5,034 Works

Storm, Stress, and Nicotine: Examining the interactive effects of adolescent stress and adolescent nicotine on the development of long-term learning deficits

In order to continue the decline of smoking prevalence, it is imperative to understand the factors that contribute to the development of nicotine and tobacco addiction, such as adolescent initiation of nicotine use, stress, and the interaction of adolescent stress and adolescent nicotine. Both clinical and preclinical literature indicates that adolescent, but not adult, nicotine administration leads to long-lasting impairments in learning and memory and affect. Specifically, chronic nicotine treatment beginning in early adolescence or...

BLACK GIRL MAGIC: EXPLORING AND UNDERSTANDING THE ACADEMIC AND ATHLETIC EXPERIENCES OF BLACK FEMALE STUDENT ATHLETES AT PREDOMINANTLY WHITE DIVISION I UNIVERSITIES

This qualitative research explored the unique experiences of Black female student athletes. Specifically, Black female student athletes at Division I (D-I), Predominantly White Institutions, academic and athletic experiences were explored as factors that may contribute to the National Collegiate Athletic Association (NCAA) graduation success rate (GSR). Participants for this study included Black female student athletes from different Division I schools on the east coast. Accounts of the findings include the collection, data analysis, and interpretations...

Anomalous Apparitions of Light in Colonial America: Visions of Comets, New Stars, the Aurora Borealis, and Rainbows

This dissertation examines the body of literature that formed around anomalous light apparitions (comets, new stars, the aurora borealis, and rainbows) as it explores questions about the representation and response to celestial and meteorological phenomena during the seventeenth and eighteenth centuries in colonial America. I further consider the ways that these texts’ meanings are informed by rational scientific thought and by other non-scientific or non-rational, emotive, or aesthetic modes of thinking. I consider how these...

DECLINE OF A HERITAGE LANGUAGE, PALAUAN: THE INTERPLAY OF LANGUAGE POLICIES, PLANNING, PRACTICES AND OPINIONS IN PALAU

This case study investigates the language policies and planning (LPP) implemented in Palau since the occupation by Japan before and during World War II, and by the United States of America under the United Nation's Trusteeship after the war. Palau is an island country in the Pacific with a population of 17,500, including 4,600 foreign-born citizens. The society is multilingual as a result of a 150-year occupation by other countries, including Japan and the United...

CURATED GROUND: PUBLIC HISTORY, MILITARY MEMORY, AND SHARED AUTHORITY AT BATTLE SITES IN NORTH AMERICA

This thesis is a synthesis of two separate research projects conducted in the summer of 2018 and the spring of 2020. The first project was conducted in conjunction with the Fort Ticonderoga Association as a means of exploring the memory and legacy of a historic military landmark in written history, interpretation, and public memory. The second project was conducted in conjunction with the National Park Service (NPS) and the American Battlefield Protection Program (ABPP) with...

CONSTRAINED β–PROLINES: I. METHANOPYRROLIDINE β-AMINO ACIDS: SYNTHESIS AND CHARACTERIZATION OF NOVEL C6- SUBSTITUTED ANALOGUES AND PEPTIDE OLIGOMERS II. SYNTHESIS OF 2,2-DISUBSTITUTED PYRROLIDINE-3-CARBOXYLIC ACIDS

In the study of structurally restricted cyclic β-amino acids and peptides, methanopyrrolidine-5-carboxylic acids (MetPyr-5-acids), or 5-syn-carboxy-2-azabicyclo[2.1.1] hexanes, and derivatives were investigated. MetPyr-5-acids are a series of highly conformationally constrained β-proline derivatives, which belong to a novel category of β-amino acids utilized as building blocks for the synthesis of β-peptides. These β-peptides lack the backbone hydrogen bonds necessary for folding in the usual manner. Substituents and functional groups in this ring system were envisioned to impact...

THE CHANGES AND CONTRIBUTORS TO THE PERCEPTION OF RETIREMENT INCOME ADEQUACY

This study examines the contributing factors that influence the variation in the perception of retirement income adequacy, analyzing U.S. households who are in the nearing retirement stage (age 55-64) in 2007 along with U.S. households who are in the first stage of retirement (age 65-74) in 2016, within the Survey of Consumer Finances. This study performs pair-matching or one-to-one propensity score matching of the cohort nearing retirement in the 2007 SCF dataset with those of...

