22,557 Works

Dynamic Modulation of In Vivo Serotonin Signaling

Serotonin signaling influences many neural processes and is highly implicated in the etiology and treatment of depression. Understanding how in vivo elements regulate serotonin signaling may provide insight into serotonergic function in the depressed brain. This work presents a modification to fast-scan cyclic voltammetric methods that enables rapid, spatially resolved, and chemically selective measurement of in vivo serotonin signaling in the substantia nigra pars reticulata. We used this modified technique to investigate the dynamics of...

Academic and Civic Outcomes of African American Graduates of Historically Black and Historically White High Schools

The purpose of this study was to examine how high school experience impacts adult outcomes for African Americans across time given changes in academic, social, and political climates. This research is very much needed to help the African American community identify what factors are related to individuals giving back to their community through civic engagement in order to promote self-sufficiency within the African American community. The study design explored the role of these factors by...

Recordkeeping practices in selected Atlanta area black churches

In Black Culture and Black Consciousness, historian Lawrence W. Levine emphasizes the role of religion in the cultural aspects of black identity formation. Through an examination of six selected black churches in the Atlanta area, this study explores the attitudes of church leaders and their congregants toward maintaining records to preserve institutional memory, as well as for legal and administrative reasons. The study examines the impact of recordkeeping practices on the churches' collective memory, and...

Concurrent Validity and Responsiveness of the Peabody Developmental Motor Scales-2(PDMS-2) in Infants and Children with Pompe Disease undergoing Enzyme Replacement Therapy

Purpose: To examine the responsiveness of the PDMS-2 in children diagnosed with Pompe disease who had different levels of functional mobility. To examine the concurrent validity between the PDMS-2 and the Alberta Infant Motor Scale (AIMS), the Pediatric Evaluation of Disability Inventory (PEDI) and the Pompe PEDI (PPEDI) in children diagnosed with Pompe disease. Methods: A secondary analysis was completed of the Genzyme Corporation Pompe efficacy trials for Myozyme. The children were divided into two...

Are We Studying Who We Think We're Studying? Role of Socioeconomic Status in the Validity of Estimates of Pneumococcal Conjugate Vaccine Effectiveness in the United States

Thirteen-valent pneumococcal conjugate vaccine (PCV13) was licensed for use in children in the United States in February 2010. Shortly thereafter the Centers for Disease Control and Prevention began a post-licensure vaccine effectiveness (VE) study in 13 surveillance sites around the US. Cases were identified through active surveillance and controls were matched to cases by age (+/- 14 days) and zip code, which was used as a proxy for socioeconomic status (SES). Due to issues locating...

Cultural Genetics: Theories of Inheritance and Nineteenth-Century American Literature

Cultural Genetics provides a new way of conceiving the separate spheres debate in nineteenth-century American literature that has traditionally opposed the natural to the cultural, the home to the marketplace, and sentimentalism to naturalism. In this project, I situate the writings of major American authors such as Nathaniel Hawthorne and Harriet Beecher Stowe, among others, within what I theorize as the convergence of biological and cultural discourses in order to reframe classic arguments about sentimentalism...

A Mirror Image of the Eurozone Balance of Payments Problem: Using Theories of Institutionalism to Explore the International Monetary Fund’s Policy Paradigm Shift Due to Germany’s Current Account Surplus

This paper serves as an exploratory look into how Germany's current account surplus triggered a policy paradigm shift in institutional response to the persistent imbalance of payments problem during the eurozone crisis. It creates a narrative of how Germany's current account balance came into political focus and why international institutions, in particular the International Monetary Fund, shifted policies away from placing the burden of financial rebalancing on debtor countries toward a more equal policy of...

Trimming teams: an examination of decision making processes in intercollegiate athletic departments when multiple varsity sport programs are eliminated

The combination of an economic downturn and the excessive increase in operating costs in intercollegiate athletics has created large deficits in the annual budgets for many institutions. As athletic departments struggle to balance their budgets, they are forced to make tough decisions on how to reduce expenses. One solution has been to eliminate multiple varsity sport programs. The purpose of this study is to determine the primary reasons why institutions eliminate varsity sports teams. Specifically,...

An Examination of Variations of Verbal Memory Performance in a Population of Children who have been Maltreated

This research examined the consequences of maltreatment on children's verbal memory, as measured by the California Verbal Learning Test (CVLT-C). The data were collected through an NIMH funded study at Duke University titled Life Events & Childhood Brain Development (funded under the title PTSD & Childhood Sexual Abuse: Psychobiology, Principal Investigator: Michael De Bellis). The analytic sample for this study consisted of 96 children who served as controls, and 91 children who had been maltreated....

