364 Works

The contribution of NMDA and AMPA receptors to persistent firing in the dorsolateral prefrontal cortex in working memory

P. R. Roelfsema, B. Van Vugt, T. Van Kerkoerle & D. Vartak
In this dataset we compared the contribution of NMDA and AMPA receptors to persistent firing in the dorsolateral prefrontal cortex (dlPFC) of male macaque monkeys performing a delayed saccade to a memorized spatial location. We used iontophoresis to eject small amounts of glutamate receptor antagonists (APV for blocking NMDA-Rs, CNQX for blocking AMPA-Rs), aiming to perturb but not abolish neuronal activity. We found that both AMPA-Rs and NMDA-Rs contributed to persistent activity. Blockers of the...

Metadata Schema of the Common Data Elements for Dementia (v3)

K. Karozos, L. Abu-Nawwas, I. Spartalis & V. Vassalos
Data in the Medical Informatics Platform (MIP) resides in hospital servers and never leaves the hospital. Analyses and experiments are executed with respect to that principle while preserving patients’ anonymity making it infeasible for their identity to be inferred. Hospitals importing their data to the Medical Informatics Platform join a federation so as to run analyses on data from other hospital nodes as well. Each federation in the MIP refers to a specific Medical Condition....

Topography of pontocerebellar neurons projecting to posterior lobe of the rat cerebellum

F. Odeh, R. Ackerley, J.G. Bjaalie & R. Apps
3D reconstructed point coordinate data representing the spatial location of the somata of pontine neurons projecting to face, forelimb, and hindlimb receiving parts of the paramedian lobe and cupula pyramidis of the rat cerebellum. The data show that somata of pontocerebellar neurons targeting to the face, forelimb and hindlimb zones of the paramedian lobule, respectively, are located in progressively more caudal parts of the pontine nuclei with little of no overlap.

Topography of the complete corticopontine projection

T.B. Leergaard & J.G. Bjaalie
3D reconstructed point coordinate data representing the spatial location of anterogradely labeled corticopontine axonal projections originating from frontal, parietal, temporal or occipital areas of the cerebral cortex. The data show that corticopontine projections from the entire cerebral cortex are topographically organized in the pontine nuclei, following a principal map that allows fairly accurate prediction of pontine target area for any site of origin in the cerebral cortex.

Blood flow simulations in realistic microvascular networks of the mouse cortex

F. Schmid, P. Jenny & B. Weber
The data set contains various time-averaged blood flow fields in realistic microvascular networks from the mouse somatosensory cortex. The underlying numerical model accounts for the key red blood cell (RBC) related flow phenomena for microvascular flow. Besides the baseline flow field we provide the time-averaged flow field for 120 cases where a single capillary has been dilated by 10%. All results are provided for the standard numerical model and for model variations where individual or...

Probabilistic cytoarchitectonic map of CA2 (Hippocampus) (v11.1)

N. Palomero-Gallagher, O. Kedo, H. Mohlberg, K. Zilles & K. Amunts
This dataset contains the distinct probabilistic cytoarchitectonic map of CA2 (Hippocampus) in the individual, single subject template of the MNI Colin 27 reference space. As part of the Julich-Brain cytoarchitectonic atlas, the area was identified using classical histological criteria and quantitative cytoarchitectonic analysis on cell-body-stained histological sections of 10 human postmortem brains obtained from the body donor program of the University of Düsseldorf. The results of the cytoarchitectonic analysis were then mapped to the reference...

Probabilistic cytoarchitectonic map of CA1 (Hippocampus) (v11.1)

N. Palomero-Gallagher, O. Kedo, H. Mohlberg, K. Zilles & K. Amunts
This dataset contains the distinct probabilistic cytoarchitectonic map of CA1 (Hippocampus) in the individual, single subject template of the MNI Colin 27 reference space. As part of the Julich-Brain cytoarchitectonic atlas, the area was identified using classical histological criteria and quantitative cytoarchitectonic analysis on cell-body-stained histological sections of 10 human postmortem brains obtained from the body donor program of the University of Düsseldorf. The results of the cytoarchitectonic analysis were then mapped to the reference...

