24 Works

Structure-phenotype associations for Julich-Brain Cytoarchitectonic Atlas regions

S. Kharabian Masouleh, S. B. Eickhoff & S. Genon
Our aim in this project was to characterize the behavioral profile of brain regions defined in the Julich-Brain Cytoarchitectonic Atlas by mapping interindividual variability in local structure as measured with grey matter volume (GMV) to interindividual variability in psychometric data. From a large cohort of healthy individuals [Nooner et al. 2012](https://doi.org/10.3389/fnins.2012.00152), we selected a subgroup of 466 participants with good quality preprocessed T1-weighted MR-scans, using CAT12 toolbox [http://www.neuro.uni-jena.de/cat/](http://www.neuro.uni-jena.de/cat/), and available scores in a broad range...

Regional and laminar distribution of receptors for adenosine in the rat brain

L. Zhao, K. Zilles & N. Palomero-Gallagher
The present dataset provides the quantitative regional and laminar distribution of key molecules in signal transfer, namely the adenosine receptors A1 and A2A, in five selected rostrocaudal levels of the rat brain. The receptors were visualized by means of quantitative *in vitro* receptor autoradiography and the selective tritiated ligands cyclopentyl-1,3-dipropylxanthine (DPCPX) and ZM 241385. The high spatial resolution of this method enables quantification of receptor densities in anatomically identifiable cortical structures as detailed as the...

Regional and laminar distribution of receptors for GABA in the rat brain

L. Zhao, K. Zilles & N. Palomero-Gallagher
The present dataset provides the quantitative regional and laminar distribution of key molecules of inhibitory neurotransmission, namely the γ-aminobutyric acid (GABA) receptors GABAA and GABAB as well as the GABAA associated benzodiazepine (GABAA/BZ) binding sites, in five selected rostrocaudal levels of the rat brain. The receptors were visualized by means of quantitative *in vitro* receptor autoradiography and the selective tritiated ligands muscimol, CGP 54626 and flumazenil. The high spatial resolution of this method enables quantification...

3D cyto- and receptor architectonic map of macaque area Opt of the inferior parietal lobe

M. Niu, L. Rapan, T. Funck, S. Froudist-Walsh, L. Zhao, K. Zilles & N. Palomero-Gallagher
A multimodal analysis of the macaque inferior parietal lobule was carried out to create a 3D atlas integrating and reconciling discrepancies between previously published maps. This involved a quantitative and statistically testable approach to the analysis of cytoarchitecture in the macaque monkey inferior parietal lobe, in combination with an in vitro quantitative receptor autoradiographic analysis of the regional and laminar distribution patterns of 15 different neurotransmitter receptors. The borders of the identified areas were traced...

Regional and laminar distribution of receptors for norepinephrine in the rat brain

L. Zhao, K. Zilles & N. Palomero-Gallagher
The present dataset provides the quantitative regional and laminar distribution of key molecules in signal transfer, namely the noradrenergic receptors α1 and α2h, in five selected rostrocaudal levels of the rat brain. The receptors were visualized by means of quantitative *in vitro* receptor autoradiography and the selective tritiated ligands prazosin and UK-14,304. The high spatial resolution of this method enables quantification of receptor densities in anatomically identifiable cortical structures as detailed as the hippocampal regions...

Regional and laminar distribution of receptors for glutamate in the rat brain

L. Zhao, K. Zilles & N. Palomero-Gallagher
The present dataset provides the quantitative regional and laminar distribution of key molecules of excitatory neurotransmission, namely the ionotropic glutamate receptors AMPA, kainate and NMDA, in five selected rostrocaudal levels of the rat brain. The receptors were visualized by means of quantitative *in vitro* receptor autoradiography and the selective tritiated ligands AMPA, kainate and MK-801. The high spatial resolution of this method enables quantification of receptor densities in anatomically identifiable cortical structures as detailed as...

Regional and laminar distribution of dopamine receptors and uptake sites in the rat brain

L. Zhao, K. Zilles & N. Palomero-Gallagher
The present dataset provides the quantitative regional and laminar distribution of key molecules in signal transfer, namely the dopamine receptors D1 and D2, as well as the dopamine uptake sites in five selected rostrocaudal levels of the rat brain. The receptors were visualized by means of quantitative *in vitro* receptor autoradiography and the selective tritiated ligands SCH 23390, racloprid and mazindol. The high spatial resolution of this method enables quantification of receptor densities in anatomically...

Regional and laminar distribution of receptors for serotonin in the rat brain

L. Zhao, K. Zilles & N. Palomero-Gallagher
The present dataset provides the quantitative regional and laminar distribution of key molecules in signal transfer, namely the serotonin receptors 5-HT1A and 5-HT2 in five selected rostrocaudal levels of the rat brain. The receptors were visualized by means of quantitative *in vitro* receptor autoradiography and the selective tritiated ligands 8-OH-DPAT and ketanserin. The high spatial resolution of this method enables quantification of receptor densities in anatomically identifiable cortical structures as detailed as the hippocampal regions...