Understanding the Synthesis, Performance, and Passivation of Metal Oxide Photocathodes

Metal oxides are ubiquitous in semiconductor technologies for their ease of synthesis, chemical stability, and tunable optical/electronic properties. These properties are especially important to fabricating efficient photoelectrodes for solar-energy applications. To counter inherent problems in these materials, new strategies were developed and successfully implemented on the widely-utilized p-type semiconductor, NiO. As the size of semiconductor materials shrink, the surface-to-volume ratio increases and surface defects dominate the performance of the materials. Surface defects can alter the...

Corruption in Latin America: Political, Economic, Structural, and Institutional Causes

This work examines the causes of corruption in eighteen Latin American countries from 1994 to 2005. With Transparency International's Corruption Perceptions Index as the dependent variable, this study utilizes a pooled cross-sectional times series design to link corruption levels with a number of explanatory variables. There is evidence that economic development, inequality, trade, structural reforms index, democracy, federal structure, and ethno-linguistic fractionalization have significant effects on corruption. However, resource exports, age of democracy, and public...

A Site of Resistance and/or Reclamation? The Role of the Black Church in the Charter School Movement

The struggle for equitable educational opportunities for students of color and those from low income families began well before the seminal Brown case, and continues with each new wave of education reform. The charter school movement is one such reform rapidly expanding across the United States and often targeting students from low-income communities of color (Berends, 2013; Reardon, 2011). Black churches have traditionally played a significant role in the education of African Americans (Billingsley, 1999; Lincoln &...

Functions of rat acyl-CoA synthetases in bacteria and mammalian cells

Long chain acyl-CoA synthetase (ACSL) activates long chain fatty acids in the initial step of lipid metabolism, and provides substrates for both anabolic and catabolic pathways. Dysregulation of fatty acid partitioning between these opposing pathways results in cellular lipid accumulation, which may cause obesity and lipotoxicity. We hypothesized that ACSL isoforms play a critical role in fatty acid channeling into different metabolic pathways and that regulation of ACSL may change the fatty acid channeling. This...

Syracuse community geography: evaluating a new approach to public participation geographic information systems

Public Participation Geographic Information Systems (PPGIS) study the applications of geospatial technologies, including Geographic Information Systems (GIS), by members of the public. PPGIS emerged in the 1990s in response to epistemological criticisms that the social, political and philosophical implications of GIS had been largely ignored by GIS practitioners. PPGIS strives to address criticisms by making GIS more widely available to grassroots groups and individuals. In the United States, access to GIS among community-based organizations (CBOs)...

Interfacial Electron Transfer at Sensitized Nanocrystalline TiO2 Electrolyte Interfaces: Influence of Surface Electric Fields and Lewis Acidic Cations

Interfacial electron transfer reactions facilitate charge separation and recombination in dye-sensitized solar cells (DSSCs). Understanding what controls these electron transfer reactions is necessary to develop efficient DSSCs. Gerischer proposed a theory for interfacial electron transfer where the rate constant was related to the energetic overlap between the donor and acceptor states. The present work focuses on understanding how the composition of the CH3CN electrolyte influenced this overlap. It was found that the identity of the...

A Study of Optical and Electronic Properties of Organic Thin Film Transistors Based on Naphthalenetetracarboxylic Diimide Derivatives

The optical properties of spin cast thin films of N,N'-bis(3-phenoxy-3-phenoxyphenoxy)- 1,4,5,8-naphthalene-tetracarboxylic diimide (NDA-n2) and N,N'-bis(3-phenoxyphenoxy)- 1,4,5,8-naphthalene-tetracarboxylic diimide (NDA-n1) were investigated using spectroscopic ellipsometry (SE) complimented by optical absorption spectroscopy in the visible-near UV optical range and atomic force microscopy (AFM) for surface roughness. A combination of Tauc-Lorentzian and Gaussian oscillators model was used to fit the measurements obtained from SE. Film roughness results were also evaluated in the optical model using Bruggman Effective Medium Approximation...

Modeling Non-linearity in Religiosity’s Relationships to Premarital Sexual Attitudes and Behaviors among Adolescents and Young Adults

Using data from three waves of the National Study of Youth and Religion, this paper examines the relationships of religiosity with premarital sexual attitudes and behaviors for adolescents and young adults. Following past research that shows evidence for non-linear relationships between these variables, particularly among the highly religious, this paper explicitly compares three functional forms of these relationships. The results show that nearly all of these relationships are best defined when non-linearity in the functional...