Simultaneous 2-photon calcium imaging in dendritic tufts & cell bodies of single pyramidal neurons in mouse V1

K. Seignette, L. De Kraker, C. Van Der Togt & C. Levelt
Although it is thought that cortical feedback is crucial for accurate sensory perception and awareness, it remains unclear how feedforward and feedback information is integrated at the level of individual neurons. It is believed that feedforward sensory information inputs mostly enter dendrites near the cell body, while feedback information about what is to be expected would enter at the dendritic tufts. We present a dataset containing semi-simultaneously recorded calcium signals in layer 5 pyramidal neurons...

3D reconstructions of mouse striatal and cerebellar neurons

A. Muñoz, D. Sánchez-Ponce, L. Blazquez-Llorca & J. DeFelipe
We have produced 3D reconstructions of D1 striatal neurons and Stellate, Basket, Golgi and Granular neurons of the cerebellum of the mouse using Neurolucida software from 3D confocal stack of images. Data from 3D reconstructions will be useful to modeling and integration of anatomical data with functional studies in these brain regions.

Co-activation based parcellation of the human intraparietal sulcus

E. C. Cieslik-Köchling, V. I. Müller, C. Grefkes, A. R. Laird, P. T. Fox & S. B. Eickhoff
It is known that the intraparietal sulcus (IPS) can be subdivided into different modules based on their cytoarchitectonic organization. We here used co-activation based parcellation to identify distinct functional submodules within human bilateral IPS based on their task-based co-activation profile across neuroimaging studies. That is, left and right IPS, were used as seed regions and for all voxels in these regions of interest the co-activation profile across neuroimaging experiments reported in the Brainmap Database was...

GapMap Frontal II (v9.1)

K. Amunts, H. Mohlberg, S. Bludau & P. Pieperhoff
This dataset contains the “Gap Map Frontal II” in the individual, single subject template of the MNI Colin 27 as well as the MNI ICBM 152 2009c nonlinear asymmetric reference space. In order to provide whole-brain coverage for the cortex within the Julich-Brain Atlas, yet uncharted parts of the frontal cortex have been combined to the brain region “Gap Map Frontal II”. The distributions were modeled so that probabilistic gap maps were computed in analogy...

GapMap Frontal to Occipital (v9.1)

K. Amunts, H. Mohlberg, S. Bludau & P. Pieperhoff
This dataset contains the “GapMap Frontal to Occipital” in the individual, single subject template of the MNI Colin 27 as well as the MNI ICBM 152 2009c nonlinear asymmetric reference space. In order to provide whole-brain coverage for the cortex within the Julich-Brain Atlas, yet uncharted parts of the frontal cortex have been combined to the brain region “GapMap Frontal to Occipital”. The distributions were modeled so that probabilistic gap maps were computed in analogy...

GapMap Frontal II (v9.2)

K. Amunts, H. Mohlberg, S. Bludau & P. Pieperhoff
This dataset contains the “Gap Map Frontal II” in the individual, single subject template of the MNI Colin 27 as well as the MNI ICBM 152 2009c nonlinear asymmetric reference space. In order to provide whole-brain coverage for the cortex within the Julich-Brain Atlas, yet uncharted parts of the frontal cortex have been combined to the brain region “Gap Map Frontal II”. The distributions were modeled so that probabilistic gap maps were computed in analogy...

GapMap Frontal I (v9.2)

K. Amunts, H. Mohlberg, S. Bludau & P. Pieperhoff
This dataset contains the “Gap Map Frontal I” in the individual, single subject template of the MNI Colin 27 as well as the MNI ICBM 152 2009c nonlinear asymmetric reference space. In order to provide whole-brain coverage for the cortex within the Julich-Brain Atlas, yet uncharted parts of the frontal cortex have been combined to the brain region “Gap Map Frontal I”. The distributions were modeled so that probabilistic gap maps were computed in analogy...

