590 Works

Utilization of physical therapy, speech therapy and occupational therapy by children and adolescents in Germany. Results of the cross-sectional KiGGS Wave 2 study and trends

Alexander Rommel, Birte Hintzpeter & Dominika Urbanski
Allied health services such as physical therapy, speech therapy and occupational therapy contribute to the early treatment of health disorders in children and adolescents and promote a healthy development. This article describes the utilization of these allied health services by children and adolescents in Germany and analyses its association with demographic and social factors. The analyses are based on the second wave of the German Health Interview and Examination Survey for Children and Adolescents (KiGGS...

Social differences in the utilization of medical services by children and adolescents in Germany. Results of the cross-sectional KiGGS Wave 2 study

Thomas Lampert, Franziska Prütz, Alexander Rommel & Benjamin Kuntz
Data from the German Health Interview and Examination Survey for Children and Adolescents (KiGGS) enable conclusions about the utilization of outpatient and inpatient medical services by children and adolescents accounting the family’s socioeconomic status (SES). Results from the second follow-up to the KiGGS survey (KiGGS Wave 2), which covers the years 2014 to 2017, clearly demonstrate that children and adolescents from families with a low SES visit specialists in general medicine, gynaecologists and psychiatrists, as...

Uptake of orthodontic treatment by children and adolescents in Germany. Results of the cross-sectional KiGGS Wave 2 study and trends

Stefanie Seeling & Franziska Prütz
For patients with considerable malfunctions, or where these could potentially develop, statutory health insurers completely cover the cost of correcting malpositionings of the teeth and jaws through orthodontic treatment in Germany. Based on the self-reported information from the second wave of the German Health Interview and Examination Survey for Children and Adolescents (KiGGS Wave 2, 2014-2017), the uptake of orthodontic treatment was analysed. A total of 25.8% of the girls and 21.1% of the boys...

Ergänzung zur Empfehlung der KRINKO „Hygienemaßnahmen bei Infektionen oder Besiedlung mit multiresistenten gramnegativen Stäbchen“ (2012) im Zusammenhang mit der von EUCAST neu definierten Kategorie „I“ bei der Antibiotikaresistenzbestimmung: Konsequenzen für die Definition von MRGN

Das European Committee on Antimicrobial Susceptibility Testing (EUCAST) hat die Kategorie "I" bei der Antibiotika-Resistenz­bestimmung neu definiert. Demnach berücksichtigen die Bewertungen "S" und "I" ab dem 1.1.2019 mit Inkrafttreten der neuen EUCAST-Grenzwert­tabellen 9.0 explizit Aspekte der Dosierung bzw. der am gewünschten Wirkort erreichbaren Konzentrationen der jeweiligen Substanzen. Das neue "I" bedeutet somit "sensibel bei erhöhter (Increased) Exposition" und "S" bedeutet "sensibel bei normaler Exposition". "R" bedeutet unverändert "resistent". Für die MRGN-Klassifikation zum Zwecke der Ableitung...

Whole Genome Characterization of Orthopoxvirus (OPV) Abatino, a Zoonotic Virus Representing a Putative Novel Clade of Old World Orthopoxviruses

Cesare E. M. Gruber, Emanuela Giombini, Marina Selleri, Simon H. Tausch, Andreas Andrusch, Alona Tyshaieva, Giusy Cardeti, Raniero Lorenzetti, Lorenzo De Marco, Fabrizio Carletti, Andreas Nitsche, Maria R. Capobianchi, Giuseppe Ippolito, Gian Luca Autorino & Concetta Castilletti
Orthopoxviruses (OPVs) are diffused over the complete Eurasian continent, but previously described strains are mostly from northern Europe, and few infections have been reported from Italy. Here we present the extended genomic characterization of OPV Abatino, a novel OPV isolated in Italy from an infected Tonkean macaque, with zoonotic potential. Phylogenetic analysis based on 102 conserved OPV genes (core gene set) showed that OPV Abatino is most closely related to the Ectromelia virus species (ECTV),...

