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DIETARY AND FOOD SUPPLEMENTS EUROPE 2016 ALL YOU NEED TO KNOW FROM A TO Z

Stoffer LOMAN
The regulatory landscape with respect to food and food supplements in the European Union (EU) is complex. Nevertheless, this complexity is not unsurmountable. Key to the issue is food safety. Although this is sometimes at odds with consumer expectations, who are more interested in health benefits, from a regulatory point of view thorough safety evaluation is the basis for consumer trust and attitude. To ensure the ‘safety first’ principle various Regulations have been issues that...

Bioaccessibil Polyphenols Recovery and Antioxidant Activity of Stirred Fortified Date Yoghurt during In Vitro Digestion

Ahmed Helal
The purpose of this study was to produce functional yoghurt and investigate the in vitro bioaccessibility of polyphenols and antioxidant activity after simulated gastro-intestinal digestion. Fortified stirred yoghurt was produced with the addition of different concentration of date palm products (powder pulp and filtered powder pulp), and stored up to 10 days at 4±1oC. Chemical characteristics, rheological properties and sensory quality of stirred yoghurt samples were determined. All results were compared to control plain stirred...

Vitamin A intake through local food recipes: can be a solution to improve immunity system in Mozambique?

Damiano Pizzol, Francesco Di Gennaro, Laura Monno, Annalisa Saracino, Guillermo Marquez, Michela Romanelli, Giovanni Putoto & Alessandro Bertoldo
Objectives: Vitamin A has fundamental roles in embryonic development, reproduction, bone metabolism, skin homeostasis and vision. Another major role is in immunity, and a vitamin A deficiency seems to undermine also the efficacy of childhood vaccination campaigns (1). In Mozambique about 2.3 million under-5 children are vitamin A deficient (2). The aim of this study is to illustrate sustainable recipes made with local foods to fight child vitamin A deficiency and malnutrition in Mozambique. Methods:...

Polyphenols, reducing sugars and soluble lignin extraction from vine shoots by High Voltage Electrical Discharges, enzymatic and alkaline hydrolyses

Hiba N. Rajha, Nicolas Louka, Sally El Kantar, Nadia Boussetta, Eugene Vorobiev & Richard G. Maroun
In this study, the efficiency of enzymatic (Viscozyme® L) and alkaline (1 M NaOH) hydrolyses in terms of polyphenol, reducing sugars’ and lignin extraction from Vitis vinifera vine shoots var. Grenache Blanc was showed. The combination of High Voltage Electrical Discharges (HVED) with enzymatic hydrolysis was also conducted prior to alkaline hydrolysis. Enzymatic hydrolysis (24 FBGU/g) extracted 2 mg/g of polyphenols, 80 mg/g of reducing sugars and 0.7 % of soluble lignin, whereas alkaline hydrolysis...

CAPER (CAPPARIS OVATA) WATER EXTRACT AS AN EFFICIENT PREPARATION FOR TREATMENT OF MULTIPLE SCLEROSIS-

Alaattin SEN, Ozden Ozgun, Gurbet Celik Turgut, Sevki Arslan, Seda Ozbal & Bekir Ergur
This study was performed to elucidate the molecular mechanisms of Capparis ovata extract on experimental animal model of multiple sclerosis. Capparis ovata water extract was prepared as described (Turkish Patent Institute, PT 2012/04 093). Animal MS model, experimental allergic encephalomyelitis (EAE) was induced in 6-8 weeks old C57BL/6 mice. MSCov was given to EAE-induced mice intragastrically for 21 days, at 500 mg/kg. At the end of the treatment, RNA was isolated, and cDNA was synthesis...

Protective effect of antioxidants consumption on diabetes, hepatic and vascular complications: alliance between chemistry and biology

Stéphanie Dal, Remmelt Van Der Werf, Catherine Walter, William Bietiger, Elodie Seyfritz, Carole Mura, Claude Peronet, Julie Legrandois, Dalal Werner, Said Ennahar, Fabien Digel, Michel Pinget, Nathalie Jeandidier, Eric Marchioni & Séverine Sigrist
Objectives: Oxidative stress plays a major role in the pathophysiology of type 2 diabetes and today new therapeutics target natural antioxidants as an alternative/additional strategy. Our studies, combining chemistry and biology, aimed to compare the anti-oxidant properties of fruits and vegetables (F&V) and to validate in vivo the effect of selected products on diabetes and complications. Methodology: HPLC-ABTS.+ assay was realized on 27 F&V extracts (polar, nonpolar, oil). In vivo, diabetes was induced by 2...

