5,828 Works

Kinder und Jugendliche mit besonderem Versorgungsbedarf im Follow-up: Ergebnisse der KiGGS-Studie 2003 – 2012

Elvira Mauz, Roma Schmitz & Christina Poethko-Müller
Weltweit ist die Häufigkeit chronischer Erkrankungen bei Kindern stark angestiegen. Chronisch kranke Kinder und ihre Familien haben diagnoseübergreifend besondere Herausforderungen zu meistern. Dazu gehört ein erschwerter Übergang in das Erwachsenenalter mit veränderten Versorgungsbedingungen und Zuständigkeiten. An einer Untergruppe der KiGGS-Kohorte wird untersucht, welche Chance chronisch kranke Kinder und Jugendliche haben, im jungen Erwachsenenalter ein Leben zu führen, ohne sich chronisch krank oder gesundheitsbedingt eingeschränkt zu fühlen und zum anderen, welche Faktoren mit einem ungünstigen Verlauf...

Predicted 10-year risk of cardiovascular mortality in the 40 to 69 year old general population without cardiovascular diseases in Germany

Claudia Diederichs, Hannelore Neuhauser, Viktoria Rücker, Markus A. Busch, Ulrich Keil, Anthony P. Fitzgerald & Peter U. Heuschmann
Aims: To estimate the 10-year risk of fatal cardiovascular disease (CVD) in the 40 to 69 year old general population in Germany stratified by sex and to analyze differences between socio-economic status (SES), region and community size in individuals without CVD. The analysis is based on the newly recalibrated SCORE Deutschland risk charts and considered other comorbidities for the classification of the high CVD risk group according to the guidelines of the European Society of...

Seasonal recurrence of cowpox virus outbreaks in captive cheetahs (Acinonyx jubatus)

Julia Stagegaard, Andreas Kurth, Daniel Stern, Piotr Wojciech Dabrowski, Ann Pocknell, Andreas Nitsche & Livia Schrick
Cowpox virus infections in captive cheetahs (Acinonyx jubatus) with high morbidity and mortality have already been reported in the UK and Russia in the 1970s. However, most of the reported cases have been singular events. Here, we report a total of five cowpox virus outbreaks in cheetahs in the same safari park in Denmark between 2010 and 2014. Nine cheetahs showed varying severity of clinical disease; two of them died (22%). All episodes occurred between...

Health and health risk behaviour of adolescents—Differences according to family structure. Results of the German KiGGS cohort study

Petra Rattay, Elena Von Der Lippe, Elvira Mauz, Felicitas Richter, Heike Hölling, Cornelia Lange & Thomas Lampert
Objective: This study’s aim was to investigate the association between family structure and different health-related outcomes in adolescence (self-rated health, emotional and behavioural problems, health-related quality of life, regular smoking, and heavy episodic drinking). Furthermore, we analysed the extent to which socio-economic status, family cohesion and the pre-transition health status explain family structure-related health disparities. Methods: We used longitudinal data from the first two waves of the German KiGGS cohort study carried out by the...

Find and treat or find and lose? Tuberculosis treatment outcomes among screened newly arrived asylum seekers in Germany 2002 to 2014

Anna Kuehne, Barbara Hauer, Bonita Brodhun, Walter Haas & Lena Fiebig
Background: Germany has a low tuberculosis (TB) incidence. A relevant and increasing proportion of TB cases is diagnosed among asylum seekers upon screening. Aim: We aimed to assess whether cases identified by screening asylum seekers had equally successful and completely reported treatment outcomes as cases diagnosed by passive case finding and contact tracing in the general population. Methods: We analysed characteristics and treatment outcomes of pulmonary TB cases notified in Germany between 2002 and 2014,...

Smoking during pregnancy

Martina Rabenberg, Johannes Zeiher, Laura Krause, Panagiotis Kamtsiuris & Thomas Ziese

Impfung gegen humane Papillomviren (HPV) bei Mädchen

Laura Krause, Nina Buttmann-Schweiger, Benjamin Kuntz, Martina Rabenberg & Thomas Ziese

Fruit and vegetable consumption today

Martina Rabenberg & Gert Mensink
This issue will focus the consumption of fruit and vegetable in Germany. One of the questions answered by this article is, if the recommened intake of fruit and vegetable is achieved within the population. The data of the telephone survey "German Health Update" 2009 (GEDA) and EsKiMo, a representative survey on food intake among children and adolescents, provide the answers.

