119,301 Works

How Corporate Social Advocacy Affects Attitude Change Toward Controversial Social Issues

Joshua M. Parcha & Catherine Y. Kingsley Westerman
The current study reveals that a corporate statement on a controversial social issue is effective in changing an individual’s attitude toward the issue depending on how much the issue is relevant to the individual’s goals and/or if the corporate statement is supported by other corporations. Advocacy fit, corporate credibility, the bandwagon heuristic, and position advocated were varied in a fully crossed 2 × 2 × 2 × 2 experiment (N = 677). The relevance of...

The Long-Term Impact of Parental Mental Health on Children’s Distress Trajectories in Adulthood

Christina Kamis
Using six waves of data from the Panel Study of Income Dynamics (2007-2017) and the Childhood Retrospective Circumstances Study (2014) (N = 3,240), this paper estimates how childhood experiences with parental mental health problems shape trajectories of children’s distress in adulthood. Findings indicate that those who experience poor parental mental health have consistently greater distress than their non-exposed counterparts throughout adulthood. More severe and longer exposures to parental mental health problems correspond to even greater...

Comparative Analysis of the Biosimilar and Innovative G-CSF Modulated Pathways on Umbilical Cord Blood–Derived Mononuclear Cells

, , , , , , &
Biosimilars of granulocyte colony-stimulating factor (G-CSF) have been routinely introduced into clinical practice. However, not functional genomics characterization has been performed yet in comparison with the innovator G-CSF. This study aimed to evaluate the transcriptomic changes in an in vitro model of umbilical cord blood cells (UBC) exposed to G-CSF for the identification of their modulated pathways. Umbilical cord blood cells–derived mononuclear cells (MNCs) were treated with biosimilar and innovator G-CSF for further gene expression...

Terms and Measures of Cognitive Health Associated With Dementia and Alzheimer’s Disease: A Scoping Review

Kelly Quinn, Christina E. Miyawaki, Raina Croff, Mia T. Vogel, , Anita M. Souza, , Valerie J. Edwards & Daniela B. Friedman
The Healthy Brain Initiative: National Public Health Road Map to Maintaining Cognitive Health (2007) called on the research community to disseminate its work on cognitive aging and cognitive health. The purpose of this scoping review was to (1) identify terminology that cognitive, social, and behavioral scientists use to describe cognitive aging and cognitive health, in association with dementia and Alzheimer’s disease, among older adults; (2) demonstrate how such terms are defined; and (3) illustrate how...

Challenge Stressors, Work Engagement, and Affective Commitment Among Chinese Public Servants

, &
Drawing on the transactional theory of stress and the person–situation interactionist perspective, we theorize that the indirect effect of challenge stressors on affective commitment through work engagement is moderated by the joint effects of core self-evaluations and perceived organizational support. In a sample of 226 Chinese public servants, we tested a new moderated moderated (three-way) mediation model using structural equation modeling. Our results show that challenge stressors positively influence work engagement, which has a significant...

A Comparative Approach to Screen the Capability of Raman and Infrared (Mid- and Near-) Spectroscopy for Quantification of Low-Active Pharmaceutical Ingredient Content Solid Dosage Forms: The Case of Alprazolam

Liljana Makraduli, Petre Makreski, Katerina Goracinova, Stefan Stefov, Maja Anevska & Nikola Geskovski
Content uniformity is a critical attribute for potent and low-dosage formulations of active pharmaceutical ingredient (API) that, in addition to the formulation parameters, plays pivotal role during pharmaceutical development and production. However, when API content is low, implementing a vibrational spectroscopic analytical tool to monitor the content and blend uniformity remains a challenging task. The aim of this study was to showcase the potentials of mid-infrared (MIR), near-infrared (NIR), and Raman spectroscopy for quantitative analysis...