Structure-Function Relationship of XCL1 Used for in vivo Targeting of Antigen Into XCR1+ Dendritic Cells

Arthur L. Kroczek, Evelyn Hartung, Stephanie Gurka, Martina Becker, Nele Reeg, Hans Werner Mages, Sebastian Voigt, Christian Freund & Richard Kroczek
XCL1 is the ligand for XCR1, a chemokine receptor uniquely expressed on crosspresenting dendritic cells (DC) in mouse and man. We are interested in establishing therapeutic vaccines based on XCL1-mediated targeting of peptides or proteins into these DC. Therefore, we have functionally analyzed various XCL1 domains in highly relevant settings in vitro and in vivo. Murine XCL1 fused to ovalbumin (XCL1-OVA) was compared to an N-terminal deletion variant lacking the first seven N-terminal amino acids...

Regionale Unterschiede der Entwicklung der Krankenhausbehandlungen

Enno Nowossadeck & Franziska Prütz
Demografische Alterung und Rückgang oder Schrumpfung der Bevölkerungszahl in vielen Gebieten der Bundesrepublik Deutschland sind Kernelemente des demografischen Wandels. Für die betroffenen Regionen ergibt sich eine sinkende Bevölkerungszahl bei gleichzeitigem Wachstum der Zahl Älterer. Welche Folgen regionale Schrumpfungs- resp. Wachstumsprozesse vor dem Hintergrund der demografischen Alterung auf die stationäre Versorgung haben, ist bislang nicht ausreichend analysiert. Im vorliegenden Beitrag wird mittels Dekompositionsanalyse untersucht, welchen Einfluss demografische Alterung und Veränderung der Bevölkerungszahl als demografische Faktoren sowie...

Population size and self-reported characteristics and sexual preferences of men-who-have-sex-with-men (MSM) in Germany based on social network data

Stefan Michael Scholz, Oliver Damm, Svenja Elkenkamp, Ulrich Marcus, Wolfgang Greiner & Axel Jeremias Schmidt
Background In the absence of detailed information about the population size and behaviour data of men-who-have-sex-with-men (MSM), the estimation of prevalence rates of sexually transmitted infections (STIs) and the design of public health interventions become difficult. The aim of the present study is to estimate the lower boundary of age-specific population sizes and retrieve self-reported information from this population. Methods We used publicly accessible data from a large online dating and social network website for...

Cost-effectiveness and budget effect of pre-exposure prophylaxis for HIV-1 prevention in Germany from 2018 to 2058

David A M C Van De Vijver, Ann-Kathrin Richter, Charles A B Boucher, Barbara Gunsenheimer-Bartmeyer, Christian Kollan, Brooke E Nichols, Christoph D Spinner, Jürgen Wasem, Knud Schewe & Anja Neumann
Background Pre-exposure prophylaxis (PrEP) is a highly effective HIV prevention strategy for men-who-have-sex-with-men (MSM). The high cost of PrEP has until recently been a primary barrier to its use. In 2017, generic PrEP became available, reducing the costs by 90%. Aim Our objective was to assess cost-effectiveness and costs of introducing PrEP in Germany. Methods We calibrated a deterministic mathematical model to the human immunodeficiency virus (HIV) epidemic among MSM in Germany. PrEP was targeted...

Participation in group-based physical activity programmes for adults in Germany and associated factors: data from a nationwide cohort study

Susanne Jordan, Susanne Krug & Elena Von Der Lippe
Background Characteristics of different participation groups can provide important information to increase participation in group-based physical activity programmes (GPAPs). This study examined four types of participation in GPAPs and the factors that characterised these participant groups. Methods The present sample comprised 3219 participants. The analyses were based on data from the ‘German Health Interview and Examination Survey for Adults’ (t1) conducted in 2009–2011, which included 3959 people who had participated in the ‘German National Health...

