55,113 Works

Anemia in people on second line antiretroviral treatment in Lilongwe, Malawi: a cross-sectional study

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Abstract Background Anemia is common among people living with HIV infection and is frequently associated with poor quality of life and poor prognosis. It has been well described in antiretroviral naïve individuals and those on non-nucleoside reverse transcriptase inhibitor-based first line antiretroviral therapy (ART) regimens. However there is limited information on anemia for ART experienced individuals on protease inhibitor-based second line ART regimens in resource limited settings. Our objective was to describe the prevalence and...

Snow and Rain Modify Neighbourhood Walkability for Older Adults

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RÉSUMÉ La littérature a documenté une relation positive entre la mobilité à l’extérieur chez les personnes âgées et les environnements bâtisables et marchables. Cependant, étonnamment, toute considération de la façon dont le temps modifie l’accessibilité piétonnière à travers les quartiers est absente. À Vancouver, au Canada, on a utilisé des données météorologiques archivées liées à des données recueillies auprès d’un échantillon d’aînés. On a constaté que, lorsqu’il neige, les quartiers où l’on dépend d’automobiles (comportant...

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Dye sublimation on aluminum

ACC/AHA Guidelines for the Management of Patients With Unstable Angina and Non–ST-Segment Elevation Myocardial Infarction: Executive Summary and Recommendations: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on the Management of Patients With Unstable Angina)

The American College of Cardiology (ACC)/American Heart Association (AHA) Task Force on Practice Guidelines was formed to make recommendations regarding the diagnosis and treatment of patients with known or suspected cardiovascular disease. Coronary artery disease (CAD) is the leading cause of death in the United States. Unstable angina (UA) and the closely related condition non–ST-segment elevation myocardial infarction (NSTEMI) are very common manifestations of this disease. These life-threatening disorders are a major cause of emergency...

Know Yourself: Effects of Interoception and Emotion Conceptualization on Anxiety

Anxiety is a major cause of distress for many Americans. Much could be gained from understanding the fundamental processes that cause this maladaptive state. According to a psychological constructionist perspective, anxiety may arise when people perceive and make meaning of their internal physical sensations as an instance of threat. As part of a separate experiment involving stress induction, we collected self-report data intended to measure interoceptive sensibility, emotion conceptualization and differentiation, and anxiety. Participants completed...

The association of diabetes and obesity with prostate cancer aggressiveness among Black Americans and White Americans in a population-based study

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Few studies have investigated the role of race in the association of diabetes and obesity with prostate cancer aggressiveness. Here we evaluate the independent association between diabetes and obesity with prostate cancer aggressiveness in White Americans and Black Americans.

A Frameless Imaging System: Architectural Design and Simulation

This report presents the work on the architectural design and simulation of the IMAGIN sensing system, a novel frameless camera sensor system that can provide a high dynamic range and fine tonal sensitivity, and allow for different update rates from different regions-of-interest. My contribution to the IMAGIN project is threefold. First, starting with a high-level functional concept of the sensor that had been developed by the group, I took it through several design and implementation...

A Program Model for Latino Family Support Services at the University of North Carolina Craniofacial Center

Latino patients face many challenges when seeking health care because of sociocultural, financial, and language barriers, which influence the overall level of support for a family within and outside of the health care system. At the University of North Carolina Craniofacial Center (UNC CFC), Latino families have identified a desire to connect with other Latino parents who have children with craniofacial differences and have also requested improvements in the Spanish craniofacial educational materials. The provision...

The Influence of Fasting, Affect, and Body Dissatisfaction on Set Shifting Ability

Set shifting, or the ability to shift back and forth between multiple tasks, operations, or mental sets (Miyake et al., 2000), is a neurocognitive construct characterized by a rigid thinking style. It has been shown to be impaired in individuals with anorexia nervosa (AN) (Roberts et al., 2007) and may impede treatment progress (Vitousek and Manke, 1994). Given the lack of effective treatments for AN (Steinhausen, 2002), examining how set shifting may be exacerbated or...

Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals

Abstract Background The genetic etiology of human lipid quantitative traits is not fully elucidated, and interactions between variants may play a role. We performed a gene-centric interaction study for four different lipid traits: low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), and triglycerides (TG). Results Our analysis consisted of a discovery phase using a merged dataset of five different cohorts (n = 12,853 to n = 16,849 depending on lipid phenotype) and a replication phase with...

Motivators for enrollment and completion of pregnancy outcomes research: A comparison of African-American and Caucasian women's perspectives

Women and minority populations, specifically African-Americans, continue to be under represented in medical research. The exclusion of women and minorities from clinical trials raises questions about whether treatment outcomes are generalizable to these populations and about equity in the provision of health care. Despite the recognition of the need to include women and minorities in medical research, many factors limit their participation. This study explored the motivators for participation, retention and satisfaction of reproductive-aged women...

The Chief Executive: Kennedy, Crisis, and Decision-Making

This thesis explores how John F. Kennedy’s style of executive management impacted his administration’s decision-making process. After the failures in Cuba and Vienna, Kennedy came to several conclusions: elaborate machinery was not innately ineffective; he should trust his advisors; and he should avail himself of more dissenting opinions. Based on these lessons, Kennedy rebuilt some of the formal foreign policy machinery that he had previously dismantled, relinquished his grip on policy creation, and halted debate...

