Population: Knowledge of Frailty Risk Factors and Symptoms.

Michael Kelleher
Introduction: Frailty is one of the most problematic conditions affecting the ageing population (Clegg et al, 2013). The World Health Organisation (2018) has projected the number Of individuals aged 60 and older is expected to nearly double from 12% to 22% by 2050 resulting in an increased incidence of frailty. The current prevalence of frailty In Ireland is 12.7% and growing (Turner et al, 2018). There is no known research Globally that has investigated the...

Frailty Awareness in the Adult Population: Knowledge of Frailty Risk Factors and Symptoms.

Michael Kelleher
Introduction: Frailty is one of the most problematic conditions affecting the ageing population (Clegg et al, 2013). The World Health Organisation (2018) has projected the number Of individuals aged 60 and older is expected to nearly double from 12% to 22% by 2050 resulting in an increased incidence of frailty. The current prevalence of frailty In Ireland is 12.7% and growing (Turner et al, 2018). There is no known research Globally that has investigated the...

The Impact of Biofeedback on Self-efficacy in Adults with Asthma

Joanne Walsh
Objective: To examine self-efficacy among adults with asthma, following a nurse led educational intervention using biofeedback of treatment use.
Method: The research design employed was a quantitative, non-experimental, cross sectional, descriptive survey. An adapted version of a previously validated closed-ended questionnaire known as the Asthma Self-Efficacy Questionnaire was used as the data collection instrument. A total of 88 participants, completed the asthma self-efficacy questionnaire once. Data was analysed using descriptive and inferential statistics. data analysis was...

Case-based Reporting and Analysis to Enhance the Value and Use of Routine Health Facility Data for Health Policy, Programming and Research: Case Study of a New Malaria Surveillance System in The Gambia

Samuel Emetu Anya
A sustained decline in the burden of malaria from 2003 to 2007 in The Gambiahighlighted the need for real-time data to monitor the changing epidemiology ofmalaria. The aim of the studies described in this thesis was to determine thevalue and use of routine case-based health facility data for malaria policy,programming and research.To achieve this aim, individual, rather than aggregate, malaria case records atthe six sentinel sites were analysed by age, sex, month, season and location.The...

A study of the androgen mediated transcriptome and AR interactome in AI resistant breast cancer

Rachel Bleach
Aromatase inhibitors (AI) are the vanguard treatment for hormone receptor positive, postmenopausal breast cancer, however, acquired resistance occurs in up to 40% of patients. AI therapies, by their mechanism of action, create a predominantly androgenic steroid environment. In this study, a multi-omic approach was undertaken to elucidate the role of the androgen receptor (AR) in AI resistant breast cancer. Evidence from this study suggests that cancer cells adapt to utilise the adrenal prohormone, androstenedione and/or...

Guidelines for the development of multiple choice items & assessments.

Jane Holland & Niall Stevens
All assessment methods have varying strengths and weaknesses, and it is appropriate that multiple formats, such as MCQs, OSCEs and portfolios, are used within a robust programme of assessment for undergraduate and postgraduate medical programmes. This booklet is designed to provide guidance to RCSI staff on the development of multiple choice items and assessments specifically. As such, it is an introduction to multiple facets of this process, such as item writing, assessment blueprinting, standard setting...

Knowledge, Behavior and Attitude of Nurses Regarding Prevention of Central Line Associated Blood Stream Infections

Iyad Salem Ahmad Al-Yateem
The level of knowledge of nursing staff handling patients with Central Venous Catheters has been reported internationally as one of the factors contributing to the increasing incidence of Central Line Associated Blood Stream Infections (Alkubati et al., 2015; Chen et al., 2015). This study aimed to identify the Level of knowledge, behavior, and attitude of nurses in Adult and Hemodialysis Units in a military hospital in the Kingdom of Saudi Arabia regarding Central Line Associated...

Attitudes of Emergency Nurses to Evidence Based Practice in the Emergency Department of a Multi-Specialty Hospital

Ciara Rooney
Background: Despite the growing body of evidence produced by and for nurses, moving evidence from research into practice remains challenging. These challenges can be attributed in part, to attitudes of nurses towards evidence based practice. This study examined attitudes to evidence based practice among Emergency Department nurses and factors which influenced these attitudes such as: years of experience in nursing, country of education, practice outside country of education, perception of the culture of the organisation,...

Attitudes of Emergency Nurses to Evidence Based Practice in the Emergency Department of a Multi-Specialty Hospital

Ciara Rooney
Background: Despite the growing body of evidence produced by and for nurses, moving evidence from research into practice remains challenging. These challenges can be attributed in part, to attitudes of nurses towards evidence based practice. This study examined attitudes to evidence based practice among Emergency Department nurses and factors which influenced these attitudes such as: years of experience in nursing, country of education, practice outside country of education, perception of the culture of the organisation,...

Registration Year

  • 2021
    55

Resource Types

  • Text
    55