The Opulent City and the Sylvan State: Art and Environmental Embodiment in Early National Philadelphia

This dissertation investigates the ways in which Philadelphia artists and architects visualized, comprehended, and reformed the city's rapidly changing urban environment in the early republic, prior to the modern articulation of "ecology" as a scientific concept by late nineteenth-century naturalists such as Ernst Haeckel. I consider a variety of different media--including popular depictions and manifestations of Penn's Treaty Elm, fireplace and stove models by Charles Willson Peale, architectural designs for the Philadelphia Waterworks by Benjamin...

FUNCTIONAL PROTEIN TYROSINE PHOSPHATASES IN PLATELETS

Platelets are small anucleate cells in blood that are derived from megakaryocytes and their primary function is to prevent bleeding. Upon vascular injury, the sub-endothelial collagen gets exposed to which platelets bind and aggregate eventually forming a platelet plug. There are several receptors on platelet surface that can be divided into two broad categories; the immune-receptor tyrosine-based activation motif (ITAM) and the G protein-coupled receptors (GPCRs). The role of several protein tyrosine kinases (PTKs) downstream...

Women of Different Desires: Disrupting the “Barren Motif” in the Hebrew Bible

It is often left unquestioned that women in the Hebrew Bible desired children. Though this is highly probable, many scholars make the assumption that all women necessarily wanted children. Universalizing the desire for children reduces complex characters to stand-ins for a supposed motif. This also essentializes the role of a female character to that of child-bearer, when actually these women have many different roles. Furthermore, many scholars make the claim that having children is the...

PRE-SERVICE EFL TEACHERS' POSSIBLE SELVES: A LONGITUDINAL STUDY OF THE SHIFTING DEVELOPMENT OF PROFESSIONAL IDENTITIES

The purpose of this interpretive qualitative case study was to explore how possible selves of four pre-service EFL teachers changed during their last 10 months at university and what factors were involved in developing and changing their possible selves. The concept of possible selves is a future-oriented self-concept that involves one's motivation to move toward one's ideal future selves and move away from one's feared selves. Ought-to selves are also believed to work as motivators....

Yogic Agency: The Yoga in Composition and Rhetoric

Eastern practices have an increasing presence in Western locations of human services, such as mental health, hospitals, non-profits, prisons, K-12 education, among others. This trend includes the university and pedagogies of first year writing. The application of Eastern contemplative practice helps some people in certain circumstances, but its use raises questions. In the university classroom, methods like mindfulness meditation and yoga may offer perspectives that inform pedagogy. But, these interventions often lack concrete applicability to...

CARAVAGGIO: PERCEPTION SHIFTS THROUGH SELECTED TWENTIETH– and TWENTY-FIRST CENTURY MUSEUM EXHIBITIONS

The focus of this thesis will be the exploration of the narrative constructs around the life and work of Michelangelo Merisi da Caravaggio (1571–1610). This exploration will occur through the study of selected exhibitions curated on the Lombard artist from the twentieth- through twenty-first centuries. It will demonstrate how museums have played a significant role in the public’s understanding and perception of Caravaggio. In this thesis, I will argue that exhibitions on Caravaggio have supported...

Priority-Based Data Transmission in Wireless Networks using Network Coding

With the rapid development of mobile devices technology, they are becoming very popular and a part of our everyday lives. These devices, which are equipped with wireless radios, such as cellular and WiFi radios, affect almost every aspect of our lives. People use smartphone and tablets to access the Internet, watch videos, chat with their friends, and etc. The wireless connections that these devices provide is more convenient than the wired connections. However, there are...

BIOCHEMICAL STUDIES OF DNA POLYMERASE THETA

POLQ is a unique multifunctional replication and repair gene that encodes a multidomain protein with a N-terminal superfamily 2 helicase and a C-terminal A-family polymerase. Although the function of the polymerase domain has been investigated, little is understood regarding the helicase domain. Multiple studies have reported that polymerase θ-helicase (Polθ-helicase) is unable to unwind DNA. However, it exhibits ATPase activity that is stimulated by single-stranded DNA, which presents a biochemical conundrum. In contrast to previous...

Discovery, Biological and Structural Characterization of ON108600, a Novel Kinase Inhibitor in Triple Negative Breast Cancer

Selective killing of tumor cells requires the identification of drug targets critical to pathways that drive or support cancer progression. Protein kinases are an important class of intracellular enzymes involved in the regulation of biochemical pathways, deregulation of these kinases has been strongly implicated in cancer progression. To identify possible oncogenic kinases to which tumor cells might be selectively addicted, we screened the ON108 series of ATP-mimetic small molecule inhibitors in various triple negative breast...