Salvage chemotherapy for adults with relapsed or refractory lymphoma in Malawi

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Abstract Background Lymphoma is highly associated with HIV in sub-Saharan Africa (SSA), which contributes to worse outcomes relative to resource-rich settings, and frequent failure of first-line chemotherapy. However, there are no second-line treatment descriptions for adults with relapsed or refractory lymphoma (RRL) in SSA. Methods We describe HIV+ and HIV- patients with RRL receiving salvage chemotherapy in Malawi. Patients were prospectively treated at a national teaching hospital in Lilongwe, with the modified EPIC regimen (etoposide,...

GIV CARE: A group intervention to reduce accommodation among relatives of individuals with fear-based disorders

Fear-based disorders (FBDs) occur in an interpersonal context as relatives (e.g., partners, parents) often accommodate symptoms. Symptom accommodation, which is ubiquitous and reinforces FBD behavior, is associated with increased FBD symptom severity and interferes with treatment. Accordingly, reducing accommodation represents a crucial aim for intervention. The current study tested a brief, manualized group intervention to decrease symptom accommodation and caregiver burden among relatives. The study was the first intervention to date that a) jointly included...

Material Evidence for Urbanism in Archaic Crete

Archaic Cretan urbanism has been described by its heterogeneity and lack of definition. Although the study of early Cretan settlements by American archaeologists dates to the turn of the 20th century, more complex analyses of these data are still emerging. This work seeks to understand Archaic urbanism in Cretan settlements by placing the specific body of material at Azoria in East Crete within a broader theoretical and analytical context. The first part, focusing on methods,...

Creation of a cardiotropic adeno-associated virus: the story of viral directed evolution

Abstract Adeno-associated virus (AAV) is an important vector system for human gene therapy. Although use of AAV serotypes can result in efficient myocardial gene transfer, improvements in the transduction efficiency and specificity are still required. As a method for artificial modification and selection of gene function, directed evolution has been used for diverse applications in genetic engineering of enzymes and proteins. Since 2000, pioneering work has been performed on directed evolution of viral vectors. We...

The Concussion Recognition Tool 5th Edition (CRT5): Background and rationale

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The Concussion Recognition Tool 5 (CRT5) is the most recent revision of the Pocket Sport Concussion Assessment Tool 2 that was initially introduced by the Concussion in Sport Group in 2005. The CRT5 is designed to assist non-medically trained individuals to recognise the signs and symptoms of possible sport-related concussion and provides guidance for removing an athlete from play/sport and to seek medical attention. This paper presents the development of the CRT5 and highlights the...

Gender's Role in the Expression of Friendship in Young Adult Literature

This content analysis of fourteen young adult novels examines the manner in which friendship behaviors and trends vary depending on the gender of the characters. Similarities and differences between male and female same-sex friendships in these novels were compared to determine the extent to which friendship patterns are determined by gender, and then the findings of the content analysis were compared to the trends observed in the psychology literature regarding gender and adolescent friendships. Results...

Factors Affecting Successful Adoption of Connectivity Devices by Hearing Aid Users

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Purpose or Research Questions * To investigate factors that affect the choice to purchase the HACD and the successful adoption of the device. * To evaluate patients’ views regarding use, benefit, and satisfaction with connectivity devices. Background Hearing aid connectivity devices - referred to as HACDs in this poster - are widely marketed to both consumers and professionals in the field of Audiology as devices that can be used to improve communication. However, studies have...

Biopsychosocial Correlates of Persistent Post-surgical Pain in Women with Endometriosis

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Background: • Endometriosis is a benign gynecologic condition associated with pain and infertility, affecting up to 30% of women • Treatment of endometriosis often includes a combination of medical and surgical management • Short term improvement of pain is more likely with surgical treatment of lesions than diagnostic laparoscopy alone • Recently, psychological factors such as catastrophization and depression have been associated with poor pain outcomes • Long term predictors of pain outcome for endometriosis...

Current Use of Global Coronary Heart Disease Risk Assessment by a Sample of US Physicians

Background: Little is known about United States (US) physicians’ understanding and utilization of global CHD risk assessment in clinical practice. Purpose: To assess the current level of evidence regarding physicians’ use of global CHD risk assessment in primary prevention of cardiovascular disease by examining if there are valid and reliable tools available for clinicians to calculate patients’ global CHD risk scores, if calculation and communication of global risk scores translate into improved patient level outcomes,...

The late ancient synagogues of southern Palestine

Following the failure of the Bar-Kokhba revolt in 135/6 C.E., the majority of the Jewish population of ancient Palestine migrated northward away from Jerusalem to join communities of Jews in Galilee and the Golan Heights. Although rabbinic sources indicate that from the 2nd c. onward the demographic center of Jewish Palestine was in Galilee, archaeological evidence of Jewish communities is found in the southern part of the country as well. Ten synagogues from the period...

Eternal Youth

Lessons on the Importance of Place: Looking at the Impact of the Rural Studio

The program’s website succinctly states, “Rural Studio is an undergraduate program of the School of Architecture, Planning, and Landscape Architecture at Auburn University. We have been in Hale County since 1993, where we hope we have been a good neighbor and friend to the community.” Through an approach that is grounded in its context, the Rural Studio illustrates the potential of creative work at the intersection of planning and design. Over the past two decades,...

Palladium-Catalyzed C-H Alkylation of Aromatic Systems

The overall goal of this project is the development of new catalytic strategies for the construction of carbon-carbon bonds. Specific interests are in the formation of aryl-sp3 hybridized carbon-carbon bonds via C-H alkylation of arenes and heteroarenes with alkyl iodides, resulting in the formation of small molecules with polycyclic aromatic cores.

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