805 Works

Visual Tactile data collected by simulated WhiskEye robot for ViTa-SLAM study

O. Struckmeier & M. Pearson
Visual tactile sensory data collected from a simulated instance of a WhiskEye robot during mobile exploration. This was used to demonstrate a multi-modal spatial navigation system developed as part of larger project task within the Human Brain Project called ViTa-SLAM (Visuo-Tactile Simultaneous Localization And Mapping).

Longitudinal imaging of motor-evoked cortical activity before and after stroke

A. L. Allegra Mascaro, E. Conti & L. Sacconi
We recorded time series of calcium activity of cortical pyramidal neurons with wide-field fluorescence microscope. Increase in GCaMP6f fluorescence was indicative of an increase in neuronal activity. The mice were head restrained during the recording session. The field of view of the microscope allows to record cortical activity in the right hemisphere and in a portion of the left one while the mouse is performing a passive extension-active retraction of the left forelimb in a...

Optogenetic stimulation of the cerebellar cortex in in vivo anesthetized mice

I. Montagna & L. Mapelli
This project investigates the effect of optogenetic activation of the cerebellar cortex on deep cerebellar nuclei activity. It is known the Purkinje cells provide the sole output of the cerebellar cortex, inhibiting the deep cerebellar nuclei neurons. In this project, we recorded the responses of the fastigial nucleus to sensory tactile stimulation (air puffs on the whisker pad, upper lip, or lower lip). In this project, extracellular recordings of the spiking activity of single-units in...

Density measurements of different receptors for CA1 (Hippocampus) [human, v2.0]

N. Palomero-Gallagher & K. Zilles
This dataset contains the densities (in fmol/mg protein) of receptors for classical neurotransmitters of CA1 (Hippocampus) obtained by means of quantitative _in vitro_ autoradiography. The receptor densities are visualized as _fingerprints_ (**fp**), which provide the mean density and standard deviation for each of the analyzed receptor types, averaged across samples. Overview of available measurements [ **receptor** \| **_neurotransmitter_** \| _labeling agent_ ]: **AMPA** \| **_glutamate_** \| _[3H]AMPA_ **kainate** \| **_glutamate_** \| _[3H]kainate_ **NMDA** \| **_glutamate_**...

Density measurements of different receptors for CA3 (Hippocampus) [rat, v2.0]

N. Palomero-Gallagher & K. Zilles
This dataset contains the densities (in fmol/mg protein) of receptors for classical neurotransmitters of CA3 (hippocampus) obtained by means of quantitative _in vitro_ autoradiography. The receptor densities are visualized as _fingerprints_ (**fp**), which provide the mean density and standard deviation for each of the analyzed receptor types, averaged across samples. Overview of available measurements [ **receptor** \| **_neurotransmitter_** \| _labeling agent_ ]: **AMPA** \| **_glutamate_** \| _[3H]AMPA_ **kainate** \| **_glutamate_** \| _[3H]kainate_ **NMDA** \| **_glutamate_**...

DiFuMo atlas (1024 dimensions)

K. Dadi, G. Varoquaux, A. Machlouzarides-Shalit, K. J. Gorgolewski, D. Wassermann, B. Thirion & A. Mensch
DiFuMo (Dictionary of Functional Modes) 1024-dimensional atlas presents a parcellation of the brain into 1024 elementary structures using sparse dictionary learning. The atlas contains two main components: (1) an image of the 1024 spatial components, sampled in MNI space, and (2) anatomical names for these 1024 regions. It is meant to serve as an atlas to extract functional signals, eg to create image-derived phenotypes. These modes are optimized to represent well raw BOLD time series,...

Densities and 3D distributions of synapses using FIB/SEM imaging in the human neocortex (Trans entorhinal cortex, TEC)

L. Alonso-Nanclares, L. Blazquez-Llorca, M. Dominguez-Alvaro, M. Montero-Crespo, J.R. Rodriguez & J. DeFelipe
Synapses have been identified, segmented and quantified in the human neocortex (trans entorhinal cortex, TEC) with 3D electron microscopy (FIB-SEM). Layer II of the TEC has been studied. 5 cases have been used (AB1, AB2, IF10, M16 and M17) to achieve a total of 15 valid images stacks. Data obtained include the number of asymmetric and symmetric synapses, their sizes and their spatial distribution. The distribution of their post-synaptic targets has also been determined.

Neurotransmitter receptors and ion channels in the somatosensory of C57BL/J6 mice

R. Luján
This dataset contains tables and histograms showing the density, expressed as number of immunoparticles/µm2) of several neurotransmitter receptors subtypes (GABAB receptors and mGlu5 receptors) and ion channel subtypes/subunits (GIRK2 channels, SK2 channels and Cav2.1 channels) along different compartments of the axo-somato-dendritic domains of pyramidal cells in a given cortical layer. We used cutting-edge experimental immunolocalization approaches, the SDS freeze-fracture labelling (SDS-FRL) in the somatosensory cortex of 4 week-old C57BL/J6 mice. The dataset also contains tables...

