590 Works

Secondary data in diabetes surveillance – co-operation projects and definition of references on the documented prevalence of diabetes

Christian Schmidt, Christin Heidemann, Alexander Rommel, Ralph Brinks, Heiner Claessen, Jochen Dreß, Bernd Hagen, Annika Hoyer, Gunter Laux, Johannes Pollmanns, Maximilian Präger, Julian Böhm, Saskia Drösler, Andrea Icks, Stephanie Kümmel, Christoph Kurz, Tatjana Kvitkina, Michael Laxy, Werner Maier, Maria Narres, Joachim Szecsenyi, Thaddäus Tönnies, Maria Weyermann, Rebecca Paprott, Lukas Reitzle … & Thomas Ziese
In addition to the Robert Koch Institute’s health surveys, analyses of secondary data are essential to successfully developing a regular and comprehensive description of the progression of diabetes as part of the Robert Koch Institute’s diabetes surveillance. Mainly, this is due to the large sample size and the fact that secondary data are routinely collected, which allows for highly stratified analyses in short time intervals. The fragmented availability of data means that various sources of...

Development of Mobile Laboratory for Viral Hemorrhagic Fever Detection in Africa

Manfred Weidmann, Ousmane Faye, Oumar Faye, Ahmed Abd El Wahed, Pranav Patel, Christophe Batejat, Jean Claude Manugerra, Aimee Adjami, Matthias Niedrig, Frank T. Hufert & Amadou A. Sall
Background A mobile laboratory transportable on commercial flights was developed to enable local response to viral hemorrhagic fever outbreaks. Methods The development progressed from use of mobile real-time reverse-transcription polymerase chain reaction to mobile real-time recombinase polymerase amplification. In this study, we describe various stages of the mobile laboratory development. Results A brief overview of mobile laboratory deployments, which culminated in the first on-site detection of Ebola virus disease (EVD) in March 2014, and their...

Rationaler Antibiotikaeinsatz als ethische Herausforderung

Jasper Littmann & Alena Buyx
Antibiotikaresistenz stellt eine der größten Herausforderungen für die Gesundheitsversorgung des 21. Jahrhunderts dar. Dieser Artikel beleuchtet die ethischen Probleme, die als Resultat der Antibiotikaresistenz entstehen. Dabei muss zwischen zwei Kategorien von ethischen Problemen im Infektionsschutz unterschieden werden: Problemen, die durch Antibiotikaresistenz verstärkt werden, und Problemen, die überhaupt erst durch Antibiotikaresistenz entstehen. In die zweite Kategorie, die in diesem Artikel näher betrachtet wird, fallen unter anderem Fragen der gerechten Verteilung von effektiven Antibiotika, wenn diese als...

The successful uptake and sustainability of rapid infectious disease and antimicrobial resistance point-of-care testing requires a complex ‘mix-and-match’ implementation package

John P. Hays, Konstantinos Mitsakakis, Saturnino Luz, Alex Van Belkum, Karsten Becker, Ann Van Den Bruel, Stephan Harbarth, John H. Rex, Gunnar Skov Simonsen, Guido Werner, Valentina Di Gregori, Gerd Lüdke, Tjeerd Van Staa, Jacob Moran-Gilad & Till T. Bachmann
The emergence and spread of antimicrobial resistance is one of the major global issues currently threatening the health and wealth of nations, with effective guidelines and intervention strategies urgently required. Such guidelines and interventions should ideally be targeted at individuals, communities, and nations, requiring international coordination for maximum effect. In this respect, the European Joint Programming Initiative on Antimicrobial Resistance Transnational Working Group ‘Antimicrobial Resistance - Rapid Diagnostic Tests’ (JPIAMR AMR-RDT) is proposing to consider...