Novel GSH analogues (UPF peptides) reduce the oxidative stress in liver of Wfs1-deficient mice

Rando Porosk, Riina Mahlapuu, Kalle Kilk, Mihkel Zilmer & Ursel Soomets
Wolfram syndrome 1 (WS) is a rare autosomal recessive neurodegenerative disease, which is characterized by DIDMOAD (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy and Deafness). WS is caused by the mutations in Wolfram syndrome 1 gene (WFS1) encoding transmembrane glycoprotein called wolframin is which primarily located in ER and Wfs1-deficiency causes ER and oxidative stress followed by cell dysfunction [1]. This research concentrates on the influence of NAC and novel GSH analogues (UPF peptides) on the...

The Radio-protective effects of Propolis and Nigella Sativa oil on oxidative stress in liver tissue of rats exposed to total head irradiation

Seyithan TAYSI
Objectives: Our purpose is to investigate Propolis and Nigella sativa oil (NSO) for their antioxidant effects on the liver tissue of rats exposed to ionizing radiation. Methodology: A total of 32 Sprague–Dawley rats were divided into five groups to test the radioprotective effectiveness of of Propolis and NSO administered by orogastric tube. Appropriate control group was also studied. Biochemical parameters in liver tissue of rats were determined by spectrophotometer. Results: Xanthine oxidase (XO), nitric oxide...

Nutritional Quality of Purslane and its Crackers

Eman Mohamrd Salem
Purslane has been described as a power food of future because of its high nutritive and its anti-oxidant properties. Purslane, also, has a high content of phenols (179.89 mg/100gm). The radical scavenging activity (RSA) of purslane is high (89.23%). Linolenic acid (omega 3 fatty acid) was the most fatty acid abundant in purslane (44.29%). Therefore, in the current study, crackers were fortified with purslane by three levels of previously prepared puslane powder (5, 10 and...

Pomegranate Antioxidants and Brain Health

Ghazi Ahmad Daradkeh & Ghazi Ahmad Daradkeh
Pomegranate Antioxidants and Brain Health Ghazi Daradkeh, Essa MM, Subash S, AL Adawi S, Akbar M, Wali MI Background: pomegranate has characteristically high content of antioxidant substances. free radicals such as ROS,NOS,O2,H2O2, OH. and nitric oxide can be scavenged effectivelly by pomegranate juice. A synergic positive relationship was found between phenolic contents and total antioxidant capacity, indicating that phenolic is dominant antioxidant components of pomegranate. 0bjectives: to evaluate the effect of pomegranate juice supplementation on...

Characterization of Antioxidant rich Cordyceps sinensis fractions by Semi- Preparative HPLC

RAKHEE Rajput, Anuja Bhardwaj1, Jigni Mishra, Raj Kishore Sharma & Kshipra Misra
Cordyceps sinensis (C. sinensis) is an exotic fungus that parasitizes on caterpillar larvae. It is called “Winter Worm and Summer Grass” due to its characteristic life cycle [1]. It is grown at heights 15,000 feet and above. C. sinensis is being used for the prevention and cure of various ailments in human beings due to its well established therapeutic importance such as anti-ageing, anticancer, anti-diabetic, antihypoxia, anti-inflammatory, antioxidant and antitumor activities. It is also known...

Can fish oil emulsion rich in omega-3 fatty acids influence symptoms of depressive disorder and antioxidant status in children?

Zdeňka Ďuračková, Jana Trebatická, Zuzana Hrsdečná, František Böhmer, Magdaléna Vaváková, Iveta Waczulíková, Iveta Garaiova, Zuzana Nagyová, Igor Škodáček & Ján Šuba
Background Omega-3 fatty acids (FA) have emerged as a adjuvant therapy for depressive disorder. The primary objective of this pilot, single-centre, randomized, double-blind and active-controlled study was to compare the efficacy of omega-3 FA fish oil with omega-6 FA sunflower oil emulsions during standard treatment of depressive symptoms in children and to investigate the antioxidant status of depressive children. Methods 36 children aged 11 to 17 years were randomised to the intervention groups. Children's Depression...