In-season and out-of-season variation of rotavirus genotype distribution and age of infection across 12 European countries before the introduction of routine vaccination, 2007/08 to 2012/13

D. Hungerford, R. Vivancos, J. M. Read, V. E. Pitzer, N. Cunliffe, N. French, M. Iturriza- Gómara & Andreas Mas Marques
The EuroRotaNet surveillance network has conducted rotavirus genotype surveillance since 2007 in 16 European countries. Using epidemiological and microbiological data from 39,786 genotyped rotavirus-positive specimens collected between September 2007 and August 2013, we assessed genotype distribution and age distribution of rotavirus gastroenteritis (RVGE) cases in and out of peak season in 12 countries which were yet to implement routine rotavirus vaccination. In multinomial multivariate logistic regression, adjusting for year, country and age, the odds of...

Hyperspectral infrared nanoimaging of organic samples based on Fourier transform infrared nanospectroscopy

Iban Amenabar, Simon Poly, Monika Goikoetxea, Wiwat Nuansing, Peter Lasch & Rainer Hillenbrand
Infrared nanospectroscopy enables novel possibilities for chemical and structural analysis of nanocomposites, biomaterials or optoelectronic devices. Here we introduce hyperspectral infrared nanoimaging based on Fourier transform infrared nanospectroscopy with a tunable bandwidth-limited laser continuum. We describe the technical implementations and present hyperspectral infrared near-field images of about 5,000 pixel, each one covering the spectral range from 1,000 to 1,900 cm−1. To verify the technique and to demonstrate its application potential, we imaged a three-component polymer blend...

Reiseassoziierte Krankheiten 2015

Robert Koch-Institut
Der Bericht basiert auf den Meldedaten nach Infektionsschutzgesetz (IfSG), die dem Robert Koch-Institut (RKI) mit Datenstand 1. März 2016 übermittelt worden waren. Diese wurden ergänzt um Angaben aus anderen Erfassungssystemen, soweit diese verfügbar waren. Eine Ausnahme bilden Leishmaniose und Zikavirus- Erkrankung. Beide Erkrankungen waren 2015 nicht meldepflichtig. Die Daten zur Leishmaniose stammen vom Institut für Tropenmedizin Berlin. Bezüglich Zikavirus-Erkrankungen wurden die Daten der Fälle ausgewertet, die gemäß IfSG § 7 Abs. 2 (Meldung bedrohlicher Erkrankungen,...

Folatversorgung in Deutschland

Gert Mensink, Anke Weißenborn & Almut Richter
Folat ist wichtig für die Zellteilung und somit für das Wachstum und die Entwicklung des Körpers. Zur Einschätzung der Versorgungslage in der Bevölkerung können im Serum gemessene Folatkonzentrationen herangezogen werden. Der Median des Serumfolats liegt für Erwachsene im Alter von 18 bis 79 Jahren bei 7,5 ng/ml (für Frauen bei 7,9 ng/ml, für Männer bei 7,2 ng/ml). Etwa 86 % der erwachsenen Bevölkerung in Deutschland sind adäquat mit Folat versorgt. In höheren Altersgruppen sowie bei...

Ongoing haemolytic uraemic syndrome (HUS) outbreak caused by sorbitol-fermenting (SF) Shiga toxinproducing Escherichia coli (STEC) O157, Germany, December 2016 to May 2017

Sabine Vygen-Bonnet, Bettina Rosner, Hendrik Wilking, Angelika Fruth, Rita Prager, A. Kossow, Christina Lang, Sandra Simon, Juliane Seidel, Mirko Faber, Anika Schielke, Kai Michaelis, Alexandra Holzer, R. Kamphausen, D. Kalhöfer, S. Thole, Alexander Mellmann, Antje Flieger & Klaus Stark
We report an ongoing, protracted and geographically dispersed outbreak of haemolytic uraemic syndrome (HUS) and gastroenteritis in Germany, involving 30 cases since December 2016. The outbreak was caused by the sorbitol-fermenting immotile variant of Shiga toxin-producing (STEC) Escherichia coli O157. Molecular typing revealed close relatedness between isolates from 14 cases. One HUS patient died. Results of a case–control study suggest packaged minced meat as the most likely food vehicle. Food safety investigations are ongoing.