Reduction of the survival time of pig xenotransplants by porcine cytomegalovirus

Joachim Denner
Background Xenotransplantation using pig cells, tissues and organs may help to overcome the shortage of human tissues and organs for the treatment of tissue and organ failure. Progress in the prevention of immunological rejection using genetically modified pigs and new, more effective, immunosuppression regimens will allow clinical application of xenotransplantation in near future. However, xenotransplantation may be associated with the transmission of potentially zoonotic porcine microorganisms. Until now the only xenotransplantation-associated transmission was the transmission...

Status, quality and specific needs of Ebola virus diagnostic capacity and capability in laboratories of the two European preparedness laboratory networks EMERGE and EVD-LabNet

Chantal B. Reusken, Ramona Mögling, Pieter W. Smit, Roland Grunow, Giuseppe Ippolito, Antonino Di Caro & Marion Koopmans
From December 2013 to March 2016, West Africa experienced the largest Ebola virus (EBOV) outbreak to date, leading to a European-wide activation of laboratory preparedness and response. At the end of the outbreak, laboratories associated with the two European preparedness networks of expert laboratories EMERGE JA and EVD-LabNet were invited to participate in an assessment of the response of European laboratories to the EBOV outbreak, to identify learning points and training needs to strengthen future...

Negligible import of enteric pathogens by newly arrived asylum seekers and no impact on incidence of notified Salmonella and Shigella infections and outbreaks in Rhineland-Palatinate, Germany, January 2015 to May 2016

Lutz Ehlkes, Maja George, Donald Knautz, Florian Burckhardt, Klaus Jahn, Manfred Vogt & Philipp Zanger
Introduction The 2015 refugee crisis raised concerns about an import of infectious diseases affecting the German population. Aims: To evaluate public and individual health benefits of stool screening, and explore whether importation of enteric pathogens by newly arrived asylum seekers impacts on the host population. Methods: We used data from mandatory stool screening to determine the overall, age, sex, and country-specific prevalence of enteric bacteria and helminths. We used surveillance data to assess whether the...

Intergenerational Educational Pathways and Self-Rated Health in Adolescence and Young Adulthood: Results of the German KiGGS Cohort

Julia Waldhauer, Benjamin Kuntz, Elvira Mauz & Thomas Lampert
Health differences in social mobility are often analysed by income differences or different occupational positions. However, in early adulthood many young people still have very diffuse income situations and are not always fully integrated into the labour market despite many having finished school. This article focusses on the link between intergenerational educational pathways and self-rated health (SRH) among young adults considering their SRH in adolescence. The data source used is the German KiGGS cohort study....

Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3

Celeste Sassi, Michael A. Nalls, Perry G. Ridge, Jesse R. Gibbs, Michelle K. Lupton, Claire Troakes, Katie Lunnon, Safa Al-Sarraj, Kristelle S. Brown, Christopher Medway, Jenny Lord, James Turton, Jose Bras, Peter Passmore, David Craig, Janet Johnston, Bernadette McGuinness, Stephen Todd, Reinhard Heun, Heike Kölsch, Patrick G. Kehoe, Emma R. L. C. Vardy, Nigel M. Hooper, A. David Smith, Gordon Wilcock … & John Hardy
Mendelian adult-onset leukodystrophies are a spectrum of rare inherited progressive neurodegenerative disorders affecting the white matter of the central nervous system. Among these, cerebral autosomal dominant and recessive arteriopathy with subcortical infarcts and leukoencephalopathy, cerebroretinal vasculopathy, metachromatic leukodystrophy, hereditary diffuse leukoencephalopathy with spheroids, and vanishing white matter disease present with rapidly progressive dementia as dominant feature and are caused by mutations in NOTCH3, HTRA1, TREX1, ARSA, CSF1R, EIF2B1, EIF2B2, EIF2B3, EIF2B4, and EIF2B5, respectively. Given...

