Deoxyribonucleic acid, more commonly known as DNA, is a complex double helix-shaped molecule present in all living organisms and hosts thousands of genes. However, only a few genes exhibit differential expression and play a vital role in a particular disease such as breast cancer. Microarray technology is one of the modern technologies developed to study these gene expressions. There are two major microarray technologies available for expression analysis: Spotted cDNA array and oligonucleotide array. The...

It is widely accepted that plasma membrane permeabilization after PEF occurs due to hydrophilic pores formation in the lipid bilayer. The concept of pore formation is confirmed by molecular dynamics (MD) simulations. However, there is increasing evidence that PEF can cause not only hydrophilic pore formation but also modulate membrane proteins and their function, and these changes could be part of increased membrane’s permeability after PEF. Ion channels, especially voltage-gated ion channels, are probable targets...

Major advances have been made in cancer immunotherapy. One example is checkpoint blockade immunotherapy which has been approved by FDA to treat numerous cancer types resulting in a substantial increase in the number of lives saved. However, two major hurdles; low response rates, especially to poorly immunogenic cancers and immune-related adverse events (irAEs), limit its broader applications. Differently, a number of tumor ablation modalities have been studied to improve antitumor immunity, nevertheless, low potency is...

The Virginia Department of Corrections (VADOC) is responsible for about 28,000 inmates and 66,000 probationers and parolees annually. Mental health services are often conducted through therapeutic groups, many of which are manualized and based in cognitive behavioral therapy theory. In the three years, 2017 through 2019, VADOC conducted 172 therapeutic group therapy studies, and the resulting data, in the form of t-test scores, were made available for academic research. This meta-analysis investigated whether cognitive behavioral...

The rapid rise of shared electric scooter (E-Scooter) systems offers many urban areas a new micro-mobility solution. The portable and flexible characteristics have made E-Scooters a competitive mode for short-distance trips. Compared to other modes such as bikes, E-Scooters allow riders to freely ride on different facilities such as streets, sidewalks, and bike lanes. However, sharing lanes with vehicles and other users tends to cause safety issues for riding E-Scooters. Conventional methods are often not...

Low molecular weight gelators (LMWGs) are small molecules that self-assemble in appropriate solvents to form three dimensional networks that immobilize the solvent, creating a supramolecular gel. The self-assembly of LMWGs occurs through non-covalent interactions such as hydrogen bonding, aromatic interactions, donor-acceptor interactions, Van der Waals interactions, hydrophobic forces, halogen bonding, etc. Due to self-assembly occurring through reversible non-covalent interactions, supramolecular gels can undergo a gel to solution transformation. Because of this, these materials can be...

Decades after the landmark United States Supreme Court decision of Brown v. The Board of Education of Topeka in 1954, the push continues to make schools a safe and welcoming environment for Black and Brown students. Black students in particular are continuing to be oppressed and marginalized in PK-12 educational settings. Accounting for approximately 15% of public PK-12 students, Black students comprise 13.7% of all students who receive out-of-school suspensions in 2017, are 16% of...

TikTok, a video sharing application, has become the center of viral internet culture. The app has risen in popularity so quickly that scholarly literature investigating its vast societal impact is still nascent. TikTok is not only used to discuss popular culture topics and create trends, but also being utilized as a tool for social justice activism in the United States in the wake of a tumultuous year with major events such as the coronavirus pandemic,...

Wind tunnels are used to study forces and moments acting on an aerodynamic body. While most results involve some interference from the mechanical supports used to hold the model, a Magnetic Suspension and Balance System (MSBS) is void of these interferences and presents an ideal test scenario. To further investigate the feasibility of dynamic stability testing at supersonic speeds using a MSBS, a preliminary design idea is currently being developed using an existing MSBS in...

Distributed systems like fluid flow and heat transfer are modeled by partial differential equations (PDEs). In control theory, distributed systems are generally reformulated in terms of a linear state space realization, where the state space is an infinite dimensional Banach space or Hilbert space. In the finite dimension case, the input-output map can always be written in terms of a Chen-Fliess functional series, that is, a weighted sum of iterated integrals of the components of...

Public and scholarly interest in the concept of work as a calling has grown considerably over the past few decades (Thompson & Bunderson, 2019). Much of this research has focused on the positive outcomes of calling, including increased work engagement (e.g., Dobrow Riza et al., 2019) and job performance (e.g., Park et al., 2016). However, a few studies have focused on the negative outcomes of calling, such as limited psychological detachment from work (Clinton et...

When space programs launch vehicles into orbit, multiple failures could arise throughout the mission and corrective actions are often not an option. Applying reliability engineering approaches during the design phase focuses on analyzing risk by anticipating potential failures and mitigating uncertainties in the design. Old Dominion University, in partnership with the U.S. Coast Guard Academy, and the U.S. Air Force Institute of Technology designed and developed a 3U CubeSat mission to validate on-orbit, three space...

