20,592 Works

MAKING WOMEN MEN: WHAT FEMALE SUPERINTENDENT STORIES TELL US ABOUT THE GENDER GAP IN THE NORTH CAROLINA SCHOOL SUPERINTENDENCY

In the early nineteenth century, the sexual division of labor in education established women as teachers and men as leaders. With the Common Schools movement and as Taylorism was applied to the process of schooling, the position of superintendent was firmly established by the late 1800s. As women gained suffrage, they launched successful campaigns for elected superintendencies, and in 1930, women held nearly 11% of all superintendencies. In response, powerful men superintendents led successful attacks...

Molecular dosimetry of 1,2 guanine-guanine intrastrand cross links of cisplatin by ultra performance liquid chromatography tandem mass spectrometry

Cisplatin has been extensively studied as an antitumor agent since the late 1960s. However the mode of action for the efficacy and adverse effects of cisplatin are poorly understood. It was previously believed that the cisplatin1,2 intrastrand guanine-guanine [CP-d(GpG)] cross link was likely responsible for much of the cytotoxic actions of the compound. But current techniques prevented accurate and specific adduct quantification using pharmacologically relevant concentrations of cisplatin. Therefore, the development of a highly sensitive...

Mechanism and timing effects on the kinematics and kinetics of the running and cutting motion

This study examines the lower extremity biomechanics, kinematics and kinetics during cutting maneuvers performed by recreational athletes by comparing the effects of anticipation, gender and training on the biomechanics of the cutting maneuver. Ankle, knee and hip injuries are thought to most likely to occur when performing such cutting maneuver. Understanding the dynamics of motions during cutting is the first step to prevent such injuries. Previous studies have compared the cutting maneuver to a straight-ahead...

Fish assemblages of Caribbean coral reefs: Effects of overfishing on coral communities under climate change

Coral reefs are threatened worldwide due to local stressors such as overfishing, pollution, and diseases outbreaks, as well as global impacts such as ocean warming. The persistence of this ecosystem will depend, in part, on addressing local impacts since humanity is failing to control climate change. However, we need a better understanding of how protection from local stressors decreases the susceptibility of reef corals to the effects of climate change across large-spatial scales. My dissertation...

The role of NF-κB in BCR-ABL-driven oncogenic transformation and in hematopoiesis

Chronic myeloid leukemia is a malignant clonal disorder of hematopoietic stem cells that results in increased and deregulated growth of myeloid cells. About 95% of CML cases arise from the formation of the Philadelphia (Ph) chromosome, resulting in the expression of BCR-ABL, an oncoprotein with constitutive tyrosine kinase activity that drives oncogenesis. Current therapeutics for CML includes the BCR-ABL inhibitor, imatinib, which results in molecular remission in only 4% of patients. Drug resistance also occurs...

Obesity and the timing of cohabitation and marriage

The prevalence of adult overweight and obesity has increased substantially in the United States over the past few decades. Besides the health consequences of obesity, it also has social and psychological consequences. As a social marker, it influences individuals' positions or status in a various social contexts and thereby contributes to social stratification. Using The National Longitudinal Study of Adolescent Health (Add Health) data, this paper analyzes the effect of obesity on the likelihood and...

Mammography maintenance: a longitudinal, population-based study of insured women

Early detection through mammography screening is an effective way to control breast cancer. Rates of mammography screening have increased dramatically over the last decade although recent data suggest that rates may now be declining. To reduce their risk of breast cancer morbidity and mortality, women should maintain regular on-schedule mammography use (i.e., mammography maintenance). Repeat use is a necessary step towards that goal. Many variables have been examined as predictors or correlates of repeat mammography...

The authority of the Catholic Church on abortion legislation: the Catholic Church's influence on the abortion law in Spain through political party influence and its competition with the rising feminist movement

The politics of abortion in Spain is a complicated case due to the fact that abortion legislation is not restricted to solely the political sphere. Since the sixth century, the Catholic Church has had a longstanding and influential role within the state of Spain and the creation of any and all policies. After the authoritarian regime of Franco in the mid-twentieth century, the Catholic Church began to, for the first time; attempt to truly separate...

