4,583 Works

Design, synthesis and evaluation of 5-HT7 antagonists for the treatment of Inflammatory Bowel Disease

The 5-HT7¬ receptor is the most recently discovered 5-HT receptor subtype. 5-HT7 is a GPCR that exhibits a regulatory role in many biological functions in both the central nervous system (CNS) and the periphery. Recent literature has demonstrated a connection between the 5-HT7 receptor and Inflammatory Bowel Disease (IBD) progression. IBD is a devastating disease that affects 1.4 million Americans. Patients suffer from life altering symptoms as a result of severe, chronic inflammation of the...

DIGITAL PAN-AFRICANSIM FOR LIBERATION: AN AFROCENTRIC ANALYSIS OF CONTEMPORARY TRAVEL DISCOURSES BY AFRICAN AMERICANS VISITING MODERN EGYPT

Utilizing Afrocentric thought, this dissertation examines digital Pan-Africanism as a new theory that demonstrates the liberatory potential of digital technology including internet-based writing and businesses. Focusing on the burgeoning Black travel industry, it specifically considers contemporary travel narratives written by African Americans visiting Egypt and includes a thematic analysis of travel blog posts. It highlights the role technology plays in making international travel more accessible to African Americans and the potential that diasporic travel has...

FUNCTION AND GOODNESS IN THE WORK OF PHILIPPA FOOT

Philippa Foot’s account of natural normativity relies on functions. For Foot, having a function is what distinguishes those traits that can serve as the basis for the evaluation of an organism from those traits that cannot. For example, Foot asserts that a blue-headed tit that lacks the blue spot on its head is merely unusual but a peacock that lacks a brightly colored tail is defective because while the blue spot does not have a...

DIGITAL MEDIA AND THE KOREAN DIASPORA: A JOURNEY OF IDENTITY CONSTRUCTION

This dissertation explores how developed digital media technology influences individuals’ daily lives and their everyday practices. Furthermore, it examines how digital media usage has impacted diasporic members’ identity construction process. With the example of the Korean diaspora in the United States as a case study, this dissertation focuses on the impact of digital media, first, in regard to the ways in which diasporic members communicate with others and respond to the national and social issues...

Poverty, Disease, and Port Cities: Global Exchanges in Hospital Architecture during the Age of Exploration

This dissertation examines the cross-cultural circulation of the cruciform design for hospitals as the early modern architectural response to charitable and urban crises, considering the emergence of the plan in Italy and its rapid dissemination during the Age of Exploration (1400-1700). Despite recent media attention on makeshift hospitals, refugee camps, and reconstruction efforts worldwide following natural disasters, wars, and pandemics, the urgency of devising architectural and urban responses to human crises associated with poverty, disease,...

SICKLE CELL CARRIER SCREENING FOR ADOLESCENTS IN SAUDI ARABIA: A MIXED-METHODS APPROACH TO UNDERSTANDING SOCIETAL ACCEPTANCE

Sickle cell disease (SCD) is one of the most common genetic diseases in Saudi Arabia, possibly due to the high rates of intrafamily marriages. This blood disease is recessive; a child can develop SCD only if the two parents carry the abnormal gene. However, carriers are typically asymptomatic, so most do not know their carrier status, which poses potentially serious health implications for future children. A possible preventive measure is early carrier screening for adolescents...

DESIGNING MEETINGS TO DEVELOP A PLAN OF ACTION TO SUPPORT BLACK MALES ENABLED CONSTRUCTIVE CONVERSATIONS REGARDING ISSUES OF RACE

There are major student discipline disparities in schools because Black males are referred to the office and suspended at an alarming rate. They are referred for a multitude of reasons, related to teacher misconceptions, their educational environment, and domestic issues. For this reason, I worked to design a series of meetings that enabled a team to develop a plan of action to reduce students’ undesired behaviors and their underlying causes. An inquiry and action process...

Interleukin 35 inhibits ischemia-induced angiogenesis essentially through the key receptor subunit Interleukin 12 receptor beta 2

Peripheral arterial disease (PAD) is a worldwide disease caused by atherosclerosis. It is a circulatory condition where narrowed blood vessels reduce blood flow to the peripheral such as legs. Although current gold standard treatment for advanced PAD patients is still based on surgical revascularization, there is no effective therapy for many patients that are not suitable for surgery. In addition, better recovery from surgical revascularization largely relies on angiogenesis in the adjacent ischemic tissue. Thus,...

Critical data studies: An introduction

Critical Data Studies (CDS) explore the unique cultural, ethical, and critical challenges posed by Big Data. Rather than treat Big Data as only scientifically empirical and therefore largely neutral phenomena, CDS advocates the view that Big Data should be seen as always-already constituted within wider data assemblages. Assemblages is a concept that helps capture the multitude of ways that already-composed data structures inflect and interact with society, its organization and functioning, and the resulting impact...

Naming and Knowing Revisited: Eyetracking Correlates of Anomia in Progressive Aphasia

Progressive naming impairment (i.e., anomia) is a core diagnostic symptom of numerous pathologies that impact anterior and inferior portions of the temporal lobe. For patients who experience such regional temporal lobe degeneration, patterns of language loss often parallel the degradation of semantic memory, an etiology of naming impairment known as semantic anomia. Previous studies of semantic anomia have focused extensively on the output of naming attempts by contrasting errors, omissions, and distortions as a function...

Syllabus: Texts and Criticism, ENG 3069 (Spring 2019)

Texts and Criticism is designed to explore the basic types of literary criticism and the theories that guide each. All criticism relies on theories, each with its own special set of terms and concepts. Students will concentrate on learning those terms, so that they understand them and can identify them in existing critical writing. The course will view all methods of critical theory as equally valid, and look at why critics might choose one method...