The development of metallic coatings with high purity and high thermal conductivity at cryogenic temperature could be very important for application to the superconducting radiofrequency (SRF) cavity technology. The deposition of such bulk coatings on the outer surface of a niobium cavity could result in higher heat conductance and mechanical stiffness, both of which are crucial for enhancing the cavity performance at a reduced cost. Cold spray technology was used to deposit bulk coatings of...

This thesis examines United States policy towards Israel from 1948 to 1952 to determine the extent to which the support given to Israel during the Truman administration reflected the major United States policy goal in the Middle East, the containment of the Soviet Union. Sources used in this thesis include: archival material; printed collections of documents; memoirs; and secondary sources. The Truman administration pursued containment in the Middle East by cooperating with Great Britain to...

Introduction: Oral health has a significant impact on pregnancy outcomes. Inter-professional collaboration can assist in bridging the gap between oral and systemic health and assist in optimizing the health of low-income pregnant women, infants, and children. Methods: A literature review was used to ascertain the impact of oral health on adverse pregnancy outcomes. Research sources used in this literature review were gathered from the U.S. National Library of Medicine at the National Institutes of Health,...

Cognitive theories suggest that attentional biases may contribute to both social anxiety and depression, such that attention may be biased to focus on or away from certain information (e.g., rejecting or sad images; Clark & McManus, 2002; Lemoult & Gotlib, 2019). Although research is mixed, recent studies using a neural measure called the N2pc (an event-related potential) has indicated attentional biases in social anxiety. However, little N2pc research has examined depression or co-occurring depression and...

This pilot project assessed cognitive and affective learning outcomes of allied dental students following a disaster victim identification (DVI) multi-media learning module. A convenience sample (n=41) of senior dental hygiene and dental assisting students from two institutions completed an IRB-exempt descriptive pretest/posttest study to assess cognitive and affective changes resulting from exposure to a multimedia DVI learning module of a PowerPoint presentation with audio/video recordings. After completing the learning module, participants were presented with 10...

African Americans have a higher prevalence of obesity compared to any other racial/ethnic group due to a variety of factors, including socioeconomic status. This research paper presents a semi-systematic literature review revealing the impact socioeconomic status has on obesity among African American adults in the United States. In order to gain a comprehensive understanding of this public health issue, we examined the risk factors, risk behaviors, and health outcomes surrounding obesity among this population. An...

Is Vladimir Putin a bad strategist, perhaps irrational? Previous military activity by Russia, such as the annexation of Crimea of 2014, yielded limited international gains, at a significant economic and reputational cost. Yet as the 2022 invasion of Ukraine shows, Putin is willing to commit military power, despite the cost of sanctions and other possible retaliation. This three-player simultaneous game, originally created in June, 2021, demonstrates how domestic and international considerations of President Vladimir Putin...

Per the U.S. Census Bureau (n.d.), a rural area is “any population, housing, or territory NOT in an urban area.” Specifically, a rural area is defined as the area of 5 to 25 miles from an urban area (Geverdt, 2015). Nationally, rural school districts represent nearly 20% of the student population in the United States, but limited attention is given to the unique needs of these areas by national policymakers (Johnson et al., 2018). Rural...

Since 1958, government agencies have used Other Transactions (OT) to encourage innovation and the development of new technology. OTs' purpose is to help government agencies acquire leading-edge technology from private sector sources in a flexible, goal-oriented manner. This dissertation is a pilot study assessing whether innovation policies, specifically 10 USC 2371b (Pub. L. No. 114-92, 2015) that authorizes DoD prototype OTs, influence the Department of Defense (DoD) alternative contracting activities to promote the development of...

Counselor education researchers have explored the need for high levels of cognitive complexity (CC) in mental health counselors due to its relationship with high quality counseling skills and counselor ways of being (e.g., Castillo, 2018; McAuliffe & Lovell, 2006; Ridley et al., 2011; Welfare & Borders, 2010b). In these studies, researchers have called for continued study of means of enhancing CC in counselors in training (CITs) through andragogical efforts (e.g., Castillo, 2018; Duys & Hedstrom,...

Proceedings of the 5th Annual Modeling, Simulation & Visualization Student Capstone Conference held on April 14, 2011 at VMASC in Suffolk, Virginia. 186 pp.

The Virginia Modeling, Analysis and Simulation Center (VMASC) of Old Dominion University hosted the 2015 Modeling, Simulation, & Visualization Student capstone Conference on April 16th. The Capstone Conference features students in Modeling and Simulation, undergraduates and graduate degree programs, and fields from many colleges and/or universities. Students present their research to an audience of fellow students, faculty, judges, and other distinguished guests. For the students, these presentations afford them the opportunity to impart their innovative...

Proceedings of the 11th Annual Modeling, Simulation & Visualization Student Capstone Conference held on April 20, 2017 at VMASC in Suffolk, Virginia.