Effect of Renal Transplantation on Selected Biomarkers of Oxidative Stress and Oxidative Modification of Biomolecules

Zuzana Országhová, Zuzana Paduchová, Martina Horváthová, Mária Chomová, Miriam Ježovičová, Zuzana Žilinská, Branislav Trebatický & Jana Muchová
It was demonstrated that oxidative stress plays important role in patients with end-stage renal disease. The aim of this study was to evaluate the effect of transplantation on oxidative stress level in patients compared to the patients on dialysis. 49 patients who underwent a renal transplantation and 63 patients on dialysis (with CKD) were included in study. Kidney transplant patients had good graft function (MDRD = 1.078 ml/s per 1.73m2, serum creatinine levels 99.18 micromol/l)....

The Role of Oxidative Stress in Inflammation in Patients with Rheumatoid Arthritis

The aim of this study is to determine the level of blood markers of cellular oxidative stress and then to establish the oxidative profile in 145 patients with rheumatoid arthritis (RA). The samples of the study include patients with RA. They were achieved four or more of the criteria of the 2010 American College of Rheumatology, the samples of the study was conducted to fifty persons apparently healthy volunteered to perform the test of this...

THE EFFECTS OF CHERRY SEED OIL, BLACK CUMIN OIL AND TAURUS FIR RESIN ON OXIDATIVE STRESS AND TRACE ELEMENTS DURING CUTANEOUS WOUND HEALING

Ergul Belge Kurutas
Background: Elimination of oxidative stress and determination of trace element status may be an important strategy to improve healing of wounds. This the first study, we aimed to investigate the levels of oxidative stress biomarkers and trace elements during cutaneous wound healing. Materials and Methods: Thirty rats were used in this study. Our study consisted of six groups such as sham group, control group, cherry seed oil group, black cumin oil and taurus fir resin...

Isolation of Anti-Allergic Activities from an Edible Plant: Implications for Development of Safe and Effective Therapeutics, Nutraceuticals and Drugs, for Allergic Diseases.

Doo Suk Lee, Min-Jung Bae, Hyun-Keun Kim & Sunyoung Kim
Allergic diseases are highly prevalent and their incidences are increasing, especially in developed countries. However, many patients have concerns about medicine-related side-effects and/or financial strains. There has been a strong need for the development of safe, cost-effective and efficacious agents for allergic diseases as currently available agents don’t provide a fundamental treatment method. Due to its complex nature involving multiple factors, these diseases cannot be effectively treated by targeting a single molecule in the body....

Ameliorating effects of HX106N, a Botanical Formulation, on Memory Impairment: Study of Underlying Mechanisms and Data from Randomized Double-blind Placebo-Controlled Clinical Study.

Doo Suk Lee, Hyun-Keun Kim & Sunyoung Kim
HX106N is a water-soluble extract prepared from a specially formulated mixture of four plant species traditionally used for the treatment of various neurological diseases. Effects of HX106N were tested in three different systems. First, it was tested on memory impairment and oxidative stress caused by the intracerebroventricular injection of Aβ25-35 peptide in mice. HX106N treatment reversed the Aβ25-35-mediated decrease in alternation percentage and latency time in the Y-maze and passive avoidance tests. Second, HX106N was...

Therapeutic effects of anti-arthritic botanical formulations, PG201 and Eucomix, in arthritis animal models and humans with osteoarthritis.

Min-Jung Bae, Doo Suk Lee, Hyun-Keun Kim & Sunyoung Kim
We developed two botanical formulations named, PG201 (drug) and Eucomix (nutraceuticals). These formulations have previously been shown to contain strong anti-inflammatory and analgesic effects in animal models, and in double-blind placebo controlled Phase II and Phase III clinical trials in the case of PG201. We found that therapeutic activities of these formulations result in part from activation of HO-1. Nrf2 is well-known to play a critical role(s) in anti-oxidative and cytoprotective processes through the induction...

MECHANISMS OF THE RESPIRATORY AND CARDIOVASCULAR EFFECTS OF WATER-PIPE (SHISHA) SMOKING: ROLE OF OXIDATIVE STRESS AND INFLAMMATION, AND THE POTENTIAL MITIGATING EFFECT OF ANTIOXIDANT

Abderrahim NEMMAR
Water-pipe smoking (WPS) is popular in the Middle East and is disseminating particularly quickly in Europe and North America. It is commonly and wrongly perceived to be less harmful than other forms of tobacco use. Clinical studies have reported difficulties in studying the isolated effects of WPS because most of the smokers are also current or past cigarette smokers. Therefore, experimental studies investigating the pathophysiological mechanisms underlying the respiratory and cardiovascular adverse effect of WPS...