Die globale Polio-Eradikation ist zum Greifen nahe - Ziel ist das Jahr 2023

Raskit Lachmann, Katalyn Rossmann, Sabine Diedrich & Ole Wichmann
Der Beitrag im Epidemiologischen Bulletin 14/2019 gibt einen Überblick über das aktuelle Vorkommen von Poliomyelitis weltweit. Die letzte in Deutschland erworbene Erkrankung an Poliomyelitis durch ein Wildvirus wurde 1990 erfasst. Die letzten beiden importierten Fälle (aus Ägypten und Indien) wurden 1992 registriert. Wegen der Möglichkeit eines Reimportes von Polioviren müssen die Pfeiler der Polioeradikation – hohe Impfquoten und Überwachung – auch in poliofreien Regionen solange intensiv weitergeführt werden, bis die globale Polioeradikation erreicht ist. In...

Influenza-Wochenbericht

Robert Koch-Institut
Die Aktivität der akuten Atemwegserkrankungen (ARE) ist in der 13. KW 2019 insgesamt zurückgegangen. Die Werte des Praxisindex lagen in der 13. KW 2019 im Bereich geringfügig erhöhter ARE-Aktivität. Im Nationalen Referenzzentrum für Influenza (NRZ) wurden in der 13. KW 2019 in 58 (56 %) von 104 Sentinelproben respiratorische Viren identifiziert. Dabei handelt es sich in der aktuellen Berichtswoche zum größten Teil um Influenzaviren. Die Influenza-Positivenrate lag bei 32 % (95 %-Vertrauensbereich 23 bis 41...

Seasonality and geographical spread of respiratory syncytial virus epidemics in 15 European countries, 2010 to 2016

Eeva K. Broberg, Matti Waris, Kari Johansen, René Snacken, Pasi Penttinen &
Respiratory syncytial virus (RSV) is considered the major pathogen causing severe lower respiratory tract infections among infants and young children [1]. RSV is the most common cause of hospitalisation for acute lower respiratory tract infection in children younger than 5 years and is estimated to cause between 66,000 and 199,000 deaths worldwide every year [2]. Its significance in causing substantial morbidity and hospitalisation in the first year of life has been affirmed in a recent...

Potential adjustment methodology for missing data and reporting delay in the HIV Surveillance System, European Union/European Economic Area, 2015

Magdalena Rosinska, Nikos Pantazis, Janusz Janiec, Anastasia Pharris, Andrew J. Amato-Gauci, Chantal Quinten &
HIV remains one of the most important public health concerns in the European Union and European Economic Area (EU/EEA). Accurate data are therefore crucial to appropriately direct and evaluate public health response. The European Centre for Disease Prevention and Control (ECDC) and the World Health Organization Regional Office for Europe (WHO/Europe) have jointly coordinated enhanced HIV/AIDS surveillance in the European Region since 2008. The general objectives of the surveillance system in EU/EEA countries include monitoring...

Editorial

Franziska Prütz
Platzhalter

(Englisch) Editorial

Franziska Prütz
Platzhalter

(Englisch) Zugangsbarrieren zur gesundheitlichen Versorgung von Frauen ab 50 Jahren

Laura Krause & Franziska Prütz
Platzhalter

Gesundheitsberichterstattung zu Menschen mit Migrationshintergrund – Auswahl und Definition von (Kern-)Indikatoren

Susanne Bartig, Alexander Rommel, Annelene Wengler, Claudia Santos-Hövener, Thomas Lampert & Thomas Ziese
Im Rahmen des Projekts Improving Health Monitoring in Migrant Populations (IMIRA) wurde ein (Kern-)Indikatorenset zur Beschreibung der Gesundheit von Menschen mit Migrationshintergrund entwickelt. Die Recherche und Bewertung von Datenquellen im Bereich Migration und Gesundheit stellte dabei eine wesentliche Voraussetzung dar. Zunächst wurden vier Handlungsfelder mit entsprechenden Themenbereichen bestimmt und mögliche Indikatoren für die jeweiligen Themen definiert. Die Auswahl der Kernindikatoren basierte auf (1) einer systematischen Gegenüberstellung anerkannter Indikatorensysteme, (2) einer Bewertung der Public-Health-Relevanz, (3) Verständlichkeit...

