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My Journey with the HeartWare Ventricular Assist Device- An Obituary

Georg Wieselthaler
Wieselthaler G. My Journey with the HeartWare Ventricular Assist Device- An Obituary. The VAD Journal. 2022; 8(1):e2022813. https://doi.org/10.11589/vad/e2022813

Pulsatility is a Predictive Marker of Improved Cardiac Function in Patients with Liquid Matrixtreated Left Ventricular Assist Devices

Philemon Mikail, Rinku S. Skaria, Marvin J. Slepian, Janny Garcia, Richard G. Smith & Zain I. Khalpey
Objective: Left ventricular assist devices (LVADs) are utilized as a bridge to transplant or as destination therapy for patients with end-stage heart failure. Although cardiac offloading from these devices rarely leads to complete remodeling and functional recovery, the use of mesenchymal cells to modulate heart failure has been explored in recent years due to its intrinsic regenerative properties. Current methods of evaluating cardiac function have too much variability, difficulty of access, or require too frequent...

What Did We Learn about VADs in 2021?

Maya Guglin
This is our 8th annual literature review on mechanical circulatory support (MCS) devices. Our previous reports were well received by the readers. The full text of the reviews for 2014, 2015, 2016, 2017, 2018, 2019, and 20201-7 were downloaded 821, 861, 701, 869, 951, 272, and 365 times, respectively. In this review, we summarized the most interesting and important, from our standpoint, publications from 2021. There may be some slight overlap with the end of...

Fondaparinux as an Alternative Anticoagulant Treatment in Patients with Left Ventricular Assist Devices and Recurrent Gastrointestinal Bleeding: Case Series

Daniela Piani, Andrea Lechiancole, Massimo Maiani Maiani, Igor Vendramin, Sandro Sponga, Elisabetta Auci & Ugolino Livi
Gastrointestinal bleeding (GIB) can occur in patients after left ventricular assist device (LVAD) implantation. In cases of recurrent GIB, the management of anticoagulation treatment represents a challenging situation in which the risk of bleeding recurrence and the need for long-term anticoagulation must be balanced. This case series describes the successful management of anticoagulation in three patients with recurrent GIB using fondaparinux. To our knowledge, these are the first reported cases of recurrent GIB in which...

Highlights of the 2021 Brano Heart Failure Forum

Rajko Radovancevic, Bojan Vrtovec & Igor D. Gregoric
Since 2007, the Branislav “Brano” Radovancevic Heart Failure Forum has been held annually to provide a venue for experts to present and discuss “Innovations and New Treatment Strategies in Heart Failure.” Clinicians and researchers gather yearly in a different Eastern European city to discuss the latest in heart failure diagnostics and therapeutics. The forum was postponed in 2020 due to the COVID-19 pandemic and then resumed in September of 2021 in Graz, Austria. It was...

Extended Cable for Left Ventricular Assist Devices for Monitoring Isolated Patients during the COVID-19 Pandemic

Neal Waxali, James M. Kenward, Yasser Varona, Laurie Loza & Arvind Bhimaraj
We present a method to create an extended cable for patients who are supported by left ventricular assist devices (LVADs) while infected with SARS-CoV-2. The arrangement described facilitates the LVAD monitor console’s positioning outside of the patient’s room to minimize exposure of the mechanical circulatory support team to the novel coronavirus.

Acute Pump Thrombosis within One Hour of a HeartMate 3 Implantation: Case Report

Zubair Shah, Noel Torres Acosta, Amandeep Goyal, Tarun Dalia, Sarah Henkel & Travis Abicht
A 39-year-old male with a history of non-ischemic cardiomyopathy underwent a HeartMate 3 (Abbott Laboratories) implantation. Within an hour of implantation, low flow alarms were noted before exiting the operating room. The alarm was secondary to acute pump thrombosis. This is the first reported case of thrombosis immediately post-implant.

Thyroidectomy in Mechanical Circulatory Support - A Salvage Treatment for Thyrotoxicosis-Induced Cardiogenic Shock: Case Series

Rody G. Bou Chaaya, Lauren M. Saint & Onyedika J. Ilonze
Amiodarone is frequently used to treat arrhythmias in patients supported with left ventricular assist devices. Long term amiodarone use can cause hyperthyroidism ultimately leading to cardiomyopathy and sometimes thyrotoxicosis-induced cardiogenic shock (CS). We describe two cases of thyrotoxicosis-induced CS rescued by successful thyroidectomy under mechanical circulatory support (MCS) – one with a Heartmate III (Abbott Laboratories) and another supported with venoarterial extracorporeal membrane oxygenation (V-A ECMO). In refractory CS, the initiation of V-A ECMO as...