Clostridium difficile

Robert Koch-Institut

Recommendations of the Standing Committee on Vaccination (STIKO) at the Robert Koch Institute – 2016/2017

Robert Koch-Institut
These STIKO vaccination recommendations were endorsed during the 82nd and 84th STIKO meetings and are considered enacted upon their publication on 29 August 2016. This 2016 version replaces the previous STIKO vaccination recommendations pub-lished in August 2015 in Epidemiologisches Bulletin (Epid. Bull.) 34/2015 of the Robert Koch Institute (RKI). The scientific rationale for the modified STIKO recommendations will be available in Epid. Bull. 35/2016, 36/2016, and 37/2016 on the RKI website.

Changes to cholesterol trafficking in macrophages by Leishmania parasites infection

Geo Semini, Daniel Paape, Athina Paterou, Juliane Schroeder, Martin Barrios-Llerena & Toni Aebischer
Leishmania spp. are protozoan parasites that are transmitted by sandfly vectors during blood sucking to vertebrate hosts and cause a spectrum of diseases called leishmaniases. It has been demonstrated that host cholesterol plays an important role during Leishmania infection. Nevertheless, little is known about the intracellular distribution of this lipid early after internalization of the parasite. Here, pulse-chase experiments with radiolabeled cholesteryl esterified to fatty acids bound to low-density lipoproteins indicated that retention of this...

External quality assessment study for ebolavirus PCR-diagnostic promotes international preparedness during the 2014 – 2016 Ebola outbreak in West Africa

Heinz Ellerbrok, Sonja Jacobsen, Pranav Patel, Toni Rieger, Markus Eickmann, Stephan Becker, Stephan Günther, Dhamari Naidoo, Livia Schrick, Kathrin Keeren, Angelina Targosz, Anette Teichmann, Pierre Formenty & Matthias Niedrig
During the recent Ebola outbreak in West Africa several international mobile laboratories were deployed to the mainly affected countries Guinea, Sierra Leone and Liberia to provide ebolavirus diagnostic capacity. Additionally, imported cases and small outbreaks in other countries required global preparedness for Ebola diagnostics. Detection of viral RNA by reverse transcription polymerase chain reaction has proven effective for diagnosis of ebolavirus disease and several assays are available. However, reliability of these assays is largely unknown...

Rauchen bei Erwachsenen in Deutschland

Johannes Zeiher & Benjamin Kuntz
Rauchen ist ein bedeutendes Gesundheitsrisiko und die führende Ursache vorzeitiger Sterblichkeit. In Deutschland wurden zahlreiche Maßnahmen (z. B. Steuererhöhungen, Nichtraucherschutz und Warnhinweise) auf den Weg gebracht, um den Tabakkonsum der Bevölkerung zu senken. Nach GEDA 2014/2015-EHIS rauchen 20,8 % der Frauen und 27,0 % der Männer ab 18 Jahren zumindest gelegentlich. Bei beiden Geschlechtern ist der Anteil der aktuell Rauchenden in den jüngeren Altersgruppen am höchsten. Das Rauchen ist in höheren Bildungsgruppen bei Frauen und...

Ernährung, Bewegung und Substanzkonsum von Kindern und Jugendlichen

Laura Krause, Christine Anding & Panagiotis Kamtsiuris
Unter dem Begriff des Gesundheitsverhaltens werden gesundheitsförderliche sowie gesundheitsriskante Komponenten des Verhaltens verstanden. Untersucht wird in dieser Arbeit das Gesundheitsverhalten von Kindern und Jugendlichen in Thüringen. Datenbasis ist eine repräsentative Teilstichprobe aus dem in KiGGS Welle 1 (Studie zur Gesundheit von Kindern und Jugendlichen in Deutschland) durchgeführten Landesmodul Thüringen (2010–2012; n = 4096; 3–17 Jahre). Das Gesundheitsverhalten wird entlang von neun Indikatoren beschrieben: Obst- und Gemüseverzehr, Softdrinkkonsum, Frühstück zu Hause, körperliche Aktivität, Sport, Schwimmfähigkeit, Alkoholkonsum,...