A Comparative Approach to Screen the Capability of Raman and Infrared (Mid- and Near-) Spectroscopy for Quantification of Low-Active Pharmaceutical Ingredient Content Solid Dosage Forms: The Case of Alprazolam

Liljana Makraduli, Petre Makreski, Katerina Goracinova, Stefan Stefov, Maja Anevska & Nikola Geskovski
Content uniformity is a critical attribute for potent and low-dosage formulations of active pharmaceutical ingredient (API) that, in addition to the formulation parameters, plays pivotal role during pharmaceutical development and production. However, when API content is low, implementing a vibrational spectroscopic analytical tool to monitor the content and blend uniformity remains a challenging task. The aim of this study was to showcase the potentials of mid-infrared (MIR), near-infrared (NIR), and Raman spectroscopy for quantitative analysis...

On the time it takes to judge grammaticality

Jonathan Mirault & Jonathan Grainger
The presentation duration of five-word sequences was varied and participants were asked to judge their grammaticality. The five-word sequences were presented for a variable duration randomly selected between 50 and 500 ms with 50-ms steps and were immediately followed by a masking stimulus. Half of the sequences were correct sentences which were randomly intermixed with ungrammatical sequences formed of the same words in scrambled order. We measured the proportion of correct responses for each presentation...

Adipose Stem Cell–Derived Exosomes Decrease Fatty Infiltration and Enhance Rotator Cuff Healing in a Rabbit Model of Chronic Tears

, , Wei Song, &
Background:Fatty infiltration and poor tendon-bone healing in chronic rotator cuff tears (RCTs) are associated with unsatisfactory prognosis. Adipose stem cell–derived exosomes (ASC-Exos), having multiple biological effects, can prevent muscle degeneration in acute RCTs. However, the effects of ASC-Exos on fatty infiltration and tendon-bone healing in chronic RCTs remain unknown.Purpose:To study the effects of ASC-Exos on fatty infiltration and tendon-bone healing in a chronic RCT rabbit model.Study Design:Controlled laboratory study.Methods:At week 0, we randomly allocated 35...

A Vigilance Explanation of Musical Chills? Effects of Loudness and Brightness Manipulations

Scott Bannister
Recent research has suggested that low-level psychoacoustic parameters such as loudness and spectral brightness are correlated with musical chills, a subjective emotional experience accompanied by goosebumps, shivers, and tingling sensations. These relationships may be explained by a vigilance theory of chills, through the process of auditory looming; however, these correlations or theories have never been causally tested. In the current study, participants (N = 40) listened to five variations (original, low loudness, high loudness, low...

Government–opposition relations in a fragmented, personalized, and multidimensional setting: The case of Israel

Patterns of legislative activity in parliamentary regimes have long been defined by political parties and the division between government and opposition. However, several trends in recent years may challenge this distinction by mitigating the electoral connection between parliamentary behavior and electoral competition. Issue multidimensionality, party system fragmentation, and political behavioral personalization, while common to most established democracies, have been extremely pronounced in Israel. Analyzing all legislation votes taken in the Knesset between 2003 and 2014,...

The fiscally moderate Italian populist voter: Evidence from a survey experiment

Fabio Franchino & Fedra Negri
Do economic policy preferences distinguish populist voters from mainstream ones? We compare the preference profile of the voters of the Five Star Movement (M5S), one of the most successful southern European populist parties, with the profile of voters of other parties at both the 2013 national and the 2014 European Parliament elections by means of a conjoint analysis experiment on economic policy programs. Despite economic insecurity and recent recessions being key drivers of populist voting,...

The multi-dimensional matrix for consultation-liaison psychiatry (mMAX-LP)

John Hopkins, Frederick Sundram & Sarah Cullum
Objective:Consultation-liaison psychiatry (CLP) services are particularly susceptible to heterogeneity, developing haphazardly in response to local interests and perceived need. This hampers the generalisability of comparisons between services in terms of service models, resource requirements and outcome data. The objective of this paper therefore is to chronicle the development of a method to meaningfully describe, map and compare different CLP services.Method:A review of the literature was followed by multiple site visits in both New Zealand and...

