PanDDA-analyzed data of a crystallographic fragment screening of F2X-Universal Library vs. ARTatjana Barthel, Jan Wollenhaupt, Gustavo M. A. Lima, Markus C. Wahl & Manfred S. Weiss
A crystallographic fragment screening (CFS) has been performed on a spliceosomal yeast protein-protein complex of Aar2 and the RNaseH-like domain of Prp8 (AR). The F2X-Universal Library is a fragment library representing the commercially available chemical space of fragments. 917 fragments have been individually screened via crystal soaking. The datasets that could be successfully auto-processed and auto-refined had been subjected to a Pan-Dataset Density Analysis (PanDDA) (Pearce et al., 2017). This analysis allows to find low...
Helmholtz-Zentrum Berlin für Materialien und Energie, Macromolecular Crystallography, Albert-Einstein-Str. 15, 12489 Berlin, Germany1
MAX IV Laboratory, BioMAX, Fotongatan 2, 224 84 Lund, Sweden1
Freie Universität Berlin, Institute of Chemistry and Biochemistry, Laboratory of Structural Biochemistry, Takustraße 6, 14195 Berlin, Germany1