A crystallographic fragment screening (CFS) has been performed on a spliceosomal yeast protein-protein complex of Aar2 and the RNaseH-like domain of Prp8 (AR). The F2X-Universal Library is a fragment library representing the commercially available chemical space of fragments. 917 fragments have been individually screened via crystal soaking. The datasets that could be successfully auto-processed and auto-refined had been subjected to a Pan-Dataset Density Analysis (PanDDA) (Pearce et al., 2017). This analysis allows to find low...