The relationship between vocabulary knowledge and L2 reading/listening comprehension: A meta-analysis

& Xian Zhang
This study set out to investigate the relationship between L2 vocabulary knowledge (VK) and second-language (L2) reading/listening comprehension. More than 100 individual studies were included in this meta-analysis, which generated 276 effect sizes from a sample of almost 21,000 learners. The current meta-analysis had several major findings. First, the overall correlation between VK and L2 reading comprehension was .57 (p < .01) and that between VK and L2 listening was .56 (p < .01). If...

Little “we’s”: How common identities improve behavior differently for ethnic majority and minority children

Rita Guerra, Sven Waldzus, , Maria Popa-Roch, Beatriz Lloret & Samuel L. Gaertner
This field experiment tested whether inducing common inclusive representations (i.e., one group, dual identity) during contact influences intergroup relations differently for ethnic majority and minority children by changing their metaperceptions and intergroup emotions differently. White (N = 113) and Black (N = 111) 8- to 10-year-old children were exposed to interactive mixed-ethnicity sessions in schools emphasizing either categorization as one group (national group), dual identity (national group with ethnic subgroups), or two ethnic groups. Overall,...

The Paralogous Krüppel-like Factors 9 and 13 Regulate the Mammalian Cellular Circadian Clock Output Gene Dbp

Joseph R. Knoedler, José Ávila-Mendoza, & Robert J. Denver
An intricate transcription-translation feedback loop (TTFL) governs cellular circadian rhythms in mammals. Here, we report that the zinc finger transcription factor Krüppel-like factor 9 (KLF9) is regulated by this TTFL, it associates in chromatin at the core circadian clock and clock-output genes, and it acts to modulate transcription of the clock-output gene Dbp. Our earlier genome-wide analysis of the mouse hippocampus-derived cell line HT22 showed that KLF9 associates in chromatin with Per1, Per3, Dbp, Tef,...

Evaluation of the ‘ring sign’ and the ‘core sign’ as a magnetic resonance imaging marker of disease activity and progression in clinically isolated syndrome and early multiple sclerosis

Nelly Blindenbacher, Eveline Brunner, Susanna Asseyer, Michael Scheel, Nadja Siebert, Ludwig Rasche, Judith Bellmann-Strobl, Alexander Brandt, Klemens Ruprecht, Dominik Meier, Jens Wuerfel, Friedemann Paul & Tim Sinnecker
BackgroundBrain lesions with a hypointense ring or core were described in multiple sclerosis on susceptibility weighted imaging.ObjectiveThe purpose of this study was to study the evolution and prognostic relevance of susceptibility weighted imaging hypointense lesions in clinically isolated syndrome and early multiple sclerosis.MethodsSixty-six early multiple sclerosis and clinically isolated syndrome patients were followed over a median period of 2.9 years (range 1.6–4.6 years) and underwent 3T magnetic resonance imaging including 3D susceptibility weighted imaging and...

Comparison of video and in-hospital consultations during early in-home care for premature infants and their families: A randomised trial

, Ram B Dessau, Annelise Norlyk, Hristo Stanchev & Hanne Kronborg
IntroductionEarly in-home care is increasingly being used in Scandinavian countries for clinically stable premature infants. Due to challenges with travel and hospital resources, alternative ways to support parents during early in-home care are being considered. The aim of this study was to test whether the proportion of mothers exclusively breastfeeding, parental confidence and mother–infant interaction increased after early in-home care with premature infants, and to compare the outcomes of in-home care involving the use of...