HIV-1 molecular transmission clusters in nine European countries and Canada: association with demographic and clinical factors

Dimitrios Paraskevis, Apostolos Beloukas, Kostantinos Stasinos, Nikos Pantazis, Carmen De Mendoza, Norbert Bannert, Laurence Meyer, Robert Zangerle, John Gill, Maria Prins, Antonella D'Arminio Montforte, Anne-Marte Bakken Kran, Kholoud Porter & Giota Touloumi
Background Knowledge of HIV-1 molecular transmission clusters (MTCs) is important, especially in large-scale datasets, for designing prevention programmes and public health intervention strategies. We used a large-scale HIV-1 sequence dataset from nine European HIV cohorts and one Canadian, to identify MTCs and investigate factors associated with the probability of belonging to MTCs. Methods To identify MTCs, we applied maximum likelihood inferences on partial pol sequences from 8955 HIV-positive individuals linked to demographic and clinical data....

The tyrosine transporter of Toxoplasma gondii is a member of the newly defined apicomplexan amino acid transporter (ApiAT) family

Kathryn E. R. Parker, Stephen J. Fairweather, Esther Rajendran, Martin Blume, Malcolm J. McConville, Stefan Bröer, Kiaran Kirk & Giel G. Van Dooren
Apicomplexan parasites are auxotrophic for a range of amino acids which must be salvaged from their host cells, either through direct uptake or degradation of host proteins. Here, we describe a family of plasma membrane-localized amino acid transporters, termed the Apicomplexan Amino acid Transporters (ApiATs), that are ubiquitous in apicomplexan parasites. Functional characterization of the ApiATs of Toxoplasma gondii indicate that several of these transporters are important for intracellular growth of the tachyzoite stage of...

Sekundärdaten in der Diabetes-Surveillance – Kooperationsprojekte und Referenzdefinition zur administrativen Diabetesprävalenz

Christian Schmidt, Christin Heidemann, Alexander Rommel, Ralph Brinks, Heiner Claessen, Jochen Dreß, Bernd Hagen, Annika Hoyer, Gunter Laux, Johannes Pollmanns, Maximilian Präger, Julian Böhm, Saskia Drösler, Andrea Icks, Stephanie Kümmel, Christoph Kurz, Tatjana Kvitkina, Michael Laxy, Werner Maier, Maria Narres, Joachim Szecsenyi, Thaddäus Tönnies, Maria Weyermann, Rebecca Paprott, Lukas Reitzle … & Thomas Ziese
Neben den Gesundheitssurveys des Robert Koch-Instituts ist die zusätzliche Verwendung von Ergebnissen aus Sekundärdatenanalysen für die Zielsetzung einer wiederkehrenden und umfassenden Beschreibung des Diabetesgeschehens im Rahmen der Diabetes-Surveillance am Robert Koch-Institut unerlässlich. Die wesentlichen Gründe hierfür liegen im großen Stichprobenumfang und der routinemäßigen Erfassung der Sekundärdaten, die tief stratifizierte Auswertungen in zeitlich dichter Folge erlauben. Aufgrund der fragmentierten Datenlage sind verschiedene Sekundärdatenquellen notwendig, um die Indikatoren der vier Handlungsfelder der Diabetes-Surveillance mit Ergebnissen zu befüllen....

Health literacy in men and women with cardiovascular diseases and its association with the use of health care services - Results from the population-based GEDA2014/2015-EHIS survey in Germany

Claudia Diederichs, Susanne Jordan, Olga Domanska & Hannelore Neuhauser
Background Health literacy (HL), defined as the ability to access, understand, appraise and apply health information, offers a promising approach to reduce the development of cardiovascular diseases (CVD) and to improve the management of CVD in populations. Design We used data from nationwide cross-sectional German Health Update (GEDA2014/2015-EHIS) survey. 13,577 adults ≥ 40 years completed a comprehensive standardized paper or online questionnaire including the short form of the European Health Literacy Survey Questionnaire (HLS-EU-Q16). Methods...

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