Topography of the complete corticopontine projection

T.B. Leergaard & J.G. Bjaalie
3D reconstructed point coordinate data representing the spatial location of anterogradely labeled corticopontine axonal projections originating from frontal, parietal, temporal or occipital areas of the cerebral cortex. The data show that corticopontine projections from the entire cerebral cortex are topographically organized in the pontine nuclei, following a principal map that allows fairly accurate prediction of pontine target area for any site of origin in the cerebral cortex.

Simultaneous 2-photon calcium imaging in dendritic tufts & cell bodies of single pyramidal neurons in mouse V1

K. Seignette, L. De Kraker, C. Van Der Togt & C. Levelt
Although it is thought that cortical feedback is crucial for accurate sensory perception and awareness, it remains unclear how feedforward and feedback information is integrated at the level of individual neurons. It is believed that feedforward sensory information inputs mostly enter dendrites near the cell body, while feedback information about what is to be expected would enter at the dendritic tufts. We present a dataset containing semi-simultaneously recorded calcium signals in layer 5 pyramidal neurons...

Topography of pontocerebellar neurons projecting to posterior lobe of the rat cerebellum

F. Odeh, R. Ackerley, J.G. Bjaalie & R. Apps
3D reconstructed point coordinate data representing the spatial location of the somata of pontine neurons projecting to face, forelimb, and hindlimb receiving parts of the paramedian lobe and cupula pyramidis of the rat cerebellum. The data show that somata of pontocerebellar neurons targeting to the face, forelimb and hindlimb zones of the paramedian lobule, respectively, are located in progressively more caudal parts of the pontine nuclei with little of no overlap.

Mechanistic analysis of ERP in rodents

A. Arena, S. Thon & J. Storm
The aim of this task is to gain a better understanding on the nature of the evoked related potentials (ERPs) induced by a current stimulation of the secondary motor cortex (M2), which has been adopted for generating the cortical perturbation in task PCI-like measure in rodents. Since a current stimulation is not physiological, it can be difficult to predict the exact brain response. We, therefore, stimulated M2 of head-restrained awake rats with current pulses of...

Paxinos & Watson’s “The Rat Brain in Stereotaxic Coordinates” (5th edition) spatially registered to the Waxholm Space atlas of the rat brain

I.E. Bjerke, U. Schlegel, M. Puchades, J.G. Bjaalie & T.B. Leergaard
The dataset contains location metadata defining the spatial registration of the 5th edition of “The Rat Brain in Stereotaxic Coordinates” (Paxinos & Watson, 2005) to the MRI/DTI image volume of the Waxholm Space atlas of the rat brain (Version 1.01; RRID:SCR017124). The stereotaxic atlas of Paxinos & Watson contains a new set of 161 coronal diagrams from a young adult Wistar rat. The schematic diagram images were spatially registered to the Waxholm Space atlas of...

Swanson's “Brain Maps: Structure of the Rat Brain” (3rd edition) spatially registered to the Waxholm Space atlas of the rat brain

I.E. Bjerke, U. Schlegel, M. Puchades, J.G. Bjaalie & T.B. Leergaard
The dataset contains location metadata defining the spatial registration of the 3rd edition of “Brain Maps: Structure of the Rat Brain” (Swanson, 2004) to the MRI/DTI image volume of the Waxholm Space atlas of the rat brain (Version 1.01; RRID:SCR017124). The stereotaxic atlas by Swanson contains 73 revised coronal diagrams from an adult Sprague-Dawley rat. The schematic diagram images were spatially registered to the Waxholm Space atlas of the Sprague-Dawley rat brain. The dataset consists...

Paxinos & Watson’s “The Rat Brain in Stereotaxic Coordinates” (6th edition) spatially registered to the Waxholm Space atlas of the rat brain

I.E. Bjerke, U. Schlegel, M. Puchades, J.G. Bjaalie & T.B. Leergaard
The dataset contains location metadata defining the spatial registration of the 6th edition of “The Rat Brain in Stereotaxic Coordinates” (Paxinos & Watson, 2007) to the MRI/DTI image volume of the Waxholm Space atlas of the rat brain (Version 1.01; RRID:SCR017124). The stereotaxic atlas of Paxinos & Watson contains revised delineations of 161 coronal, 27 horizontal and 19 sagittal diagrams from young adult Wistar rats. The schematic diagram images were spatially registered to the Waxholm...

Hippocampal image volume derived from Thy1-GFP-M transgenic mouse

F. Pavone & L. Silvestri
Reconstruction of the hippocampus of a Thy1-GFP-M transgenic mouse, where a subset of pyramidal neurons and of interneurons are labeled. Data obtained with serial two-photon tomography.