U.S. AND INDIAN MANAGERIAL BOUNDARY SPANNING BEHAVIORS IN GLOBALLY DISTRIBUTED SOFTWARE TEAMS

This paper explores the construct of Boundaries and Boundary Spanning in software development teams that consist of members located in both the U.S. and in India. Drawing on literature pertaining to boundaries in business, global boundaries, cultural boundaries, virtual team boundaries, and organizational boundaries, two studies were conducted. The first study measured the boundary spanning behaviors of software team managers of 25 teams. These results were analyzed in conjunction with a standard measure of software...

A Thumping From Within Unanswered By Any Beckoning From Without: Resilience Among African American Women, Farmville, Virginia 1951-1963

In 1959, as a reaction to the 1954 Supreme Court's Brown vs Board of Education desegregation decision all public schools in Prince Edward County, Virginia were closed. This dissertation explores one group's response to the schools closings by examining the patterns of resilience that emerged among a group of African American women in Farmville, Prince Edward County, Virginia. Using a multi-disciplinary synthesis of research in education, history, geography, sociology, social movements, personal interviews and questionnaires...

ELUCIDATING THE FUNDAMENTALS OF LASER ELECTROSPRAY MASS SPECTROMETRY AND CHARACTERIZATION OF COMPOSITE EXPLOSIVES AND CLASSIFICATION OF SMOKELESS POWDER AND ITS RESIDUE USING MULTIVARIATE STATISTICAL ANALYSIS

This dissertation expounds growing insight of the electrospray droplet ionization mechanism following ablation of dried hydrophobic and hydrophilic molecules using femtosecond laser pulses and mass analysis of the gas phase ions. Both hydrophobic and hydrophilic molecules were laser vaporized into an electrospray solvent opposite in polarity revealing appreciable ion intensity for all samples in contrast to ESI-MS and DESI measurements were solubility of the analyte in the spray solvent is a prerequisite. Quantitative analysis of...

Rogier van der Weyden: A Netherlandish Artist and the Ferrarese Court

Northern European and Italian Renaissance art have tended to be treated art historically as two opposing styles. Rooted in statements by artists such as Michelangelo and Leon Battista Alberti, it has become a common misconception that Italians did not hold Northern European art in high regard during the late fifteenth and early sixteenth centuries. This thesis seeks to complicate and critique this conventional understanding by looking at the similarities and transalpine exchanges between the artistic...

Guys and Dolls: Scenic Design

This thesis will document the design process and execution of the scenery for Temple University's Fall 2017 production of Guys and Dolls. We will discuss the production process through analysis, research and communication of the design.

Biomechanical control mechanisms and morphology for locomotion in challenging scenarios

Everyday ecologically relevant tasks that affect organismal fitness, such as foraging, reproduction, predator avoidance, and escape responses, rely upon successful locomotion. The effectiveness of animal locomotion depends on many underlying factors, such as the morphology of the locomotor limbs, which evolved to fulfill specific locomotor tasks. Besides morphology, the material properties of the limbs also play a crucial role in locomotion. The skeletal structures of locomotor limbs must be able to withstand the repeated stresses...

Remembrance and The American Revolution: Women and the 1876 Centennial Exhibition

The United States Centennial was a pivotal event to celebrate the founding of the American nation. People came together to show the unity and progress of the United States, specifically after the division of the Civil War. As the industrial revolution took off in earnest, Americans were keen to show the world that they were united and taking the lead in industrial change. Further, to show that the United States was a force in the...

Framing Fitness: Gender, Experts, Popular Magazines, and Healthism

I examined the extent to which Bourdieu's field theory applied to the fitness industry through analysis of magazine content and interviews with a variety of field participants. I found that the processes through which people come to understand and define fitness in different ways, and, at times, develop contradictory positions on the importance and benefits of fitness are in concert with Bourdieu's theory. I argue that in addition to the historical macro forces identified by...

Effect of rhCC10 on the Pro/Anti-Inflammatory Profile of the Immature Lung

There is a gap in the treatment of preterm infants with respiratory distress syndrome. Despite addressing surfactant insufficiency and mechanical instability, currently available exogenous surfactant does not reduce the inflammation that results from aggressive ventilation and hyperoxia. Preterm infants are also deficient in anti-oxidant and anti-inflammatory defenses. All of these factors predispose the infant to bronchopulmonary dysplasia. Recombinant human Club Cell Secretory Protein 10 (rhCC10), known to inhibit sPLA2, has been used to reduce ventilator...

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