Effects of the Weight-to-Stress Principle in English Speakers Learning Japanese Prosody

This thesis explores the effect of the Weight-to-Stress Principle (WSP) in second language transfer of word-level accent from English stress accent to Japanese pitch accent within the framework of Optimality Theory. A model is proposed that predicts some English speakers will be more likely to insert pitch accents into unaccented Japanese words containing heavy syllables (Heavy words) than ones consisting only of light syllables (Light words), due to the effects of WSP. I performed an...

Preventing HIV by Creating SISTA Strength: An Analysis of One U.S.-Sponsored Intervention into Black Women's Health

The United States’ modes of intervening into HIV/AIDS are inextricably sutured to contemporary understandings of blackness. In this dissertation, I explore these articulations by rhetorically examining one state-sponsored intervention into black women’s health—the SISTA HIV prevention program. I use a rhetorical lens to examine this program’s texts and its conditions of emergence, variously focusing on SISTA’s unique materials and the larger cultural, political, and economic forces that give it meaning. Specifically, I trace SISTA’s redeployment...

Molecular visualization of individual molecules during flow

Wetting and flow properties of molecularly thin polymer films are at the heart of many practical applications such as coatings, composites, microfluidics, and lubrication In some applications, these properties ensure even surface coverage; while in others, molecular flows act as new tools for surface patterning and performing biochemical assays on microchips. Further advances in these fields depend on our understanding (i) the mechanisms controlling the kinetics of flow and (ii) molecular organization of thin polymer...

Studies toward Understanding the Biosynthesis of Sactipeptides and the Creation of Peptide Natural Product Libraries through mRNA Display

Ribosomally-synthesized and post-translationally modified peptides (RiPPs) are a class of natural products that are an attractive starting point for new antibiotics due to their wide range of structural diversity and biological activities. The post-translational modifications imparted upon the peptide substrate are carried out by promiscuous RiPP enzymes. Sactipeptides are members of the RiPPs family that are made through radical-mediated cysteine sulfur to α-carbon coupling reactions. The resulting thioether linkages give rise to sactipeptides defined structures...

Communicating with Viewers: Examining the Use of Graphics in Cable Television

A comparative content analysis examined the use of graphics as promotional tools by cable networks. The cable networks chosen for analysis were USA, TNT, Nickelodeon, and the Disney Channel. Comparisons of the use of graphics by these cable networks were made based on target audiences and business models. Key findings included the use of graphics to drive viewers to social media by the adult-targeted networks and the exclusive use of graphics to promote programming by...

Evaluating the therapeutic potential of the PAK1 and TBK1 kinases in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is an extremely lethal cancer characterized by a high frequency (>95%) of activating mutations in the KRAS oncogene, which is a well-validated driver of PDAC growth. However, to date, no successful anti-KRAS therapies have been developed. Inhibitors targeting components of KRAS downstream signaling pathways, when used as monotherapy or in combination, have been ineffective for long-term treatment of KRAS-mutant cancers. Decidedly, the most studied and most targeted KRAS effector pathways have...

Immortal Longings: Towards a Poetics of Preservation on the Early Modern Stage

“Continually we bear about us,” John Webster asserts through Bosola, “A rotten and dead body.” In a late fifteenth-century copy of the popular medieval pharmacopia, the Livre des simples médecines, the entry for momie—or mummy, a corpse drug often in the form of a powder made from embalmed bodies—is illustrated by “an image of an open tomb displaying its grisly contents: a blackened skeletal corpse with its abdomen sliced open, its head thrust back and...

Land use affects the timing and magnitude of material delivery to headwater streams in coastal North Carolina

Headwater streams are both the transport vectors and receiving waters for landscape-derived materials. This high level of connectivity to their surrounding watershed imparts headwater streams with the ability to act as sentinels of impacts that may occur due to changing land uses. Determining the impacts of land use and precipitation patterns on material delivery by streams is requisite for quantifying and mitigating degradation resulting from watershed development. Headwater streams in the New River Estuary, NC,...

Interactions between dengue type 3 viruses and human dendritic cells

Dengue is a mosquito-borne viral disease of global public health significance. Throughout the world more than 2.5 billion people are at risk of contracting dengue virus (DENV) infection. Each year, an estimated 100 million cases of dengue viral infection are reported worldwide with 250,000 people developing the more severe dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS), which is often fatal. The pathogenesis of dengue is poorly understood due to the lack of an animal model. Both...