Characterization of striatal neurons in Parkinson’s disease patients and healthy individuals using scRNA-seq

S. Warnat-Herresthal, T. Varga, K. Händler, S. Bourry, E. Hinkley, A. Ulusoy, S. Weber, D. A. Di Monte, J. L. Schultze & M. Beyer
The goal was to define the cellular subpopulation structure in the striatum of humans and the characterization of the functional and pathologic changes associated with nigro-striatal denervation and L-dopa treatment for striatal neurons and interneurons. Therefore, after isolation of NeunN-expressing nuclei from fresh-frozen striatal tissues (putamen and caudate nucleus), nuclei were used to generate single-cell transcriptomes using a commercial microwell-based assay. After library preparation and sequencing, the generated data were further processed and aligned against...

3D reconstruction and analysis of four human brain cortex samples with two-photon fluorescence microscopy

I. Constantini, G. Mazzamuto, M. Roffilli, A. Laurino, F. Castelli, M. Neri, G. Lughi, A. Simonetto, E. Lazzeri, L. Pesce, C. Destrieux, L. Silvestri, V. Conti, R. Guerrini & F. Pavone
Following the SWITCH/TDE tissue transformation method, a robust methodology to clear and label human brain tissue, we use Two-Photon Fluorescence Microscopy to acquire 4 samples of human brain cortex originating from subjects of different ages and health condition (young, adult and elderly, both healthy and pathological). Then, a 2.5D method based on Convolutional Neural Networks is applied to automatically segment individual neurons. The raw images acquired at the microscope and the resulting vectorial data in...

Coregistration of simultaneous HD-EEG and intracranial EEG during single pulse intracerebral stimulation in wakefulness and sleep

A. Pigorini, E. Mikulan, S. Russo, A. Cattani, S. Parmigiani, S. Sarasso, F.M. Zauli, A. Rubino, M. Fecchio, C. Campana, S. Gibbs, F. Amico, L. Tassi, G. Lo Russo, I. Sartori, L. Nobili & M. Massimini
Complexity, defined as the coexistence of functional differentiation and functional integration is a general property of thalamo-cortical circuits that can be characterized at multiscale level. Previously, we mainly focused on the relationship between slow waves and complexity, explored by perturbations and electrophysiological recordings, from micro- to macro-scale. The final goal was to link dynamics occurring at the micro-scale, such as sleep-like neuronal bistability, to the collapse/emergence of global patterns of complex interactions among brain areas...

TMS-EEG perturbation in patients with disorders of consciousness

F. Raimondo, A. Wolff, L. Sanz, A. Barra, H. Cassol, M. Carrière, S. Laureys & O. Gosseries
Patients with disorders of consciousness (DOC) are awake but are unable to communicate and report upon their level of awareness. While standardized behavioral evaluation has been the most reliable clinical tool to diagnose DOC, neuroimaging and electrophysiology have proven to be techniques that can provide complementary information to the behavioral assessment. This multimodal dataset contains data from DOC patients, including structural magnetic resonance imaging, resting state high-density electroencephalography, electroencephalography during stimulation with transcranial magnetic pulses...

Densities and 3D distributions of synapses using FIB/SEM imaging in the human Hippocampus (CA1) – Extension with additional subregions

M. Dominguez-Alvaro, M. Montero, L. Alonso-Nanclares, R. Rodriguez & J. DeFelipe
For this dataset synapses have been identified, segmented and quantified in the deep part of the pyramidal layer, the stratum oriens and the stratum lacunosum-moleculare of the CA1 field of the human hippocampus with 3D electron microscopy (FIB-SEM). 5 human autopsies have been used to achieve a total of 15 valid images stacks (3 stacks per case) per investigated region. Data include the number and density per volume of asymmetric and symmetric synapses, their sizes...