Epidemiologisches Bulletin 13 / 2019

Robert Koch-Institut

Cancers Potentially Preventable through Excess Weight Reduction in Germany in 2010

Antje Wienecke, Hannelore Neuhauser, Klaus Kraywinkel & Benjamin Barnes
Objective: In order to quantify the preventive potential of body weight reduction in Germany, population-attributable risks (PARs) were estimated for 13 cancer types. Methods: PARs were calculated using body weight prevalence from a nationwide survey from 1998, cancer incidence estimates for 2010 from cancer registry data and relative risk estimates from published meta-analyses. Three counterfactual scenarios were evaluated: reducing BMI to maximally 21 kg/m² (main analysis) and weight reductions among overweight and obese persons of...

Epidemiologisches Bulletin 15 / 2019

Robert Koch-Institut

RKI-Ratgeber Lyme-Borreliose

Robert Koch-Institut
Das Robert Koch-Institut hat den RKI-Ratgeber zu Lyme-Borreliose überarbeitet und im Epidemiologischen Bulletin 17/2019 veröffentlicht. Die Herausgabe der Ratgeber-Reihe erfolgt auf der Grundlage des § 4 Infektionsschutzgesetz. Zielgruppe sind Fachkreise, unter anderem Ärzte, medizinisches Fachpersonal und der Öffentliche Gesundheitsdienst. Die Ratgeber werden in Zusammenarbeit mit den Nationalen Referenzzentren, Konsiliarlaboren sowie weiteren Experten erarbeitet.

Human papillomavirus (HPV) vaccination of girls in Germany. Results of the cross-sectional KiGGS Wave 2 study and trends

Christina Poethko-Müller, Nina Buttmann-Schweiger & Anja Takla
Since 2007, the Standing Committee on Vaccination (STIKO) has recommended that all girls receive vaccinations against the human papillomavirus (HPV) in order to reduce the disease burden of cervical cancer. Persistent infections with high-risk HPV subtypes increase a woman’s risk of developing cancer. In the second wave of the German Health Interview and Examination Survey for Children and Adolescents (KiGGS Wave 2, 2014-2017), 42% of 2,958 11- to 17-year-old girls reported that they had received...

Gesundheit: Die Region im Fokus

Joseph Kuhn & Anke-Christine Saß

Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

Background The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 comparative risk assessment (CRA) is a comprehensive approach to risk factor quantification that offers a useful tool for synthesising evidence on risks and risk–outcome associations. With each annual GBD study, we update the GBD CRA to incorporate improved methods, new risks and risk–outcome pairs, and new data on risk exposure levels and risk–outcome associations. Methods We used the CRA framework developed for...

Comparative Secretome Analyses of Human and Zoonotic Staphylococcus aureus Isolates CC8, CC22, and CC398

Tobias Busche, Mélanie Hillion, Vu Van Loi, David Berg, Birgit Walther, Torsten Semmler, Birgit Strommenger, Wolfgang Witte, Christiane Cuny, Alexander Mellmann, Mark A. Holmes, Jörn Kalinowski, Lorenz Adrian, Jörg Bernhardt & Haike Antelmann
The spread of methicillin-resistant Staphylococcus aureus (MRSA) in the community, hospitals and in livestock is mediated by highly diverse virulence factors that include secreted toxins, superantigens, enzymes and surface-associated adhesins allowing host adaptation and colonization. Here, we combined proteogenomics, secretome and phenotype analyses to compare the secreted virulence factors in selected S. aureus isolates of the dominant human- and livestock-associated genetic lineages CC8, CC22, and CC398. The proteogenomic comparison revealed 2181 core genes and 1306...

Registration Year

  • 2019
    590

Resource Types

  • Text
    372
  • Dataset
    7