Repeated cycles of binge-like ethanol drinking in C57BL/6J mice augments subsequent voluntary ethanol intake but not other dependence-like phenotypes

Background: Recently, procedures have been developed to model specific facets of human alcohol abuse disorders, including those that model excessive binge-like drinking (i.e., drinking in the dark, or DID) and excessive dependence-like drinking (i.e., resulting from intermittent ethanol vapor exposure). Similar neuropeptide systems modulate excessive ethanol drinking stemming from both procedures, raising the possibility that both paradigms are actually modeling the same phenotypes and triggering the same central neuroplasticity. Therefore, the goal of the present...

An EM Algorithm for Maximum Likelihood Estimation of Process Factor Analysis Models

In this dissertation, an Expectation-Maximization (EM) algorithm is developed and implemented to obtain maximum likelihood estimates of the parameters and the associated standard error estimates characterizing temporal flows for the latent variable time series following stationary vector ARMA processes, as well as the parameters defining the relationship between the latent stochastic vector and the observed scores taking measurement errors into account. Such models have been known as Process Factor Analysis (PFA) models (Browne & Nesselroade,...

Mapping machines: activist cartographies of the border and labor lands of Europe

This dissertation explores how cartographic and geographic methods are being utilized as tools by social movements for new ends. In particular, I focus on social movements based in Spain that are developing cartographies of the conflicting territories of the European Union and its construction. The activist mapping projects engaged in this dissertation are understood as a form of "other" cartography: a form of social movement-based knowledge deploying the traditional research tool of cartography to new...

Clinician Patterns of Ankle Brace Recommendation and Perception of Factors Associated with Brace Use

A group of athletic trainers and physical therapists were surveyed to determine which ankle braces they recommend most frequently to prevent ankle sprain injury, which factors associated with brace use influence decisions about ankle brace recommendation, and to determine if perceptions about factors associated with brace use are related to patterns of ankle brace recommendation. The ASO brace was the ankle brace recommended most frequently. Clinicians reported effectiveness in preventing ankle sprain injury was the...

The new face of cigarette advertising: cigarette marketing strategies emerging after the MSA

This thesis explores new advertising and promotional strategies cigarette manufacturers have developed and augmented since the 1998 Master Settlement Agreement (MSA). A literature review examines recent academic research on cigarette advertising strategies and smoking behavioral patterns. Three stories, written in the style of in-depth newspaper articles, each cover one new development. The first article discusses the growth of cigarette advertising and promotions at the point of sale, as well as how these promotions have affected...

A Place at the Table: The Process of Personal and Community LGBT Engagement in the Gay Movement

Social movements are, by their very nature, public relations initiatives which exact change at the societal level. The modern American gay movement is no exception. Its leap onto America's front page is often marked by the Stonewall Riots of 1969. Indicative of most social movements, the gay experience has witnessed social unrest, community mobilization, and certainly push-back from a mainstream, heterocentric dominant culture. But as more critical battles are waged, and as more milestones are...

The Regency novel and the British constitution: Austen, Brunton, Shelley, and the culture of Romantic decline

During the Regency period (1811-1820), Britons were faced at home with daunting political problems: a scandal-plagued royal family; ongoing war with France; a weak postwar economy; a complicated and relatively new union of Scotland with England and Wales; and an enormous new empire abroad that few understood and none knew how to manage. As a hedge against this apparent national decline, Britons made frequent recourse to an ideal of national cohesion they called the British...

Influence of Shoreline Stabilization Structures on Nekton and Avian Assemblages in Salt Marsh Habitats

Bulkheads represent a hardened shoreline stabilization structure designed to inhibit shoreline erosion and damage to coastal property. As sea level continues to rise, natural marshes can be sustained by transgression landward. The presence of a bulkhead, rip-rap revetment, or hybrid of those two, however, prevents transgression by fixing the location of the upper marsh. Simultaneously, as sea levels rise, wind-driven waves from storms and boat wakes erode the lower edge of the marsh, inducing slumping...

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  • 2019
    20,592

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    20,592