Purkinje cell distribution in mouse cerebellum

F. Pavone & L. Silvestri
The dataset contains the complete reconstruction of the cerebellum from an L7-GFP mouse (PND 10), where all Purkinje cells are fluorescently labeled. The dataset includes raw imaging data obtained with confocal light sheet microscopy of cleared sample and cell localization (position of somata expressed as xyz coordinates).

Maps of neurons stained with anti-Parvalbumin antibody

F. Pavone & I. Costantini
This dataset is about 3D-imaging at high resolution of parvalbumin expressing neurons of selected regions (area 17 of visual cortex) of human brain. The dataset contains the final fused volume in tiff format, the originally acquired 3D stacks, as well as stitching file generated by ZetaStitcher.

Maps of GLUR2 receptors in human cortex

F. Pavone & I. Costantini
This dataset contains the image of spatial distribution of GLUR2 subunit in AMPA receptor in human cortex using serial two photons microscopy. The individual 3D tiles acquired with the two photon fluorescence microscope were fused together to produce the final image.

Ca2+/calmodulin-dependent protein kinase II tetracycline-transactivator expression: coronal sections (case 317.8)

F. Odeh, T.B. Leergaard, J. Boy, T. Schmidt, O. Riess & J.G. Bjaalie
Bright-field microscopy images of serial coronal brain sections showing Ca2+/calmodulin-dependent protein kinase II (Camk2a) promoter expression in a bigenic Camk2a-tetracycline-transactivator (tTA) mouse brain (case 317.8, adult female), using a driver-reporter construct in which the Camk2a-tTA promoter regulates the expression of the E. coli derived LacZ reporter gene encoding β-galactosidase, which is visualized histologically using X-gal (5-Bromo-4-chloro-3-indolyl β-d-galactopyranoside) as a substrate. Methodological details are provided in Odeh et al., Neuroimage 54:2603-11, 2011. Our data show that...

Brain-wide distribution of vesicular glutamate transporter type 3 (VGLUT3)

M. Stensrud, F. Chaudhry, T.B. Leergaard, J.G. Bjaalie & V. Gundersen
Vesicular glutamate transporters (VGLUT1-3) carry glutamate into synaptic vesicles. This dataset is a brain-wide collection of microscopic images showing the distribution of vesicular glutamate transporter 3 (VGLUT3) in the normal rodent brain, visualized by for light microscopy using immunohistochemistry using an antibody against VGLUT3.

sIPSCs from juvenile (P21-30) C57Bl6/J male mice from CA1 pyramidal neurons receiving input from PV+ interneurons

E. Cherubini, C. Marchetti & S. Marinelli
A general procedure to fit individual synaptic events recorded from voltage clamp experiments was tested with various sets of experimental data on GABAergic synapses; gephyrin and gephyrin-dependent pathways were chosen as a suitable example of a kinetic model of synaptic transmission. The data used here are obtained from coronal hippocampal slices (300 μm thick) from juvenile (P21-30) C57B16/J male mice receiving input from parvalbumin positive (PV+) interneurons. The dataset contains 614 individual events recorded from...

Map of astrocytes in human brain cortex

F. Pavone & I. Costantini
This dataset contains images of astrocytes in the human cortex obtained using serial two-photon microscopy. The individual 3D tiles acquired with the two photon fluorescence microscope were fused together to produce the final image.

Neuropsin tetracycline-transactivator expression: coronal sections (case 2849)

M. Yetman, S. Lillehaug, J.G. Bjaalie, T.B. Leergaard & J. Jankowsky
Bright-field microscopy images of serial coronal brain sections showing neuropsin (Nop) promoter expression in a bigenic Nop-tetracycline-transactivator (tTA) mouse brain, (case 2849 adult female), using a driver-reporter construct in which the Nop-tTA promoter regulates the expression of the E. coli derived LacZ reporter gene encoding β-galactosidase, which is visualized histologically using X-gal (5-Bromo-4-chloro-3-indolyl β-d-galactopyranoside) as a substrate. Methodological details are provided in Yetman et al., Brain Struct Funct 221:2231-49, 2016. Our data show that the...

Pituitary homeobox 3 tetracycline-transactivator expression: horizontal sections (case 5154)

S. Lillehaug, M. Yetman, M. Puchades, M. Checinska, J. Jankowsky, J.G. Bjaalie & T.B. Leergaard
Bright-field microscopy images of serial horizontal brain sections showing Pituitary homeobox 3 (Pitx3) promoter expression in a bigenic Pitx3-tetracycline-transactivator (tTA) mouse brain (case 5154, adult female), using a driver-reporter construct in which the Pitx3-tTA promoter regulates the expression of the E. coli derived LacZ reporter gene encoding β-galactosidase, which is visualized histologically using X-gal (5-Bromo-4-chloro-3-indolyl β-d-galactopyranoside) as a substrate. Our data show that the Pitx3-tTA promoter is spatially restricted to the substantia nigra, ventral tegmental...

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