Geographic influences on autism diagnosis: accessibility of health services and exposure to hazardous air pollutants

We evaluated two geographic determinants of autism: early-life geographic access to health services on the timing of autism diagnosis and perinatal exposure to hazardous air pollutants (HAPs) on the prevalence of autism. We included children identified by the Autism and Developmental Disabilities Monitoring Network records-based surveillance who resided in the surveillance regions at age 8 and at birth (in 1992, 1994, 1996). Geographic access to health services was measured as individual-level density of and proximity...

Variation in the vocalizations of tamarins (saguinus) in Amazonian Peru

Tamarins (Saguinus) are a diverse genus of Amazonian primates with distributions that often coincide with rivers. This distributional pattern might be explained by the riverine barrier hypothesis, which suggests that rivers reduce gene flow by limiting dispersal. I investigated the differences in vocalizations among populations of Saguinus separated by rivers of different widths. I recorded alarm calls and long calls of four populations of Saguinus in three river compartments of northeastern Peru. ANOVAs and hierarchical...

NON-PARAMETRIC MACHINE LEARNING METHODS FOR CLUSTERING AND VARIABLE SELECTION

Non-parametric machine learning methods have been popular and widely used in many scientific research areas, especially when dealing with high-dimension low sample size (HDLSS) data. In particular, clustering and biclustering approaches can serve as exploratory analysis tools to uncover informative data structures, and random forest models have their advantage in coping with complex variable interactions. In many situations it is desirable to identify clusters that differ with respect to only a subset of features. Such...

Kindergarten Linguistic Awareness Intervention: The Effects of Phonological, Morphological, and Orthographic Instruction on Early Reading Outcomes in At-Risk Students

The primary purpose of this study was to determine if a three-pronged linguistic awareness intervention (i.e., phonological awareness [PA], letter knowledge [LK], & morphological awareness [MA]) was more effective than the commonly implemented two-pronged intervention (i.e., PA & LK) at increasing the early literacy skills of kindergarten students at risk for reading difficulties. The study also investigated the effectiveness of an intervention targeting morphological awareness alone as compared to the two other interventions. Seventeen kindergarten...

Land use/land cover change in Orange County, North Carolina from 1955 to 2001

Land use/land cover change (LULCC) has significant implications in terrestrial ecosystem goods and services. Current studies on LULCC are primarily based on space-borne satellite images. These studies are limited by the data availability. In this study, I extend the land-use land cover change analysis back to 1955 for Orange County, North Carolina based on historical aerial photos. I also analyzed the spatial configuration of the landscapes based on pattern matrix analysis and geospatial analysis. Results...

Getting back what you put in: the perceived reality of online interactions

Past research on the consequences of online social interactions demonstrates a wealth of contradictions; however, incorporating attitudes as a predictor of specific online behaviors may clarify when online interactions are beneficial and when they are detrimental. Study 1 examined the perceived reality of online interactions (PROI; the extent to which an individual views online interactions as suitable for the maintenance and formation of close relationships) as a predictor of perceived social support from online sources....

Twitter takeover: an examination of the United States Women's National Soccer Team twitter during the 2011 World Cup and recommendations for the 2012 Olympics

This project looks at how social media can be beneficial to women's sports through examining the context of tweets from the United States Women's National Soccer Team's (USWNT) tweets during the 2011 FIFA Women's World Cup. By creating best practices lists for social media, this project also proposes a Twitter campaign for the 2012 London Olympics for the USWNT.

The impact of pharmacodynamic parameters on prediction of clinical outcome in HIV-1 infected patients and HCV patients with HIV co-infection

The objective of this project was to use pharmacometric approaches to investigate the impact of in vivo pharmacodynamic (PD) parameters on clinical outcome in patients infected with human immunodeficiency (HIV) or hepatitis C (HCV) virus. Pharmacometrics is an emerging science based on developing and applying mathematical/statistical methods to characterize and predict pharmacokinetic (PK) and PD behavior, and to quantify uncertainty inherent in information about that behavior. The degree to which viral infection is inhibited at...

Registration Year

  • 2019
    22,557

Resource Types

  • Text
    20,592
  • Image
    1,758
  • Interactive Resource
    91
  • Other
    32
  • Audiovisual
    23
  • Dataset
    22
  • Collection
    19
  • Sound
    18
  • Software
    2