Video-interpreting for cognitive assessments: An intervention study and micro-costing analysis

Kerry Hwang, , Julie A Simpson, Dina LoGiudice, Lidia Engel, Andrew S Gilbert, Samantha Croy & Betty Haralambous
IntroductionEvidence in the literature demonstrates the reliability of cognitive screening assessments using video technology in English-speaking older populations. However, this has not been tested in older culturally and linguistically diverse (CALD) populations who require an interpreter, and what the associated costs would be. The aim was to determine if the Rowland Universal Dementia Assessment Scale (RUDAS) and the Geriatric Depression Scale (GDS) could be reliably administered over video-interpreting methods compared with face-to-face interpreting. In addition,...

Associations between perceived injustice, unforgiveness, and psychological well-being among ex-communicants

Susan D. Boon & Jac Brown
Through the experiences of individuals excommunicated from a small religious sect (N = 95), we explored the association between perceptions of injustice resulting from chronic social exclusion and reduced psychological well-being. We also tested whether unforgiveness toward the church—particularly a tendency for participants to experience lingering negative affect and rumination about their treatment by the church—mediates this association. Analysis of responses to an online survey about participants’ experiences of chronic ostracism revealed the predicted association...

The Effects of Serious Leisure Involvement on Subjective Well-Being and Successful Aging: A Case Study of Young-Old Participants in Chinese Seniors’ Universities

Jin Wu, Xi Li, Bo Gao &
China is the only country with more than 200 million people aged 60 years and above. The Chinese government considers seniors’ universities to be an important form of leisure in which older people spend their free time. To explore the benefits of this education-oriented form of serious leisure, this study investigates the concept of successful aging and tests the effect of serious leisure involvement in seniors’ universities on the subjective well-being and successful aging of...

A mixed-methods systematic review and meta-analysis of barriers and facilitators to paediatric symptom management at end of life

Katie Greenfield, Simone Holley, Daniel E Schoth, Emily Harrop, Richard F Howard, Julie Bayliss, Lynda Brook, , Margaret Johnson, Ian Wong & Christina Liossi
Background:Symptom management for infants, children and young people at end of life is complex and challenging due to the range of conditions and differing care needs of individuals of different ages. A greater understanding of these challenges could inform the development of effective interventions.Aim:To investigate the barriers and facilitators experienced by patients, carers and healthcare professionals managing symptoms in infants, children and young people at end of life.Design:A mixed-methods systematic review and meta-analysis was undertaken...

How Dementia Caregivers Make Health Service Decisions: A Scoping Review and Implications for Grounded Theory Studies

Kristina M. Kokorelias & Rachelle Ashcroft
The purpose of this study is to explore the grounded theory literature surrounding the health care decisions of dementia caregivers and to evaluate the rigor of these studies according to methodological guidelines. This scoping review was guided by Arksey and O’Malley’s scoping review framework. Articles were then evaluated against key principals of grounded theory. Results from five included articles show that while researchers label their study as grounded theory, some aspects of the methodological principles...

Association between splenectomy and portal hypertension in the development of pulmonary hypertension

Li Huang, Wen Li, Tao Yang, , , Qing Gu &
Both portal hypertension and splenectomy are risk factors for pulmonary hypertension. However, the interactions between portal hypertension and splenectomy in the development of pulmonary hypertension remain unclear. Twelve newly diagnosed pulmonary hypertension patients with a previous history of splenectomy induced by portal hypertension were recruited between November 2008 and May 2017. We compared their clinical features, hemodynamics, and prognosis with idiopathic pulmonary arterial hypertension patients, who were matched by cardiac index, mean pulmonary arterial pressure,...

Using a systematic review to uncover theory and outcomes for a complex intervention in health and social care: a worked example using life story work for people with dementia

Gillian Parker, Kate Gridley, Yvonne Birks & Julie Glanville
ObjectivesLife story work involves gathering information about a person, their history and interests, and producing a tangible output, usually a book. It is used increasingly in dementia care. However, theory about if, how, and why it affects outcomes is poorly developed, making the choice of evaluation methods and appropriate outcomes difficult. This article uses a systematic review to uncover theories of change and outcomes for life story work in dementia care. We describe the methods...

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