3D cyto- and receptor architectonic map of macaque area PGop of the inferior parietal lobe

M. Niu, L. Rapan, T. Funck, S. Froudist-Walsh, L. Zhao, K. Zilles & N. Palomero-Gallagher
A multimodal analysis of the macaque inferior parietal lobule was carried out to create a 3D atlas integrating and reconciling discrepancies between previously published maps. This involved a quantitative and statistically testable approach to the analysis of cytoarchitecture in the macaque monkey inferior parietal lobe, in combination with an in vitro quantitative receptor autoradiographic analysis of the regional and laminar distribution patterns of 15 different neurotransmitter receptors. The borders of the identified areas were traced...

3D cyto- and receptor architectonic map of macaque area PG of the inferior parietal lobe

M. Niu, L. Rapan, T. Funck, S. Froudist-Walsh, L. Zhao, K. Zilles & N. Palomero-Gallagher
A multimodal analysis of the macaque inferior parietal lobule was carried out to create a 3D atlas integrating and reconciling discrepancies between previously published maps. This involved a quantitative and statistically testable approach to the analysis of cytoarchitecture in the macaque monkey inferior parietal lobe, in combination with an in vitro quantitative receptor autoradiographic analysis of the regional and laminar distribution patterns of 15 different neurotransmitter receptors. The borders of the identified areas were traced...

Stimulation of the ventral tegmental area in macaques drives category-selective learning in the absence of attention

S. Murris, J. T. Arsenault, R. Raman, R. Vogels & W. Vanduffel
Perception improves by repeated practice with visual stimuli, a phenomenon known as visual perceptual learning (VPL). The interplay of attentional and neuromodulatory reward signals is hypothesized to cause these behavioral and associated neuronal changes, although VPL can occur without attention (i.e. task-irrelevant VPL). In addition, task-relevant VPL can be category-selective for simple attended oriented stimuli. Yet, it is unclear whether category-selective task-irrelevant VPL occurs, nor which brain centers mediate underlying form of adult cortical plasticity....

Whole-brain parcellation of the Julich-Brain Cytoarchitectonic Atlas (v2.6)

K. Amunts, H. Mohlberg, S. Bludau, S. Caspers, S. B. Eickhoff & P. Pieperhoff
This dataset contains the whole-brain parcellation of the Julich-Brain Cytoarchitectonic Atlas in the MNI ICBM 152 2009c nonlinear asymmetric reference space ([Evans et al., 2012](https://www.sciencedirect.com/science/article/pii/S1053811912000419?via%3Dihub)). The parcellation is derived from the individual probability maps (PMs) of the cytoarchitectonic regions released in the Julich-Brain Cytoarchitectonic Atlas, that are further combined into a Maximum Probability Map (MPM). The MPM is calculated by considering for each voxel the probability of all cytoarchitectonic areas released in the atlas, and...

Anterograde projections of the macaque ventral midbrain

M. Zubair, S. Murris, K. Isa, H. Onoe, Y. Koshimizu, K. Kobayashi, W. Vanduffel & T. Isa
To understand the connectome of the axonal arborizations of dopaminergic midbrain neurons, we investigated the anterograde spread of highly sensitive viral tracers injected into the ventral tegmental area (VTA) and adjacent areas in three macaques. In two monkeys, injections were centered on the lateral VTA with some spread into the substantia nigra, while in one animal the injection targeted the medial VTA with partial spread into the ventromedial thalamus. Double-labeling with antibodies against transduced fluorescent...

3D cyto- and receptor architectonic map of macaque area PFop of the inferior parietal lobe

M. Niu, L. Rapan, T. Funck, S. Froudist-Walsh, L. Zhao, K. Zilles & N. Palomero-Gallagher
A multimodal analysis of the macaque inferior parietal lobule was carried out to create a 3D atlas integrating and reconciling discrepancies between previously published maps. This involved a quantitative and statistically testable approach to the analysis of cytoarchitecture in the macaque monkey inferior parietal lobe, in combination with an in vitro quantitative receptor autoradiographic analysis of the regional and laminar distribution patterns of 15 different neurotransmitter receptors. The borders of the identified areas were traced...

3D cyto- and receptor architectonic map of macaque area PFG of the inferior parietal lobe

M. Niu, L. Rapan, T. Funck, S. Froudist-Walsh, L. Zhao, K. Zilles & N. Palomero-Gallagher
A multimodal analysis of the macaque inferior parietal lobule was carried out to create a 3D atlas integrating and reconciling discrepancies between previously published maps. This involved a quantitative and statistically testable approach to the analysis of cytoarchitecture in the macaque monkey inferior parietal lobe, in combination with an in vitro quantitative receptor autoradiographic analysis of the regional and laminar distribution patterns of 15 different neurotransmitter receptors. The borders of the identified areas were traced...

Genetic variants in autistic and typically developing individuals

C. Leblond, F. Cliquet, A. Mathieu, R. Delorme & T. Bourgeron
The main goal was to analyze the relationship between genotype and phenotype for individuals carrying synaptic mutations. Thus, we extracted from the PARIS cohort individuals (175 autistic individuals and 128 typically developing) all the impactful mutations that are synaptic or directly associated with autism.