Wissenschaftliche Begründung für die Empfehlung des quadrivalenten saisonalen Influenzaimpfstoffs

Gerhard Falkenhorst, Cornelius Remschmidt, Felix Weidemann, Ole Wichmann, Edeltraut Garbe, Thomas Ledig, Martin Terhardt, Sabine Wicker, Fred Zepp & Thomas Mertens
Die STIKO hat auf ihrer Sitzung im November 2017 beschlossen, die Impfung gegen saisonale Influenza mit einem quadrivalenten Influenzaimpfstoff zu empfehlen. Im Epidemiologischen Bulletin 2/2018 ist die ausführliche wissenschaftliche Begründung für diese Entscheidung erschienen.

Comparative Genomics of Escherichia coli Isolated from Skin and Soft Tissue and Other Extraintestinal Infections

Amit Ranjan, Sabiha Shaik, Nishant Nandanwar, Arif Hussain, Sumeet K. Tiwari, Torsten Semmler, Savita Jadhav, Lothar H. Wieler, Munirul Alam, Rita R. Colwell & Niyaz Ahmed
Escherichia coli, an intestinal Gram-negative bacterium, has been shown to be associated with a variety of diseases in addition to intestinal infections, such as urinary tract infections (UTIs), meningitis in neonates, septicemia, skin and soft tissue infections (SSTIs), and colisepticemia. Thus, for nonintestinal infections, it is categorized as extraintestinal pathogenic E. coli (ExPEC). It is also an opportunistic pathogen, causing cross infections, notably as an agent of zoonotic diseases. However, comparative genomic data providing functional...

Handlungsempfehlungen für die Erstellung von Hitzeaktionsplänen zum Schutz der menschlichen Gesundheit

Robert Koch-Institut
Die im nachfolgenden Dokument gegebenen Empfehlungen zur Prävention hitzebedingter Erkrankungen wurden von einem Autorenteam der oben genannten Ad-hoc Arbeitsgruppe erstellt. Sie sollen eine hohe Bekanntheit und eine möglichst breite Anwendung u.a. im öffentlichen Gesundheitsdienst erfahren.

Implementation of the European health interview survey (EHIS) into the German health update (GEDA)

Cornelia Lange, Jonas D. Finger, Jennifer Allen, Sabine Born, Jens Hoebel, Ronny Kuhnert, Stephan Müters, Jürgen Thelen, Patrick Schmich, Marike Varga, Elena Von Der Lippe, Matthias Wetzstein & Thomas Ziese
Background: This methodological paper describes the integration of the ‘European Health Interview Survey wave 2’ (EHIS 2) into the ‘German Health Update’ 2014/2015 (GEDA 2014/2015-EHIS). Methods: GEDA 2014/2015-EHIS is a cross-sectional health survey. A two-stage stratified cluster sampling approach was used to recruit persons aged 15 years and older with permanent residence in Germany. Two different modes of data collection were used, self-administered web questionnaire and self-administered paper questionnaire. The survey instrument implemented the EHIS...

The Flagellar Regulon of Legionella—A Review

Sandra Appelt & Klaus Heuner
The Legionella genus comprises more than 60 species. In particular, Legionella pneumophila is known to cause severe illnesses in humans. Legionellaceae are ubiquitous inhabitants of aquatic environments. Some Legionellaceae are motile and their motility is important to move around in habitats. Motility can be considered as a potential virulence factor as already shown for various human pathogens. The genes of the flagellar system, regulator and structural genes, are structured in hierarchical levels described as the...

Utilization of outpatient medical care in Germany

Franziska Prütz & Alexander Rommel
Outpatient care in Germany is mainly provided in physicians’ private practices. Data from health surveys enable to analyse the utilization of outpatient services from the patient’s perspective, and to identify associations with social determinants and other influencing factors. As part of the GEDA 2014/2015-EHIS study, data was collected for the indicator ‘utilization of outpatient medical care in the last 12 months’. The analysis found that 90.9% of women aged 18 years and over and 84.1%...

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