OXIDATIVE STRESS IN DIABETES-INDUCED CANCER:MASTER PLAYERS IN A NEW COMPLICATION

Antoine Eid ASSAAD
Both diabetes and cancer are prevalent diseases whose incidence is increasing worldwide. Epidemiological studies provide strong evidence that subjects with diabetes are at significantly higher risk of developing many forms of cancer and especially solid tumors. In addition to pancreatic and breast cancer, the incidence of colorectal cancer is increased in type 2 diabetes. While diabetes and especially type 2 diabetes and cancer share many risk factors, the biological links between the two diseases are...

ON THE ROLE OF ROS AND ANTIOXIDANTS IN TUMOR INITIATION AND PROGRESSION

Martin BERGÔ
It is well established that reactive oxygen species (ROS) can cause DNA damage that can turn a normal cell into a cancer cell and that antioxidant supplementation can prevent this process and inhibit tumor initiation. However, recent studies indicate that ROS can inhibit the proliferation of lung cancer cells and inhibit metastasis of malignant melanoma cells, and consequently, antioxidant supplementation can accelerate tumor growth and facilitate metastasis. Thus, Pr Bergö's team argues that ROS is...

Effect of weight loss on antioxidant enzymes and their relationship with the antioxidant vitamins A,C, E food intake in obese women

Masoud Ramezanipour
General information, anthropometric measurements, 3-day food recall, and fasting blood samples were collected from 30 obese women at the beginning of the study and after 3 months intervention. Weight loss was set at about 10% of their weight before the intervention. Glutathione reductase and catalase activities showed a significant increase (P<0.01) after weight reduction, but no significant changes were seen in the superoxide dismutase and glutathione peroxidase activities. There was a positive linear correlation between...

Bioaccessibil Polyphenols Recovery and Antioxidant Activity of Stirred Fortified Date Yoghurt during In Vitro Digestion

Ahmed Helal
The purpose of this study was to produce functional yoghurt and investigate the in vitro bioaccessibility of polyphenols and antioxidant activity after simulated gastro-intestinal digestion. Fortified stirred yoghurt was produced with the addition of different concentration of date palm products (powder pulp and filtered powder pulp), and stored up to 10 days at 4±1oC. Chemical characteristics, rheological properties and sensory quality of stirred yoghurt samples were determined. All results were compared to control plain stirred...

EVALUATION OF ANTIOXIDANTS ISOLATED FROM SOME PLANTS, GROWN IN EUROPE AND MIDDLE EAST BY HIGH PRESSURE EXTRACTION METHODS

Vaida Kraujalienė, Paulius Kraujalis, Audrius Pukalskas & Petras Rimantas Venskutonis
The aim of this study was to evaluate the effectiveness of isolation of antioxidants from bergenia (Bergenia rassifolia L.) (BCr), buckwheat flowers (Fogopyrum esculentum) (BF) and European goldenrod leaves (Solidago virgaulea) (RL) using pressurised liquid extraction (PSE) with increasing polarity solvents (hexane, acetone, ethanol:water(80:20) and water), and supercritical fluid extraction with pure carbon dioxide (SFE–CO2) and with added co–solvent ethanol. The yields of BCr, BF and RL extracts obtained by SFE–CO2 varied from 0.37 (BCr)...

Ameliorating effects of HX106N, a Botanical Formulation, on Memory Impairment: Study of Underlying Mechanisms and Data from Randomized Double-blind Placebo-Controlled Clinical Study.

Doo Suk Lee, Hyun-Keun Kim & Sunyoung Kim
HX106N is a water-soluble extract prepared from a specially formulated mixture of four plant species traditionally used for the treatment of various neurological diseases. Effects of HX106N were tested in three different systems. First, it was tested on memory impairment and oxidative stress caused by the intracerebroventricular injection of Aβ25-35 peptide in mice. HX106N treatment reversed the Aβ25-35-mediated decrease in alternation percentage and latency time in the Y-maze and passive avoidance tests. Second, HX106N was...

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