Human ultra-high resolution functional imaging data (7 Tesla) on multi-element event memories (general raw data)

X. Grande, D. Berron, A. J. Horner, J. A. Bisby, E. Düzel & N. Burgess
Ultra-high resolution 7Tesla functional MRI data (0.8 mm isotropic) was acquired in 30 young, healthy adults. During data acquisition, participants performed the encoding and retrieval phase of a memory task. Participants learned events, consisting of a popular person, an object (or animal) and a location in a pairwise associative manner. At retrieval, in a 4-alternative forced choice recognition task, one event element served as a cue while a belonging target element was presented among familiar...

Layer-specific excitatory and inhibitory neuronal maps of hippocampus (v1.1)

I. Costantini, G. Mazzamuto, L. Pesce, V. Gavryusev, A. Laurino, M. Scardigli & F. Pavone
The aim of this work is to reconstruct the 3D organization of neurons in a left hippocampus from sub-cellular resolution images obtained by a custom-made dual view inverted light sheet fluorescence microscope. We analyze the left hippocampus of a 99-year old woman, not affected by Alzheimer’s disease, nor hypertension, but presenting a cognitive decline, obtained from the University of Tours. The sample was cut into 72 slices of 500 um thickness before imaging. Each slice...

Molecular characterization of the interneurons in human temporal neocortex by two photon fluorescence microscopy (v1.1)

I. Costantini, G. Mazzamuto, L. Pesce, M. Scardigli & F. Pavone
The aim of this work is to study the 3D organization of some population of interneurons within a sample of interest, previously analyzed for physiological information, using two photon fluorescence microscopy (TPFM). We exploit the high axial and radial resolution of TPFM optical sectioning (0.44 x 0.44 x 2 μm³) in combination with a protocol for tissue clearing and labeling to perform the 3D reconstruction of 300 um thick brain sections. We clear the sections...

Regional and laminar distribution of silver stained cell bodies in the rat brain

L. Zhao, K. Zilles & N. Palomero-Gallagher
Classical mapping studies relied on the analysis of histologically processed sections from formalin-fixed brains for the identification of borders between cortical areas or of the boundaries of subcortical nuclei. Differences in the regional and laminar distribution patterns of neurotransmitter receptors are known to complement and extend the insights into the structural organization of the brain, which are provided by cytoarchitectonic observations alone. Since the method of quantitative *in vitro* receptor autoradiography requires processing of unfixed,...

Dose-dependent effects of ketamine on spontaneous and evoked EEG activity in rats

A. Arena, S. Thon & J. Storm
This dataset contains recordings of spontaneous epidural EEG from a large number of cortical areas and evoked related potentials (ERPs) following local electrical cortical stimulation in 6 rats during deep ketamine anesthesia (keta2). These data can be used in combination with the EBRAINS dataset [PCI-like measure in rodents](https://doi.org/10.25493/S0DM-BK5), where the same rats were recorded during wakefulness (wake) and light ketamine anesthesia (keta1), to identify dose dependent effects of ketamine in cortical activity. For subject j07,...

Regional and laminar distribution of receptors for acetylcholine in the rat brain

L. Zhao, K. Zilles & N. Palomero-Gallagher
The present dataset provides the quantitative regional and laminar distribution of key molecules in signal transfer, namely the muscarinic acetylcholine M1, M2 and M3 receptors as well as the nicotinic acetylcholine α4β2 receptor, in five selected rostrocaudal levels of the rat brain. The receptors were visualized by means of quantitative *in vitro* receptor autoradiography and the selective tritiated ligands pirenzepine, oxotremorine-M, 4-DAMP and epibatidine. The high spatial resolution of this method enables quantification of receptor...

A configurable and empirical model of the synaptic proteome (SQLite database) - Extension with ASD mutations

O. Sorokina, C. McLean, D. Sterratt & D. Armstrong
Integration of 57 published synaptic proteomic datasets reveals a stunningly complex picture involving over 7000 proteins. At the post-synaptic side, multiple studies over the past 19 years appear to be reaching a consensus in terms of gross number and identity of the constituent proteins. Presynaptically the story remains more dynamic with fewer studies and each new study adding new components to the landscape. Molecular complexes were reconstructed using evidence-based protein-protein interaction data available from public...

3D cyto- and receptor architectonic map of macaque area PF of the inferior parietal lobe

M. Niu, L. Rapan, T. Funck, S. Froudist-Walsh, L. Zhao, K. Zilles & N. Palomero-Gallagher
A multimodal analysis of the macaque inferior parietal lobule was carried out to create a 3D atlas integrating and reconciling discrepancies between previously published maps. This involved a quantitative and statistically testable approach to the analysis of cytoarchitecture in the macaque monkey inferior parietal lobe, in combination with an in vitro quantitative receptor autoradiographic analysis of the regional and laminar distribution patterns of 15 different neurotransmitter receptors. The borders of the identified areas were traced...

Registration Year

  • 2021
    24

Resource Types

  • Dataset
    24