Volume fraction of the mouse HLS1 cortical column per layer at light microscopy

L. Alonso-Nanclares & A. Kastanauskaite
Data on the volume occupied by the different elements (neuropil, neurons, glia and blood vessels) will be used to complete microanatomical data for the model of the mouse somatosensory cortex and to help the functional interpretation of the data obtained from in vivo physiological experiments. Volume fraction has been determined in the mouse hindlimb region of the somatosensory cortex (HLS1) using light microscopy in the following cortical layers: I, II, III, IV, Va, Vb and...

Densities and 3D distributions of synapses using FIB/SEM imaging in the human neocortex (Trans entorhinal cortex, TEC)

L. Alonso-Nanclares, L. Blazquez-Llorca, M. Dominguez-Alvaro, M. Montero-Crespo, J.R. Rodriguez & J. DeFelipe
Synapses have been identified, segmented and quantified in the human neocortex (trans entorhinal cortex, TEC) with 3D electron microscopy (FIB-SEM). Layer II of the TEC has been studied. 5 cases have been used (AB1, AB2, IF10, M16 and M17) to achieve a total of 15 valid images stacks. Data obtained include the number of asymmetric and symmetric synapses, their sizes and their spatial distribution. The distribution of their post-synaptic targets has also been determined.

CCEP database of the Medical Informatics Platform

O. David, A. Jegou, A. Boyer, M. Jedynak, V. Tuyisenge, C. Saubat-Guigui, R. Zouglech, B. Chanteloup-Foret, C. Benar, A. Trebuchon, F. Bartolomei, A. Schulze-Bonhage, S. Rheims, S. Francione, L. Minotti & P. Kahane
Single-pulse direct electrical stimulation of cortical regions in patients suffering from focal drug-resistant epilepsy who are explored using intracranial electrodes induces electrophysiological responses. Such cortico-cortical evoked potentials (CCEP) can be used to infer functional and anatomical brain connectivity. This pseudonymized database in BIDS-iEEG format contains stereotactic EEG data obtained in implanted epileptic patients who were candidates to resective surgery and undergone intracortical stimulations. The data were collected from a multicenter population of 217 patients. This...

Longitudinal imaging of motor-evoked cortical activity before and after stroke

A. L. Allegra Mascaro, E. Conti & L. Sacconi
We recorded time series of calcium activity of cortical pyramidal neurons with wide-field fluorescence microscope. Increase in GCaMP6f fluorescence was indicative of an increase in neuronal activity. The mice were head restrained during the recording session. The field of view of the microscope allows to record cortical activity in the right hemisphere and in a portion of the left one while the mouse is performing a passive extension-active retraction of the left forelimb in a...

Distribution of dopamine 1 receptor positive neurons in the adult male mouse brain

E.R. Cullity, I.E. Bjerke, K. Kjelsberg, T.B. Leergaard & J.H. Kim
High-resolution bright-field microscopy images of coronal brain sections showing dopamine 1 receptor positive neurons across the adult (70 days old) male mouse brain. The dataset consists of image series covering the rostral part of the brain from Drd1a-EGFP mice. For each brain, every fourth section was processed by diaminobenzidine (DAB) immunohistochemistry using a polyclonal anti-GFP (RRID:AB_300798) antibody. The publication related to the dataset furthermore includes stereological counts of positive neurons in the prelimbic, infralimbic and...

3-D point data representing the spatial distribution of corticopontine projections originating in the mouse visual cortex

M. Ovsthus, SC Yates, N Groeneboom, M. Puchades, J.G. Bjaalie & T.B. Leergaard
The 3-D point coordinate data represent the spatial distribution of mouse brain subcortical projections from different parts of the visual cortex to the caudoputamen, thalamus, superior colliculus and pontine nuclei. The point data are derived from segmented images series programmatically downloaded from the Allen Brain Atlas Data Portal. The data are suited for 3-D visualization and comparison the spatial arrangement of visual corticostriatal, corticothalamic, corticocollicular, and corticopontine projections.

Registration Year

  • 2020
    364

Resource Types

  • Dataset
    364