Impact of Atrial Fibrillation on Outcomes after Left Ventricular Assist Device Implantation: Systematic Review and Meta-Analysis

Chandan Buttar, Sofia Lakhdar, Mahmood Nassar, Nso Nso, Giovina Collura & Most Sirajum Munira
Background: Atrial fibrillation (AF) is a common finding in patients with heart failure and is well-known for its deleterious effects on cardiac function and hemodynamics; however, there are gaps in knowledge regarding the impact of AF on patients with left ventricular assist devices (LVADs). Methods: In this study, we searched PubMed/Medline, Embase, and Cochrane Library databases through September 2021 to find articles that assessed the outcomes of AF in patients with LVADs. Results: A total...

Successful Percutaneous Management of LVAD Outflow Graft Stenosis: Role of Invasive Hemodynamics in Decision Making

Tarun Dalia, Amandeep Goyal, Harsh Mehta, Henedine C. Foster, Eric Hockstad, Aaron Rohr, Philip Johnson, Travis O. Abicht & Bhanu P. Gupta
Left ventricular assist device (LVAD) outflow graft stenosis (OGS) is a rare but lethal complication. We present a case of a 79-year-old male with pertinent past medical history of an LVAD implanted as destination therapy, stage III chronic kidney disease, and hypertension. He was admitted for low-flow alarms, and the echocardiogram showed stable right ventricle function and no pericardial effusion. Invasive hemodynamic assessments demonstrated a peak-to-peak gradient of 90 mm Hg in the outflow graft...

A Unique Case of Inflow Cannula Obstruction by a Tissue Membrane

Roopa A. Rao, Kashif Saleem, Bistees George & Maya Guglin
The use of a left ventricular assist device has increased and is a primary surgical treatment for heart failure. However, one major complication of left ventricular assist device support is an obstruction in the blood flow pathway. Pump thrombosis and outflow graft occlusion are some of the common causes of such obstructions. Here, we describe a unique case of HeartMate II (Abbott Laboratories) inflow cannula obstruction from a membranous structure without evidence of thrombus. The...

Predicting Left Ventricular Assist Device Outcomes Utilizing the Stanford Integrated Psychosocial Assessment for Transplant Measure

Nicholas J. Chesher, Kristina L. Greenwood, Candace Fanale, Cody Gustavenson, Brian Jaski, Hirsch S. Mehta, Peter Hoagland, Kristine Ortiz, Marc Verlasky, Robert Adamson & Walter Dembitsky
Objective: Durable mechanical circulatory support is a proven therapy to extend survival for patients with end-stage heart failure (HF). The International Society for Heart and Lung Transplantation guidelines recommend a detailed psychosocial assessment when selecting candidates for durable mechanical circulatory support. Currently, there are no formally validated psychosocial evaluation tools for left ventricular assist device (LVAD) candidacy. The Stanford Integrated Psychosocial Assessment for Transplantation (SIPAT) uses a multidisciplinary algorithm to evaluate the impact of pre-transplant...

Intra-aortic Balloon Pump may Attenuate Adverse Hemodynamic Effects of Negative Intrathoracic Pressure in Cardiogenic Shock: Case Report

Faris G. Araj
High negative intrathoracic pressure (NIP), as occurs during obstructive sleep apnea or hiccups, results in adverse hemodynamic consequences, specifically decreased left ventricle (LV) performance. These untoward effects can potentially be catastrophic in the case of an already compromised LV in cardiogenic shock. The interplay of intra-aortic balloon pump counterpulsation during abrupt high NIP in cardiogenic shock is described.

Left Atrial Veno-Arterial Extracorporeal Membrane Oxygenation (LAVA-ECMO): Percutaneous Bi-Atrial Drainage to Avoid Pulmonary Edema in a Patient with Left Ventricular Systolic Dysfunction

Kenneth R. Dulnuan, Joseph B. Zwischenberger, John G. Gurley & Maya Guglin
Veno-arterial extracorporeal membrane oxygenation (V-A ECMO) is used in patients with severe cardiogenic shock refractory to medical therapy. During V-A ECMO, retrograde flow in the aorta towards the left ventricle (LV) causes increased left-sided filling pressures, which may lead to pulmonary edema. Different strategies have been proposed to decompress the left heart, including placement of an intraaortic balloon pump (IABP), Impella® (Abiomed), or TandemHeart® (Cardiac Assist).1-3 Percutaneous decompression of the left atrium via placement of...

Registration Year

  • 2022

Resource Types

  • Data Paper


  • Indiana University
  • Robert Wood Johnson University Hospital
  • Medtronic (United States)
  • Houston Methodist
  • Ochsner Medical Center
  • University of Kentucky
  • University of Kansas Medical Center
  • University of Arizona
  • HonorHealth
  • Icahn School of Medicine at Mount Sinai