Aggregation, Clickbait and Their Effect on Perceptions of Journalistic Credibility and Quality

Many journalists and industry observers lament that aggregating news underneath sensational headlines will erode credibility and turn off readers. While some scholarly work has studied journalists’ perspectives of this practice, little has been done to understand what audiences think of aggregation and clickbait. This study uses published original and aggregated news articles as stimuli in two online experiments to test readers’ perceptions of news aggregation and clickbait. Aggregation itself has little effect on perceptions of...

Twitter’s influence on news judgment: An experiment among journalists

The literature suggests that journalists give a substantial amount of attention to Twitter and use the platform widely, but the impact of that use on news judgment has not been assessed. We hypothesize that Twitter affects journalists’ news judgment, impacting coverage decisions. To test this, we conducted an online survey experiment on working US journalists (N = 212). We find that journalists who use Twitter less in their work discount news they see on the...

Multiplatform news consumption and its connections to civic engagement

Studies of informational media use have focused on individual platforms or pitted platforms against each other when investigating their connections to civic engagement. This study offers evidence, collected in a 2016 survey of US adults, of how civically engaged individuals consume various types of news content across multiple platforms. Results suggest that the best condition is the most varied one, wherein consumers get news on all six platforms studied. A breakdown of content categories finds...

Tweeting Conventions: Political journalists' use of Twitter to cover the 2012 presidential campaign

This study explores the use of Twitter by political reporters and commentators—an understudied population within the rapidly growing literature on digital journalism—covering the 2012 Republican and Democratic conventions. In particular, we want to know if and how the “affordances” of Twitter are shaping the traditional norms and routines of US campaign reporting surrounding objectivity, transparency, gatekeeping, and horse race coverage, and whether Twitter is bursting the “bubble” of insider talk among reporters and the campaigns...

Identity lost? The personal impact of brand journalism

Researchers have explored the role of organizational and personal branding in journalism, paying particular attention to digital media and social network sites. While these studies have observed a rise in the incorporation of branding practices among journalists, they have largely avoided questions about the implications such shifts in practice may have on the personal identities of journalists. This study addresses that gap, drawing on interviews with 41 reporters and editors from US newspapers. The findings...

Fact Checking the Campaign: How Political Reporters Use Twitter to Set the Record Straight (or Not)

In a multichannel era of fragmented and contested political communication, both misinformation and fact checking have taken on new significance. The rise of Twitter as a key venue for political journalists would seem to support their fact-checking activities. Through a content analysis of political journalists’ Twitter discourse surrounding the 2012 presidential debates, this study examines the degree to which fact-checking techniques were used on Twitter and the ways in which journalists on Twitter adhered to...

Configuration Modeling and Diagnosis in Data Centers

The behavior of all cyber-systems in a data center or an enterprise system largely depends on their configuration which describes the resource allocations to achieve the desired goal under certain constraints. Poorly configured systems become a bottleneck for satisfying the desired goal and add to unnecessary overheads such as under-utilization, loss of functionality, poor performance, economic burden, energy consumption, etc. Ill-effects related to system misconfiguration are well documented with quantifiable metrics showing their impact on...

COMPARING STUDENTS’ LEARNING OUTCOMES AND SATISFACTION IN ONLINE, HYBRID AND FACE-TO-FACE EDUCATION COURSES

The this study examined courses taught within a single College of Education over six semeters to compare face-to-face, hybrid, and online instructional methods as related to student achievement, persistence, and satisfaction. Additionally, a comparison of key student characteristics including sex, race/ethnicity, and residency status was conducted. This study extends the existing literature supporting “no meaningful significant difference” between instructional delivery methods by specifically focusing on courses of similar curriculum as offered within the specific discipline...

An Analysis of Sleep and Ergometer Performance in Collegiate Male Rowers

Introduction: Research has increasingly looked at the effects of sleep on athletic performance. Although there is currently a plethora of data expressing the detrimental effects of sleep deprivation on athletic performance, fewer studies have assessed the effects of sleep extension. Of those studies that have been done, all have been with field or team sport athletes and all have been conducted with athletes who traditionally have practice times later in the day. Rowing is a...

PRESENTING IN THE PRESENT: PUBLIC SPEAKING IN ONLINE COURSES

During the 21st century, colleges have increasingly leveraged online-based courses as a means of instruction, and although public speaking ability is among employers’ most in-demand skills for college graduates, there exists a scarcity of research measuring students’ public speaking skill development in online courses. Even fewer studies measure public speaking skill development in online courses compared to the same skill development in classroom-based versions of the same courses taught by the same instructors. Given this...

Network Update and Service Chain Management in Software Defined Networks

Software Defined Networking (SDN) emerged in recent years to fundamentally change how we design, build and manage networks. To maximize the network utilization, its control plane needs to frequently update the data plane via flow migration as the network conditions change dynamically, which is known as network update. Network Function Virtualization (NFV) addresses the problems of traditional expensive hardware appliances by leveraging virtualization technology to implement network functions in software modules (middleboxes). These software modules,...

Formation and Pathogenicity of Cytotoxic Curli Intermediates

The first observations of biofilms were made by the “father of microbiology” Antonie van Leeuwenhoek in the 17th century. The number of publications on biofilms has grown exponentially in the last 20 years, highlighting the medical relevance of the field. The complexity of the bacterial biofilm as well as its variability across species provides a continual channel for discovery. While all biofilms differ, there are some components that remain standard such as proteins, polysaccharides and...

Registration Year

  • 2020
    4,583

Resource Types

  • Collection
    4,150
  • Text
    428
  • Image
    3
  • Dataset
    2